{"id":"https://openalex.org/W267712403","doi":null,"title":"The Chromatin Insulator Protein CTCF delays DNA Replication Timing","display_name":"The Chromatin Insulator Protein CTCF delays DNA Replication Timing","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W267712403","mag":"267712403"},"language":"en","primary_location":{"id":"mag:267712403","doi":null,"is_oa":false,"landing_page_url":"http://www.diva-portal.org/smash/record.jsf?pid=diva2:169014","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050519122","display_name":"Rosita Bergstr\u00f6m","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rosita Bergstr\u00f6m","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015347428","display_name":"Magda Lezcano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Magda Lezcano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026919134","display_name":"Mikael Sj\u00f6linder","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mikael Sj\u00f6linder","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088024497","display_name":"Rituparna Mukhopadhyay","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rituparna Mukhopadhyay","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005117443","display_name":"Joanne Whitehead","orcid":"https://orcid.org/0000-0002-9602-2081","observed_orcids":["https://orcid.org/0000-0002-9602-2081"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joanne Whitehead","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9602-2081","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076814487","display_name":"Vijay Kumar Tiwari","orcid":"https://orcid.org/0000-0003-0292-6635","observed_orcids":["https://orcid.org/0000-0003-0292-6635","https://orcid.org/0000-0001-5693-2841"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vijay Tiwari","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0292-6635","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028688287","display_name":"Sreenivasulu Kurukuti","orcid":"https://orcid.org/0000-0002-3485-9214","observed_orcids":["https://orcid.org/0000-0002-3485-9214"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sreenivasulu Kurukuti","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3485-9214","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Anita Mattsson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anita Mattsson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5054367458","display_name":"Rolf I. OHLSSON","orcid":"https://orcid.org/0000-0001-7308-3300","observed_orcids":["https://orcid.org/0000-0001-7308-3300"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rolf Ohlsson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7308-3300","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02033726,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ctcf","display_name":"CTCF","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chromatin-insulators","display_name":"chromatin insulators","score":0.7590000033378601},{"id":"https://openalex.org/keywords/replication-timing","display_name":"DNA replication timing","score":0.9959999918937683},{"id":"https://openalex.org/keywords/igf2-h19-domain","display_name":"Igf2-H19 domain","score":0.777999997138977},{"id":"https://openalex.org/keywords/genomic-imprinting","display_name":"genomic imprinting","score":0.9760000109672546},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.949999988079071},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.828000009059906},{"id":"https://openalex.org/keywords/chromatin-looping","display_name":"chromatin looping","score":0.5199999809265137},{"id":"https://openalex.org/keywords/subnuclear-compartments","display_name":"subnuclear compartments","score":0.7480000257492065},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.7139999866485596},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9150000214576721},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C2778760011","wikidata":"https://www.wikidata.org/wiki/Q21163346","display_name":"CTCF","level":5,"score":0.9824779629707336},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.763208270072937},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6952317357063293},{"id":"https://openalex.org/C2778512757","wikidata":"https://www.wikidata.org/wiki/Q7314076","display_name":"Replication timing","level":4,"score":0.6553752422332764},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6325233578681946},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5943114757537842},{"id":"https://openalex.org/C201492766","wikidata":"https://www.wikidata.org/wiki/Q84087","display_name":"Genomic imprinting","level":5,"score":0.5785451531410217},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.49627214670181274},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47427329421043396},{"id":"https://openalex.org/C212702","wikidata":"https://www.wikidata.org/wiki/Q178150","display_name":"Insulator (electricity)","level":2,"score":0.4388730227947235},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.41496947407722473},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.41493356227874756},{"id":"https://openalex.org/C94715292","wikidata":"https://www.wikidata.org/wiki/Q624349","display_name":"Imprinting (psychology)","level":3,"score":0.4129788279533386},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.20461368560791016},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.14016756415367126},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.1111314594745636},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:267712403","doi":null,"is_oa":false,"landing_page_url":"http://www.diva-portal.org/smash/record.jsf?pid=diva2:169014","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W314535818","https://openalex.org/W213401734","https://openalex.org/W2104770779","https://openalex.org/W308738794","https://openalex.org/W284616400","https://openalex.org/W350989695","https://openalex.org/W2165984435","https://openalex.org/W160720852","https://openalex.org/W2010016618","https://openalex.org/W2122029913"],"abstract_inverted_index":{"The":[0],"genetic":[1],"information":[2,19,74],"required":[3],"for":[4,101,318],"the":[5,17,22,37,57,65,89,112,116,121,130,133,139,184,198,203,210,230,240,243,249,299,315,321,324,333,340,352,363],"existence":[6],"of":[7,11,186,191,205,242,248,254,267,323,335,354],"a":[8,263,311],"living":[9],"cell":[10,46,264,341,364],"any":[12],"kind":[13],"is":[14,62,70,127],"encoded":[15],"in":[16,21,29,48,94,106,226,229,239,343,351],"sequence":[18],"scripted":[20],"double":[23],"helix":[24],"DNA.":[25],"A":[26],"modern":[27],"trend":[28],"biology":[30],"struggles":[31],"to":[32,34,67,172,223,270,292,298,320,332,345,365],"come":[33],"grip":[35],"with":[36,108,151],"amazing":[38],"fact":[39],"that":[40,52,64,75,97,148,156,166,276,306,339,361],"there":[41,356],"are":[42,54,159,302,357],"so":[43],"many":[44,152,295],"different":[45],"types":[47],"our":[49,330],"body":[50],"and":[51,79,105,138,155,193,287,350],"they":[53],"directed":[55],"from":[56,162],"same":[58],"genomic":[59],"blueprint.":[60],"It":[61],"clear,":[63],"key":[66,102],"this":[68,125,218,259],"feature":[69,126],"provided":[71],"by":[72,91,129,197,262],"epigenetic":[73,277,308],"dictates":[76],"how,":[77],"where":[78],"when":[80],"genes":[81,296],"should":[82],"be":[83,285],"expressed.":[84],"Epigenetic":[85],"states":[86,176,283],"\u201cdress":[87],"up\u201d":[88],"genome":[90],"packaging":[92],"it":[93],"chromatin":[95,134],"conformations":[96],"differentially":[98],"regulate":[99],"accessibility":[100],"nuclear":[103],"factors":[104],"coordination":[107],"differential":[109],"localizations":[110],"within":[111],"nucleus":[113],"will":[114],"dictate":[115],"ultimate":[117],"task,":[118],"expression.":[119],"In":[120],"imprinted":[122,175],"Igf2/H19":[123],"domain,":[124],"determined":[128],"interaction":[131],"between":[132],"insulator":[135],"protein":[136],"CTCF":[137,149,167,206,234],"unmethylated":[140],"H19":[141,211],"imprinting":[142,212],"control":[143,213],"region.":[144],"Here":[145],"I":[146,274],"show":[147,275],"interacts":[150],"sites":[153,158,208],"genome-wide":[154],"these":[157],"generally":[160],"protected":[161],"DNA":[163],"methylation,":[164],"suggesting":[165],"function":[168],"has":[169,342],"been":[170],"recruited":[171],"manifest":[173],"novel":[174],"during":[177],"mammalian":[178],"development.":[179],"This":[180,326],"thesis":[181],"also":[182,221,253],"describes":[183],"discovery":[185],"an":[187,236],"epigenetically":[188],"regulated":[189],"network":[190],"intra":[192],"interchromosomal":[194],"complexes,":[195],"identified":[196],"invented":[199],"4C":[200],"method.":[201],"Importantly,":[202],"disruption":[204],"binding":[207,258],"at":[209],"region":[214],"not":[215,246],"only":[216,247],"disconnects":[217],"network,":[219],"but":[220,252],"leads":[222],"significant":[224],"changes":[225],"expression":[227],"patterns":[228],"interacting":[231],"partners.":[232],"Interestingly,":[233],"plays":[235],"important":[237,327,367],"role":[238],"regulation":[241],"replication":[244],"timing":[245],"Igf2":[250],"gene,":[251],"all":[255],"other":[256],"sequences":[257],"factor":[260],"potentially":[261],"cycle-specific":[265],"relocation":[266],"CTCF-DNA":[268],"complexes":[269],"subnuclear":[271],"compartments.":[272],"Finally,":[273],"marks":[278],"signifying":[279],"active":[280],"or":[281],"inactive":[282],"can":[284],"gained":[286],"lost,":[288],"respectively,":[289],"upon":[290],"exposure":[291],"stress.":[293],"As":[294],"belonging":[297],"apoptotic":[300],"pathway":[301],"upregulated":[303],"we":[304],"propose":[305],"stress-induced":[307],"lesions":[309],"represent":[310],"surveillance":[312],"system":[313],"marking":[314],"affected":[316],"cells":[317],"death":[319],"benefit":[322],"individual.":[325],"observation":[328],"opens":[329],"minds":[331],"view":[334],"new":[336],"intrinsic":[337],"mechanisms":[338],"order":[344],"maintain":[346],"proper":[347],"gene":[348],"expression,":[349],"case":[353],"misleads":[355],"several":[358],"check":[359],"points":[360],"direct":[362],"towards":[366],"survival":[368],"decisions.":[369]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
