{"id":"https://openalex.org/W267684348","doi":null,"title":"Effect of electrolytic lesion of the median raphe nucleus on behavioral and physiological measures of stress.","display_name":"Effect of electrolytic lesion of the median raphe nucleus on behavioral and physiological measures of stress.","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W267684348","mag":"267684348","pmid":"https://pubmed.ncbi.nlm.nih.gov/10797871"},"language":"en","primary_location":{"id":"pmid:10797871","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10797871","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta physiologica, pharmacologica et therapeutica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y [de] la Asociacion Latinoamericana de Farmacologia","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"T G Andrade","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I879563668","display_name":"Universidade Estadual Paulista (Unesp)","ror":"https://ror.org/00987cb86","country_code":"BR","type":"education","lineage":["https://openalex.org/I879563668"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"T G Andrade","raw_affiliation_strings":["Departamento de Ci\u00eancias Biol\u00f3gicas, FCLA, Universidade Estadual Paulista, Assis, SP, Brasil. raica@assis,unesp.br"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Ci\u00eancias Biol\u00f3gicas, FCLA, Universidade Estadual Paulista, Assis, SP, Brasil. raica@assis,unesp.br","institution_ids":["https://openalex.org/I879563668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061683004","display_name":"Ayli Micaelly da Silva","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A M Silva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065248353","display_name":"Carla Luciana Queiroz da Silva","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C L Silva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5086794252","display_name":"Frederico Guilherme Graeff","orcid":"https://orcid.org/0000-0002-0746-3118","observed_orcids":["https://orcid.org/0000-0002-0746-3118"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F G Graeff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3025,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.45235487,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"49","issue":"4","first_page":"279","last_page":"89"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.8881999850273132,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.8881999850273132,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.08410000056028366,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/median-raphe-nucleus","display_name":"median raphe nucleus","score":0.9890000224113464},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.7910000085830688},{"id":"https://openalex.org/keywords/stress","display_name":"stress","score":0.5519999861717224},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.9879999756813049},{"id":"https://openalex.org/keywords/elevated-plus-maze","display_name":"elevated plus maze","score":0.7649999856948853},{"id":"https://openalex.org/keywords/light-dark-box-test","display_name":"light-dark box","score":0.9150000214576721},{"id":"https://openalex.org/keywords/plasma-prolactin","display_name":"plasma prolactin","score":0.8339999914169312},{"id":"https://openalex.org/keywords/corticosterone","display_name":"corticosterone","score":0.9350000023841858},{"id":"https://openalex.org/keywords/gastric-ulcer","display_name":"gastric ulcer","score":0.8960000276565552},{"id":"https://openalex.org/keywords/concanavalin-a","display_name":"concanavalin A","score":0.871999979019165},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.890999972820282}],"concepts":[{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.8035283088684082},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.5150246620178223},{"id":"https://openalex.org/C2776570665","wikidata":"https://www.wikidata.org/wiki/Q6806127","display_name":"Median raphe nucleus","level":5,"score":0.4969518482685089},{"id":"https://openalex.org/C173586616","wikidata":"https://www.wikidata.org/wiki/Q5359685","display_name":"Elevated plus maze","level":3,"score":0.4749184548854828},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47431254386901855},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4705246686935425},{"id":"https://openalex.org/C2780352252","wikidata":"https://www.wikidata.org/wiki/Q422543","display_name":"Corticosterone","level":3,"score":0.463714599609375},{"id":"https://openalex.org/C2777865548","wikidata":"https://www.wikidata.org/wiki/Q2061493","display_name":"Raphe nuclei","level":5,"score":0.45847418904304504},{"id":"https://openalex.org/C2777615928","wikidata":"https://www.wikidata.org/wiki/Q26261774","display_name":"Raphe","level":5,"score":0.4329023063182831},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39319705963134766},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3826349377632141},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.23876023292541504},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2130250632762909},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.20446118712425232},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.11970347166061401},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.06644505262374878},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000305","descriptor_name":"Adrenal Cortex Hormones","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003208","descriptor_name":"Concanavalin A","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011388","descriptor_name":"Prolactin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011903","descriptor_name":"Raphe Nuclei","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":false},{"descriptor_ui":"D011903","descriptor_name":"Raphe Nuclei","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013276","descriptor_name":"Stomach Ulcer","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D015431","descriptor_name":"Weight Loss","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:10797871","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10797871","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta physiologica, pharmacologica et therapeutica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y [de] la Asociacion Latinoamericana de Farmacologia","raw_type":"Journal Article"},{"id":"pmh:oai:acervodigital.unesp.br:11449/66021","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11449/66021","pdf_url":null,"source":{"id":"https://openalex.org/S4306400256","display_name":"Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115194","host_organization_name":"Funda\u00e7\u00e3o para o Desenvolvimento da UNESP","host_organization_lineage":["https://openalex.org/I4210115194"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"outro"},{"id":"pmh:oai:repositorio.unesp.br:11449/66021","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11449/66021","pdf_url":null,"source":{"id":"https://openalex.org/S4377196277","display_name":"UNESP Institutional Repository (S\u00e3o Paulo State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I879563668","host_organization_name":"Universidade Estadual Paulista (Unesp)","host_organization_lineage":["https://openalex.org/I879563668"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:267684348","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10797871","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2057374306","https://openalex.org/W2000040230","https://openalex.org/W2095340530","https://openalex.org/W2025630191","https://openalex.org/W2905102715","https://openalex.org/W2094631617","https://openalex.org/W7133349306","https://openalex.org/W2018824328","https://openalex.org/W2042201157","https://openalex.org/W2047692008"],"abstract_inverted_index":{"The":[0],"effect":[1],"of":[2,5,26,35,69,92,147,168,176,188],"electrolytic":[3],"lesion":[4,31,58],"the":[6,23,27,30,33,43,47,57,61,65,70,80,83,90,100,102,107,112,125,151,159,166,169,174],"median":[7,170],"raphe":[8,171],"nucleus":[9,172],"was":[10,97],"measured":[11],"on":[12,46],"behavioral":[13,184],"and":[14,39,73,121,153,178,185],"physiological":[15,103,186],"parameters":[16],"related":[17],"to":[18,41,77,158],"stress":[19,177,189],"24":[20],"h":[21],"after":[22,124],"lesion.":[24],"In":[25,55,135],"elevated":[28],"plus-maze":[29],"decreased":[32],"percentage":[34],"open":[36,48],"arm":[37],"entries":[38],"tended":[40],"shorten":[42],"time":[44,62],"spent":[45,63],"arms":[49],"indicating":[50],"an":[51,86],"increase":[52],"in":[53,64,75,106,129,132,150,173],"anxiety.":[54,179],"contrast,":[56],"markedly":[59],"increased":[60],"bright":[66,84],"(aversive)":[67],"compartment":[68],"light-dark":[71],"box":[72],"decrease":[74],"attempts":[76],"cross":[78],"from":[79],"dark":[81],"toward":[82],"compartment,":[85],"anxiolyic":[87],"effect.":[88],"With":[89],"exception":[91],"plasma":[93,141],"prolactin":[94],"level,":[95],"which":[96],"lowered":[98],"by":[99],"lesion,":[101],"measures":[104,187],"used":[105],"present":[108],"study":[109],"indicate":[110],"that":[111,183],"lesioned":[113,130,137],"animals":[114,138],"are":[115],"under":[116],"stress.":[117],"Thus,":[118],"death":[119],"rate":[120],"weight":[122],"loss":[123],"surgery":[126],"were":[127],"higher":[128,140],"than":[131],"control":[133],"animals.":[134],"addition,":[136],"showed":[139],"corticosterone":[142],"levels,":[143],"a":[144,154],"high":[145],"incidence":[146],"gastric":[148],"ulcers":[149],"fundus":[152],"depressed":[155],"immune":[156],"response":[157],"mitogen":[160],"concavaline":[161],"A.":[162],"These":[163],"results":[164],"highlight":[165],"importance":[167],"regulation":[175],"They":[180],"also":[181],"show":[182],"may":[190],"be":[191],"dissociated.":[192]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}