{"id":"https://openalex.org/W264883526","doi":null,"title":"Lipolysis in Adipose Tissue: Roles of Desnutrin and Adipose-specific phospholipase A2","display_name":"Lipolysis in Adipose Tissue: Roles of Desnutrin and Adipose-specific phospholipase A2","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W264883526","mag":"264883526"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt5d08b36w","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/5d08b36w","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103512536","display_name":"Maryam Ahmadian","orcid":"https://orcid.org/0000-0002-8326-8752","observed_orcids":["https://orcid.org/0000-0002-8326-8752"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Maryam Ahmadian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5103512536"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.6098999977111816,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.6098999977111816,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.3774000108242035,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipolysis","display_name":"lipolysis","score":0.8240000009536743},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.9100000262260437},{"id":"https://openalex.org/keywords/adipose-triglyceride-lipase","display_name":"adipose triglyceride lipase","score":0.8920000195503235},{"id":"https://openalex.org/keywords/diet-induced-obesity","display_name":"diet-induced obesity","score":0.6869999766349792},{"id":"https://openalex.org/keywords/brown-adipose-tissue","display_name":"brown adipose tissue","score":0.7369999885559082},{"id":"https://openalex.org/keywords/white-adipose-tissue","display_name":"white adipose tissue","score":0.824999988079071},{"id":"https://openalex.org/keywords/thermogenesis","display_name":"thermogenesis","score":0.8799999952316284},{"id":"https://openalex.org/keywords/energy-expenditure","display_name":"energy expenditure","score":0.734000027179718},{"id":"https://openalex.org/keywords/fatty-acid-oxidation","display_name":"fatty acid oxidation","score":0.777999997138977},{"id":"https://openalex.org/keywords/free-fatty-acids","display_name":"free fatty acids","score":0.8370000123977661},{"id":"https://openalex.org/keywords/autocrine-and-paracrine-regulation","display_name":"autocrine and paracrine regulation","score":0.8659999966621399},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.9380000233650208},{"id":"https://openalex.org/keywords/ep3-receptor","display_name":"EP3 receptor","score":0.9629999995231628},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.9150000214576721},{"id":"https://openalex.org/keywords/adipogenic-differentiation","display_name":"adipogenesis","score":0.4790000021457672},{"id":"https://openalex.org/keywords/adipose-tissue-browning","display_name":"adipose tissue browning","score":0.4410000145435333}],"concepts":[{"id":"https://openalex.org/C140985366","wikidata":"https://www.wikidata.org/wiki/Q898489","display_name":"Lipolysis","level":3,"score":0.9125127196311951},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.8846409320831299},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7404733896255493},{"id":"https://openalex.org/C151955695","wikidata":"https://www.wikidata.org/wiki/Q654528","display_name":"White adipose tissue","level":3,"score":0.7381003499031067},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7155551910400391},{"id":"https://openalex.org/C44353895","wikidata":"https://www.wikidata.org/wiki/Q6556772","display_name":"Lipotoxicity","level":4,"score":0.5410247445106506},{"id":"https://openalex.org/C2780642333","wikidata":"https://www.wikidata.org/wiki/Q901269","display_name":"Brown adipose tissue","level":3,"score":0.5347268581390381},{"id":"https://openalex.org/C151279926","wikidata":"https://www.wikidata.org/wiki/Q965695","display_name":"Thermogenesis","level":3,"score":0.4962788224220276},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48345717787742615},{"id":"https://openalex.org/C2776175234","wikidata":"https://www.wikidata.org/wiki/Q357519","display_name":"Adipocyte","level":3,"score":0.4814392924308777},{"id":"https://openalex.org/C17675752","wikidata":"https://www.wikidata.org/wiki/Q12898553","display_name":"Adipose tissue macrophages","level":4,"score":0.47654038667678833},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.4341796636581421},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36350059509277344},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.1881309151649475},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.14457517862319946},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07850384712219238},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06219199299812317}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:escholarship.org/ark:/13030/qt5d08b36w","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/5d08b36w","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},{"id":"pmh:qt5d08b36w","doi":null,"is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/5d08b36w","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Ahmadian, Maryam. (2010). Lipolysis in Adipose Tissue: Roles of Desnutrin and Adipose-specific phospholipase A2. UC Berkeley: Molecular & Biochemical Nutrition. Retrieved from: http://www.escholarship.org/uc/item/5d08b36w","raw_type":"dissertation"},{"id":"mag:264883526","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/5d08b36w.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W201890761","https://openalex.org/W7005346221","https://openalex.org/W3176241364","https://openalex.org/W7096993367","https://openalex.org/W1987849310","https://openalex.org/W2006251119","https://openalex.org/W2472054870","https://openalex.org/W7098698064","https://openalex.org/W98946124","https://openalex.org/W2098518710"],"abstract_inverted_index":{"Adipose":[0],"tissue":[1,54,74,86,99,241,329,427],"is":[2,41,245,288],"the":[3,13,60,133,210,217,221,234,266,276,282,297,302,308,320,406,412,423],"major":[4],"energy":[5,11,20,30,124,384,440],"storage":[6],"depot":[7],"in":[8,12,49,64,72,84,97,103,122,143,170,180,194,209,239,265,291,301,312,327,330,338,343,360,369,379,382,411],"mammals,":[9],"storing":[10],"form":[14],"triacylglycerol":[15],"(TAG)":[16],"during":[17,27],"times":[18,28],"of":[19,29,62,106,136,178,212,220,224,237,250,269,278,285,304,310,408,425],"excess,":[21],"and":[22,51,56,87,126,173,188,200,228,259,348,373,386,399,415,422,432],"mobilizing":[23],"TAG,":[24],"via":[25],"lipolysis,":[26],"need":[31],"to":[32,90,149,161,214,345,388,405,428,437],"generate":[33,150],"fatty":[34,109,115,279,374,430],"acids.":[35],"Desnutrin":[36],"(also":[37],"known":[38],"as":[39],"ATGL)":[40],"a":[42,127,256,272],"novel":[43,409],"TAG":[44,179],"hydrolase":[45],"expressed":[46],"highly":[47],"only":[48],"white":[50],"brown":[52],"adipose":[53,73,85,98,240,328,361,426],"(WAT":[55],"BAT).":[57],"To":[58,130,306],"investigate":[59,132,307],"role":[61,135,261,309],"desnutrin":[63,70,153,205,396],"vivo,":[65,313],"transgenic":[66],"mice":[67,80,155,165,184,196,316,341,372,402],"that":[68,204,287],"overexpress":[69],"predominantly":[71],"(aP2-desnutrin":[75],"mice)":[76],"were":[77,88,317,366],"generated.":[78,318],"aP2-desnutrin":[79,162,355,394],"had":[81,166,185],"increased":[82,95,378],"lipolysis":[83,96,169,225,238,326,337,359,421],"resistant":[89],"diet-induced":[91,347],"obesity.":[92,350,389],"Surprisingly,":[93],"this":[94],"did":[100],"not":[101,246,367],"result":[102],"higher":[104,123,383],"levels":[105,365],"serum":[107,363],"non-esterified":[108],"acids":[110,280,431],"(NEFA),":[111],"but":[112],"instead":[113],"promoted":[114],"acid":[116,375],"oxidation":[117,376],"directly":[118],"within":[119],"adipocytes":[120],"resulting":[121,381],"expenditure":[125,385],"leaner":[128],"phenotype.":[129],"further":[131],"adipose-specific":[134,151,251],"desnutrin,":[137],"gene":[138],"targeting":[139],"by":[140,226,242],"homologous":[141],"recombination":[142],"embryonic":[144],"stem":[145],"cells":[146],"was":[147,197,377],"performed":[148],"conditional":[152],"knockout":[154],"(desnutrin":[156],"ASKO":[157,397],"mice).":[158],"In":[159],"contrast":[160],"mice,":[163,356,395,398],"these":[164,181,195],"markedly":[167],"decreased":[168,189],"both":[171,346],"WAT":[172,213],"BAT":[174,193],"with":[175,352],"massive":[176],"accumulation":[177],"tissues.":[182],"These":[183],"impaired":[186],"thermogenesis":[187],"oxygen":[190],"consumption.":[191],"Notably,":[192],"drastically":[198],"enlarged,":[199],"resembled":[201],"WAT,":[202,380],"indicating":[203],"may":[206],"be":[207],"important":[208,258],"conversion":[211],"BAT.":[215],"While":[216],"classic":[218],"model":[219],"endocrine":[222],"regulation":[223,236,268],"catecholamines":[227],"insulin":[229],"has":[230],"been":[231],"extensively":[232],"studied,":[233],"local":[235],"autocrine/paracrine":[243,267,332],"factors":[244],"well":[247],"understood.":[248],"Identification":[249],"phospholipase":[252],"A2":[253],"(AdPLA)":[254],"revealed":[255,416],"surprisingly":[257],"dominant":[260],"for":[262,296,441],"adipocyte-derived":[263],"PGE2":[264],"lipolysis.":[270],"As":[271],"PLA2,":[273],"AdPLA":[274,311,314,323,339,370,400],"catalyzes":[275],"release":[277,433],"from":[281,354,393],"sn-2":[283],"position":[284],"phospholipids":[286],"typically":[289],"enriched":[290],"arachidonic":[292],"acid,":[293],"providing":[294],"substrate":[295],"initial,":[298],"rate-limiting":[299],"step":[300],"synthesis":[303],"eicosanoids.":[305],"null":[315,340,371,401],"Through":[319],"PGE2/EP3/cAMP":[321],"pathway,":[322],"dominantly":[324],"regulates":[325],"an":[331,417],"manner.":[333],"The":[334],"unrestrained":[335],"adipocyte":[336],"resulted":[342],"resistance":[344,387],"genetic":[349],"Consistent":[351],"results":[353],"despite":[357],"elevated":[358,368],"tissue,":[362],"NEFA":[364],"Taken":[390],"together,":[391],"findings":[392],"have":[403],"led":[404],"discovery":[407],"players":[410],"lipolytic":[413],"cascade,":[414],"unexpected":[418],"link":[419],"between":[420],"ability":[424],"oxidize":[429],"heat,":[434],"rather":[435],"than":[436],"provide":[438],"useful":[439],"work.":[442]},"counts_by_year":[],"updated_date":"2026-08-26T07:47:46.906454","created_date":"2016-06-24T00:00:00"}