{"id":"https://openalex.org/W26645948","doi":null,"title":"Endocannabinoids and the gastrointestinal tract.","display_name":"Endocannabinoids and the gastrointestinal tract.","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W26645948","mag":"26645948","pmid":"https://pubmed.ncbi.nlm.nih.gov/16751708"},"language":"en","primary_location":{"id":"pmid:16751708","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16751708","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of endocrinological investigation","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023021929","display_name":"Federico Massa","orcid":"https://orcid.org/0000-0002-9427-3418","observed_orcids":["https://orcid.org/0000-0002-9427-3418"]},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"F Massa","raw_affiliation_strings":["Department of Physiological Chemistry, Johannes Gutenberg-University Mainz, 55099 Mainz, Germany. massa@uni-mainz.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Chemistry, Johannes Gutenberg-University Mainz, 55099 Mainz, Germany. massa@uni-mainz.de","institution_ids":["https://openalex.org/I197323543"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035231059","display_name":"Krisztina Monory","orcid":"https://orcid.org/0000-0002-1548-7718","observed_orcids":["https://orcid.org/0000-0002-1548-7718"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Monory","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.0443,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.90586213,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"29","issue":"3 Suppl","first_page":"47","last_page":"57"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endocannabinoids","display_name":"endocannabinoids","score":0.9330000281333923},{"id":"https://openalex.org/keywords/endocannabinoid-system","display_name":"endocannabinoid system","score":0.8859999775886536},{"id":"https://openalex.org/keywords/gastrointestinal-tract","display_name":"gastrointestinal tract","score":0.9660000205039978},{"id":"https://openalex.org/keywords/cannabinoid-receptors","display_name":"cannabinoid receptors","score":0.8920000195503235},{"id":"https://openalex.org/keywords/cb1-receptor","display_name":"CB1 receptor","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cb2-receptor","display_name":"CB2 receptor","score":1.0},{"id":"https://openalex.org/keywords/delta9-tetrahydrocannabinol","display_name":"delta-9-tetrahydrocannabinol","score":0.9160000085830688},{"id":"https://openalex.org/keywords/cannabis","display_name":"cannabis","score":0.5070000290870667},{"id":"https://openalex.org/keywords/enteric-nervous-system","display_name":"enteric nervous system","score":0.8080000281333923},{"id":"https://openalex.org/keywords/gastrointestinal-pain","display_name":"gastrointestinal pain","score":0.699999988079071},{"id":"https://openalex.org/keywords/gastroenteritis","display_name":"gastroenteritis","score":0.7609999775886536},{"id":"https://openalex.org/keywords/diarrhea","display_name":"diarrhea","score":0.9950000047683716},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.781000018119812},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.9789999723434448},{"id":"https://openalex.org/keywords/irritable-bowel-syndrome","display_name":"irritable bowel syndrome","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gastrointestinal-secretion","display_name":"gastrointestinal secretion","score":0.5699999928474426},{"id":"https://openalex.org/keywords/gastrointestinal-motility","display_name":"gastrointestinal motility","score":0.8880000114440918},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C46721173","wikidata":"https://www.wikidata.org/wiki/Q368952","display_name":"Endocannabinoid system","level":3,"score":0.8771876692771912},{"id":"https://openalex.org/C148001335","wikidata":"https://www.wikidata.org/wiki/Q421237","display_name":"Cannabinoid receptor","level":4,"score":0.7995413541793823},{"id":"https://openalex.org/C2780871563","wikidata":"https://www.wikidata.org/wiki/Q422936","display_name":"Cannabinoid","level":3,"score":0.715807318687439},{"id":"https://openalex.org/C2778271842","wikidata":"https://www.wikidata.org/wiki/Q838966","display_name":"Irritable bowel syndrome","level":2,"score":0.6450633406639099},{"id":"https://openalex.org/C93248783","wikidata":"https://www.wikidata.org/wiki/Q21150595","display_name":"Cannabinoid receptor type 2","level":5,"score":0.6332948803901672},{"id":"https://openalex.org/C2777439022","wikidata":"https://www.wikidata.org/wiki/Q586582","display_name":"Enteric nervous system","level":2,"score":0.5719617605209351},{"id":"https://openalex.org/C2780512811","wikidata":"https://www.wikidata.org/wiki/Q11829360","display_name":"Gastrointestinal tract","level":2,"score":0.5554496049880981},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.509767472743988},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46934330463409424},{"id":"https://openalex.org/C2910065304","wikidata":"https://www.wikidata.org/wiki/Q422936","display_name":"Cannabinoid Receptor Agonists","level":5,"score":0.44548171758651733},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37955242395401},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35675519704818726},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34885287284851074},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34275394678115845},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.08649635314941406}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005767","descriptor_name":"Gastrointestinal Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D005767","descriptor_name":"Gastrointestinal Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D043882","descriptor_name":"Receptors, Cannabinoid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D063385","descriptor_name":"Cannabinoid Receptor Modulators","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D063385","descriptor_name":"Cannabinoid Receptor Modulators","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D063388","descriptor_name":"Endocannabinoids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:16751708","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16751708","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of endocrinological investigation","raw_type":"Journal Article"},{"id":"mag:26645948","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16751708","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W1964990533","https://openalex.org/W2106016308","https://openalex.org/W2036455760","https://openalex.org/W2090619341"],"related_works":["https://openalex.org/W2061375344","https://openalex.org/W2143719410","https://openalex.org/W2517712805","https://openalex.org/W1989289560","https://openalex.org/W2885227121","https://openalex.org/W7075694164","https://openalex.org/W2117012026","https://openalex.org/W2116203147","https://openalex.org/W2544245819","https://openalex.org/W1985110054"],"abstract_inverted_index":{"In":[0],"the":[1,12,27,44,73,96,110,116,133],"past":[2],"centuries,":[3],"different":[4,144],"preparations":[5],"of":[6,14,30,51,81],"marijuana":[7],"have":[8],"been":[9],"used":[10],"for":[11],"treatment":[13],"gastrointestinal":[15,45],"(GI)":[16],"disorders,":[17,146],"such":[18,130],"as":[19,32,34],"GI":[20,117,145],"pain,":[21],"gastroenteritis":[22],"and":[23,36,60,77,83,86,122,126,162,164],"diarrhea.":[24],"Delta9-tetrahydrocannabinol":[25],"(THC;":[26],"active":[28],"component":[29],"marijuana),":[31],"well":[33],"endogenous":[35],"synthetic":[37],"cannabinoids,":[38],"exert":[39],"their":[40],"biological":[41],"functions":[42],"on":[43],"tract":[46],"by":[47],"activating":[48],"two":[49],"types":[50],"cannabinoid":[52,54,61],"receptors,":[53],"type":[55,62],"1":[56],"receptor":[57,64],"(CB1":[58],"receptor)":[59],"2":[63],"(CB2":[65],"receptor).":[66],"While":[67],"CB1":[68],"receptors":[69,91],"are":[70,92],"located":[71],"in":[72,78,95],"enteric":[74,127],"nervous":[75],"system":[76,112,135],"sensory":[79],"terminals":[80],"vagal":[82],"spinal":[84],"neurons":[85],"regulate":[87],"neurotransmitter":[88],"release,":[89],"CB2":[90],"mostly":[93],"distributed":[94],"immune":[97],"system,":[98],"with":[99],"a":[100,138],"role":[101],"presently":[102],"still":[103],"difficult":[104],"to":[105,115],"establish.":[106],"Under":[107],"pathophysiological":[108],"conditions,":[109],"endocannabinoid":[111,134],"conveys":[113],"protection":[114],"tract,":[118],"eg":[119],"from":[120],"inflammation":[121],"abnormally":[123],"high":[124],"gastric":[125],"secretion.":[128],"For":[129],"protective":[131],"activities,":[132],"may":[136],"represent":[137],"new":[139],"promising":[140],"therapeutic":[141],"target":[142],"against":[143],"including":[147],"frankly":[148],"inflammatory":[149],"bowel":[150,156,160],"diseases":[151,157],"(eg,":[152,158],"Crohn's":[153],"disease),":[154],"functional":[155],"irritable":[159],"syndrome),":[161],"secretion-":[163],"motility-related":[165],"disorders.":[166]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
