{"id":"https://openalex.org/W265165147","doi":null,"title":"Electroporation as a tool for biotechnology and medicine with specific emphasize on its application for drug and gene delivery review","display_name":"Electroporation as a tool for biotechnology and medicine with specific emphasize on its application for drug and gene delivery review","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W265165147","mag":"265165147"},"language":"en","primary_location":{"id":"mag:265165147","doi":null,"is_oa":false,"landing_page_url":"https://vetzoo.lsmuni.lt/data/vols/2004/26/pdf/satkauskas.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051170300","display_name":"Saulius \u0160atkauskas","orcid":"https://orcid.org/0000-0002-9001-7767","observed_orcids":["https://orcid.org/0000-0002-9001-7767"]},"institutions":[{"id":"https://openalex.org/I188730046","display_name":"Vytautas Magnus University","ror":"https://ror.org/04y7eh037","country_code":"LT","type":"education","lineage":["https://openalex.org/I188730046"]}],"countries":["LT"],"is_corresponding":false,"raw_author_name":"Saulius \u0160atkauskas","raw_affiliation_strings":["Vytautas Magnus University;"],"raw_orcid":"https://orcid.org/0000-0002-9001-7767","affiliations":[{"raw_affiliation_string":"Vytautas Magnus University;","institution_ids":["https://openalex.org/I188730046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077390839","display_name":"Gintautas Saulis","orcid":"https://orcid.org/0000-0003-0562-8406","observed_orcids":["https://orcid.org/0000-0003-0562-8406"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gintautas Saulis","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0562-8406","affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.02077527,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11455","display_name":"Microbial Inactivation Methods","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11455","display_name":"Microbial Inactivation Methods","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/electroporation","display_name":"electroporation","score":1.0},{"id":"https://openalex.org/keywords/electrochemotherapy","display_name":"electrochemotherapy","score":0.8009999990463257},{"id":"https://openalex.org/keywords/bleomycin","display_name":"bleomycin","score":0.8790000081062317},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.7599999904632568},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.8930000066757202},{"id":"https://openalex.org/keywords/electrofusion","display_name":"electrofusion","score":0.8009999990463257},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.5920000076293945},{"id":"https://openalex.org/keywords/cell-membrane-permeability","display_name":"cell membrane permeability","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C186852380","wikidata":"https://www.wikidata.org/wiki/Q1142521","display_name":"Electroporation","level":3,"score":0.9863890409469604},{"id":"https://openalex.org/C2777108052","wikidata":"https://www.wikidata.org/wiki/Q3137263","display_name":"Electrochemotherapy","level":4,"score":0.9297420978546143},{"id":"https://openalex.org/C2776232574","wikidata":"https://www.wikidata.org/wiki/Q415571","display_name":"Bleomycin","level":3,"score":0.7536956071853638},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.6010434627532959},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5972358584403992},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5291783213615417},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5141704082489014},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.5088715553283691},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39217066764831543},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3814663887023926},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29501068592071533},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.26854991912841797},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.22021469473838806},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1591174602508545},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15165725350379944},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.10860592126846313},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.08873283863067627}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:265165147","doi":null,"is_oa":false,"landing_page_url":"https://vetzoo.lsmuni.lt/data/vols/2004/26/pdf/satkauskas.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":120,"referenced_works":["https://openalex.org/W1000084","https://openalex.org/W97065253","https://openalex.org/W152288020","https://openalex.org/W185927998","https://openalex.org/W306155290","https://openalex.org/W1034404816","https://openalex.org/W1490324405","https://openalex.org/W1494985759","https://openalex.org/W1521669594","https://openalex.org/W1549185832","https://openalex.org/W1554324421","https://openalex.org/W1556018645","https://openalex.org/W1556915790","https://openalex.org/W1622592612","https://openalex.org/W1641450356","https://openalex.org/W1780574990","https://openalex.org/W1867649178","https://openalex.org/W1963765275","https://openalex.org/W1964982943","https://openalex.org/W1965899442","https://openalex.org/W1966132229","https://openalex.org/W1966969135","https://openalex.org/W1967142154","https://openalex.org/W1967908943","https://openalex.org/W1976817000","https://openalex.org/W1976896860","https://openalex.org/W1977712028","https://openalex.org/W1978542226","https://openalex.org/W1978548543","https://openalex.org/W1979382701","https://openalex.org/W1981579055","https://openalex.org/W1983770983","https://openalex.org/W1987374274","https://openalex.org/W1988230026","https://openalex.org/W1989463054","https://openalex.org/W1990386681","https://openalex.org/W1991474165","https://openalex.org/W1992492962","https://openalex.org/W1992733609","https://openalex.org/W1992847158","https://openalex.org/W1993711956","https://openalex.org/W1994248239","https://openalex.org/W1995340682","https://openalex.org/W1997178536","https://openalex.org/W2004469159","https://openalex.org/W2004952803","https://openalex.org/W2005868314","https://openalex.org/W2008522415","https://openalex.org/W2009644962","https://openalex.org/W2010359511","https://openalex.org/W2016256497","https://openalex.org/W2016865253","https://openalex.org/W2018744718","https://openalex.org/W2019612613","https://openalex.org/W2028898357","https://openalex.org/W2031145204","https://openalex.org/W2031385493","https://openalex.org/W2033516066","https://openalex.org/W2033756314","https://openalex.org/W2033954774","https://openalex.org/W2034688094","https://openalex.org/W2039490956","https://openalex.org/W2039942347","https://openalex.org/W2040190838","https://openalex.org/W2041472987","https://openalex.org/W2045382036","https://openalex.org/W2047256102","https://openalex.org/W2047670061","https://openalex.org/W2047905524","https://openalex.org/W2054044903","https://openalex.org/W2054457322","https://openalex.org/W2054970879","https://openalex.org/W2056104198","https://openalex.org/W2061703524","https://openalex.org/W2064605119","https://openalex.org/W2064776542","https://openalex.org/W2067738057","https://openalex.org/W2068196810","https://openalex.org/W2069934604","https://openalex.org/W2072397057","https://openalex.org/W2072958183","https://openalex.org/W2075010947","https://openalex.org/W2075127196","https://openalex.org/W2080708811","https://openalex.org/W2085989006","https://openalex.org/W2086656837","https://openalex.org/W2088312858","https://openalex.org/W2090087191","https://openalex.org/W2091924611","https://openalex.org/W2092776514","https://openalex.org/W2100820352","https://openalex.org/W2108153643","https://openalex.org/W2110316450","https://openalex.org/W2111409695","https://openalex.org/W2120200192","https://openalex.org/W2121830723","https://openalex.org/W2126457128","https://openalex.org/W2141109897","https://openalex.org/W2144688973","https://openalex.org/W2145028145","https://openalex.org/W2146362841","https://openalex.org/W2155226038","https://openalex.org/W2157455777","https://openalex.org/W2159703660","https://openalex.org/W2159995158","https://openalex.org/W2162346759","https://openalex.org/W2162917941","https://openalex.org/W2314632036","https://openalex.org/W2315165762","https://openalex.org/W2323583773","https://openalex.org/W2326611690","https://openalex.org/W2327204353","https://openalex.org/W2328143196","https://openalex.org/W2330442656","https://openalex.org/W2409788302","https://openalex.org/W2416502325","https://openalex.org/W2432965240","https://openalex.org/W2482358093","https://openalex.org/W3024831056","https://openalex.org/W3216873059"],"related_works":["https://openalex.org/W1985709366","https://openalex.org/W2118885206","https://openalex.org/W77671357","https://openalex.org/W196747630","https://openalex.org/W2592193589","https://openalex.org/W7096890846","https://openalex.org/W2028604810","https://openalex.org/W1995299442","https://openalex.org/W1205726088","https://openalex.org/W2140031668"],"abstract_inverted_index":{"It":[0,156],"is":[1,32,126,157,201],"known":[2,33],"that":[3,159],"short":[4],"and":[5,28,43,57,153,178,196],"sufficiently":[6],"strong":[7],"electric":[8],"field":[9],"pulses":[10],"may":[11],"temporary":[12],"increase":[13],"permeability":[14],"of":[15,22,39,64,72,109,122,128,162,186,191],"the":[16,26,61,67,85,110,171,183,192],"cell":[17,53],"membranes":[18],"providing":[19],"facilitated":[20],"access":[21],"exogenous":[23],"molecules":[24],"into":[25,95,199],"cells":[27,97],"tissues.":[29,132,155],"The":[30,118,133],"phenomenon":[31],"as":[34],"electroporation":[35,47,81,125,193],"or":[36],"electropermeabilization.":[37],"Because":[38],"its":[40],"physical":[41],"nature":[42],"easiness":[44],"to":[45,84,88,104,130,138,141,145,165,174],"use,":[46],"has":[48,135],"gained":[49],"wide":[50],"application":[51,121],"in":[52,69,98,123,170,182],"biology,":[54],"biotechnology,":[55],"human":[56],"veterinary":[58],"medicine.":[59],"In":[60],"first":[62],"part":[63,185],"this":[65,187],"review":[66],"main":[68],"vitro":[70],"applications":[71],"electroporation:":[73],"electrosterilization,":[74],"electroloading,":[75],"electrofusion,":[76],"electroinsertion":[77],"are":[78],"presented.":[79],"Recently":[80],"was":[82],"applied":[83,169],"tumor":[86,96,111],"tissues":[87,166,200],"introduce":[89],"nonpermeant":[90],"cytotoxic":[91],"drugs":[92],"(like":[93],"bleomycin)":[94],"vivo.":[99],"Such":[100],"electrochemotherapy":[101],"allows":[102],"one":[103],"obtain":[105],"very":[106],"high":[107],"responses":[108],"treatment":[112],"with":[113],"highly":[114],"reduced":[115],"bleomycin":[116],"doses.":[117],"most":[119],"recent":[120],"vivo":[124],"delivery":[127,198],"genes":[129],"various":[131,176],"method":[134,161],"been":[136],"shown":[137],"be":[139,168],"effective":[140],"electrotransfer":[142,164],"plasmid":[143],"DNA":[144,163],"muscles,":[146],"liver,":[147],"skin,":[148],"tumors,":[149],"mouse":[150],"testis,":[151],"arteries":[152],"nervous":[154],"believed":[158],"such":[160],"can":[167],"gene":[172,197],"therapy":[173],"treat":[175],"acquired":[177],"congenital":[179],"diseases.":[180],"Thus,":[181],"second":[184],"review,":[188],"current":[189],"status":[190],"for":[194],"drug":[195],"discussed.":[202]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}