{"id":"https://openalex.org/W2675174","doi":null,"title":"Effect of MPEP treatment on brain-derived neurotrophic factor gene expression.","display_name":"Effect of MPEP treatment on brain-derived neurotrophic factor gene expression.","publication_year":2006,"publication_date":"2006-05-01","ids":{"openalex":"https://openalex.org/W2675174","mag":"2675174","pmid":"https://pubmed.ncbi.nlm.nih.gov/16845218"},"language":"en","primary_location":{"id":"pmid:16845218","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16845218","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological reports : PR","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053117785","display_name":"Beata Legutko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120768","display_name":"Maj Institute of Pharmacology","ror":"https://ror.org/0288swk05","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210120768","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Beata Legutko","raw_affiliation_strings":["Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL 31-343 Krak\u00f3w, Poland. nflegutk@cyf-kr.edu.pl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL 31-343 Krak\u00f3w, Poland. nflegutk@cyf-kr.edu.pl","institution_ids":["https://openalex.org/I4210120768","https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045678056","display_name":"Bernadeta Szewczyk","orcid":"https://orcid.org/0000-0002-6863-7951","observed_orcids":["https://orcid.org/0000-0002-6863-7951"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bernadeta Szewczyk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086755187","display_name":"Lucyna Pomierny-Chamio\u0142o","orcid":"https://orcid.org/0000-0002-8308-8030","observed_orcids":["https://orcid.org/0000-0002-8308-8030"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lucyna Pomierny-Chamio\u0142o","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044015773","display_name":"Gabriel Nowak","orcid":"https://orcid.org/0000-0002-3000-7938","observed_orcids":["https://orcid.org/0000-0002-3000-7938","https://orcid.org/0000-0003-4864-7164"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabriel Nowak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5082517862","display_name":"Andrzej Pilc","orcid":"https://orcid.org/0000-0002-4045-0597","observed_orcids":["https://orcid.org/0000-0002-4045-0597"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrzej Pilc","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0929,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.8535421,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"58","issue":"3","first_page":"427","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mpep","display_name":"MPEP","score":0.9750000238418579},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.8500000238418579},{"id":"https://openalex.org/keywords/bdnf-expression","display_name":"BDNF expression","score":0.9359999895095825},{"id":"https://openalex.org/keywords/mglu5-receptor-antagonists","display_name":"mGlu5 receptor antagonists","score":0.8859999775886536},{"id":"https://openalex.org/keywords/group-i-metabotropic-glutamate-receptors","display_name":"group I metabotropic glutamate receptors","score":0.8889999985694885},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.8420000076293945},{"id":"https://openalex.org/keywords/cerebral-cortex","display_name":"cerebral cortex","score":0.9940000176429749},{"id":"https://openalex.org/keywords/desipramine","display_name":"desipramine","score":0.9440000057220459},{"id":"https://openalex.org/keywords/antidepressant-effects","display_name":"antidepressant effects","score":0.7760000228881836},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.6779999732971191},{"id":"https://openalex.org/keywords/chronic-antidepressant-treatment","display_name":"chronic antidepressant treatment","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.6503490805625916},{"id":"https://openalex.org/C2778790584","wikidata":"https://www.wikidata.org/wiki/Q123045","display_name":"Brain-derived neurotrophic factor","level":4,"score":0.6433312296867371},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.5785918831825256},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5689533352851868},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.5162453651428223},{"id":"https://openalex.org/C97124661","wikidata":"https://www.wikidata.org/wiki/Q14897782","display_name":"Tropomyosin receptor kinase B","level":4,"score":0.4920503497123718},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.48617881536483765},{"id":"https://openalex.org/C41653306","wikidata":"https://www.wikidata.org/wiki/Q6589190","display_name":"Metabotropic glutamate receptor 5","level":5,"score":0.4770697355270386},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.4619828164577484},{"id":"https://openalex.org/C26702167","wikidata":"https://www.wikidata.org/wiki/Q901988","display_name":"Metabotropic receptor","level":4,"score":0.43499961495399475},{"id":"https://openalex.org/C207951395","wikidata":"https://www.wikidata.org/wiki/Q288431","display_name":"Metabotropic glutamate receptor 1","level":5,"score":0.42574185132980347},{"id":"https://openalex.org/C2778122271","wikidata":"https://www.wikidata.org/wiki/Q410943","display_name":"Receptor antagonist","level":4,"score":0.4111956059932709},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4061531126499176},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.38226866722106934},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.36126333475112915},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34963899850845337},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.30265408754348755},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.296000212430954},{"id":"https://openalex.org/C49051014","wikidata":"https://www.wikidata.org/wiki/Q2033959","display_name":"Metabotropic glutamate receptor","level":4,"score":0.23324894905090332}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003891","descriptor_name":"Desipramine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018094","descriptor_name":"Receptors, Metabotropic Glutamate","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064529","descriptor_name":"Receptor, Metabotropic Glutamate 5","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:16845218","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16845218","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological reports : PR","raw_type":"Journal Article"},{"id":"mag:2675174","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16845218","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1694922823","https://openalex.org/W1716703308","https://openalex.org/W1966653229","https://openalex.org/W1967356386","https://openalex.org/W1977237592","https://openalex.org/W1978157729","https://openalex.org/W2029046909","https://openalex.org/W2073047063","https://openalex.org/W2077532061","https://openalex.org/W2081070804","https://openalex.org/W2088577867","https://openalex.org/W2121651624","https://openalex.org/W2140178312","https://openalex.org/W2168950597","https://openalex.org/W2171321056","https://openalex.org/W2429080792"],"related_works":["https://openalex.org/W1984864623","https://openalex.org/W1977237592","https://openalex.org/W2039158439","https://openalex.org/W2429080792","https://openalex.org/W3173571589","https://openalex.org/W2025282204","https://openalex.org/W2054489616","https://openalex.org/W1969755097","https://openalex.org/W2096021943","https://openalex.org/W2636251805"],"abstract_inverted_index":{"Treatment":[0],"with":[1,44],"most":[2],"antidepressants":[3],"induces":[4,92],"expression":[5],"of":[6,26,83,89,99,118],"the":[7,16,77,119],"gene":[8,95],"coding":[9],"for":[10],"brain-derived":[11],"neurotrophic":[12],"factor":[13],"(BDNF)":[14],"in":[15,35,70,125],"hippocampus":[17],"(and":[18],"cerebral":[19],"cortex).":[20],"Recent":[21],"data":[22],"indicate":[23],"antidepressant-like":[24],"activity":[25,117],"group":[27,120],"I":[28,121],"mGlu":[29,122],"receptor":[30,50,123],"(mGluR1":[31],"and":[32],"mGluR5)":[33],"antagonists":[34,124],"animal":[36],"tests/models.":[37],"We":[38],"now":[39],"report":[40],"that":[41,80],"chronic":[42],"treatment":[43],"2-methyl-6-(phenylethynyl)-pyridine":[45],"(MPEP),":[46],"a":[47,63,87,114],"selective":[48],"mGlu5":[49,84],"antagonist,":[51],"increased":[52,66],"hippocampal":[53,93],"but":[54],"reduced":[55],"cortical":[56,104],"BDNF":[57,67,94,105],"mRNA":[58,68],"level":[59,69],"(Northern":[60],"blot).":[61],"Desipramine,":[62],"classic":[64],"antidepressant,":[65],"both":[71],"examined":[72],"brain":[73],"regions.":[74],"This":[75],"is":[76],"first":[78],"demonstration":[79],"an":[81],"antagonist":[82],"receptors,":[85],"like":[86],"majority":[88],"well-established":[90],"antidepressants,":[91],"expression.":[96],"A":[97],"significance":[98],"MPEP":[100],"ability":[101],"to":[102],"reduce":[103],"needs":[106],"further":[107,112],"study.":[108],"Nevertheless,":[109],"this":[110],"observation":[111],"indicates":[113],"potential":[115],"antidepressant":[116],"human":[126],"depression.":[127]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
