{"id":"https://openalex.org/W26875263","doi":null,"title":"Growth hormone and insulin-like growth factor in non-uremic acidosis and uremic acidosis.","display_name":"Growth hormone and insulin-like growth factor in non-uremic acidosis and uremic acidosis.","publication_year":1997,"publication_date":"1997-03-01","ids":{"openalex":"https://openalex.org/W26875263","mag":"26875263","pmid":"https://pubmed.ncbi.nlm.nih.gov/9067956"},"language":"en","primary_location":{"id":"pmid:9067956","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9067956","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney international. Supplement","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055358969","display_name":"Nancy B. Kuemmerle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N Kuemmerle","raw_affiliation_strings":["Division of Pediatric Nephrology, Virginia Commonwealth University, Medical College of Virginia, Richmond, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Nephrology, Virginia Commonwealth University, Medical College of Virginia, Richmond, USA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I72019824"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113769316","display_name":"Krieg Rj","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R J Krieg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018092191","display_name":"K. Latta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Latta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113849498","display_name":"Anna S. Challa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Challa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005025526","display_name":"James D. Hanna","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J D Hanna","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5091832416","display_name":"Juliana C.N. Chan","orcid":"https://orcid.org/0000-0003-1325-1194","observed_orcids":["https://orcid.org/0000-0003-1325-1194"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J C Chan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.186,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.76174918,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"58","issue":null,"first_page":"S102","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/growth-hormone","display_name":"growth hormone","score":0.972000002861023},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9810000061988831},{"id":"https://openalex.org/keywords/uremic-acidosis","display_name":"uremic acidosis","score":0.9330000281333923},{"id":"https://openalex.org/keywords/renal-tubular-acidosis","display_name":"renal tubular acidosis","score":0.8999999761581421},{"id":"https://openalex.org/keywords/growth-retardation","display_name":"growth retardation","score":0.8759999871253967},{"id":"https://openalex.org/keywords/uremia","display_name":"uremia","score":0.6000000238418579},{"id":"https://openalex.org/keywords/growth-hormone-secretion","display_name":"growth hormone secretion","score":0.5490000247955322},{"id":"https://openalex.org/keywords/chondrocyte-proliferation","display_name":"chondrocyte proliferation","score":0.6940000057220459},{"id":"https://openalex.org/keywords/growth-plate","display_name":"growth plate","score":0.5960000157356262},{"id":"https://openalex.org/keywords/nephrocalcinosis","display_name":"nephrocalcinosis","score":0.8399999737739563},{"id":"https://openalex.org/keywords/hypocitraturia","display_name":"hypocitraturia","score":0.7099999785423279},{"id":"https://openalex.org/keywords/growth-hormone-resistance","display_name":"growth hormone resistance","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8760215044021606},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8510958552360535},{"id":"https://openalex.org/C2776635150","wikidata":"https://www.wikidata.org/wiki/Q13365776","display_name":"Uremia","level":2,"score":0.6635690927505493},{"id":"https://openalex.org/C2779246250","wikidata":"https://www.wikidata.org/wiki/Q1598200","display_name":"Metabolic acidosis","level":2,"score":0.6456816792488098},{"id":"https://openalex.org/C2778553927","wikidata":"https://www.wikidata.org/wiki/Q185089","display_name":"Acidosis","level":2,"score":0.47032034397125244},{"id":"https://openalex.org/C2781079508","wikidata":"https://www.wikidata.org/wiki/Q1516211","display_name":"Renal tubular acidosis","level":3,"score":0.45054352283477783},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.4158458113670349},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39438384771347046},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3290642499923706},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12108370661735535}],"mesh":[{"descriptor_ui":"D000138","descriptor_name":"Acidosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D000138","descriptor_name":"Acidosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000138","descriptor_name":"Acidosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014511","descriptor_name":"Uremia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D014511","descriptor_name":"Uremia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014511","descriptor_name":"Uremia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:9067956","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9067956","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney international. Supplement","raw_type":"Journal Article"},{"id":"mag:26875263","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9067956","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G532277115","display_name":"VITAMIN E MODULATION OF PROGRESSIVE RENAL DISEASE","funder_award_id":"5r01dk050419-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1981607919","https://openalex.org/W2417893680","https://openalex.org/W2243359242","https://openalex.org/W92965314","https://openalex.org/W2071982302","https://openalex.org/W2010494546","https://openalex.org/W1984327286","https://openalex.org/W1993501296","https://openalex.org/W4235558816","https://openalex.org/W1578830422"],"abstract_inverted_index":{"Growth":[0,149,197],"retardation":[1,72,122],"is":[2,13,77,123],"a":[3,83,126],"cardinal":[4],"feature":[5],"of":[6,39,65,69,85,128,139,165,173,184,218,222,240,242],"children":[7],"with":[8,20],"renal":[9,74,133],"tubular":[10,75],"acidosis.":[11,118],"This":[12],"reversible":[14],"by":[15,152,158],"correcting":[16],"the":[17,36,63,70,95,136,146,162,171,215,219,233,243],"non-uremic":[18],"acidosis":[19,53,76],"alkali":[21],"therapy.":[22],"Sodium":[23],"bicarbonate":[24],"solutions":[25,28],"or":[26],"citrate":[27],"have":[29],"been":[30],"used":[31],"for":[32],"this":[33],"purpose.":[34],"However,":[35],"odious":[37],"taste":[38],"these":[40],"medications":[41],"almost":[42],"invariably":[43],"causes":[44],"medical":[45,55],"noncompliance.":[46],"The":[47,67,208,238],"persistent":[48],"and":[49,59,61,111,135,211,235,249],"often":[50],"profound":[51],"metabolic":[52,93,117,131],"from":[54,179],"noncompliance,":[56],"precipitates":[57],"hypercalciuria":[58],"hypocitraturia,":[60],"increases":[62],"risk":[64],"nephrocalcinosis.":[66],"mechanism":[68],"growth":[71,88,96,107,121,147,174,209,216,241,247],"in":[73,116,194,204,231,252],"thought":[78],"to":[79,82,125],"be":[80],"related":[81],"blunting":[84],"anterior":[86],"pituitary":[87,154],"hormone":[89,97,108,150,175,186,198,210,248],"secretion.":[90],"In":[91,119,169],"experimental":[92],"acidosis,":[94,132],"secretory":[98],"pulse":[99],"areas":[100],"are":[101],"reduced.":[102,226],"Just":[103],"as":[104,142],"importantly,":[105],"hepatic":[106],"receptor":[109,199],"expression":[110,200,213],"IGF-I":[112,189,212,227,250],"mRNA":[113,190],"were":[114],"blunted":[115],"uremia,":[120,170],"secondary":[124],"host":[127],"factors":[129],"including":[130],"osteodystrophy,":[134],"side":[137],"effects":[138],"treatment":[140],"such":[141],"corticosteroids,":[143],"which":[144],"compound":[145],"retardation.":[148],"secretion":[151,172],"individual":[153],"cells":[155],"was":[156,167,176,191,201,225,229],"stimulated":[157],"corticosteroids":[159],"but,":[160],"paradoxically,":[161],"total":[163],"number":[164],"somatotropes":[166],"suppressed.":[168],"not":[177],"different":[178],"controls":[180],"at":[181],"any":[182],"level":[183],"growth-hormone-releasing":[185],"challenges.":[187],"Hepatic":[188],"markedly":[192],"reduced":[193,203],"uremic":[195,205,223,253],"rats.":[196,207],"significantly":[202],"acidotic":[206],"on":[214],"plate":[217],"long":[220],"bone":[221],"rats":[224],"immunoreactivity":[228],"present":[230],"both":[232],"hypertrophic":[234],"proliferative":[236,244],"zones.":[237],"lack":[239],"zones":[245],"suggested":[246],"resistance":[251],"chondrocytes.":[254]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}