{"id":"https://openalex.org/W26641395","doi":"https://doi.org/10.17037/pubs.01544172","title":"Prognostic and surrogate markers for outcome in the treatment of pulmonary tuberculosis","display_name":"Prognostic and surrogate markers for outcome in the treatment of pulmonary tuberculosis","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W26641395","doi":"https://doi.org/10.17037/pubs.01544172","mag":"26641395"},"language":"en","primary_location":{"id":"pmh:oai:researchonline.lshtm.ac.uk:1544172","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.17037/PUBS.01544172>","pdf_url":null,"source":{"id":"https://openalex.org/S4306402527","display_name":"LSHTM Research Online (London School of Hygiene and Tropical Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210089966","host_organization_name":"London School of Hygiene & Tropical Medicine","host_organization_lineage":["https://openalex.org/I4210089966"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.17037/pubs.01544172","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019513252","display_name":"Patrick P. J. Phillips","orcid":"https://orcid.org/0000-0002-6336-7024","observed_orcids":["https://orcid.org/0000-0002-6336-7024"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Phillips, Patrick Peter John","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5019513252"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.7343999743461609,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.7343999743461609,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.24770000576972961,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10845","display_name":"Advanced Causal Inference Techniques","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulmonary-tuberculosis","display_name":"pulmonary tuberculosis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/surrogate-markers","display_name":"surrogate markers","score":0.8579999804496765},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9890000224113464},{"id":"https://openalex.org/keywords/treatment-failure","display_name":"treatment failure","score":0.656000018119812},{"id":"https://openalex.org/keywords/tuberculosis-relapse","display_name":"tuberculosis relapse","score":0.7200000286102295},{"id":"https://openalex.org/keywords/meta-analytic-methods","display_name":"meta-analytic methods","score":0.7329999804496765},{"id":"https://openalex.org/keywords/tuberculosis-treatment-regimens","display_name":"tuberculosis treatment regimens","score":0.6230000257492065},{"id":"https://openalex.org/keywords/east-africa","display_name":"East Africa","score":0.8360000252723694},{"id":"https://openalex.org/keywords/east-asia","display_name":"East Asia","score":0.921999990940094}],"concepts":[{"id":"https://openalex.org/C141341695","wikidata":"https://www.wikidata.org/wiki/Q2368661","display_name":"Surrogate endpoint","level":2,"score":0.9194276332855225},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6308517456054688},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.553342878818512},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4813540577888489},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.457361102104187},{"id":"https://openalex.org/C2780521871","wikidata":"https://www.wikidata.org/wiki/Q7239671","display_name":"Predictive marker","level":3,"score":0.4122544527053833},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:researchonline.lshtm.ac.uk:1544172","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.17037/PUBS.01544172>","pdf_url":null,"source":{"id":"https://openalex.org/S4306402527","display_name":"LSHTM Research Online (London School of Hygiene and Tropical Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210089966","host_organization_name":"London School of Hygiene & Tropical Medicine","host_organization_lineage":["https://openalex.org/I4210089966"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"doi:10.17037/pubs.01544172","doi":"https://doi.org/10.17037/pubs.01544172","is_oa":true,"landing_page_url":"https://doi.org/10.17037/pubs.01544172","pdf_url":null,"source":{"id":"https://openalex.org/S4306400091","display_name":"London School of Hygiene & Tropical Medicine","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210089966","host_organization_name":"London School of Hygiene & Tropical Medicine","host_organization_lineage":["https://openalex.org/I4210089966"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"mag:26641395","doi":null,"is_oa":false,"landing_page_url":"http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.536901","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.17037/pubs.01544172","doi":"https://doi.org/10.17037/pubs.01544172","is_oa":true,"landing_page_url":"https://doi.org/10.17037/pubs.01544172","pdf_url":null,"source":{"id":"https://openalex.org/S4306400091","display_name":"London School of Hygiene & Tropical Medicine","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210089966","host_organization_name":"London School of Hygiene & Tropical Medicine","host_organization_lineage":["https://openalex.org/I4210089966"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7900000214576721,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2045152401","https://openalex.org/W2183881668","https://openalex.org/W2265525897","https://openalex.org/W2518330669","https://openalex.org/W7135094779","https://openalex.org/W1972367452","https://openalex.org/W2101922274","https://openalex.org/W2140400276","https://openalex.org/W7171652937","https://openalex.org/W2146416369"],"abstract_inverted_index":{"Phase":[0],"III":[1],"trials":[2,103,156,183],"for":[3,24,88,143,238,263],"new":[4],"tuberculosis":[5,98],"treatment":[6,31,57,80,99,120,211,217,269],"regimens":[7],"require":[8],"large":[9],"numbers":[10],"of":[11,30,56,132,154,215,255],"participants":[12],"and":[13,47,85,108,121,138,160,184,231,274],"can":[14],"take":[15],"over":[16],"five":[17],"years":[18],"to":[19,65,151,172,191],"complete.":[20],"A":[21,111],"surrogate":[22,86,145,161,176,195,240,275],"marker":[23,177,196],"poor":[25,89,122,133],"outcome":[26,90,134],"(failure":[27],"at":[28],"end":[29],"or":[32],"recurrence":[33],"following":[34],"successful":[35],"treatment),":[36],"the":[37,60,166,185,216,225,228,256,265,268,272,286],"established":[38],"endpoint":[39],"in":[40,105,223,242,260,294],"such":[41],"trials,":[42],"could":[43],"shorten":[44],"trial":[45,49],"duration":[46],"reduce":[48],"size.":[50],"Culture":[51],"results":[52,78,118,126,204],"after":[53],"two":[54,167,287],"months":[55],"have":[58],"shown":[59],"most":[61],"promise":[62],"but,":[63],"prior":[64],"this":[66,75,152,243,261],"research,":[67],"no":[68],"formal":[69],"evaluation":[70,254],"had":[71],"been":[72],"performed.":[73],"In":[74],"thesis,":[76],"culture":[77,117,125,169,188],"during":[79,119,210],"are":[81,147,205],"evaluated":[82],"as":[83],"prognostic":[84],"markers":[87,146,241],"using":[91,178,197],"data":[92,179,198],"on":[93,271],"6974":[94],"patients":[95],"from":[96,180,199],"twelve":[97],"randomised":[100],"controlled":[101],"multi-arm":[102,155],"conducted":[104],"East":[106,109,200,232],"Africa":[107],"Asia.":[110],"strong":[112],"association":[113],"was":[114,170,189],"found":[115,171,190],"between":[116,227,267],"outcome.":[123],"Nevertheless,":[124],"were":[127,277,282],"not":[128,148,278,283],"good":[129,175,194],"patient-specific":[130],"predictors":[131],"with":[135,157,285],"low":[136],"sensitivities":[137],"specificities.":[139],"Existing":[140],"meta-analytic":[141,236],"methods":[142,237],"evaluating":[144,239],"wholly":[149],"suited":[150],"setting":[153],"binary":[158],"true":[159,273],"endpoints.":[162],"Extending":[163],"these":[164],"methods,":[165],"month":[168,187],"be":[173,192],"a":[174,193,246,251,296],"Hong":[181,229],"Kong":[182,230],"three":[186],"African":[201,233],"trials.":[202,234],"These":[203],"an":[206],"indication":[207],"that":[208,249],"cultures":[209],"do":[212],"capture":[213],"some":[214],"effect.":[218],"Further":[219,290],"work":[220,291],"is":[221,292],"needed":[222,293],"understanding":[224],"differences":[226],"The":[235,280],"thesis":[244,262],"included":[245],"graphical":[247],"representation":[248],"permitted":[250],"clear":[252],"visual":[253],"surrogate.":[257],"Methods":[258],"developed":[259],"modelling":[264],"relationship":[266],"effects":[270],"endpoints":[276],"satisfactory.":[279],"deficiencies":[281],"overcome":[284],"extensions":[288],"proposed.":[289],"developing":[295],"more":[297],"appropriate":[298],"model.":[299]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2016-06-24T00:00:00"}
