{"id":"https://openalex.org/W26656319","doi":null,"title":"The correlation between serum VEGF levels and known prognostic risk factors in colorectal carcinoma.","display_name":"The correlation between serum VEGF levels and known prognostic risk factors in colorectal carcinoma.","publication_year":2014,"publication_date":"2014-03-01","ids":{"openalex":"https://openalex.org/W26656319","mag":"26656319","pmid":"https://pubmed.ncbi.nlm.nih.gov/24901122"},"language":"en","primary_location":{"id":"pmid:24901122","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24901122","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepato-gastroenterology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008401465","display_name":"Remzi Be\u015fta\u015f","orcid":"https://orcid.org/0000-0001-5852-2117","observed_orcids":["https://orcid.org/0000-0001-5852-2117"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Remzi Be\u015fta\u015f","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068468956","display_name":"Kaplan Ma","orcid":"https://orcid.org/0000-0003-0882-0524","observed_orcids":["https://orcid.org/0000-0003-0882-0524"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Ali Kaplan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5000554665","display_name":"Abdurrahman I\u015f\u0131kdo\u011fan","orcid":"https://orcid.org/0000-0002-7451-7286","observed_orcids":["https://orcid.org/0000-0002-7451-7286"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abdurrahman I\u015fikdo\u011fan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1016,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.73819606,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"61","issue":"130","first_page":"267","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0471000000834465,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9290000200271606},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9089999794960022},{"id":"https://openalex.org/keywords/serum-vegf-levels","display_name":"serum VEGF levels","score":0.8159999847412109},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8840000033378601},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.6669999957084656},{"id":"https://openalex.org/keywords/carcinoembryonic-antigen","display_name":"carcinoembryonic antigen","score":0.9900000095367432},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8270000219345093},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.7490000128746033},{"id":"https://openalex.org/keywords/tumor-location","display_name":"tumor location","score":0.5189999938011169},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.6399999856948853},{"id":"https://openalex.org/keywords/rectal-cancer","display_name":"rectal cancer","score":0.996999979019165}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7899259328842163},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7649438977241516},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.7230060696601868},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6765875220298767},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.5834996104240417},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.5733359456062317},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5502896904945374},{"id":"https://openalex.org/C2781074409","wikidata":"https://www.wikidata.org/wiki/Q158716","display_name":"Rectum","level":2,"score":0.5470125079154968},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4986231327056885},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.47280755639076233},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.45851847529411316},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.4138437807559967},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33634448051452637},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.32392895221710205},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10085952281951904},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002272","descriptor_name":"Carcinoembryonic Antigen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:24901122","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24901122","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepato-gastroenterology","raw_type":"Journal Article"},{"id":"mag:26656319","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24901122","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W339662228","https://openalex.org/W1893341214","https://openalex.org/W2417116748"],"related_works":["https://openalex.org/W2303346607","https://openalex.org/W2354764961","https://openalex.org/W1990212098","https://openalex.org/W2062761613","https://openalex.org/W2352929554","https://openalex.org/W2353426576","https://openalex.org/W2380230282","https://openalex.org/W2953630960","https://openalex.org/W2354863096","https://openalex.org/W2368559257"],"abstract_inverted_index":{"BACKGROUND/AIMS:":[0],"In":[1],"the":[2,18,92,97,110,115,194],"present":[3],"study,":[4],"we":[5],"analyzed":[6],"serum":[7,46,105,137],"vascular":[8],"endothelial":[9],"growth":[10],"factor":[11],"(VEGF)":[12],"levels":[13,103],"and":[14,58,143,164,178,184,196],"its":[15],"correlation":[16],"with":[17,24,50,64,80,91,109,136,158,175],"other":[19],"clinicopathological":[20],"characteristics":[21],"of":[22,45,72,104,146,198],"patients":[23,30,79,108],"colorectal":[25,147],"carcinoma":[26],"(CRC).":[27],"METHODOLOGY:":[28],"Seventy-one":[29],"(F/M,":[31],"29/42;":[32],"Mean":[33],"age":[34,160],"+/-":[35,38,76,85,118,123],"SD,":[36],"53.3":[37],"13.1":[39],"years)":[40],"were":[41,48],"included.":[42],"The":[43,131,152,170],"results":[44],"VEGF":[47,73,106,132,153,171,187,201],"analysed":[49],"respect":[51],"to":[52],"stage,":[53,177],"gender,":[54,183],"age,":[55,182],"CEA,":[56],"metastases":[57,179],"topographical":[59],"tumour":[60,94,112,185],"localization.":[61,186],"RESULTS:":[62],"Patients":[63,90],"stage":[65,81],"3-4":[66],"disease":[67],"had":[68,99],"significantly":[69,101,134,173],"higher":[70,102],"values":[71],"(253.41":[74],"pg/mL":[75,120],"302.24)":[77],"than":[78,107],"1-2":[82],"(49.99":[83],"pg/L":[84],"100.30)":[86],"(P":[87,140,149,161,166],"<":[88,141,150],"0.003).":[89],"primary":[93,111],"localized":[95,113],"in":[96,114,193,208],"colon":[98],"no":[100],"rectum":[116],"(225.97":[117],"324.88":[119],"vs.":[121],"153.76":[122],"205.66":[124],"pg/":[125],"mL,":[126],"respectively,":[127],"P":[128],"=":[129,162,167],"0.269).":[130],"expression":[133,154,172],"correlated":[135,157,174],"CEA":[138],"level":[139],"0.01)":[142],"clinical":[144],"stages":[145],"cancer":[148],"0.01).":[151],"was":[155],"not":[156,181],"patients'":[159],"0.955)":[163],"gender":[165],"0.740).":[168],"CONCLUSIONS:":[169],"advanced":[176],"but":[180],"may":[188],"play":[189],"an":[190],"important":[191],"role":[192],"invasion":[195],"metastasis":[197],"CRC.":[199,209],"Therefore,":[200],"could":[202],"be":[203],"applied":[204],"as":[205],"prognostic":[206],"markers":[207]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}