{"id":"https://openalex.org/W268886103","doi":null,"title":"Reconnecting the CNS and PNS with Stem Cell Transplantation","display_name":"Reconnecting the CNS and PNS with Stem Cell Transplantation","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W268886103","mag":"268886103"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:uu-251546","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-251546","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-251546","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066997907","display_name":"Niclas K\u00f6nig","orcid":"https://orcid.org/0000-0003-0899-046X","observed_orcids":["https://orcid.org/0000-0003-0899-046X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Niclas K\u00f6nig","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5066997907"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.9429000020027161,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.9429000020027161,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.02889999933540821,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.016200000420212746,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sensory-neuron-regeneration","display_name":"sensory neuron regeneration","score":0.7609999775886536},{"id":"https://openalex.org/keywords/neural-stem-cell-transplantation","display_name":"neural stem cell transplantation","score":0.746999979019165},{"id":"https://openalex.org/keywords/human-embryonic-stem-cells","display_name":"human embryonic stem cells","score":0.7860000133514404},{"id":"https://openalex.org/keywords/dorsal-root-ganglia","display_name":"dorsal root ganglia","score":0.8370000123977661},{"id":"https://openalex.org/keywords/axon-regeneration","display_name":"axon regeneration","score":0.5680000185966492},{"id":"https://openalex.org/keywords/neurotrophic-factor-delivery","display_name":"neurotrophic factor delivery","score":0.7039999961853027},{"id":"https://openalex.org/keywords/mesoporous-silica-nanoparticles","display_name":"mesoporous silica nanoparticles","score":1.0},{"id":"https://openalex.org/keywords/glial-differentiation","display_name":"glial differentiation","score":0.5109999775886536}],"concepts":[{"id":"https://openalex.org/C2780371621","wikidata":"https://www.wikidata.org/wiki/Q3709910","display_name":"Disconnection","level":2,"score":0.7535467147827148},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.6715759634971619},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6504043936729431},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6485113501548767},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.6366513967514038},{"id":"https://openalex.org/C2778334475","wikidata":"https://www.wikidata.org/wiki/Q1415275","display_name":"Spinal cord injury","level":3,"score":0.5477874875068665},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5231710076332092},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.5041686296463013},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4658699035644531},{"id":"https://openalex.org/C545314008","wikidata":"https://www.wikidata.org/wiki/Q169953","display_name":"Peripheral nervous system","level":3,"score":0.45388680696487427},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40236759185791016},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.13879433274269104},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.06654268503189087},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:uu-251546","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-251546","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:268886103","doi":null,"is_oa":false,"landing_page_url":"http://uu.diva-portal.org/smash/get/diva2:806430/FULLTEXT01.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:uu-251546","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-251546","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":122,"referenced_works":["https://openalex.org/W290132061","https://openalex.org/W561101863","https://openalex.org/W590414447","https://openalex.org/W1540646074","https://openalex.org/W1895617235","https://openalex.org/W1900293717","https://openalex.org/W1936342032","https://openalex.org/W1962276180","https://openalex.org/W1965571714","https://openalex.org/W1969999459","https://openalex.org/W1971208141","https://openalex.org/W1976594128","https://openalex.org/W1977132072","https://openalex.org/W1979737782","https://openalex.org/W1979963150","https://openalex.org/W1981007362","https://openalex.org/W1982196248","https://openalex.org/W1983488614","https://openalex.org/W1987464002","https://openalex.org/W1992056577","https://openalex.org/W1993405361","https://openalex.org/W1994346389","https://openalex.org/W1995243515","https://openalex.org/W1996648228","https://openalex.org/W1998324254","https://openalex.org/W2002397995","https://openalex.org/W2003382110","https://openalex.org/W2003851213","https://openalex.org/W2006015294","https://openalex.org/W2008325064","https://openalex.org/W2012928251","https://openalex.org/W2013483540","https://openalex.org/W2013895271","https://openalex.org/W2015210486","https://openalex.org/W2015711242","https://openalex.org/W2016898853","https://openalex.org/W2017856054","https://openalex.org/W2018288956","https://openalex.org/W2020943746","https://openalex.org/W2023563139","https://openalex.org/W2023849839","https://openalex.org/W2024490785","https://openalex.org/W2026100132","https://openalex.org/W2029768920","https://openalex.org/W2030665584","https://openalex.org/W2030951541","https://openalex.org/W2033284482","https://openalex.org/W2034500742","https://openalex.org/W2036117048","https://openalex.org/W2037059852","https://openalex.org/W2037438288","https://openalex.org/W2037621645","https://openalex.org/W2040994806","https://openalex.org/W2041900617","https://openalex.org/W2042138711","https://openalex.org/W2042829415","https://openalex.org/W2043740371","https://openalex.org/W2044689537","https://openalex.org/W2045546113","https://openalex.org/W2046265664","https://openalex.org/W2046450144","https://openalex.org/W2047507622","https://openalex.org/W2049516248","https://openalex.org/W2049689731","https://openalex.org/W2050704958","https://openalex.org/W2054300604","https://openalex.org/W2056328978","https://openalex.org/W2056918626","https://openalex.org/W2059673504","https://openalex.org/W2060587384","https://openalex.org/W2060791247","https://openalex.org/W2061558355","https://openalex.org/W2063428082","https://openalex.org/W2067242816","https://openalex.org/W2068364567","https://openalex.org/W2068634777","https://openalex.org/W2069591450","https://openalex.org/W2070645102","https://openalex.org/W2071356679","https://openalex.org/W2079613928","https://openalex.org/W2079616858","https://openalex.org/W2081176154","https://openalex.org/W2081502532","https://openalex.org/W2081874461","https://openalex.org/W2081947473","https://openalex.org/W2082486277","https://openalex.org/W2083347736","https://openalex.org/W2084103197","https://openalex.org/W2085112737","https://openalex.org/W2087211932","https://openalex.org/W2087538987","https://openalex.org/W2088134619","https://openalex.org/W2090325797","https://openalex.org/W2091448816","https://openalex.org/W2092895250","https://openalex.org/W2093696471","https://openalex.org/W2093774327","https://openalex.org/W2095397861","https://openalex.org/W2096902307","https://openalex.org/W2103580807","https://openalex.org/W2106394806","https://openalex.org/W2109715557","https://openalex.org/W2110258673","https://openalex.org/W2112747602","https://openalex.org/W2113249378","https://openalex.org/W2117058176","https://openalex.org/W2129477953","https://openalex.org/W2130745132","https://openalex.org/W2131830199","https://openalex.org/W2135107819","https://openalex.org/W2135769528","https://openalex.org/W2136511265","https://openalex.org/W2144947607","https://openalex.org/W2151293049","https://openalex.org/W2152658454","https://openalex.org/W2157189603","https://openalex.org/W2158626764","https://openalex.org/W2162471211","https://openalex.org/W2162892919","https://openalex.org/W2165725127","https://openalex.org/W2330483953","https://openalex.org/W2407035717"],"related_works":["https://openalex.org/W2042138711","https://openalex.org/W1660324194","https://openalex.org/W2220987653","https://openalex.org/W2205817767","https://openalex.org/W2569338497","https://openalex.org/W2616985385","https://openalex.org/W2242394234","https://openalex.org/W2096902307","https://openalex.org/W2561130149","https://openalex.org/W2205028025"],"abstract_inverted_index":{"Severe":[0],"injury":[1],"may":[2],"result":[3],"in":[4,28,43,79,184,237],"disconnection":[5],"between":[6,97],"the":[7,15,22,86,98,124,130,148,154,258],"peripheral":[8],"and":[9,35,68,100,119,133,153,162,174,183,203,231],"central":[10,16,38],"nervous":[11],"system.":[12],"Regeneration":[13],"of":[14,18,46,51,60,65,70,88,109,137,189,196,215,251,263],"portion":[17],"sensory":[19,47,139,190,253],"neurons":[20,91,118],"into":[21,129],"spinal":[23,101,131,180,199,210,259],"cord":[24,181,200,211,260],"is":[25,266],"notoriously":[26],"poor":[27],"adult":[29],"mammals,":[30],"with":[31,257],"low":[32],"regenerative":[33],"drive":[34],"an":[36],"unpermissive":[37],"environment,":[39],"most":[40],"likely":[41],"resulting":[42],"persistent":[44],"loss":[45],"function.":[48],"A":[49],"variety":[50],"strategies":[52],"have":[53,76,105,142],"been":[54,77,143],"addressedto":[55],"augment":[56],"regeneration,":[57],"including":[58],"application":[59],"growth":[61,71],"promoting":[62],"factors,":[63],"counteraction":[64],"inhibitory":[66],"molecules,":[67],"provision":[69],"permissive":[72],"substrates.":[73],"Stem":[74],"cells":[75,112,173,265],"investigated":[78,106],"these":[80],"contexts,":[81],"as":[82,84,94],"well":[83],"for":[85,113,227],"possibility":[87],"providing":[89],"new":[90],"to":[92,116,123,126,134,186,255],"act":[93],"a":[95,224,240,267],"relay":[96],"periphery":[99],"cord.":[102],"Here":[103],"we":[104],"different":[107],"sources":[108],"neural":[110,170],"stem":[111,172,176,206,228,264],"their":[114],"ability":[115],"form":[117,166],"glia":[120,163],"after":[121,194],"transplantation":[122,195,262],"periphery;":[125],"project":[127],"axons":[128],"cord;":[132],"assist":[135],"regeneration":[136,188,250],"surviving":[138],"neurons.":[140],"These":[141],"performed":[144],"at":[145],"two":[146],"locations:":[147],"\"dorsal":[149],"root":[150,159],"ganglion":[151],"cavity\",":[152],"transitional":[155],"zone":[156],"following":[157],"dorsal":[158],"avulsion.":[160],"Neurons":[161],"were":[164],"generated":[165],"mouse":[167],"boundary":[168],"cap":[169],"crest":[171],"embryonic":[175,205],"cell":[177,207,229],"derived":[178,201,208],"ventral":[179,209],"progenitors,":[182],"addition":[185],"this,":[187],"fibers":[191,254],"was":[192],"observed":[193],"human":[197,204],"fetal":[198],"progenitors":[202],"progenitors.":[212],"Further,":[213],"delivery":[214],"neurotrophic":[216],"factor":[217],"mimetics":[218],"via":[219],"mesoporous":[220],"silica":[221],"nanoparticles":[222],"proved":[223],"valuable":[225],"tool":[226],"survival":[230],"differentiation.":[232],"While":[233],"technological":[234],"advances":[235],"make":[236],"vivo":[238],"differentiation":[239],"realistic":[241],"goal,":[242],"our":[243],"findings":[244],"indicate":[245],"that":[246],"so":[247],"far":[248],"assisting":[249],"host":[252],"reconnect":[256],"by":[261],"more":[268],"reliable":[269],"strategy.":[270]},"counts_by_year":[],"updated_date":"2026-08-13T07:04:57.449891","created_date":"2016-06-24T00:00:00"}