{"id":"https://openalex.org/W265207058","doi":null,"title":"Experimental Studies of BMP Signalling in Neuronal Cells","display_name":"Experimental Studies of BMP Signalling in Neuronal Cells","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W265207058","mag":"265207058"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:uu-3398","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3398","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3398","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088656590","display_name":"Susanna Althini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Susanna Althini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5088656590"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.6801999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.6801999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.1387999951839447,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.1200999990105629,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bmp-signaling","display_name":"BMP signaling","score":0.8360000252723694},{"id":"https://openalex.org/keywords/gdf10","display_name":"GDF10","score":0.7680000066757202},{"id":"https://openalex.org/keywords/hippocampal-development","display_name":"hippocampal development","score":0.6439999938011169},{"id":"https://openalex.org/keywords/dopaminergic-neurons","display_name":"dopaminergic neurons","score":0.8420000076293945},{"id":"https://openalex.org/keywords/tyrosine-hydroxylase","display_name":"tyrosine hydroxylase","score":0.9760000109672546},{"id":"https://openalex.org/keywords/dopamine-deficiency","display_name":"dopamine deficiency","score":0.9330000281333923},{"id":"https://openalex.org/keywords/smad-signaling","display_name":"Smad signaling","score":0.8479999899864197},{"id":"https://openalex.org/keywords/tgf-beta-superfamily","display_name":"TGF-beta superfamily","score":0.9079999923706055},{"id":"https://openalex.org/keywords/pc12-cells","display_name":"PC12 cells","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C39743133","wikidata":"https://www.wikidata.org/wiki/Q3262595","display_name":"Signalling","level":2,"score":0.5366595983505249},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4890538156032562},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4778296947479248},{"id":"https://openalex.org/C3018449070","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signalling pathways","level":3,"score":0.42020222544670105},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39576664566993713},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.325771689414978},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2233630120754242}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:uu-3398","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3398","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:265207058","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/theses/ETH/8248","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:uu-3398","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3398","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":225,"referenced_works":["https://openalex.org/W97702262","https://openalex.org/W165654455","https://openalex.org/W176331650","https://openalex.org/W1480928262","https://openalex.org/W1492349549","https://openalex.org/W1501777420","https://openalex.org/W1519258930","https://openalex.org/W1522901071","https://openalex.org/W1530364143","https://openalex.org/W1532872348","https://openalex.org/W1545645579","https://openalex.org/W1553444759","https://openalex.org/W1554206058","https://openalex.org/W1591488168","https://openalex.org/W1609684706","https://openalex.org/W1663371441","https://openalex.org/W1666089077","https://openalex.org/W1668580308","https://openalex.org/W1701092691","https://openalex.org/W1840163537","https://openalex.org/W1858153082","https://openalex.org/W1883183385","https://openalex.org/W1893606807","https://openalex.org/W1901605442","https://openalex.org/W1911890413","https://openalex.org/W1914368934","https://openalex.org/W1921573595","https://openalex.org/W1930281617","https://openalex.org/W1963505173","https://openalex.org/W1964325390","https://openalex.org/W1967380741","https://openalex.org/W1968822620","https://openalex.org/W1969349734","https://openalex.org/W1970587959","https://openalex.org/W1971075145","https://openalex.org/W1971208141","https://openalex.org/W1971764800","https://openalex.org/W1971991362","https://openalex.org/W1972548606","https://openalex.org/W1975244118","https://openalex.org/W1976385326","https://openalex.org/W1976441097","https://openalex.org/W1977831309","https://openalex.org/W1978202073","https://openalex.org/W1978912394","https://openalex.org/W1980815930","https://openalex.org/W1980930604","https://openalex.org/W1980987752","https://openalex.org/W1981173539","https://openalex.org/W1981373313","https://openalex.org/W1983165764","https://openalex.org/W1983441282","https://openalex.org/W1985822867","https://openalex.org/W1987361483","https://openalex.org/W1987506486","https://openalex.org/W1988613013","https://openalex.org/W1990285237","https://openalex.org/W1991945116","https://openalex.org/W1992618022","https://openalex.org/W1993439547","https://openalex.org/W1993496211","https://openalex.org/W1994377715","https://openalex.org/W1994560336","https://openalex.org/W1994761680","https://openalex.org/W1995169214","https://openalex.org/W1996700871","https://openalex.org/W1996973708","https://openalex.org/W1997043987","https://openalex.org/W1997438162","https://openalex.org/W1998885927","https://openalex.org/W2000667008","https://openalex.org/W2000791321","https://openalex.org/W2001130710","https://openalex.org/W2001713621","https://openalex.org/W2003573512","https://openalex.org/W2007044718","https://openalex.org/W2007092780","https://openalex.org/W2007530728","https://openalex.org/W2009451238","https://openalex.org/W2011381918","https://openalex.org/W2012141473","https://openalex.org/W2012868552","https://openalex.org/W2012919466","https://openalex.org/W2013151734","https://openalex.org/W2013666305","https://openalex.org/W2016686600","https://openalex.org/W2016727307","https://openalex.org/W2017298052","https://openalex.org/W2018820156","https://openalex.org/W2018882616","https://openalex.org/W2020244870","https://openalex.org/W2022751249","https://openalex.org/W2024946238","https://openalex.org/W2028742041","https://openalex.org/W2028854652","https://openalex.org/W2030204732","https://openalex.org/W2032243789","https://openalex.org/W2032700434","https://openalex.org/W2033418096","https://openalex.org/W2033727409","https://openalex.org/W2034342175","https://openalex.org/W2036509369","https://openalex.org/W2037831105","https://openalex.org/W2038972058","https://openalex.org/W2039458025","https://openalex.org/W2040027102","https://openalex.org/W2040135080","https://openalex.org/W2040471409","https://openalex.org/W2041190857","https://openalex.org/W2042193781","https://openalex.org/W2042505270","https://openalex.org/W2044440492","https://openalex.org/W2045248371","https://openalex.org/W2046051277","https://openalex.org/W2046061363","https://openalex.org/W2046194583","https://openalex.org/W2046929321","https://openalex.org/W2047284199","https://openalex.org/W2048121649","https://openalex.org/W2049153479","https://openalex.org/W2050230570","https://openalex.org/W2051729090","https://openalex.org/W2054263994","https://openalex.org/W2054810445","https://openalex.org/W2054990893","https://openalex.org/W2055110202","https://openalex.org/W2056404105","https://openalex.org/W2056587633","https://openalex.org/W2057216898","https://openalex.org/W2058127856","https://openalex.org/W2059383094","https://openalex.org/W2060165686","https://openalex.org/W2060840668","https://openalex.org/W2061482527","https://openalex.org/W2062514032","https://openalex.org/W2063103796","https://openalex.org/W2063493248","https://openalex.org/W2063907656","https://openalex.org/W2066068720","https://openalex.org/W2068118161","https://openalex.org/W2068132469","https://openalex.org/W2069312841","https://openalex.org/W2069598734","https://openalex.org/W2071251725","https://openalex.org/W2071788329","https://openalex.org/W2072742464","https://openalex.org/W2073611916","https://openalex.org/W2074753686","https://openalex.org/W2074778351","https://openalex.org/W2075963709","https://openalex.org/W2076766254","https://openalex.org/W2078107700","https://openalex.org/W2082684861","https://openalex.org/W2084562439","https://openalex.org/W2085747258","https://openalex.org/W2086054038","https://openalex.org/W2086465672","https://openalex.org/W2087262420","https://openalex.org/W2088078672","https://openalex.org/W2088885861","https://openalex.org/W2090905598","https://openalex.org/W2091746877","https://openalex.org/W2092165212","https://openalex.org/W2092778272","https://openalex.org/W2093417867","https://openalex.org/W2094389804","https://openalex.org/W2096590212","https://openalex.org/W2099628695","https://openalex.org/W2099635835","https://openalex.org/W2100522747","https://openalex.org/W2101294380","https://openalex.org/W2101741807","https://openalex.org/W2102410706","https://openalex.org/W2103031848","https://openalex.org/W2103256978","https://openalex.org/W2107034917","https://openalex.org/W2109046553","https://openalex.org/W2110586785","https://openalex.org/W2112393462","https://openalex.org/W2113449040","https://openalex.org/W2115438940","https://openalex.org/W2118195657","https://openalex.org/W2120410199","https://openalex.org/W2121790796","https://openalex.org/W2121795027","https://openalex.org/W2123297155","https://openalex.org/W2124366353","https://openalex.org/W2128351720","https://openalex.org/W2128960139","https://openalex.org/W2130122556","https://openalex.org/W2131211068","https://openalex.org/W2131282078","https://openalex.org/W2131983181","https://openalex.org/W2132527997","https://openalex.org/W2133083344","https://openalex.org/W2133193835","https://openalex.org/W2136006230","https://openalex.org/W2136024488","https://openalex.org/W2136190597","https://openalex.org/W2137281565","https://openalex.org/W2139696718","https://openalex.org/W2145107163","https://openalex.org/W2147012768","https://openalex.org/W2153068303","https://openalex.org/W2153406820","https://openalex.org/W2154601080","https://openalex.org/W2155008473","https://openalex.org/W2156383829","https://openalex.org/W2158129482","https://openalex.org/W2163072180","https://openalex.org/W2163504684","https://openalex.org/W2163639252","https://openalex.org/W2164246575","https://openalex.org/W2164615751","https://openalex.org/W2166919582","https://openalex.org/W2166988918","https://openalex.org/W2169473035","https://openalex.org/W2170560272","https://openalex.org/W2179259141","https://openalex.org/W2181316944","https://openalex.org/W2217868403","https://openalex.org/W2268197299","https://openalex.org/W2325267678","https://openalex.org/W2395525054","https://openalex.org/W7005762757"],"related_works":["https://openalex.org/W311351693","https://openalex.org/W270315015","https://openalex.org/W1829627666","https://openalex.org/W1966668454","https://openalex.org/W109812912","https://openalex.org/W318485589","https://openalex.org/W2112393462","https://openalex.org/W2068092703","https://openalex.org/W2019124119","https://openalex.org/W2051405849"],"abstract_inverted_index":{"The":[0,192,240,259,340],"developing":[1,66],"nervous":[2,69,106],"system":[3],"depends":[4],"largely":[5],"on":[6,271],"extracellular":[7],"cues":[8],"to":[9,20,34,48,78,86,126,142,185,199,236,248,254,302,307,314],"shape":[10],"its":[11],"complex":[12],"network":[13],"of":[14,42,53,92,102,111,118,130,150,159,203,210,221,231,242,262,269,293,296,311,326,333],"neurons.":[15,191],"Classically,":[16],"neurotrophins":[17],"are":[18,348],"known":[19,141],"be":[21,143],"important":[22],"mediators":[23],"in":[24,64,104,121,134,145,165,189,218,234,277,284,305,336],"this":[25,131,263],"process.":[26],"More":[27],"recently,":[28],"Bone":[29],"Morphogenetic":[30],"Proteins":[31],"(BMPs),":[32],"belonging":[33],"the":[35,65,79,84,87,90,100,105,122,128,135,151,157,183,201,215,219,224,243,249,255,266,285,303,309,315,321,330,337,344],"Transforming":[36],"Growth":[37],"Factor":[38],"beta":[39],"(TGF\u03b2)":[40],"superfamily":[41,153],"secreted":[43],"cytokines,":[44],"have":[45,172],"been":[46,173],"shown":[47],"exert":[49],"a":[50,109,115,138,176,228],"wide":[51],"range":[52],"effects,":[54,346],"such":[55],"as":[56,275],"cellular":[57],"growth,":[58],"differentiation,":[59],"survival":[60],"and":[61,67,223,283],"apoptosis,":[62],"both":[63],"adult":[68],"system.":[70,339],"They":[71],"signal":[72,85],"via":[73],"serine/threonine":[74],"kinase":[75],"receptor":[76],"essentially":[77],"Smad":[80],"pathway,":[81],"which":[82],"carries":[83],"nucleus":[88],"where":[89],"transcription":[91,170],"target":[93],"genes":[94],"is":[95,214,251,265],"regulated.":[96],"This":[97],"thesis":[98,264],"investigates":[99],"functions":[101],"BMPs":[103,270],"system,":[107],"using":[108],"set":[110,180],"different":[112,312],"models.":[113],"Firstly,":[114],"targeted":[116],"deletion":[117],"GDF10":[119],"(BMP3b)":[120],"mouse":[123,177],"was":[124,179,197],"established":[125],"evaluate":[127],"role":[129],"growth/differentiation":[132],"factor":[133],"hippocampal":[136,166],"formation,":[137],"brain":[139],"area":[140],"involved":[144],"memory":[146],"processing.":[147],"Other":[148],"members":[149],"TGF\u03b2":[152],"likely":[154],"compensate":[155],"for":[156,343],"lack":[158],"GDF10,":[160],"since":[161],"no":[162],"detectable":[163],"alterations":[164],"function":[167],"or":[168],"gene":[169],"profile":[171],"found.":[174],"Secondly,":[175],"model":[178],"up,":[181],"with":[182],"aim":[184],"study":[186],"impaired":[187],"BMP-signalling":[188],"dopaminergic":[190],"tyrosine":[193],"hydroxylase":[194],"(TH)":[195],"locus":[196],"used":[198],"drive":[200],"expression":[202],"dominant":[204,244],"negative":[205,245],"BMP":[206,246,334],"receptors":[207,247],"by":[208],"means":[209],"bicistronic":[211],"mRNAs.":[212],"TH":[213,257],"rate-limiting":[216],"enzyme":[217],"biosynthesis":[220],"catecholamine":[222],"mice":[225],"described,":[226],"show":[227],"graded":[229],"decrease":[230],"TH-activity":[232],"resulting":[233],"severe":[235],"mild":[237],"dopamine":[238],"deficiency.":[239],"contribution":[241,310],"phenotype":[250],"however":[252],"secondary":[253],"apparent":[256],"hypomorphism.":[258],"final":[260],"theme":[261],"potentiating":[267,331],"effects":[268,332],"neurotrophin-induced":[272],"neurite":[273,317],"outgrowth":[274],"studied":[276],"explanted":[278],"ganglia":[279],"from":[280],"chick":[281,338],"embryos":[282],"rat":[286],"phaeochromocytoma":[287],"cell":[288],"line":[289],"PC12.":[290],"A":[291],"number":[292],"pharmacological":[294],"inhibitors":[295],"intracellular":[297],"signalling":[298,328],"kinases":[299],"were":[300],"applied":[301],"cultures":[304],"order":[306],"reveal":[308],"pathways":[313],"enhanced":[316],"outgrowth.":[318],"We":[319],"made":[320],"unexpected":[322],"finding":[323],"that":[324],"inhibition":[325],"MEK":[327],"mimicked":[329],"stimulation":[335],"underlying":[341],"mechanisms":[342],"synergistic":[345],"however,":[347],"still":[349],"an":[350],"enigma.":[351]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
