{"id":"https://openalex.org/W266123765","doi":null,"title":"Expression of migfilin is increased in esophageal cancer and represses the Akt-\u03b2-catenin activation.","display_name":"Expression of migfilin is increased in esophageal cancer and represses the Akt-\u03b2-catenin activation.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W266123765","mag":"266123765","pmid":"https://pubmed.ncbi.nlm.nih.gov/24959381","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4065407"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4065407","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4065407","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4065407","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020818764","display_name":"Huan He","orcid":"https://orcid.org/0000-0001-8123-5765","observed_orcids":["https://orcid.org/0000-0001-8123-5765"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4391767655","display_name":"State Key Laboratory of Molecular Oncology","ror":"https://ror.org/014gmtw23","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210141458","https://openalex.org/I4391767655"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huan He","raw_affiliation_strings":["The State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4391767655"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065829118","display_name":"Fang Ding","orcid":"https://orcid.org/0000-0002-9697-7179","observed_orcids":["https://orcid.org/0000-0002-9697-7179"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4391767655","display_name":"State Key Laboratory of Molecular Oncology","ror":"https://ror.org/014gmtw23","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210141458","https://openalex.org/I4391767655"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fang Ding","raw_affiliation_strings":["The State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4391767655"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100359793","display_name":"Sheng Li","orcid":"https://orcid.org/0000-0001-8080-9712","observed_orcids":["https://orcid.org/0000-0001-8080-9712"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4391767655","display_name":"State Key Laboratory of Molecular Oncology","ror":"https://ror.org/014gmtw23","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210141458","https://openalex.org/I4391767655"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sheng Li","raw_affiliation_strings":["The State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4391767655"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101448009","display_name":"Hongyan Chen","orcid":"https://orcid.org/0000-0001-9477-2260","observed_orcids":["https://orcid.org/0000-0001-9477-2260"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4391767655","display_name":"State Key Laboratory of Molecular Oncology","ror":"https://ror.org/014gmtw23","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210141458","https://openalex.org/I4391767655"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongyan Chen","raw_affiliation_strings":["The State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4391767655"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100406779","display_name":"Zhihua Liu","orcid":"https://orcid.org/0000-0003-4242-033X","observed_orcids":["https://orcid.org/0000-0003-4242-033X"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4391767655","display_name":"State Key Laboratory of Molecular Oncology","ror":"https://ror.org/014gmtw23","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210141458","https://openalex.org/I4391767655"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhihua Liu","raw_affiliation_strings":["The State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4391767655"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4167,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.79850493,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"4","issue":"3","first_page":"270","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.4180000126361847,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.4180000126361847,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.24410000443458557,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.1860000044107437,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/esophageal-squamous-cell-carcinoma","display_name":"esophageal squamous cell carcinoma","score":0.984000027179718},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.9210000038146973},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.9330000281333923},{"id":"https://openalex.org/keywords/gsk-3beta","display_name":"GSK3\u03b2","score":0.9729999899864197},{"id":"https://openalex.org/keywords/lim-domain-proteins","display_name":"LIM domain proteins","score":0.6269999742507935},{"id":"https://openalex.org/keywords/focal-adhesions","display_name":"focal adhesions","score":0.7739999890327454},{"id":"https://openalex.org/keywords/cytoskeleton","display_name":"cytoskeleton","score":0.8640000224113464},{"id":"https://openalex.org/keywords/nuclear-cytoplasmic-translocation","display_name":"nuclear-cytoplasmic translocation","score":0.9089999794960022},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.527999997138977},{"id":"https://openalex.org/keywords/cell-adhesion-proteins","display_name":"cell adhesion proteins","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C30145163","wikidata":"https://www.wikidata.org/wiki/Q384104","display_name":"Catenin","level":4,"score":0.6785901188850403},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.6181811690330505},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.5797477960586548},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5761670470237732},{"id":"https://openalex.org/C151166631","wikidata":"https://www.wikidata.org/wiki/Q904514","display_name":"Focal adhesion","level":3,"score":0.5753011703491211},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5703117251396179},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5621623992919922},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.48450085520744324},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.45801180601119995},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.44600972533226013},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.43687188625335693},{"id":"https://openalex.org/C2779742542","wikidata":"https://www.wikidata.org/wiki/Q372701","display_name":"Esophageal cancer","level":3,"score":0.431810200214386},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.42704036831855774},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4256681799888611},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.42342451214790344},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3732643127441406},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3706486225128174},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3532719612121582},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33612632751464844},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.18176519870758057},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06731098890304565},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:4065407","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4065407","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},{"id":"pmid:24959381","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24959381","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"},{"id":"mag:266123765","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24959381","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4065407","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4065407","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1822029953","https://openalex.org/W1863238068","https://openalex.org/W1973298073","https://openalex.org/W1975024491","https://openalex.org/W1975932893","https://openalex.org/W1980627480","https://openalex.org/W1981989535","https://openalex.org/W1994215553","https://openalex.org/W1997261925","https://openalex.org/W1998701837","https://openalex.org/W2004542682","https://openalex.org/W2006591164","https://openalex.org/W2013841398","https://openalex.org/W2016952508","https://openalex.org/W2031793283","https://openalex.org/W2035245937","https://openalex.org/W2037345997","https://openalex.org/W2049520420","https://openalex.org/W2049635996","https://openalex.org/W2063212204","https://openalex.org/W2067016596","https://openalex.org/W2069839886","https://openalex.org/W2076193716","https://openalex.org/W2085261895","https://openalex.org/W2091912608","https://openalex.org/W2093873926","https://openalex.org/W2104222404","https://openalex.org/W2106887050","https://openalex.org/W2118530396","https://openalex.org/W2123522555","https://openalex.org/W2131309206","https://openalex.org/W2139362027","https://openalex.org/W2144319052","https://openalex.org/W2155429083","https://openalex.org/W2160578485","https://openalex.org/W2165801694","https://openalex.org/W2170090330","https://openalex.org/W2318489987","https://openalex.org/W2417987998"],"related_works":["https://openalex.org/W2157816760","https://openalex.org/W2417987998","https://openalex.org/W2034346294","https://openalex.org/W2168523475","https://openalex.org/W2150789050","https://openalex.org/W2384769858","https://openalex.org/W2766366638","https://openalex.org/W4224291086","https://openalex.org/W2016291097","https://openalex.org/W4392198248"],"abstract_inverted_index":{"Cell":[0],"adhesion":[1,38,48],"proteins":[2,43],"that":[3,73,101,127,147],"connect":[4],"each":[5],"cell":[6,19,47,68,123],"to":[7,71,90],"neighboring":[8],"cells":[9,111],"and":[10,21,36,44,49,56,152],"the":[11,32,74,96,102,128,137],"extracellular":[12],"matrix":[13],"are":[14],"an":[15,156],"important":[16],"determinant":[17],"of":[18,27,60,65,76,104,131,139],"morphology":[20],"metastasis.":[22],"Migfilin":[23],"is":[24],"a":[25,86],"member":[26],"LIM-containing":[28],"protein":[29],"family,":[30],"mediated":[31],"linkage":[33],"between":[34],"cytoskeleton":[35],"focal":[37,113],"through":[39,136],"interacting":[40],"with":[41,85,112,118],"other":[42],"involved":[45],"in":[46,62,81,83,108,120,150,155],"motility.":[50],"The":[51],"present":[52],"study":[53],"used":[54],"immunohistochemistry":[55],"Western":[57],"blot":[58],"analysis":[59],"migfilin":[61,77,119,134,148],"clinical":[63],"specimens":[64],"esophageal":[66,109,121],"squamous":[67],"carcinoma":[69],"(ESCC)":[70],"identify":[72],"expression":[75,103,130],"was":[78,106,135],"significantly":[79],"upregulated":[80,107,149],"ESCC":[82],"concomitance":[84],"nuclear-cytoplasm":[87],"translocation":[88],"compared":[89],"normal":[91],"adjacent":[92],"tissue.":[93],"Alternately,":[94],"using":[95],"published":[97],"datasets":[98],"we":[99],"identified":[100],"\u03b2-catenin":[105,132,154],"cancer":[110,122],"invasion,":[114],"while":[115],"inversely":[116],"correlated":[117],"lines.":[124],"We":[125],"demonstrated":[126],"reduced":[129],"by":[133],"inhibition":[138],"Akt":[140],"activation.":[141],"In":[142],"conclusion,":[143],"these":[144],"results":[145],"illustrated":[146],"ESCCs":[151],"repressed":[153],"Akt-GSK3\u03b2":[157],"signaling":[158],"dependent":[159],"manner.":[160]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}