{"id":"https://openalex.org/W26527426","doi":null,"title":"Different carcinogenic process in cholangiocarcinoma cases epidemically developing among workers of a printing company in Japan.","display_name":"Different carcinogenic process in cholangiocarcinoma cases epidemically developing among workers of a printing company in Japan.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W26527426","mag":"26527426","pmid":"https://pubmed.ncbi.nlm.nih.gov/25197345","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4152035"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:3124722","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4152035","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4152035","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067352401","display_name":"Yasunori Sato","orcid":"https://orcid.org/0000-0002-3244-8972","observed_orcids":["https://orcid.org/0000-0002-3244-8972"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasunori Sato","raw_affiliation_strings":["Department of Human Pathology, Kanazawa University Graduate School of Medicine Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Pathology, Kanazawa University Graduate School of Medicine Kanazawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049137704","display_name":"Shoji Kubo","orcid":"https://orcid.org/0000-0002-4353-8033","observed_orcids":["https://orcid.org/0000-0002-4353-8033"]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shoji Kubo","raw_affiliation_strings":["Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine Osaka, Japan","institution_ids":["https://openalex.org/I317356780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071589326","display_name":"Shigekazu Takemura","orcid":"https://orcid.org/0000-0002-5221-7258","observed_orcids":["https://orcid.org/0000-0002-5221-7258"]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigekazu Takemura","raw_affiliation_strings":["Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine Osaka, Japan","institution_ids":["https://openalex.org/I317356780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012898538","display_name":"Yasuhiko Sugawara","orcid":"https://orcid.org/0000-0002-9638-1084","observed_orcids":["https://orcid.org/0000-0002-9638-1084"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhiko Sugawara","raw_affiliation_strings":["Artificial Organ & Transplantation Division, Department of Surgery, University of Tokyo Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Artificial Organ & Transplantation Division, Department of Surgery, University of Tokyo Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060248247","display_name":"Shogo Tanaka","orcid":"https://orcid.org/0000-0002-5629-5691","observed_orcids":["https://orcid.org/0000-0002-5629-5691"]},"institutions":[{"id":"https://openalex.org/I4210105311","display_name":"Ishikiriseiki Hospital","ror":"https://ror.org/01pvgz545","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210105311"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shogo Tanaka","raw_affiliation_strings":["Department of Surgery, Ishikiri Seiki Hospital Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Ishikiri Seiki Hospital Osaka, Japan","institution_ids":["https://openalex.org/I4210105311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110353986","display_name":"Masahiro Fujikawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164826","display_name":"Nippon Life Hospital","ror":"https://ror.org/05kp9zx42","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210164826"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Fujikawa","raw_affiliation_strings":["Department of Surgery, Nissay Hospital Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Nissay Hospital Osaka, Japan","institution_ids":["https://openalex.org/I4210164826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111995049","display_name":"Akira Arimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151887","display_name":"Osaka Red Cross Hospital","ror":"https://ror.org/05h4q5j46","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2799517759","https://openalex.org/I4210151887"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Arimoto","raw_affiliation_strings":["Department of Hepato-Biliary-Pancreatic Surgery, Osaka Red Cross Hospital Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepato-Biliary-Pancreatic Surgery, Osaka Red Cross Hospital Osaka, Japan","institution_ids":["https://openalex.org/I4210151887"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008794738","display_name":"Kenichi Harada","orcid":"https://orcid.org/0000-0002-6451-0638","observed_orcids":["https://orcid.org/0000-0002-6451-0638"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenichi Harada","raw_affiliation_strings":["Department of Human Pathology, Kanazawa University Graduate School of Medicine Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Pathology, Kanazawa University Graduate School of Medicine Kanazawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064494964","display_name":"Motoko Sasaki","orcid":"https://orcid.org/0000-0003-2514-760X","observed_orcids":["https://orcid.org/0000-0003-2514-760X"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Motoko Sasaki","raw_affiliation_strings":["Department of Human Pathology, Kanazawa University Graduate School of Medicine Kanazawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Pathology, Kanazawa University Graduate School of Medicine Kanazawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008003570","display_name":"Yasuni Nakanuma","orcid":"https://orcid.org/0000-0003-4117-6611","observed_orcids":["https://orcid.org/0000-0003-4117-6611"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]},{"id":"https://openalex.org/I4210088324","display_name":"Shizuoka Cancer Center","ror":"https://ror.org/0042ytd14","country_code":"JP","type":"funder","lineage":["https://openalex.org/I4210088324"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuni Nakanuma","raw_affiliation_strings":["Department of Human Pathology, Kanazawa University Graduate School of Medicine Kanazawa, Japan ; Department of Pathology, Shizuoka Cancer Center Shizuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Pathology, Kanazawa University Graduate School of Medicine Kanazawa, Japan ; Department of Pathology, Shizuoka Cancer Center Shizuoka, Japan","institution_ids":["https://openalex.org/I10091056","https://openalex.org/I4210088324"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.7944,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.97180374,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"7","issue":"8","first_page":"4745","last_page":"54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholangiocarcinoma","display_name":"cholangiocarcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/printing-workers","display_name":"printing workers","score":0.6819999814033508},{"id":"https://openalex.org/keywords/occupational-exposure","display_name":"occupational exposure","score":0.7979999780654907},{"id":"https://openalex.org/keywords/organic-solvents","display_name":"organic solvents","score":0.8939999938011169},{"id":"https://openalex.org/keywords/dichloromethane","display_name":"dichloromethane","score":0.9649999737739563},{"id":"https://openalex.org/keywords/1-2-dichloropropane","display_name":"1,2-dichloropropane","score":0.9950000047683716},{"id":"https://openalex.org/keywords/biliary-intraepithelial-neoplasia","display_name":"biliary intraepithelial neoplasia","score":0.949999988079071},{"id":"https://openalex.org/keywords/intraductal-papillary-neoplasm-of-the-bile-duct","display_name":"intraductal papillary neoplasm of the bile duct","score":0.9940000176429749},{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.7799999713897705},{"id":"https://openalex.org/keywords/gamma-h2ax","display_name":"\u03b3H2AX","score":0.902999997138977},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8709999918937683},{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.9369999766349792},{"id":"https://openalex.org/keywords/gnas-mutation","display_name":"GNAS mutation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.7250000238418579},{"id":"https://openalex.org/keywords/cholangiocytes","display_name":"cholangiocytes","score":0.7379999756813049},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.8474351167678833},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6719090342521667},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5183309316635132},{"id":"https://openalex.org/C2775982439","wikidata":"https://www.wikidata.org/wiki/Q3562150","display_name":"Biliary tract","level":2,"score":0.4957445561885834},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.4928460121154785},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.4884587824344635},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4595434069633484},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.44791093468666077},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4393326938152313},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36780500411987305},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3494327962398529},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3197278082370758},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.24675485491752625},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.089305579662323},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001650","descriptor_name":"Bile Duct Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001650","descriptor_name":"Bile Duct Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001650","descriptor_name":"Bile Duct Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001653","descriptor_name":"Bile Ducts, Intrahepatic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002864","descriptor_name":"Chromogranins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008813","descriptor_name":"Mice, Inbred ICR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009784","descriptor_name":"Occupational Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009784","descriptor_name":"Occupational Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009784","descriptor_name":"Occupational Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011327","descriptor_name":"Printing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012997","descriptor_name":"Solvents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016273","descriptor_name":"Occupational Exposure","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019205","descriptor_name":"GTP-Binding Protein alpha Subunits, Gs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055549","descriptor_name":"Volatile Organic Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:3124722","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4152035","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4152035","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4152035","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},{"id":"pmid:25197345","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25197345","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},{"id":"mag:26527426","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25197345","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3124722","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4152035","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":93,"referenced_works":["https://openalex.org/W1500284214","https://openalex.org/W1529811042","https://openalex.org/W1589204269","https://openalex.org/W1605504568","https://openalex.org/W1663962512","https://openalex.org/W1744376040","https://openalex.org/W1755743558","https://openalex.org/W1785290851","https://openalex.org/W1964895886","https://openalex.org/W1965071920","https://openalex.org/W1966353799","https://openalex.org/W1967201899","https://openalex.org/W1970598946","https://openalex.org/W1971426502","https://openalex.org/W1975676115","https://openalex.org/W1980597479","https://openalex.org/W1983379130","https://openalex.org/W1983542630","https://openalex.org/W1984714695","https://openalex.org/W1985888449","https://openalex.org/W1988449494","https://openalex.org/W1989423327","https://openalex.org/W1990107856","https://openalex.org/W1991202028","https://openalex.org/W1998123792","https://openalex.org/W1999600791","https://openalex.org/W2002199595","https://openalex.org/W2002642158","https://openalex.org/W2003089350","https://openalex.org/W2005981883","https://openalex.org/W2008688929","https://openalex.org/W2017234408","https://openalex.org/W2020323703","https://openalex.org/W2021637981","https://openalex.org/W2026382594","https://openalex.org/W2027375453","https://openalex.org/W2028096022","https://openalex.org/W2028606217","https://openalex.org/W2030877388","https://openalex.org/W2033311628","https://openalex.org/W2033960653","https://openalex.org/W2034924919","https://openalex.org/W2037280078","https://openalex.org/W2040641212","https://openalex.org/W2042697486","https://openalex.org/W2044458057","https://openalex.org/W2045086791","https://openalex.org/W2045320558","https://openalex.org/W2046530016","https://openalex.org/W2047663493","https://openalex.org/W2048635321","https://openalex.org/W2049538608","https://openalex.org/W2049661372","https://openalex.org/W2049800847","https://openalex.org/W2050451463","https://openalex.org/W2051491158","https://openalex.org/W2055378014","https://openalex.org/W2064391685","https://openalex.org/W2069051470","https://openalex.org/W2069071523","https://openalex.org/W2079635243","https://openalex.org/W2080131164","https://openalex.org/W2080848331","https://openalex.org/W2086147744","https://openalex.org/W2086461796","https://openalex.org/W2086519181","https://openalex.org/W2092825834","https://openalex.org/W2093604448","https://openalex.org/W2097336697","https://openalex.org/W2105115063","https://openalex.org/W2106196860","https://openalex.org/W2108298583","https://openalex.org/W2125747195","https://openalex.org/W2130107168","https://openalex.org/W2132608478","https://openalex.org/W2132812582","https://openalex.org/W2135059159","https://openalex.org/W2135131688","https://openalex.org/W2136044059","https://openalex.org/W2138926779","https://openalex.org/W2140655321","https://openalex.org/W2141498607","https://openalex.org/W2142278112","https://openalex.org/W2145989829","https://openalex.org/W2150678321","https://openalex.org/W2153267965","https://openalex.org/W2153862971","https://openalex.org/W2155233847","https://openalex.org/W2160190761","https://openalex.org/W2200274876","https://openalex.org/W2340099036","https://openalex.org/W4230612836","https://openalex.org/W4248430854"],"related_works":["https://openalex.org/W2769890434","https://openalex.org/W4404310335","https://openalex.org/W2106015641","https://openalex.org/W2049538608","https://openalex.org/W3017051374","https://openalex.org/W1926439666","https://openalex.org/W2947386127","https://openalex.org/W7098034351","https://openalex.org/W2413309626","https://openalex.org/W2001334146"],"abstract_inverted_index":{"Recently,":[0],"cholangiocarcinoma":[1,66,77],"has":[2],"epidemically":[3],"developed":[4,67],"among":[5],"young":[6],"adult":[7],"workers":[8],"of":[9,34,60,64,75,99,109,117,121,135,149,158,168,180,188,193,196,206],"a":[10,38,119,220],"printing":[11,70,151,163,198,208],"company":[12,152,164,209],"in":[13,52,68,112,133,144,172,186,190],"Japan.":[14],"Exposure":[15],"to":[16,25,156,232],"organic":[17,215],"solvents":[18,216],"including":[19],"1,2-dichloropropane":[20],"and/or":[21,95],"dichloromethane":[22,35],"is":[23],"supposed":[24],"be":[26],"associated":[27,85],"with":[28,86],"the":[29,61,65,69,76,100,150,162,197,207,213,233],"carcinoma":[30,140,234],"development.":[31,235],"The":[32],"metabolism":[33],"proceeds":[36],"through":[37],"Theta-class":[39],"glutathione":[40],"S-transferase":[41],"(GST)":[42],"T1-1-catalyzed":[43],"pathway,":[44],"where":[45,81],"its":[46,128],"reactive":[47],"intermediates":[48],"have":[49],"been":[50],"implicated":[51],"genotoxicity":[53],"and":[54,138,177,182],"carcinogenicity.":[55],"This":[56],"study":[57],"examined":[58],"features":[59],"carcinogenic":[62,204],"process":[63,205],"company.":[71,199],"Surgically":[72],"resected":[73],"specimens":[74],"cases":[78,83,153,195],"were":[79,84,184],"analyzed,":[80],"all":[82],"precursor":[87],"lesions":[88],"such":[89],"as":[90,141,143,219],"biliary":[91,146,174,223],"intraepithelial":[92],"neoplasia":[93],"(BilIN)":[94],"intraductal":[96],"papillary":[97],"neoplasm":[98],"bile":[101],"duct":[102],"(IPNB).":[103],"Immunohistochemical":[104],"analysis":[105],"confirmed":[106],"constitutional":[107],"expression":[108,129,167],"GST":[110],"T1-1":[111],"normal":[113],"hepatobiliary":[114],"tract.":[115],"Immunostaining":[116],"\u03b3-H2AX,":[118],"marker":[120],"DNA":[122,228],"double":[123],"strand":[124],"break,":[125],"showed":[126],"that":[127,157,212],"was":[130,170],"significantly":[131],"increased":[132],"foci":[134,187],"BilIN,":[136],"IPNB":[137],"invasive":[139],"well":[142],"non-neoplastic":[145,173],"epithelial":[147,175,224],"cells":[148,176,225],"when":[154],"compared":[155],"control":[159],"groups.":[160],"In":[161],"cases,":[165,210],"immunohistochemical":[166],"p53":[169],"observed":[171],"BilIN-1.":[178],"Mutations":[179],"KRAS":[181],"GNAS":[183],"detected":[185],"BilIN":[189],"one":[191],"out":[192],"3":[194],"These":[200],"results":[201],"revealed":[202],"different":[203],"suggesting":[211],"exposed":[214],"might":[217],"act":[218],"carcinogen":[221],"for":[222],"by":[226],"causing":[227],"damage,":[229],"thereby":[230],"contributing":[231]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}