{"id":"https://openalex.org/W267308031","doi":null,"title":"Desensitization of mammalian. beta. -adrenergic receptors: receptor sequestration vs. receptor function","display_name":"Desensitization of mammalian. beta. -adrenergic receptors: receptor sequestration vs. receptor function","publication_year":1986,"publication_date":"1986-05-01","ids":{"openalex":"https://openalex.org/W267308031","mag":"267308031"},"language":"en","primary_location":{"id":"mag:267308031","doi":null,"is_oa":false,"landing_page_url":"http://www.osti.gov/scitech/biblio/5220263-desensitization-mammalian-beta-adrenergic-receptors-receptor-sequestration-vs-receptor-function","pdf_url":null,"source":{"id":"https://openalex.org/S4306510388","display_name":"Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033322590","display_name":"Shouki Kassis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shouki Kassis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086840163","display_name":"Marjut Olasmaa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marjut Olasmaa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5087034581","display_name":"Peter H. Fishman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter H. Fishman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02133645,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-adrenergic-receptor-desensitization","display_name":"beta-adrenergic receptor desensitization","score":0.9750000238418579},{"id":"https://openalex.org/keywords/receptor-sequestration","display_name":"receptor sequestration","score":0.9850000143051147},{"id":"https://openalex.org/keywords/isoproterenol","display_name":"isoproterenol","score":0.9390000104904175},{"id":"https://openalex.org/keywords/adenylate-cyclase","display_name":"adenylate cyclase","score":0.9639999866485596},{"id":"https://openalex.org/keywords/cgp-12177","display_name":"CGP 12177","score":0.8339999914169312},{"id":"https://openalex.org/keywords/concanavalin-a","display_name":"concanavalin A","score":0.9559999704360962},{"id":"https://openalex.org/keywords/phenylarsine-oxide","display_name":"phenylarsine oxide","score":0.9950000047683716},{"id":"https://openalex.org/keywords/receptor-internalization","display_name":"receptor internalization","score":0.574999988079071},{"id":"https://openalex.org/keywords/receptor-function","display_name":"receptor function","score":0.40400001406669617},{"id":"https://openalex.org/keywords/a431-cells","display_name":"A431 cells","score":0.8429999947547913},{"id":"https://openalex.org/keywords/c6-glioma-cells","display_name":"C6 glioma cells","score":0.8820000290870667},{"id":"https://openalex.org/keywords/membrane-fusion","display_name":"membrane fusion","score":0.5519999861717224},{"id":"https://openalex.org/keywords/polyethylene-glycol","display_name":"polyethylene glycol","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.672570526599884},{"id":"https://openalex.org/C2779779143","wikidata":"https://www.wikidata.org/wiki/Q3493547","display_name":"Desensitization (medicine)","level":3,"score":0.6671421527862549},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.638982892036438},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.511303186416626},{"id":"https://openalex.org/C92759361","wikidata":"https://www.wikidata.org/wiki/Q5891436","display_name":"Homologous desensitization","level":4,"score":0.4870474636554718},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.44051697850227356},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.41755443811416626},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4048881530761719},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.38496339321136475},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3355260491371155},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25636738538742065},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21981027722358704},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09376305341720581},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:267308031","doi":null,"is_oa":false,"landing_page_url":"http://www.osti.gov/scitech/biblio/5220263-desensitization-mammalian-beta-adrenergic-receptors-receptor-sequestration-vs-receptor-function","pdf_url":null,"source":{"id":"https://openalex.org/S4306510388","display_name":"Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1480109394","https://openalex.org/W2083849658","https://openalex.org/W2056773948","https://openalex.org/W1589354481","https://openalex.org/W329411700","https://openalex.org/W2425690845","https://openalex.org/W2462297192","https://openalex.org/W2082358296","https://openalex.org/W242407950","https://openalex.org/W2339178571"],"abstract_inverted_index":{"Human":[0],"A431":[1],"and":[2,14,39,101,116,142,144],"rat":[3],"glioma":[4],"C6":[5],"cells":[6,58,79,133,158],"exposed":[7,110],"to":[8,33,48,97,102,111,113,120,148,161],"isoproterenol":[9],"(ISO)":[10],"underwent":[11],"a":[12,49,81,121,135,145,179,190,193],"time":[13],"dose":[15],"dependent":[16],"loss":[17],"of":[18,56,73,94],"ISO-stimulated":[19],"adenylate":[20],"cyclase":[21],"(AC)":[22],"activity":[23],"(desensitization).":[24],"In":[25,153,184],"addition,":[26,154],"..beta..-adrenergic":[27],"receptors":[28],"(..beta..AR)":[29],"became":[30],"less":[31],"accessible":[32,160],"the":[34,42,57,91,150,165,172,197],"hydrophilic":[35],"antagonist":[36,105],"(/sup":[37,162],"3/H)CGP-12177":[38,163],"redistributed":[40],"from":[41,76,131,156],"heavier":[43],"density":[44,51],"plasma":[45],"membrane":[46,52,125],"fraction":[47,53],"lighter":[50],"(sequestration).":[54],"Pretreatment":[55],"with":[59,127],"Concanavalin":[60],"A":[61],"(Con":[62],"A)":[63],"or":[64],"phenylarsine":[65],"oxide":[66],"blocked":[67],"sequestration":[68,187],"but":[69,192],"not":[70,189],"desensitization.":[71],"..beta..AR":[72,117,130,155,182,186],"membranes":[74],"prepared":[75],"Con":[77],"A-pretreated":[78],"exhibited":[80,134],"reduced":[82,136,146],"affinity":[83,137],"for":[84,104,138],"ISO":[85,95,139],"after":[86],"desensitization":[87,177,198],"as":[88],"measured":[89],"by":[90,124],"half-maximal":[92],"concentration":[93],"required":[96],"stimulate":[98,149],"AC":[99,115,123],"(Kact)":[100],"compete":[103],"binding":[106],"(IC50).":[107],"Membranes":[108],"were":[109],"alkali":[112],"inactivate":[114],"was":[118],"transferred":[119],"foreign":[122,151],"fusion":[126],"polyethylene":[128],"glycol.":[129],"desensitized":[132,157],"(both":[140],"Kact":[141],"IC50)":[143],"ability":[147],"AC.":[152],"remained":[159],"in":[164,176,181,196],"fused":[166],"membranes.":[167],"The":[168],"authors":[169],"conclude":[170],"that":[171],"primary,":[173],"essential":[174],"step":[175],"is":[178,188],"reduction":[180],"function.":[183],"contrast,":[185],"prerequisite":[191],"secondary":[194],"event":[195],"process.":[199]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}
