{"id":"https://openalex.org/W2671684","doi":"https://doi.org/10.1096/fasebj.20.4.a515-d","title":"The C\u2010terminal globular domain of fibrinogen \u03b3 chain suppresses angiogenesis and tumor growth","display_name":"The C\u2010terminal globular domain of fibrinogen \u03b3 chain suppresses angiogenesis and tumor growth","publication_year":2006,"publication_date":"2006-03-01","ids":{"openalex":"https://openalex.org/W2671684","doi":"https://doi.org/10.1096/fasebj.20.4.a515-d","mag":"2671684"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.20.4.a515-d","doi":"https://doi.org/10.1096/fasebj.20.4.a515-d","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.20.4.a515-d","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037929411","display_name":"Yoshikazu Takada","orcid":"https://orcid.org/0000-0001-5481-9589","observed_orcids":["https://orcid.org/0000-0001-5481-9589"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"yoshikazu takada","raw_affiliation_strings":["Dermatology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105368547","display_name":"Nobuaki Akakura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nobuaki Akakura","raw_affiliation_strings":["Dermatology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110613322","display_name":"Yoko K. Takada","orcid":"https://orcid.org/0000-0001-5481-9589","observed_orcids":["https://orcid.org/0000-0001-5481-9589"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoko K Takada","raw_affiliation_strings":["Dermatology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065246421","display_name":"Case Hoogland","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Case Hoogland","raw_affiliation_strings":["Dermatology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106084393","display_name":"Fu\u2010Tong Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fu\u2010Tong Liu","raw_affiliation_strings":["Dermatology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108610073","display_name":"Anthony Cheung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony Cheung","raw_affiliation_strings":["Pathology, UC Davis Medical Center, 4645 2nd Avenue, Sacramento, California, 95817"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, UC Davis Medical Center, 4645 2nd Avenue, Sacramento, California, 95817","institution_ids":["https://openalex.org/I4210160527"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00033313,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.8984000086784363,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.8984000086784363,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.07259999960660934,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.018300000578165054,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fibrinogen-gamma-chain","display_name":"fibrinogen gamma chain","score":0.8090000152587891},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.6290000081062317},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.8870000243186951},{"id":"https://openalex.org/keywords/endothelial-cell-apoptosis","display_name":"endothelial cell apoptosis","score":0.9279999732971191},{"id":"https://openalex.org/keywords/integrin-alphavbeta3","display_name":"integrin \u03b1v\u03b23","score":0.8429999947547913},{"id":"https://openalex.org/keywords/alphaiibbeta3","display_name":"integrin alpha IIb beta 3","score":0.8700000047683716},{"id":"https://openalex.org/keywords/fibrinogen-fragment-d","display_name":"fibrinogen fragment D","score":0.8029999732971191},{"id":"https://openalex.org/keywords/tumor-vasculature","display_name":"tumor vasculature","score":0.6959999799728394},{"id":"https://openalex.org/keywords/pro-apoptotic-proteins","display_name":"pro-apoptotic proteins","score":0.7419999837875366},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.6933740377426147},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5858922600746155},{"id":"https://openalex.org/C2778608917","wikidata":"https://www.wikidata.org/wiki/Q6787805","display_name":"Matrigel","level":3,"score":0.5526766777038574},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5359256267547607},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5149932503700256},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5089192390441895},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4487636089324951},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.44473740458488464},{"id":"https://openalex.org/C54173615","wikidata":"https://www.wikidata.org/wiki/Q27205","display_name":"Fibrin","level":2,"score":0.433106929063797},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41503986716270447},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.40394705533981323},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3466028571128845},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24186530709266663},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.23779815435409546},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.13715970516204834},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.20.4.a515-d","doi":"https://doi.org/10.1096/fasebj.20.4.a515-d","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.20.4.a515-d","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.5199999809265137,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2166933347","https://openalex.org/W2332159697","https://openalex.org/W2062440390","https://openalex.org/W2043445480","https://openalex.org/W7100612802","https://openalex.org/W2052288","https://openalex.org/W2132915377","https://openalex.org/W2128596050","https://openalex.org/W2986667451","https://openalex.org/W2087818376"],"abstract_inverted_index":{"Fibrinogen":[0,10],"is":[1,109,126,200],"a":[2,127,201,208],"major":[3,128],"blood":[4,8],"protein":[5,205],"involved":[6,105],"in":[7,23,26,62,73,106,111,118,132,156,178,189],"clotting.":[9],"induces":[11],"cell":[12],"proliferation,":[13],"but":[14,89,116,150],"fibrin(ogen)":[15],"degradation":[16],"products":[17],"(e.g.,":[18],"fragment":[19,78,90,114],"D)":[20],"are":[21],"implicated":[22],"tissue":[24],"injury":[25],"pathological":[27],"situations.":[28],"Fragment":[29],"D":[30,79,91],"contains":[31,168],"the":[32,103,160,169],"conserved":[33],"fibrinogen":[34,76,94,112],"\u03b3":[35,41,46,49,86,119,129,135,147,151,163,183,198],"chain":[36],"C\u2010terminal":[37],"globular":[38],"domain":[39],"(designated":[40],"C).":[42],"We":[43,121,180],"found":[44],"that":[45,102,123,159,167,182,197],"C411":[47,152,164],"and":[48,53,64,144,206],"C399":[50,148,184,199],"(residues":[51,165],"150\u2013411":[52],"150\u2013399,":[54],"respectively)":[55],"effectively":[56],"induced":[57],"apoptosis":[58,107,140],"of":[59,68,141,162],"endothelial":[60,69,99,133],"cells":[61,70,143],"vitro,":[63],"blocked":[65],"tube":[66],"formation":[67],"on":[71],"matrigel":[72],"vitro.":[74],"Native":[75],"or":[77,92,113],"did":[80,95,137],"not":[81,96,138],"induce":[82,139],"such":[83],"effects.":[84],"Consistently,":[85],"C":[87,130,136],"bound,":[88],"native":[93],"bind":[97],"to":[98],"cells,":[100],"suggesting":[101,158],"epitope":[104],"induction":[108],"cryptic":[110],"D,":[115],"exposed":[117],"C.":[120],"show":[122,181],"integrin":[124,171],"\u03b1v\u03b23":[125],"receptor":[131],"cells.":[134],"cancer":[142],"keratinocytes.":[145],"Further,":[146],"suppressed,":[149],"enhanced,":[153],"tumor":[154],"growth":[155],"vivo,":[157],"C\u2010terminus":[161],"400\u2013411)":[166],"platelet":[170],"\u03b1IIb\u03b23\u2010binding":[172],"motif":[173],"may":[174],"have":[175],"tumor\u2010promoting":[176],"effects":[177],"vivo.":[179],"suppressed":[185],"intratumoral":[186],"vascularature":[187],"development":[188],"vivo":[190],"using":[191],"intravital":[192],"microscopy.":[193],"These":[194],"results":[195],"suggest":[196],"novel":[202],"potent":[203],"proapoptotic":[204],"has":[207],"therapeutic":[209],"potential.":[210]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
