{"id":"https://openalex.org/W26788940","doi":null,"title":"Cell senescence in human aging: a review of the theory.","display_name":"Cell senescence in human aging: a review of the theory.","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W26788940","mag":"26788940","pmid":"https://pubmed.ncbi.nlm.nih.gov/10757058"},"language":"en","primary_location":{"id":"pmid:10757058","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10757058","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In vivo (Athens, Greece)","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086201600","display_name":"Michael Fossel","orcid":"https://orcid.org/0000-0003-0726-2276","observed_orcids":["https://orcid.org/0000-0003-0726-2276"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M Fossel","raw_affiliation_strings":["Michigan State University, Ada 49301, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Michigan State University, Ada 49301, USA","institution_ids":["https://openalex.org/I87216513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5086201600"],"corresponding_institution_ids":["https://openalex.org/I87216513"],"apc_list":null,"apc_paid":null,"fwci":2.4491,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.87844875,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"14","issue":"1","first_page":"29","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9079999923706055},{"id":"https://openalex.org/keywords/human-aging","display_name":"human aging","score":0.8600000143051147},{"id":"https://openalex.org/keywords/age-related-diseases","display_name":"age-related diseases","score":0.9959999918937683},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.6809999942779541},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":1.0},{"id":"https://openalex.org/keywords/immunosenescence","display_name":"immunosenescence","score":0.9959999918937683},{"id":"https://openalex.org/keywords/skin-aging","display_name":"skin aging","score":0.9990000128746033},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9240000247955322},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.9039999842643738},{"id":"https://openalex.org/keywords/replicative-senescence","display_name":"replicative senescence","score":0.7319999933242798},{"id":"https://openalex.org/keywords/senescence-associated-secretory-phenotype","display_name":"senescence-associated secretory phenotype","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.8705536127090454},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5497584342956543},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.5397592186927795},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5113017559051514},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46153366565704346},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.4397833049297333},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.42870187759399414},{"id":"https://openalex.org/C2779523775","wikidata":"https://www.wikidata.org/wiki/Q9075999","display_name":"Cellular senescence","level":4,"score":0.42576634883880615},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.41224706172943115},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.412243127822876},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.39817631244659424},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39211586117744446},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.35190725326538086},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.31553617119789124},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2888758182525635},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27817004919052124},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.24209782481193542},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.15114399790763855},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14626413583755493},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:10757058","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10757058","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In vivo (Athens, Greece)","raw_type":"Journal Article"},{"id":"mag:26788940","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10757058","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":2,"referenced_works":["https://openalex.org/W2406347693","https://openalex.org/W2521298622"],"related_works":["https://openalex.org/W2315400613","https://openalex.org/W6957705426","https://openalex.org/W1533909325","https://openalex.org/W2396623896","https://openalex.org/W4399612745","https://openalex.org/W7101060458","https://openalex.org/W2118456529","https://openalex.org/W2117001429","https://openalex.org/W4225323918","https://openalex.org/W2134465683"],"abstract_inverted_index":{"Cell":[0],"senescence":[1,27],"limits":[2],"cell":[3,26,51,53],"divisions":[4],"in":[5,15,34,77,91],"normal":[6],"somatic":[7],"cells":[8],"and":[9,29,37,55,72,79],"may":[10],"play":[11],"a":[12,31],"central":[13],"role":[14],"age-related":[16,38,61],"diseases.":[17,39],"In":[18],"this":[19],"review,":[20],"we":[21,47],"examine":[22],"the":[23,56,85,95],"theory":[24],"that":[25],"underlies":[28],"is":[30,76,88,99],"pivotal":[32],"event":[33],"human":[35,60],"aging":[36],"The":[40],"model":[41],"remains":[42],"completely":[43],"consistent":[44],"with":[45],"what":[46],"currently":[48,89],"know":[49],"of":[50,58],"biology,":[52],"senescence,":[54,67],"pathology":[57],"all":[59],"diseases":[62],"including":[63],"atherosclerosis,":[64],"osteoarthritis,":[65],"immune":[66],"skin":[68],"aging,":[69],"Alzheimer's":[70],"dementia,":[71],"cancer.":[73],"Although":[74],"there":[75,87],"vitro":[78],"ex":[80],"vivo":[81,92],"data":[82,93,98],"to":[83],"support":[84],"model,":[86],"no":[90],"supporting":[94],"theory.":[96],"Such":[97],"probably":[100],"obtainable":[101],"using":[102],"available":[103],"methods":[104],"and,":[105],"if":[106],"confirmatory,":[107],"would":[108],"not":[109],"only":[110],"have":[111],"stunning":[112],"therapeutic":[113],"consequences,":[114],"but":[115],"significant":[116],"commercial":[117],"consequences":[118],"as":[119],"well.":[120]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}