{"id":"https://openalex.org/W2673666934","doi":"https://doi.org/10.1200/jco.2017.35.15_suppl.2059","title":"Immunological targeting of CD133 in recurrent glioblastoma: A multi-center phase I translational and clinical study of autologous CD133 dendritic cell immunotherapy.","display_name":"Immunological targeting of CD133 in recurrent glioblastoma: A multi-center phase I translational and clinical study of autologous CD133 dendritic cell immunotherapy.","publication_year":2017,"publication_date":"2017-05-20","ids":{"openalex":"https://openalex.org/W2673666934","doi":"https://doi.org/10.1200/jco.2017.35.15_suppl.2059","mag":"2673666934"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2017.35.15_suppl.2059","doi":"https://doi.org/10.1200/jco.2017.35.15_suppl.2059","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2017.35.15_suppl.2059","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006853372","display_name":"Jeremy David Rudnick","orcid":"https://orcid.org/0000-0002-1442-4299","observed_orcids":["https://orcid.org/0000-0002-1442-4299"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy David Rudnick","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA;","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110242027","display_name":"Karen Fink","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karen L. Fink","raw_affiliation_strings":["Baylor Research Institute, Dallas, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor Research Institute, Dallas, TX;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070492766","display_name":"Joseph C. Landolfi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162446","display_name":"John F. Kennedy Medical Center","ror":"https://ror.org/05brmpx55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph C. Landolfi","raw_affiliation_strings":["NJ Neuroscience Institute at JFK Medical Center, Edison, NJ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NJ Neuroscience Institute at JFK Medical Center, Edison, NJ;","institution_ids":["https://openalex.org/I4210162446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059491130","display_name":"James M. Markert","orcid":"https://orcid.org/0000-0001-7457-7329","observed_orcids":["https://orcid.org/0000-0001-7457-7329"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Markert","raw_affiliation_strings":["University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham, AL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham, AL;","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062289529","display_name":"David Eric Piccioni","orcid":"https://orcid.org/0000-0001-6006-0126","observed_orcids":["https://orcid.org/0000-0001-6006-0126"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Eric Piccioni","raw_affiliation_strings":["Center for Personalized Cancer Therapy and Division of Hematology and Oncology, UCSD Moores Cancer Center, San Diego, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Personalized Cancer Therapy and Division of Hematology and Oncology, UCSD Moores Cancer Center, San Diego, CA;","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070567202","display_name":"Michael Glantz","orcid":"https://orcid.org/0000-0003-4877-5094","observed_orcids":["https://orcid.org/0000-0003-4877-5094"]},"institutions":[{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Glantz","raw_affiliation_strings":["Penn State Milton S. Hershey Medical Center, Hinsdale, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Penn State Milton S. Hershey Medical Center, Hinsdale, MA;","institution_ids":["https://openalex.org/I82783531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015264403","display_name":"Steven J. Swanson","orcid":"https://orcid.org/0009-0005-6320-1461","observed_orcids":["https://orcid.org/0009-0005-6320-1461"]},"institutions":[{"id":"https://openalex.org/I4210103854","display_name":"ImmunoCellular Therapeutics (United States)","ror":"https://ror.org/01axv9229","country_code":"US","type":"company","lineage":["https://openalex.org/I4210103854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven J. Swanson","raw_affiliation_strings":["ImmunoCellular Therapeutics, Calabasas, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ImmunoCellular Therapeutics, Calabasas, CA;","institution_ids":["https://openalex.org/I4210103854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112101799","display_name":"Anthony J. Gringeri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103854","display_name":"ImmunoCellular Therapeutics (United States)","ror":"https://ror.org/01axv9229","country_code":"US","type":"company","lineage":["https://openalex.org/I4210103854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony Gringeri","raw_affiliation_strings":["Immunocellular Therapeutics, Calabasas, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunocellular Therapeutics, Calabasas, CA;","institution_ids":["https://openalex.org/I4210103854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064689690","display_name":"John S. Yu","orcid":"https://orcid.org/0000-0003-1230-8494","observed_orcids":["https://orcid.org/0000-0003-1230-8494"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Yu","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA;","institution_ids":["https://openalex.org/I1282927834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"35","issue":"15_suppl","first_page":"2059","last_page":"2059"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.7515000104904175,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.7515000104904175,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.24719999730587006,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recurrent-glioblastoma","display_name":"recurrent glioblastoma","score":0.9279999732971191},{"id":"https://openalex.org/keywords/cd133","display_name":"CD133","score":0.996999979019165},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.7979999780654907},{"id":"https://openalex.org/keywords/dendritic-cell-immunotherapy","display_name":"dendritic cell immunotherapy","score":0.9210000038146973},{"id":"https://openalex.org/keywords/autologous-dendritic-cells","display_name":"autologous dendritic cells","score":0.9789999723434448},{"id":"https://openalex.org/keywords/hla-a2-restricted-epitopes","display_name":"HLA-A2-restricted epitopes","score":0.8970000147819519},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.531000018119812},{"id":"https://openalex.org/keywords/safety-and-tolerability","display_name":"safety and tolerability","score":0.8579999804496765},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7070000171661377},{"id":"https://openalex.org/keywords/cytokine-mrna-expression","display_name":"cytokine mRNA expression","score":0.699999988079071},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7075536847114563},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6085354089736938},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5125622749328613},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4993631839752197},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47680923342704773},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4710376560688019},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.4480147063732147},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4388030469417572},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.43330785632133484},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3955395221710205},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38185641169548035},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3057234287261963},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14881214499473572},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.11651197075843811},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2017.35.15_suppl.2059","doi":"https://doi.org/10.1200/jco.2017.35.15_suppl.2059","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2017.35.15_suppl.2059","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4238671429","https://openalex.org/W2020604769","https://openalex.org/W3029252496","https://openalex.org/W2587000238","https://openalex.org/W2224421517","https://openalex.org/W2548887552","https://openalex.org/W2968544148","https://openalex.org/W2018457522","https://openalex.org/W1493594926","https://openalex.org/W4415939852"],"abstract_inverted_index":{"2059":[0],"Background:":[1],"A":[2,257,286],"hallmark":[3],"of":[4,10,106,163,189,201,222,259,266,288,295,325],"glioblastoma":[5,50,209,223],"is":[6,69,187,206,312],"the":[7,62,74,104,115,202,235,245,283],"high":[8],"incidence":[9],"tumor":[11,112,124,135],"recurrence,":[12],"thought":[13],"to":[14,26,95,102,120,169,177,282],"be":[15,138,150],"triggered":[16],"by":[17,97],"cancer":[18,44,146,210],"stem":[19,45,147,211],"cells.":[20,212],"These":[21],"tumorigenic":[22],"cells":[23,109,113,125,148,192],"are":[24,194,269,298],"resistant":[25],"irradiation":[27],"and":[28,52,172,176,181,238,264,293,315],"chemotherapeutic":[29],"agents.":[30],"The":[31,213,302],"target":[32,116],"antigen,":[33],"CD-133,":[34],"was":[35,167],"chosen":[36],"because":[37],"it":[38],"has":[39],"been":[40],"reported":[41],"as":[42,90,142],"a":[43,129,229,280,323],"cell":[46,87],"antigen":[47],"overexpressed":[48,207],"in":[49,79,322],"tumors":[51],"associated":[53],"with":[54,196,226,275,317],"shorter":[55],"survival.":[56],"Recent":[57],"clinical":[58],"trials":[59],"suggest":[60,309],"that":[61,110,144,193,216,310],"mean":[63],"overall":[64,179],"survival":[65,180,183],"for":[66,154,220,231],"these":[67,267,296],"patients":[68,96,215,261,268,290,297],"roughly":[70],"5-9":[71],"months,":[72],"emphasizing":[73],"important":[75,152],"unmet":[76],"medical":[77],"need":[78],"this":[80,155,305],"disease":[81,249],"requiring":[82],"additional":[83],"strategic":[84],"approaches.":[85],"Dendritic":[86],"immunotherapies":[88],"such":[89,141],"ICT-121":[91,164,186,227,252,311],"could":[92,149],"provide":[93],"benefit":[94],"educating":[98],"their":[99],"immune":[100,319],"systems":[101],"induce":[103],"formation":[105],"cytotoxic":[107],"T":[108],"attack":[111,122],"bearing":[114],"antigen.":[117,204],"In":[118],"addition":[119],"immediate":[121],"on":[123,208],"present":[126],"at":[127],"dosing,":[128],"long-term":[130],"memory":[131],"response":[132,273,281,320],"effective":[133],"against":[134],"recurrence":[136,221],"might":[137],"induced.":[139],"Immunotherapy,":[140],"ICT-121,":[143],"targets":[145],"an":[151,318],"treatment":[153],"disease.":[156],"Methods:":[157],"This":[158],"Phase":[159,306],"I":[160,307],"multi-center":[161],"trial":[162,308,328],"targeting":[165],"CD133":[166,203,205,284],"designed":[168],"assess":[170],"safety":[171],"tolerability":[173],"(primary":[174],"endpoint)":[175],"monitor":[178],"progression-free":[182],"(secondary":[184],"endpoints).":[185],"comprised":[188],"autologous":[190],"dendritic":[191],"loaded":[195],"two":[197],"HLA-A2":[198,214],"restricted":[199],"epitopes":[200],"had":[217],"undergone":[218],"resection":[219],"were":[224,262,291],"treated":[225,263,292],"once":[228,240],"week":[230],"4":[232],"weeks":[233],"during":[234,244],"induction":[236],"phase":[237,247],"then":[239],"every":[241],"2":[242],"months":[243],"maintenance":[246],"until":[248],"progression,":[250],"death,":[251],"depletion":[253],"or":[254],"discontinuation.":[255],"Results:":[256],"total":[258,287],"20":[260,289],"eight":[265,294],"still":[270,299],"alive.":[271,300],"Immune":[272],"data":[274],"cytokine":[276],"mRNA":[277],"expression":[278],"demonstrated":[279],"epitopes.":[285],"Conclusions:":[301],"results":[303],"from":[304],"both":[313],"safe":[314],"well-tolerated":[316],"seen":[321],"subset":[324],"patients.":[326],"Clinical":[327],"information:":[329],"NCT02049489.":[330]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-06-30T00:00:00"}
