{"id":"https://openalex.org/W2659316636","doi":"https://doi.org/10.18203/2319-2003.ijbcp20172723","title":"Evaluation of lipid lowering ability of atorvastatin and ezetimibe combination as compared with atorvastatin monotherapy","display_name":"Evaluation of lipid lowering ability of atorvastatin and ezetimibe combination as compared with atorvastatin monotherapy","publication_year":2017,"publication_date":"2017-06-23","ids":{"openalex":"https://openalex.org/W2659316636","doi":"https://doi.org/10.18203/2319-2003.ijbcp20172723","mag":"2659316636"},"language":"en","primary_location":{"id":"doi:10.18203/2319-2003.ijbcp20172723","doi":"https://doi.org/10.18203/2319-2003.ijbcp20172723","is_oa":true,"landing_page_url":"https://doi.org/10.18203/2319-2003.ijbcp20172723","pdf_url":"https://www.ijbcp.com/index.php/ijbcp/article/download/1665/1505","source":{"id":"https://openalex.org/S2764844374","display_name":"International Journal of Basic & Clinical Pharmacology","issn_l":"2279-0780","issn":["2279-0780","2319-2003"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322697004","host_organization_name":"Medip Academy","host_organization_lineage":["https://openalex.org/P4322697004"],"host_organization_lineage_names":["Medip Academy"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Basic &amp; Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.ijbcp.com/index.php/ijbcp/article/download/1665/1505","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015389900","display_name":"Kalpana S. Dudhal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49124879","display_name":"Dr. V. M. Government Medical College","ror":"https://ror.org/01k22c722","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I49124879"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kalpana S. Dudhal","raw_affiliation_strings":["Department of Pharmacology, Dr. Vaishampayan Memorial Govt. Medical College, Solapur, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Dr. Vaishampayan Memorial Govt. Medical College, Solapur, Maharashtra, India","institution_ids":["https://openalex.org/I49124879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108236951","display_name":"Tushar R Bapat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49124879","display_name":"Dr. V. M. Government Medical College","ror":"https://ror.org/01k22c722","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I49124879"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Tushar R. Bapat","raw_affiliation_strings":["Department of Pharmacology, Dr. Vaishampayan Memorial Govt. Medical College, Solapur, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Dr. Vaishampayan Memorial Govt. Medical College, Solapur, Maharashtra, India","institution_ids":["https://openalex.org/I49124879"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022218561","display_name":"Amit Amrut Bansode","orcid":"https://orcid.org/0000-0003-3685-1627","observed_orcids":["https://orcid.org/0000-0003-3685-1627"]},"institutions":[{"id":"https://openalex.org/I49124879","display_name":"Dr. V. M. Government Medical College","ror":"https://ror.org/01k22c722","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I49124879"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Amit A. Bansode","raw_affiliation_strings":["Department of Pharmacology, Dr. Vaishampayan Memorial Govt. Medical College, Solapur, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Dr. Vaishampayan Memorial Govt. Medical College, Solapur, Maharashtra, India","institution_ids":["https://openalex.org/I49124879"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I49124879"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"7","first_page":"1643","last_page":"1643"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atorvastatin","display_name":"atorvastatin","score":1.0},{"id":"https://openalex.org/keywords/ezetimibe","display_name":"ezetimibe","score":1.0},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.753000020980835},{"id":"https://openalex.org/keywords/ldl-cholesterol-lowering","display_name":"LDL cholesterol lowering","score":0.7390000224113464},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.9100000262260437},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.8100000023841858},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.996999979019165},{"id":"https://openalex.org/keywords/total-cholesterol","display_name":"total cholesterol","score":0.8529999852180481},{"id":"https://openalex.org/keywords/serum-triglycerides","display_name":"serum triglycerides","score":0.9319999814033508},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.6570000052452087},{"id":"https://openalex.org/keywords/lipid-lowering-drugs","display_name":"lipid-lowering drugs","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C2778657065","wikidata":"https://www.wikidata.org/wiki/Q417997","display_name":"Ezetimibe","level":3,"score":0.9836024045944214},{"id":"https://openalex.org/C2777482532","wikidata":"https://www.wikidata.org/wiki/Q668093","display_name":"Atorvastatin","level":2,"score":0.979120671749115},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9123362302780151},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.7296960353851318},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.6173357963562012},{"id":"https://openalex.org/C3019550498","wikidata":"https://www.wikidata.org/wiki/Q28749","display_name":"Ldl cholesterol","level":3,"score":0.5064777135848999},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49755457043647766},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.47306811809539795},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.4549911916255951},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.44940420985221863},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.44058772921562195},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.434967964887619},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.41431164741516113},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.3632587790489197},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3255140781402588}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.18203/2319-2003.ijbcp20172723","doi":"https://doi.org/10.18203/2319-2003.ijbcp20172723","is_oa":true,"landing_page_url":"https://doi.org/10.18203/2319-2003.ijbcp20172723","pdf_url":"https://www.ijbcp.com/index.php/ijbcp/article/download/1665/1505","source":{"id":"https://openalex.org/S2764844374","display_name":"International Journal of Basic & Clinical Pharmacology","issn_l":"2279-0780","issn":["2279-0780","2319-2003"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322697004","host_organization_name":"Medip Academy","host_organization_lineage":["https://openalex.org/P4322697004"],"host_organization_lineage_names":["Medip Academy"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Basic &amp; Clinical Pharmacology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.18203/2319-2003.ijbcp20172723","doi":"https://doi.org/10.18203/2319-2003.ijbcp20172723","is_oa":true,"landing_page_url":"https://doi.org/10.18203/2319-2003.ijbcp20172723","pdf_url":"https://www.ijbcp.com/index.php/ijbcp/article/download/1665/1505","source":{"id":"https://openalex.org/S2764844374","display_name":"International Journal of Basic & Clinical Pharmacology","issn_l":"2279-0780","issn":["2279-0780","2319-2003"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322697004","host_organization_name":"Medip Academy","host_organization_lineage":["https://openalex.org/P4322697004"],"host_organization_lineage_names":["Medip Academy"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Basic &amp; Clinical Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2659316636.pdf","grobid_xml":"https://content.openalex.org/works/W2659316636.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W321467173","https://openalex.org/W1596948422","https://openalex.org/W2006199723","https://openalex.org/W2022128185","https://openalex.org/W2051441972","https://openalex.org/W2069227492","https://openalex.org/W2111385165","https://openalex.org/W2113284407","https://openalex.org/W2128240207","https://openalex.org/W2132211266","https://openalex.org/W2145653235","https://openalex.org/W2159449551","https://openalex.org/W2398524106","https://openalex.org/W4237314255","https://openalex.org/W4238251256"],"related_works":["https://openalex.org/W7217342079","https://openalex.org/W1987507883","https://openalex.org/W2087274346","https://openalex.org/W2360517029","https://openalex.org/W2897098703","https://openalex.org/W2560573087","https://openalex.org/W2350152005","https://openalex.org/W3155692460","https://openalex.org/W2027595428","https://openalex.org/W4225748325"],"abstract_inverted_index":{"Background:":[0],"Many":[1],"patients":[2,47,86,134,159,170,215],"on":[3,105],"statin":[4,18],"therapy":[5],"do":[6],"not":[7],"achieve":[8],"recommended":[9],"LDL":[10],"cholesterol":[11,154,183,234],"goals.":[12],"They":[13],"require":[14],"either":[15],"high":[16],"dose":[17],"regimen":[19],"or":[20,50],"combination":[21,91,165],"of":[22,57,92,108,141,151,202,223],"statins":[23],"with":[24,48,161,172,216,232],"other":[25],"lipid":[26],"modifying":[27],"agents.":[28],"Ezetimibe":[29,96,164,203],"is":[30],"a":[31,207],"novel":[32],"drug":[33],"when":[34],"added":[35],"to":[36,69,168,204],"statins,":[37],"will":[38],"provide":[39],"additional":[40],"reduction":[41,148,179],"in":[42,149,158,177,180,188],"LDL-C":[43,55,221,230],"level.Methods:":[44],"Total":[45,153,182],"100":[46],"CHD":[49,217],"hypertension":[51,219],"and":[52,65,85,95,110,115,124,133,137,155,184,197,210,218,235],"having":[53,220],"serum":[54,156,185],"levels":[56,150,187,222],"\u2265100":[58],"mg/dl":[59],"were":[60,66,119,135],"enrolled":[61],"for":[62,112,139,214],"the":[63,106,229],"study":[64],"randomly":[67],"allocated":[68],"two":[70,189],"groups.":[71],"Baseline":[72],"investigations":[73,131],"done.":[74],"Patients":[75],"from":[76,87],"Group":[77],"I":[78],"received":[79,90],"Atorvastatin":[80,93,162,173,205],"(10mg)":[81,94,97],"per":[82,98],"day":[83,99,107],"orally":[84],"group":[88],"II":[89],"orally.":[100],"Study":[101],"treatment":[102],"was":[103,146,191],"started":[104],"randomization":[109],"continued":[111],"12":[113,125,198],"weeks":[114,199],"follow":[116,129],"up":[117,130],"visits":[118],"scheduled":[120],"at":[121,194],"4,":[122,195],"8,":[123],"weeks.":[126],"During":[127],"each":[128],"repeated":[132],"interviewed":[136],"examined":[138],"occurrence":[140],"any":[142],"adverse":[143],"effect.Results:":[144],"There":[145],"greater":[147],"LDL-C,":[152,181],"triglycerides":[157,186],"treated":[160,171],"plus":[163],"as":[166,225],"compared":[167],"those":[169],"alone.":[174],"This":[175],"difference":[176],"percentage":[178],"groups":[190],"highly":[192],"significant":[193],"8":[196],"(p<0.01).Conclusions:":[200],"Addition":[201],"offers":[206],"very":[208],"effective":[209],"well":[211],"tolerated":[212],"option":[213],">100mg/dl":[224],"it":[226],"significantly":[227],"lowers":[228],"along":[231],"total":[233],"triglycerides.":[236]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2017-06-30T00:00:00"}