{"id":"https://openalex.org/W2662802425","doi":"https://doi.org/10.1002/gcc.22479","title":"Relationship between pancreatic intraepithelial neoplasias, pancreatic ductal adenocarcinomas, and single nucleotide polymorphisms in autopsied elderly patients","display_name":"Relationship between pancreatic intraepithelial neoplasias, pancreatic ductal adenocarcinomas, and single nucleotide polymorphisms in autopsied elderly patients","publication_year":2017,"publication_date":"2017-06-22","ids":{"openalex":"https://openalex.org/W2662802425","doi":"https://doi.org/10.1002/gcc.22479","mag":"2662802425","pmid":"https://pubmed.ncbi.nlm.nih.gov/28639428"},"language":"en","primary_location":{"id":"doi:10.1002/gcc.22479","doi":"https://doi.org/10.1002/gcc.22479","is_oa":false,"landing_page_url":"https://doi.org/10.1002/gcc.22479","pdf_url":null,"source":{"id":"https://openalex.org/S200862508","display_name":"Genes Chromosomes and Cancer","issn_l":"1045-2257","issn":["1045-2257","1098-2264"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes, Chromosomes and Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069983125","display_name":"Yoko Matsuda","orcid":"https://orcid.org/0000-0002-3235-655X","observed_orcids":["https://orcid.org/0000-0002-3235-655X"]},"institutions":[{"id":"https://openalex.org/I4210152580","display_name":"Tokyo Metropolitan Geriatric Hospital","ror":"https://ror.org/04emv5a43","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210152580"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yoko Matsuda","raw_affiliation_strings":["Department of Pathology Tokyo Metropolitan Geriatric Hospital Tokyo Japan","Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0002-3235-655X","affiliations":[{"raw_affiliation_string":"Department of Pathology Tokyo Metropolitan Geriatric Hospital Tokyo Japan","institution_ids":["https://openalex.org/I4210152580"]},{"raw_affiliation_string":"Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan","institution_ids":["https://openalex.org/I4210152580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029317814","display_name":"Masashi Tanaka","orcid":"https://orcid.org/0000-0002-9311-2831","observed_orcids":["https://orcid.org/0000-0002-9311-2831"]},"institutions":[{"id":"https://openalex.org/I4210140609","display_name":"Tokyo Metropolitan Institute of Gerontology","ror":"https://ror.org/03rd0p893","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210140609"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masashi Tanaka","raw_affiliation_strings":["Department of Genomics for Longevity and Health Tokyo Metropolitan Institute of Gerontology Tokyo Japan","Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genomics for Longevity and Health Tokyo Metropolitan Institute of Gerontology Tokyo Japan","institution_ids":["https://openalex.org/I4210140609"]},{"raw_affiliation_string":"Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan","institution_ids":["https://openalex.org/I4210140609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004173815","display_name":"Motoji Sawabe","orcid":"https://orcid.org/0000-0002-7212-2547","observed_orcids":["https://orcid.org/0000-0002-7212-2547"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Motoji Sawabe","raw_affiliation_strings":["Molecular Pathophysiology, Graduate School of Health Care Science, Tokyo Medical and Dental University Tokyo Japan","Molecular Pathophysiology, Graduate School of Health Care Science, Tokyo Medical and Dental University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Pathophysiology, Graduate School of Health Care Science, Tokyo Medical and Dental University Tokyo Japan","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Molecular Pathophysiology, Graduate School of Health Care Science, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081919892","display_name":"Seijiro Mori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152580","display_name":"Tokyo Metropolitan Geriatric Hospital","ror":"https://ror.org/04emv5a43","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210152580"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Seijiro Mori","raw_affiliation_strings":["Center for Promotion of Clinical Investigation, Tokyo Metropolitan Geriatric Hospital Tokyo Japan","Center for Promotion of Clinical Investigation, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Promotion of Clinical Investigation, Tokyo Metropolitan Geriatric Hospital Tokyo Japan","institution_ids":["https://openalex.org/I4210152580"]},{"raw_affiliation_string":"Center for Promotion of Clinical Investigation, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan","institution_ids":["https://openalex.org/I4210152580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103259430","display_name":"Masaaki Muramatsu","orcid":"https://orcid.org/0000-0001-6740-6900","observed_orcids":["https://orcid.org/0000-0001-6740-6900"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaaki Muramatsu","raw_affiliation_strings":["Department of Molecular Epidemiology Medical Research Institute, Tokyo Medical and Dental University Tokyo Japan","Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Epidemiology Medical Research Institute, Tokyo Medical and Dental University Tokyo Japan","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015785069","display_name":"Makiko Mieno","orcid":"https://orcid.org/0000-0002-3510-9941","observed_orcids":["https://orcid.org/0000-0002-3510-9941"]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makiko Naka Mieno","raw_affiliation_strings":["Department of Medical Informatics Center for Information, Jichi Medical University Tochigi Japan","Department of Medical Informatics, Center for Information, Jichi Medical University, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Informatics Center for Information, Jichi Medical University Tochigi Japan","institution_ids":["https://openalex.org/I146500386"]},{"raw_affiliation_string":"Department of Medical Informatics, Center for Information, Jichi Medical University, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012989108","display_name":"Toru Furukawa","orcid":"https://orcid.org/0000-0002-1083-2324","observed_orcids":["https://orcid.org/0000-0002-1083-2324"]},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toru Furukawa","raw_affiliation_strings":["Institute for Integrated Medical Sciences, Tokyo Women's Medical University Tokyo Japan","Institute for Integrated Medical Sciences, Tokyo Women's Medical University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Integrated Medical Sciences, Tokyo Women's Medical University Tokyo Japan","institution_ids":["https://openalex.org/I4210136522"]},{"raw_affiliation_string":"Institute for Integrated Medical Sciences, Tokyo Women's Medical University, Tokyo, Japan","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043840057","display_name":"Tomio Arai","orcid":"https://orcid.org/0000-0003-4583-8301","observed_orcids":["https://orcid.org/0000-0003-4583-8301"]},"institutions":[{"id":"https://openalex.org/I4210152580","display_name":"Tokyo Metropolitan Geriatric Hospital","ror":"https://ror.org/04emv5a43","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210152580"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomio Arai","raw_affiliation_strings":["Department of Pathology Tokyo Metropolitan Geriatric Hospital Tokyo Japan","Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology Tokyo Metropolitan Geriatric Hospital Tokyo Japan","institution_ids":["https://openalex.org/I4210152580"]},{"raw_affiliation_string":"Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan","institution_ids":["https://openalex.org/I4210152580"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5069983125"],"corresponding_institution_ids":["https://openalex.org/I4210152580"],"apc_list":{"value":4810,"currency":"USD","value_usd":4810},"apc_paid":null,"fwci":0.5388,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.67882255,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"57","issue":"1","first_page":"12","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-intraepithelial-neoplasia","display_name":"pancreatic intraepithelial neoplasia","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9919999837875366},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7089999914169312},{"id":"https://openalex.org/keywords/pancreatic-carcinogenesis","display_name":"pancreatic carcinogenesis","score":0.7360000014305115},{"id":"https://openalex.org/keywords/autopsy-findings","display_name":"autopsy findings","score":0.5440000295639038},{"id":"https://openalex.org/keywords/nr5a2","display_name":"NR5A2","score":0.9829999804496765},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.5120000243186951},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.9449999928474426}],"concepts":[{"id":"https://openalex.org/C2909925829","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic Intraepithelial Neoplasia","level":5,"score":0.7867433428764343},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.731575608253479},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.6205331087112427},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5426386594772339},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.514037013053894},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.45786386728286743},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.434036523103714},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4297448694705963},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.348682165145874},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.32757484912872314},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.32643580436706543},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32162851095199585},{"id":"https://openalex.org/C2992026798","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic ductal adenocarcinoma","level":4,"score":0.30263617634773254},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.22988921403884888},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10505133867263794},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09961053729057312}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002278","descriptor_name":"Carcinoma in Situ","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002278","descriptor_name":"Carcinoma in Situ","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002278","descriptor_name":"Carcinoma in Situ","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002278","descriptor_name":"Carcinoma in Situ","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002278","descriptor_name":"Carcinoma in Situ","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002278","descriptor_name":"Carcinoma in Situ","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/gcc.22479","doi":"https://doi.org/10.1002/gcc.22479","is_oa":false,"landing_page_url":"https://doi.org/10.1002/gcc.22479","pdf_url":null,"source":{"id":"https://openalex.org/S200862508","display_name":"Genes Chromosomes and Cancer","issn_l":"1045-2257","issn":["1045-2257","1098-2264"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes, Chromosomes and Cancer","raw_type":"journal-article"},{"id":"pmid:28639428","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28639428","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes, chromosomes & cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7699999809265137}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G6171657686","display_name":"Elucidation of exercise performance-related genes by whole genome sequencing of world elite sprinters and long distance runners","funder_award_id":"16H01872","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6791148986","display_name":"Mechanisms of aging in the tissue progenitor cells and tissue regeneration","funder_award_id":"16KT0125","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320307762","display_name":"International Business Machines Corporation","ror":"https://ror.org/05hh8d621"},{"id":"https://openalex.org/F4320309807","display_name":"Takeda Science Foundation","ror":"https://ror.org/02y123g31"},{"id":"https://openalex.org/F4320322555","display_name":"Smoking Research Foundation","ror":"https://ror.org/04q4hbm31"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1559867802","https://openalex.org/W1572960859","https://openalex.org/W1578083272","https://openalex.org/W1772544612","https://openalex.org/W1964064067","https://openalex.org/W1968812902","https://openalex.org/W1997220928","https://openalex.org/W2011571454","https://openalex.org/W2012505970","https://openalex.org/W2015291115","https://openalex.org/W2021708309","https://openalex.org/W2025970479","https://openalex.org/W2032202543","https://openalex.org/W2041973922","https://openalex.org/W2044518804","https://openalex.org/W2048755332","https://openalex.org/W2074189641","https://openalex.org/W2078675213","https://openalex.org/W2081681778","https://openalex.org/W2090380335","https://openalex.org/W2096779733","https://openalex.org/W2102413929","https://openalex.org/W2111898090","https://openalex.org/W2120369611","https://openalex.org/W2138978019","https://openalex.org/W2142769596","https://openalex.org/W2146849323","https://openalex.org/W2149813409","https://openalex.org/W2169961966","https://openalex.org/W2183332479","https://openalex.org/W2215458091","https://openalex.org/W2335031400","https://openalex.org/W2397171404","https://openalex.org/W2411554822","https://openalex.org/W2431396139","https://openalex.org/W2509403461","https://openalex.org/W4231031590"],"related_works":["https://openalex.org/W2350096948","https://openalex.org/W2767720677","https://openalex.org/W1993396840","https://openalex.org/W2560328198","https://openalex.org/W4248401158","https://openalex.org/W2086951674","https://openalex.org/W2896376457","https://openalex.org/W2354969507","https://openalex.org/W2087836279","https://openalex.org/W1486596979"],"abstract_inverted_index":{"We":[0,69],"comparatively":[1],"analyzed":[2],"serially":[3],"autopsied,":[4],"elderly":[5,147],"Japanese":[6,148],"patients":[7,45],"(n":[8],"=":[9],"2205)":[10],"with":[11,59,86,106,122,128],"pancreatic":[12,17,26,97,144],"intraepithelial":[13],"neoplasias":[14],"(PanINs)":[15],"and":[16,30,41,50,64,78,88,92,140],"ductal":[18],"adenocarcinomas":[19],"(PDACs)":[20],"on":[21],"the":[22,129],"basis":[23],"of":[24,37,55],"their":[25],"lesions,":[27],"clinical":[28],"information,":[29],"single":[31],"nucleotide":[32],"polymorphisms":[33],"(SNPs).":[34],"The":[35,53],"incidence":[36],"PanIN-1,":[38],"-2,":[39],"-3,":[40],"PDACs":[42,89],"in":[43,108,146],"these":[44],"was":[46,57],"55%,":[47],"12%,":[48],"1.4%,":[49],"2.4%,":[51],"respectively.":[52],"occurrence":[54],"PanINs":[56,77,87],"associated":[58,85,127],"female":[60],"sex,":[61],"increasing":[62],"age,":[63],"lower":[65],"body":[66],"mass":[67],"index.":[68],"did":[70],"not":[71],"identify":[72],"any":[73],"common":[74,83],"SNPs":[75,84,112],"between":[76,90],"PDACs.":[79,132],"There":[80],"were":[81,120,126],"no":[82],"men":[91],"women.":[93],"In":[94],"previously":[95],"reported":[96],"cancer-associated":[98],"SNPs,":[99],"rs3790844":[100],"(NR5A2)":[101],"showed":[102],"a":[103],"significant":[104],"correlation":[105],"PDAC":[107],"our":[109],"cohort.":[110],"Six":[111],"(rs7016880,":[113],"rs10096633,":[114],"rs10503669,":[115],"rs12678919,":[116],"rs17482753,":[117],"rs328)":[118],"that":[119,136],"correlated":[121],"blood":[123],"lipid":[124],"levels":[125],"risk":[130],"for":[131],"Our":[133],"data":[134],"suggest":[135],"different":[137],"clinicopathological":[138],"characteristics":[139],"predispositions":[141],"may":[142],"affect":[143],"carcinogenesis":[145],"patients.":[149]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}