{"id":"https://openalex.org/W26707319","doi":"https://doi.org/10.4049/jimmunol.186.supp.163.12","title":"Genetic analysis of arginase 1 in Th2-dominated lung inflammation (163.12)","display_name":"Genetic analysis of arginase 1 in Th2-dominated lung inflammation (163.12)","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W26707319","doi":"https://doi.org/10.4049/jimmunol.186.supp.163.12","mag":"26707319"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.186.supp.163.12","doi":"https://doi.org/10.4049/jimmunol.186.supp.163.12","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.186.supp.163.12","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112015986","display_name":"Luke Barron","orcid":"https://orcid.org/0000-0002-8660-3069","observed_orcids":["https://orcid.org/0000-0002-8660-3069"]},"institutions":[{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luke Barron","raw_affiliation_strings":["Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases , Bethesda, MD","1Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases , Bethesda, MD","institution_ids":["https://openalex.org/I4210134534"]},{"raw_affiliation_string":"1Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD","institution_ids":["https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102872190","display_name":"Amber Lanae Smith","orcid":"https://orcid.org/0000-0002-5612-1368","observed_orcids":["https://orcid.org/0000-0002-5612-1368"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amber Smith","raw_affiliation_strings":["Departments of Infectious Diseases and Immunology, St. Jude Children's Res. Hosp. , Memphis, TN","2Departments of Infectious Diseases and Immunology, St. Jude Children's Res. Hosp., Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Infectious Diseases and Immunology, St. Jude Children's Res. Hosp. , Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"2Departments of Infectious Diseases and Immunology, St. Jude Children's Res. Hosp., Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088435320","display_name":"Karim El Kasmi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karim El Kasmi","raw_affiliation_strings":["Department of Pediatrics, University of Colorado , Denver, Denver, CO","Departments of Infectious Diseases and Immunology, St. Jude Children's Res. Hosp. , Memphis, TN","2Departments of Infectious Diseases and Immunology, St. Jude Children's Res. Hosp., Memphis, TN","4Department of Pediatrics, University of Colorado, Denver, Denver, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Colorado , Denver, Denver, CO","institution_ids":["https://openalex.org/I921990950"]},{"raw_affiliation_string":"Departments of Infectious Diseases and Immunology, St. Jude Children's Res. Hosp. , Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"2Departments of Infectious Diseases and Immunology, St. Jude Children's Res. Hosp., Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"4Department of Pediatrics, University of Colorado, Denver, Denver, CO","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022004093","display_name":"Joseph E. Qualls","orcid":"https://orcid.org/0000-0002-0113-2166","observed_orcids":["https://orcid.org/0000-0002-0113-2166"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Qualls","raw_affiliation_strings":["Departments of Infectious Diseases and Immunology, St. Jude Children's Res. Hosp. , Memphis, TN","2Departments of Infectious Diseases and Immunology, St. Jude Children's Res. Hosp., Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Infectious Diseases and Immunology, St. Jude Children's Res. Hosp. , Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"2Departments of Infectious Diseases and Immunology, St. Jude Children's Res. Hosp., Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030063085","display_name":"Xiaozhu Huang","orcid":"https://orcid.org/0000-0003-1165-0749","observed_orcids":["https://orcid.org/0000-0003-1165-0749"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaozhu Huang","raw_affiliation_strings":["Sandler Asthma Basic Research Center, University of California San Francisco , San Francisco, CA","3Sandler Asthma Basic Research Center, University of California, San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sandler Asthma Basic Research Center, University of California San Francisco , San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"3Sandler Asthma Basic Research Center, University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085255411","display_name":"Thomas A. Wynn","orcid":"https://orcid.org/0000-0002-7244-8731","observed_orcids":["https://orcid.org/0000-0002-7244-8731"]},"institutions":[{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Wynn","raw_affiliation_strings":["Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases , Bethesda, MD","1Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases , Bethesda, MD","institution_ids":["https://openalex.org/I4210134534"]},{"raw_affiliation_string":"1Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD","institution_ids":["https://openalex.org/I4210134534"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019030969","display_name":"Peter J. Murray","orcid":"https://orcid.org/0000-0001-6329-9802","observed_orcids":["https://orcid.org/0000-0001-6329-9802"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Murray","raw_affiliation_strings":["Departments of Infectious Diseases and Immunology, St. Jude Children's Res. Hosp. , Memphis, TN","2Departments of Infectious Diseases and Immunology, St. Jude Children's Res. Hosp., Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Infectious Diseases and Immunology, St. Jude Children's Res. Hosp. , Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"2Departments of Infectious Diseases and Immunology, St. Jude Children's Res. Hosp., Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"186","issue":"1_Supplement","first_page":"163.12","last_page":"163.12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.022299999371170998,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arginase-1","display_name":"arginase-1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.6930000185966492},{"id":"https://openalex.org/keywords/m2-macrophages","display_name":"M2 macrophages","score":0.8759999871253967},{"id":"https://openalex.org/keywords/myeloid-cells","display_name":"myeloid cells","score":0.8330000042915344},{"id":"https://openalex.org/keywords/arginase-inhibitors","display_name":"arginase inhibitors","score":0.7409999966621399},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.7210000157356262},{"id":"https://openalex.org/keywords/arginine-metabolism","display_name":"arginine metabolism","score":0.7350000143051147},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.7089999914169312},{"id":"https://openalex.org/keywords/polyamines","display_name":"polyamines","score":0.781000018119812},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C164007495","wikidata":"https://www.wikidata.org/wiki/Q24721374","display_name":"Arginase","level":4,"score":0.9258146286010742},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7392470836639404},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5876017808914185},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5521612167358398},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.5338379740715027},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5335049629211426},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5224315524101257},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.4854314923286438},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.4158518314361572},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.4120846390724182},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32935404777526855},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2757640779018402},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.20752853155136108},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15545281767845154},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10984158515930176},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10634896159172058},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0904061496257782},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.186.supp.163.12","doi":"https://doi.org/10.4049/jimmunol.186.supp.163.12","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.186.supp.163.12","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1994718754","https://openalex.org/W2318838020","https://openalex.org/W2769820168","https://openalex.org/W2325579732","https://openalex.org/W1975966377","https://openalex.org/W2148441972","https://openalex.org/W4248852970","https://openalex.org/W4232744455","https://openalex.org/W2008214282","https://openalex.org/W7098527235"],"abstract_inverted_index":{"Abstract":[0],"Arginase":[1],"1":[2],"(Arg1)":[3],"expression":[4],"in":[5,15,60,74,112,129],"myeloid":[6,75],"lineage":[7,76],"cells,":[8,77],"and":[9,22,52,63,87,97,144,158],"especially":[10],"alternatively-activated":[11],"macrophages,":[12],"increases":[13],"dramatically":[14],"the":[16,42,56,61,80,130,156],"lungs":[17],"of":[18,44,58,82,116,160],"mice":[19,71],"with":[20,142],"acute":[21,96],"chronic":[23,98],"Th2-driven":[24],"inflammation.":[25,89],"Arg1":[26,73,83,111,149],"has":[27],"been":[28],"proposed":[29],"to":[30,32,78,84,126,150],"contribute":[31],"asthma":[33,85],"pathogenesis":[34],"by":[35,47,132],"regulating":[36,50,55],"at":[37],"least":[38],"four":[39],"pathways:":[40],"inhibiting":[41,64],"production":[43],"nitric":[45],"oxide":[46],"substrate":[48],"competition,":[49],"fibrosis":[51],"polyamine":[53],"supply,":[54],"bioavailability":[57],"arginine":[59],"lung,":[62],"T":[65],"cell":[66],"proliferation.":[67],"Here":[68],"we":[69,101],"used":[70],"lacking":[72],"investigate":[79],"contribution":[81],"pathophysiology":[86],"lung":[88,117,131],"In":[90],"six":[91],"distinct":[92],"model":[93],"systems":[94],"encompassing":[95],"Th2-mediated":[99],"inflammation,":[100],"observed":[102],"neither":[103],"a":[104],"pathogenic":[105],"nor":[106],"protective":[107],"role":[108],"for":[109],"myeloid-expressed":[110],"any":[113],"measured":[114],"parameter":[115],"pathophysiology.":[118],"Collectively,":[119],"our":[120],"results":[121],"argue":[122],"that":[123],"(i)":[124],"attempts":[125],"inhibit":[127],"arginases":[128],"small":[133],"molecule":[134],"arginase":[135],"inhibitors":[136],"or":[137,162],"RNAi":[138],"should":[139],"be":[140],"examined":[141],"caution":[143],"(ii)":[145],"whether":[146],"macrophages":[147],"use":[148],"limit":[151],"Th2":[152],"responses":[153],"depends":[154],"on":[155],"organ":[157],"type":[159],"infection":[161],"injury.":[163]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}