{"id":"https://openalex.org/W26778389","doi":null,"title":"Are reduced quinones necessarily involved in the antitumour activity of quinone drugs?","display_name":"Are reduced quinones necessarily involved in the antitumour activity of quinone drugs?","publication_year":1987,"publication_date":"1987-06-01","ids":{"openalex":"https://openalex.org/W26778389","mag":"26778389","pmid":"https://pubmed.ncbi.nlm.nih.gov/3307874","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2149497"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:1521247","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2149497","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2149497","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108802946","display_name":"John Butler","orcid":"https://orcid.org/0000-0001-8086-0964","observed_orcids":["https://orcid.org/0000-0001-8086-0964"]},"institutions":[{"id":"https://openalex.org/I4210129527","display_name":"Cancer Research UK Manchester Institute","ror":"https://ror.org/037405c78","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I28407311","https://openalex.org/I4210129527"]},{"id":"https://openalex.org/I4210131968","display_name":"The Christie Hospital","ror":"https://ror.org/03nd63441","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J Butler","raw_affiliation_strings":["Department of Biophysical Chemistry, Christie Hospital & Holt Radium Institute, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biophysical Chemistry, Christie Hospital & Holt Radium Institute, Manchester, UK","institution_ids":["https://openalex.org/I4210129527","https://openalex.org/I4210131968"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012851826","display_name":"Brigid M. Hoey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B M Hoey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.446,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.93700557,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"8","issue":null,"first_page":"53","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13012","display_name":"Coenzyme Q10 studies and effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/semiquinone-radicals","display_name":"semiquinone","score":0.871999979019165},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9470000267028809},{"id":"https://openalex.org/keywords/mitomycin-c","display_name":"mitomycin C","score":0.9860000014305115},{"id":"https://openalex.org/keywords/mitoxantrone","display_name":"mitoxantrone","score":0.9940000176429749},{"id":"https://openalex.org/keywords/azq","display_name":"AZQ","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cytotoxicity-mechanism","display_name":"cytotoxicity mechanism","score":0.8769999742507935},{"id":"https://openalex.org/keywords/anticancer-drug-mechanism","display_name":"anticancer drug mechanism","score":0.4560000002384186}],"concepts":[{"id":"https://openalex.org/C2780643102","wikidata":"https://www.wikidata.org/wiki/Q412382","display_name":"Quinone","level":2,"score":0.9185481071472168},{"id":"https://openalex.org/C2776370595","wikidata":"https://www.wikidata.org/wiki/Q3955012","display_name":"Semiquinone","level":3,"score":0.8479369878768921},{"id":"https://openalex.org/C2779686393","wikidata":"https://www.wikidata.org/wiki/Q509361","display_name":"Benzoquinone","level":2,"score":0.7290455102920532},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7062652111053467},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6510847210884094},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6239778399467468},{"id":"https://openalex.org/C139066938","wikidata":"https://www.wikidata.org/wiki/Q185056","display_name":"Radical","level":2,"score":0.6134283542633057},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5209685564041138},{"id":"https://openalex.org/C2779338040","wikidata":"https://www.wikidata.org/wiki/Q19856779","display_name":"Mitomycin C","level":2,"score":0.48768937587738037},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.35350799560546875},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3376346826553345},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25348544120788574},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11183339357376099},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011808","descriptor_name":"Quinone Reductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011809","descriptor_name":"Quinones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011809","descriptor_name":"Quinones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:1521247","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2149497","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2149497","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2149497","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Cancer Suppl","raw_type":"Text"},{"id":"pmid:3307874","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3307874","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of cancer. Supplement","raw_type":"Journal Article"},{"id":"mag:26778389","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3307874","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1521247","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2149497","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W111687522","https://openalex.org/W131431086","https://openalex.org/W1498062955","https://openalex.org/W1509068857","https://openalex.org/W1583228069","https://openalex.org/W1585464718","https://openalex.org/W1611237318","https://openalex.org/W1772882854","https://openalex.org/W1969600052","https://openalex.org/W1972380212","https://openalex.org/W1978470731","https://openalex.org/W1979756814","https://openalex.org/W1985348295","https://openalex.org/W1991818344","https://openalex.org/W1995995023","https://openalex.org/W1996829902","https://openalex.org/W2000387947","https://openalex.org/W2000604632","https://openalex.org/W2001834244","https://openalex.org/W2012207829","https://openalex.org/W2020390042","https://openalex.org/W2021236154","https://openalex.org/W2024425650","https://openalex.org/W2027403336","https://openalex.org/W2040063499","https://openalex.org/W2049829048","https://openalex.org/W2054425281","https://openalex.org/W2069415301","https://openalex.org/W2072275020","https://openalex.org/W2090073585","https://openalex.org/W2093468577","https://openalex.org/W2150263866","https://openalex.org/W2395431819","https://openalex.org/W2417533812","https://openalex.org/W2460205691"],"related_works":["https://openalex.org/W1980022601","https://openalex.org/W1986831247","https://openalex.org/W1035600054","https://openalex.org/W1422261578","https://openalex.org/W2161262276","https://openalex.org/W4233729049","https://openalex.org/W2994116005","https://openalex.org/W1994788263","https://openalex.org/W4406107413","https://openalex.org/W2074272160"],"abstract_inverted_index":{"Several":[0],"studies":[1],"have":[2,80],"shown":[3],"that":[4],"the":[5,30,33,40,52,58,65,84,89,92],"antitumour":[6,98],"quinones,":[7],"adriamycin,":[8],"mitomycin":[9],"C,":[10],"mitozantrone":[11],"and":[12,29,63,88],"3,6-diaziridinyl-2,5-bis":[13],"(carboethoxyamino)-1,4-benzoquinone":[14],"(AZQ)":[15],"can":[16],"form":[17],"semiquinone":[18],"radicals":[19],"in":[20,54,67,97],"vitro.":[21],"The":[22],"biophysical":[23],"chemistry":[24],"data":[25,56],"for":[26,43,57,91],"these":[27,74],"reactions":[28],"properties":[31],"of":[32,73,78,86,94],"radical":[34],"quinones":[35,59,96],"are":[36],"presented":[37],"together":[38],"with":[39,60,64],"proposed":[41,82],"mechanisms":[42],"cytotoxicity.":[44],"An":[45],"attempt":[46],"has":[47],"been":[48,81],"made":[49],"to":[50],"correlate":[51],"available":[53,66],"vitro":[55],"each":[61],"other":[62],"vivo":[68],"data.":[69],"As":[70],"a":[71,76],"consequence":[72],"correlations":[75],"number":[77],"conclusions":[79],"regarding":[83],"techniques":[85],"investigation":[87],"evidence":[90],"role":[93],"reduced":[95],"activity.":[99]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
