{"id":"https://openalex.org/W2667907301","doi":"https://doi.org/10.1039/c7np00023e","title":"Recent advances and perspectives in the design and development of polymyxins","display_name":"Recent advances and perspectives in the design and development of polymyxins","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2667907301","doi":"https://doi.org/10.1039/c7np00023e","mag":"2667907301","pmid":"https://pubmed.ncbi.nlm.nih.gov/28628170"},"language":"en","primary_location":{"id":"doi:10.1039/c7np00023e","doi":"https://doi.org/10.1039/c7np00023e","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c7np00023e","pdf_url":null,"source":{"id":"https://openalex.org/S18855311","display_name":"Natural Product Reports","issn_l":"0265-0568","issn":["0265-0568","1460-4752"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural Product Reports","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035322142","display_name":"Francesc Rabanal","orcid":"https://orcid.org/0000-0002-4913-155X","observed_orcids":["https://orcid.org/0000-0002-4913-155X"]},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Francesc Rabanal","raw_affiliation_strings":["Department of Inorganic and Organic Chemistry","Faculty of Chemistry","Organic Chemistry Section","Spain","University of Barcelona","Organic Chemistry Section, Department of Inorganic and Organic Chemistry, Faculty of Chemistry, University of Barcelona, Spain"],"raw_orcid":"https://orcid.org/0000-0002-4913-155X","affiliations":[{"raw_affiliation_string":"Department of Inorganic and Organic Chemistry","institution_ids":[]},{"raw_affiliation_string":"Faculty of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Organic Chemistry Section","institution_ids":[]},{"raw_affiliation_string":"Spain","institution_ids":[]},{"raw_affiliation_string":"University of Barcelona","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"Organic Chemistry Section, Department of Inorganic and Organic Chemistry, Faculty of Chemistry, University of Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087570303","display_name":"Yolanda Cajal","orcid":"https://orcid.org/0000-0003-1603-8313","observed_orcids":["https://orcid.org/0000-0003-1603-8313"]},"institutions":[{"id":"https://openalex.org/I4401200369","display_name":"Institut de Nanoci\u00e8ncia i Nanotecnologia de la Universitat de Barcelona","ror":"https://ror.org/034nc1205","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4401200369","https://openalex.org/I71999127"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Yolanda Cajal","raw_affiliation_strings":["Department of Pharmacy","Faculty of Pharmacy and Food Sciences","Pharmaceutical Technology and Physical Chemistry","Spain","University of Barcelona","Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Spain","Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, Spain"],"raw_orcid":"https://orcid.org/0000-0003-1603-8313","affiliations":[{"raw_affiliation_string":"Department of Pharmacy","institution_ids":[]},{"raw_affiliation_string":"Faculty of Pharmacy and Food Sciences","institution_ids":[]},{"raw_affiliation_string":"Pharmaceutical Technology and Physical Chemistry","institution_ids":[]},{"raw_affiliation_string":"Spain","institution_ids":[]},{"raw_affiliation_string":"University of Barcelona","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, Spain","institution_ids":["https://openalex.org/I4401200369","https://openalex.org/I71999127"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5035322142"],"corresponding_institution_ids":["https://openalex.org/I71999127"],"apc_list":null,"apc_paid":null,"fwci":2.0776,"has_fulltext":false,"cited_by_count":149,"citation_normalized_percentile":{"value":0.89408867,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"34","issue":"7","first_page":"886","last_page":"908"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.6654999852180481,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.6654999852180481,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.23180000483989716,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.07039999961853027,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polymyxins","display_name":"polymyxins","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.6790000200271606},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.9390000104904175},{"id":"https://openalex.org/keywords/antibacterial-mechanism","display_name":"antibacterial mechanism","score":0.6589999794960022},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.5429999828338623},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.6539999842643738},{"id":"https://openalex.org/keywords/antibiofilm-activity","display_name":"antibiofilm activity","score":0.9279999732971191},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.6660000085830688},{"id":"https://openalex.org/keywords/drug-design","display_name":"drug design","score":0.6520000100135803},{"id":"https://openalex.org/keywords/detoxification","display_name":"detoxification","score":0.4350000023841858},{"id":"https://openalex.org/keywords/last-line-therapy","display_name":"last-line therapy","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C2780675486","wikidata":"https://www.wikidata.org/wiki/Q423765","display_name":"Polymyxin","level":3,"score":0.9218425750732422},{"id":"https://openalex.org/C2780497538","wikidata":"https://www.wikidata.org/wiki/Q1192006","display_name":"Detoxification (alternative medicine)","level":3,"score":0.5977298617362976},{"id":"https://openalex.org/C2779259085","wikidata":"https://www.wikidata.org/wiki/Q418946","display_name":"Colistin","level":3,"score":0.5250270962715149},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.49152907729148865},{"id":"https://openalex.org/C126189478","wikidata":"https://www.wikidata.org/wiki/Q1468324","display_name":"Nephrotoxicity","level":3,"score":0.48218005895614624},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.3618859052658081},{"id":"https://openalex.org/C55587333","wikidata":"https://www.wikidata.org/wiki/Q1133029","display_name":"Engineering ethics","level":1,"score":0.3603714108467102},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33165860176086426},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.27858787775039673},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2743149399757385},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24355632066726685},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22111424803733826},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.19879832863807678},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.14560428261756897},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.06623414158821106},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.06157746911048889},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011113","descriptor_name":"Polymyxins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1039/c7np00023e","doi":"https://doi.org/10.1039/c7np00023e","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c7np00023e","pdf_url":null,"source":{"id":"https://openalex.org/S18855311","display_name":"Natural Product Reports","issn_l":"0265-0568","issn":["0265-0568","1460-4752"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural Product Reports","raw_type":"journal-article"},{"id":"pmid:28628170","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28628170","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural product reports","raw_type":"Journal Article"},{"id":"pmh:oai:diposit.ub.edu:2445/167742","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2445/167742","pdf_url":null,"source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Articles publicats en revistes (Qu\u00edmica Inorg\u00e0nica i Org\u00e0nica)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334685","display_name":"European Institute of Innovation and Technology","ror":"https://ror.org/036dxts37"},{"id":"https://openalex.org/F4320337669","display_name":"H2020 European Institute of Innovation and Technology","ror":"https://ror.org/036dxts37"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":215,"referenced_works":["https://openalex.org/W18840079","https://openalex.org/W1123269954","https://openalex.org/W1183649710","https://openalex.org/W1471870375","https://openalex.org/W1536293424","https://openalex.org/W1538888362","https://openalex.org/W1582342805","https://openalex.org/W1584251165","https://openalex.org/W1602597014","https://openalex.org/W1722440501","https://openalex.org/W1798723734","https://openalex.org/W1820765431","https://openalex.org/W1879248731","https://openalex.org/W1895129045","https://openalex.org/W1964226118","https://openalex.org/W1964868326","https://openalex.org/W1965083442","https://openalex.org/W1967346383","https://openalex.org/W1969396348","https://openalex.org/W1970911875","https://openalex.org/W1971242747","https://openalex.org/W1974951926","https://openalex.org/W1975806824","https://openalex.org/W1976301815","https://openalex.org/W1977304173","https://openalex.org/W1977371637","https://openalex.org/W1979593019","https://openalex.org/W1980325515","https://openalex.org/W1982047822","https://openalex.org/W1984229760","https://openalex.org/W1985069389","https://openalex.org/W1988482986","https://openalex.org/W1988549330","https://openalex.org/W1988595672","https://openalex.org/W1988783083","https://openalex.org/W1989998611","https://openalex.org/W1990745522","https://openalex.org/W1993044982","https://openalex.org/W1995612252","https://openalex.org/W1997214259","https://openalex.org/W1997330909","https://openalex.org/W1999935229","https://openalex.org/W2002126352","https://openalex.org/W2004428159","https://openalex.org/W2004918900","https://openalex.org/W2006484084","https://openalex.org/W2009293264","https://openalex.org/W2011347701","https://openalex.org/W2011909200","https://openalex.org/W2013726928","https://openalex.org/W2015031708","https://openalex.org/W2017808289","https://openalex.org/W2021041146","https://openalex.org/W2023313344","https://openalex.org/W2024040601","https://openalex.org/W2024956881","https://openalex.org/W2026760212","https://openalex.org/W2026940625","https://openalex.org/W2027986692","https://openalex.org/W2031122806","https://openalex.org/W2033705339","https://openalex.org/W2034248364","https://openalex.org/W2035868177","https://openalex.org/W2038305694","https://openalex.org/W2039967992","https://openalex.org/W2040736753","https://openalex.org/W2041514788","https://openalex.org/W2042510224","https://openalex.org/W2043209435","https://openalex.org/W2044746614","https://openalex.org/W2045110384","https://openalex.org/W2049890007","https://openalex.org/W2051644797","https://openalex.org/W2052288044","https://openalex.org/W2052459767","https://openalex.org/W2052899239","https://openalex.org/W2055188126","https://openalex.org/W2056583460","https://openalex.org/W2058968158","https://openalex.org/W2059938224","https://openalex.org/W2060170554","https://openalex.org/W2067922742","https://openalex.org/W2068852170","https://openalex.org/W2069480047","https://openalex.org/W2071413887","https://openalex.org/W2072437323","https://openalex.org/W2072926813","https://openalex.org/W2074066513","https://openalex.org/W2074594048","https://openalex.org/W2076818299","https://openalex.org/W2085787795","https://openalex.org/W2087108989","https://openalex.org/W2087446651","https://openalex.org/W2089032671","https://openalex.org/W2090910966","https://openalex.org/W2093239356","https://openalex.org/W2094523041","https://openalex.org/W2096250787","https://openalex.org/W2096864263","https://openalex.org/W2097173594","https://openalex.org/W2103186295","https://openalex.org/W2103868673","https://openalex.org/W2109461076","https://openalex.org/W2114523818","https://openalex.org/W2115494622","https://openalex.org/W2116245384","https://openalex.org/W2117795567","https://openalex.org/W2118070771","https://openalex.org/W2118489529","https://openalex.org/W2120061656","https://openalex.org/W2120266293","https://openalex.org/W2120292666","https://openalex.org/W2122863984","https://openalex.org/W2123135656","https://openalex.org/W2124863830","https://openalex.org/W2126902106","https://openalex.org/W2127374749","https://openalex.org/W2128630890","https://openalex.org/W2128824216","https://openalex.org/W2130440479","https://openalex.org/W2130701276","https://openalex.org/W2132274120","https://openalex.org/W2133195314","https://openalex.org/W2137863756","https://openalex.org/W2137992445","https://openalex.org/W2139976486","https://openalex.org/W2140344617","https://openalex.org/W2140345819","https://openalex.org/W2141002021","https://openalex.org/W2142212618","https://openalex.org/W2142343447","https://openalex.org/W2142947267","https://openalex.org/W2144783676","https://openalex.org/W2145892893","https://openalex.org/W2149623513","https://openalex.org/W2150502003","https://openalex.org/W2151717289","https://openalex.org/W2152155052","https://openalex.org/W2153862563","https://openalex.org/W2155833698","https://openalex.org/W2156233344","https://openalex.org/W2157512160","https://openalex.org/W2159640725","https://openalex.org/W2160312473","https://openalex.org/W2160653375","https://openalex.org/W2160900386","https://openalex.org/W2162661622","https://openalex.org/W2162745520","https://openalex.org/W2164292002","https://openalex.org/W2164327772","https://openalex.org/W2165186684","https://openalex.org/W2166679468","https://openalex.org/W2166960535","https://openalex.org/W2168064490","https://openalex.org/W2169488267","https://openalex.org/W2169646524","https://openalex.org/W2171142540","https://openalex.org/W2175068438","https://openalex.org/W2179036997","https://openalex.org/W2183518823","https://openalex.org/W2187275914","https://openalex.org/W2206136994","https://openalex.org/W2206905236","https://openalex.org/W2209212686","https://openalex.org/W2212629349","https://openalex.org/W2222885062","https://openalex.org/W2243245614","https://openalex.org/W2279108563","https://openalex.org/W2287827867","https://openalex.org/W2296621547","https://openalex.org/W2297086543","https://openalex.org/W2312561647","https://openalex.org/W2315431324","https://openalex.org/W2317765000","https://openalex.org/W2323689626","https://openalex.org/W2358053226","https://openalex.org/W2403299959","https://openalex.org/W2411551763","https://openalex.org/W2437321033","https://openalex.org/W2462098506","https://openalex.org/W2470176545","https://openalex.org/W2474449496","https://openalex.org/W2489954172","https://openalex.org/W2509216003","https://openalex.org/W2510999942","https://openalex.org/W2513532815","https://openalex.org/W2514965787","https://openalex.org/W2519173806","https://openalex.org/W2520256066","https://openalex.org/W2529173597","https://openalex.org/W2538573429","https://openalex.org/W2539247392","https://openalex.org/W2556936397","https://openalex.org/W2563455121","https://openalex.org/W2564750454","https://openalex.org/W2565590011","https://openalex.org/W2566076583","https://openalex.org/W2571059898","https://openalex.org/W2573177864","https://openalex.org/W2575788678","https://openalex.org/W2576205983","https://openalex.org/W2583196822","https://openalex.org/W2587593076","https://openalex.org/W2592013065","https://openalex.org/W2593444269","https://openalex.org/W2593714885","https://openalex.org/W2605235260","https://openalex.org/W2606584122","https://openalex.org/W2613613983","https://openalex.org/W2750444011","https://openalex.org/W3157395131","https://openalex.org/W4234317413","https://openalex.org/W4244732422","https://openalex.org/W4255310200","https://openalex.org/W4406059085"],"related_works":["https://openalex.org/W2770971180","https://openalex.org/W4392700794","https://openalex.org/W7122439364","https://openalex.org/W2960188650","https://openalex.org/W2910530290","https://openalex.org/W7030242447","https://openalex.org/W2040811291","https://openalex.org/W2576205983","https://openalex.org/W2097322935","https://openalex.org/W7105794743"],"abstract_inverted_index":{"Covering:":[0],"1947-early":[1],"2017,":[2],"particularly":[3],"from":[4],"2005-early":[5],"2017The":[6],"rise":[7],"of":[8,37,69,87,95,99,111,114],"bacterial":[9],"pathogens":[10],"with":[11,78],"acquired":[12],"resistance":[13],"to":[14,47,116,132],"almost":[15],"all":[16],"available":[17],"antibiotics":[18,27],"is":[19,102,127],"becoming":[20],"a":[21,32,44,96,128],"serious":[22],"public":[23],"health":[24],"issue.":[25],"Polymyxins,":[26],"that":[28],"were":[29],"mostly":[30],"abandoned":[31],"few":[33],"decades":[34],"ago":[35],"because":[36],"toxicity":[38],"concerns,":[39],"are":[40],"ultimately":[41],"considered":[42],"as":[43],"last-line":[45],"therapy":[46],"treat":[48],"infections":[49],"caused":[50],"by":[51],"multi-drug":[52],"resistant":[53],"Gram-negative":[54],"bacteria.":[55],"This":[56],"review":[57],"surveys":[58],"the":[59,91,109,112,123,137],"progress":[60],"in":[61,90,136],"understanding":[62],"polymyxin":[63,100],"structure,":[64],"and":[65,72,76,82,93,119,139],"their":[66],"chemistry,":[67],"mechanisms":[68],"antibacterial":[70],"activity":[71],"nephrotoxicity,":[73],"biomarkers,":[74],"synergy":[75],"combination":[77],"other":[79],"antimicrobial":[80],"agents":[81],"antibiofilm":[83],"properties.":[84],"An":[85],"update":[86],"recent":[88],"efforts":[89],"design":[92,125],"development":[94],"new":[97,130],"generation":[98],"drugs":[101],"also":[103],"discussed.":[104],"A":[105],"novel":[106],"approach":[107],"considering":[108],"modification":[110],"scaffold":[113],"polymyxins":[115],"integrate":[117],"metabolism":[118],"detoxification":[120],"issues":[121],"into":[122],"drug":[124],"process":[126],"promising":[129],"line":[131],"potentially":[133],"prevent":[134],"accumulation":[135],"kidneys":[138],"reduce":[140],"nephrotoxicity.":[141]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":21},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":22},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":19},{"year":2019,"cited_by_count":20},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-06-30T00:00:00"}