{"id":"https://openalex.org/W26531992","doi":null,"title":"Down-regulation of E-cadherin in mouse skin carcinoma cells enhances a migratory and invasive phenotype linked to matrix metalloproteinase-9 gelatinase expression.","display_name":"Down-regulation of E-cadherin in mouse skin carcinoma cells enhances a migratory and invasive phenotype linked to matrix metalloproteinase-9 gelatinase expression.","publication_year":1998,"publication_date":"1998-09-01","ids":{"openalex":"https://openalex.org/W26531992","mag":"26531992","pmid":"https://pubmed.ncbi.nlm.nih.gov/9759657"},"language":"en","primary_location":{"id":"pmid:9759657","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9759657","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080458067","display_name":"Ana Llorens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107147","display_name":"Institut Catal\u00e0 d'Oncologia","ror":"https://ror.org/01j1eb875","country_code":"ES","type":"government","lineage":["https://openalex.org/I4210107147"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"A Llorens","raw_affiliation_strings":["Department of Cancer and Metastasis, Institut de Recerca Oncol\u00f2gica, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer and Metastasis, Institut de Recerca Oncol\u00f2gica, Barcelona, Spain","institution_ids":["https://openalex.org/I4210107147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111575852","display_name":"Isabel Rodrigo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Rodrigo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087820972","display_name":"Lluis A. Lopez-Barcons","orcid":"https://orcid.org/0000-0001-9950-9090","observed_orcids":["https://orcid.org/0000-0001-9950-9090"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L L\u00f3pez-Barcons","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038601536","display_name":"Milagro Gonz\u00e1lez-Garrigues","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Gonzalez-Garrigues","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056769047","display_name":"Encarnaci\u00f3n Lozano","orcid":"https://orcid.org/0000-0003-0254-0935","observed_orcids":["https://orcid.org/0000-0003-0254-0935"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Lozano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004233851","display_name":"Ant\u00f2nia Vinyals","orcid":"https://orcid.org/0000-0003-3925-0050","observed_orcids":["https://orcid.org/0000-0003-3925-0050"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Vinyals","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003692339","display_name":"Michael Quintanilla","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Quintanilla","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108089795","display_name":"Amparo Cano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Cano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5062447219","display_name":"\u00c0ngels Fabra","orcid":"https://orcid.org/0000-0003-3288-523X","observed_orcids":["https://orcid.org/0000-0003-3288-523X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Fabra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4568,"has_fulltext":false,"cited_by_count":86,"citation_normalized_percentile":{"value":0.89700306,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"78","issue":"9","first_page":"1131","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9919999837875366},{"id":"https://openalex.org/keywords/gelatinase","display_name":"gelatinase","score":0.9089999794960022},{"id":"https://openalex.org/keywords/cutaneous-squamous-cell-carcinoma","display_name":"cutaneous squamous cell carcinoma","score":0.8140000104904175},{"id":"https://openalex.org/keywords/cell-cell-adhesion","display_name":"cell-cell adhesion","score":0.9150000214576721},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.7649999856948853},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.9589999914169312},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cell-density","display_name":"cell density","score":0.5809999704360962},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.4519999921321869}],"concepts":[{"id":"https://openalex.org/C2776232661","wikidata":"https://www.wikidata.org/wiki/Q5530373","display_name":"Gelatinase","level":3,"score":0.7286551594734192},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7123832702636719},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.6436872482299805},{"id":"https://openalex.org/C149402561","wikidata":"https://www.wikidata.org/wiki/Q24776048","display_name":"Cadherin","level":3,"score":0.6151826977729797},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5643130540847778},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5633978843688965},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.5614094734191895},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.5170938968658447},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.46636924147605896},{"id":"https://openalex.org/C2776223131","wikidata":"https://www.wikidata.org/wiki/Q13033733","display_name":"Gelatinase A","level":3,"score":0.43919551372528076},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.4364951252937317},{"id":"https://openalex.org/C183521119","wikidata":"https://www.wikidata.org/wiki/Q5058397","display_name":"Cell\u2013cell interaction","level":3,"score":0.4131573438644409},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3711335062980652},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3315858840942383},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.2656739354133606},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14236176013946533},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06609711050987244}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016375","descriptor_name":"Antisense Elements (Genetics)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016375","descriptor_name":"Antisense Elements (Genetics)","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017364","descriptor_name":"Collagenases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017364","descriptor_name":"Collagenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9759657","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9759657","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},{"id":"mag:26531992","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9759657","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2070023824","https://openalex.org/W1963861194","https://openalex.org/W1973467290","https://openalex.org/W2044827665","https://openalex.org/W2102411854","https://openalex.org/W4389071043","https://openalex.org/W1988078115","https://openalex.org/W2013214765","https://openalex.org/W2147469407","https://openalex.org/W2358980583"],"abstract_inverted_index":{"To":[0,79],"assess":[1],"the":[2,15,20,26,41,81,85,104,136,158,163,168,188,195,201],"role":[3],"of":[4,17,40,46,84,121,133,162,170,197,203],"gelatinases":[5],"in":[6,56,63,70,125,130,135,153,184,194,211],"mouse":[7,42,99,212],"skin":[8],"tumor":[9],"progression":[10],"and":[11,33,51,60,75,127,172,208],"their":[12],"link":[13],"to":[14],"expression":[16,117,169],"E-cadherin":[18],"(E-CD),":[19],"cell-cell":[21,86,174,190],"adhesion":[22],"protein,":[23],"we":[24,94],"used":[25],"highly":[27],"metastatic":[28,128],"squamous":[29,213],"HaCa4":[30,59],"cell":[31,106,138,145,164,178,186],"line":[32],"several":[34],"HaCa4-derived":[35],"clones":[36,62,73,139,165],"obtained":[37,111],"by":[38,89,144],"transfection":[39],"E-CD":[43,57,71,90,100,116,154,204],"cDNA.":[44],"Expression":[45,132],"matrix":[47],"metalloproteinase-9":[48],"(MMP-9)":[49],"mRNA":[50],"protein":[52],"activity":[53],"were":[54,67],"present":[55],"(-)":[58],"control":[61],"culture,":[64],"but":[65,147],"they":[66],"strongly":[68],"diminished":[69],"(+)":[72,155],"(E24":[74],"E62)":[76],"at":[77,176],"subconfluence.":[78],"explore":[80],"suppressive":[82],"effect":[83,149],"contacts":[87,175,191],"mediated":[88],"on":[91],"MMP-9":[92,122,134,198],"expression,":[93],"introduced":[95],"a":[96,206],"plasmid":[97],"encoding":[98],"antisense":[101],"cDNA":[102],"into":[103],"E24":[105],"clone.":[107],"The":[108],"transfectant":[109],"P1-clones":[110],"with":[112],"reduced":[113],"or":[114],"absent":[115],"showed":[118],"increased":[119],"levels":[120],"gelatinase,":[123],"motility":[124],"vitro,":[126],"potential":[129],"vivo.":[131],"various":[137],"was":[140,150],"also":[141],"negatively":[142],"modulated":[143],"density,":[146],"this":[148,185],"much":[151],"stronger":[152],"cells,":[156],"despite":[157],"fact":[159],"that":[160,183],"all":[161],"analyzed":[166],"maintained":[167],"P-cadherin":[171],"made":[173],"high":[177],"density.":[179],"Our":[180],"results":[181],"indicate":[182],"system,":[187],"E-CD-mediated":[189],"are":[192],"involved":[193],"down-regulation":[196],"expression.":[199],"Thus,":[200],"loss":[202],"triggers":[205],"migratory":[207],"invasive":[209],"phenotype":[210],"carcinoma":[214],"cells.":[215]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}