{"id":"https://openalex.org/W264682240","doi":"https://doi.org/10.1096/fasebj.21.6.a1326-a","title":"The villi contribute to the mechanics in the guinea pig small intestine","display_name":"The villi contribute to the mechanics in the guinea pig small intestine","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W264682240","doi":"https://doi.org/10.1096/fasebj.21.6.a1326-a","mag":"264682240"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.21.6.a1326-a","doi":"https://doi.org/10.1096/fasebj.21.6.a1326-a","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.6.a1326-a","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077415554","display_name":"Jingbo Zhao","orcid":"https://orcid.org/0000-0002-4430-4829","observed_orcids":["https://orcid.org/0000-0002-4430-4829"]},"institutions":[{"id":"https://openalex.org/I2799976261","display_name":"Aalborg University Hospital","ror":"https://ror.org/02jk5qe80","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799976261"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jingbo Zhao","raw_affiliation_strings":["Center of Excellence in Visceral Biomechanics and Pain, Aalborg Hospital Science and Innovation Center (AHSIC), Soendre Skovvej 15, Aalborg, 9000 Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Excellence in Visceral Biomechanics and Pain, Aalborg Hospital Science and Innovation Center (AHSIC), Soendre Skovvej 15, Aalborg, 9000 Denmark","institution_ids":["https://openalex.org/I2799976261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100326721","display_name":"Xudong Chen","orcid":"https://orcid.org/0000-0002-1673-4696","observed_orcids":["https://orcid.org/0000-0002-1673-4696"]},"institutions":[{"id":"https://openalex.org/I2799976261","display_name":"Aalborg University Hospital","ror":"https://ror.org/02jk5qe80","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799976261"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Xudong Chen","raw_affiliation_strings":["Center of Excellence in Visceral Biomechanics and Pain, Aalborg Hospital Science and Innovation Center (AHSIC), Soendre Skovvej 15, Aalborg, 9000 Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Excellence in Visceral Biomechanics and Pain, Aalborg Hospital Science and Innovation Center (AHSIC), Soendre Skovvej 15, Aalborg, 9000 Denmark","institution_ids":["https://openalex.org/I2799976261"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060244358","display_name":"Hans N. Gregersen","orcid":"https://orcid.org/0000-0002-5792-2845","observed_orcids":["https://orcid.org/0000-0002-5792-2845"]},"institutions":[{"id":"https://openalex.org/I2799976261","display_name":"Aalborg University Hospital","ror":"https://ror.org/02jk5qe80","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799976261"]},{"id":"https://openalex.org/I4387153671","display_name":"Institute of Technology Tallaght","ror":"https://ror.org/037qxb619","country_code":"IE","type":"education","lineage":["https://openalex.org/I4210144925","https://openalex.org/I4387153671"]}],"countries":["DK","IE"],"is_corresponding":false,"raw_author_name":"Hans Gregersen","raw_affiliation_strings":["Center of Excellence in Visceral Biomechanics and Pain, Aalborg Hospital Science and Innovation Center (AHSIC), Soendre Skovvej 15, Aalborg, 9000 Denmark","Department of mechanical engineering, ITT, Tallaght, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Excellence in Visceral Biomechanics and Pain, Aalborg Hospital Science and Innovation Center (AHSIC), Soendre Skovvej 15, Aalborg, 9000 Denmark","institution_ids":["https://openalex.org/I2799976261"]},{"raw_affiliation_string":"Department of mechanical engineering, ITT, Tallaght, Dublin, Ireland","institution_ids":["https://openalex.org/I4387153671"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0328763,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"21","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intestinal-villi","display_name":"intestinal villi","score":0.9760000109672546},{"id":"https://openalex.org/keywords/jejunum","display_name":"jejunum","score":0.9509999752044678},{"id":"https://openalex.org/keywords/zero-stress-state","display_name":"zero-stress state","score":0.734000027179718},{"id":"https://openalex.org/keywords/stress-strain-curves","display_name":"stress-strain curves","score":0.6859999895095825},{"id":"https://openalex.org/keywords/guinea-pig","display_name":"guinea pig","score":0.8640000224113464}],"concepts":[{"id":"https://openalex.org/C2776366702","wikidata":"https://www.wikidata.org/wiki/Q185765","display_name":"Jejunum","level":2,"score":0.6987841129302979},{"id":"https://openalex.org/C2778815084","wikidata":"https://www.wikidata.org/wiki/Q79803","display_name":"Guinea pig","level":2,"score":0.6951555609703064},{"id":"https://openalex.org/C2776625112","wikidata":"https://www.wikidata.org/wiki/Q5282934","display_name":"Distension","level":2,"score":0.6676360368728638},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.6245999336242676},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.5133768320083618},{"id":"https://openalex.org/C2777882243","wikidata":"https://www.wikidata.org/wiki/Q11090","display_name":"Small intestine","level":2,"score":0.5132207870483398},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3670646548271179},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34067922830581665},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15869110822677612},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14508092403411865},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0849272608757019},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.059097886085510254}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1096/fasebj.21.6.a1326-a","doi":"https://doi.org/10.1096/fasebj.21.6.a1326-a","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.6.a1326-a","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},{"id":"pmh:oai:pure.atira.dk:publications/1c9d73cf-d76a-47ce-a3d6-404e6a87bd9f","doi":null,"is_oa":false,"landing_page_url":"https://pure.au.dk/portal/en/publications/1c9d73cf-d76a-47ce-a3d6-404e6a87bd9f","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Zhao , J , Chen , X & Gregersen , H 2007 , ' The villi contribute to the mechanics in the guinea pig small intestine. ' , F A S E B Journal , vol. 21 , pp. 935.2 .","raw_type":"conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2102519590","https://openalex.org/W1987845179","https://openalex.org/W2079929286","https://openalex.org/W2090133250","https://openalex.org/W1979667275","https://openalex.org/W2098243645","https://openalex.org/W110635970","https://openalex.org/W2065371720","https://openalex.org/W2355298506","https://openalex.org/W2027341726"],"abstract_inverted_index":{"Previous":[0],"studies":[1],"have":[2],"indicated":[3],"that":[4],"intestinal":[5],"mucosa":[6,105],"is":[7],"compressed":[8],"in":[9,24,27,36,69,107,174,180,211],"vivo.":[10],"The":[11,54,139,216],"present":[12],"study":[13],"investigated":[14],"the":[15,18,21,28,62,65,93,97,104,143,150,154,159,167,175,178,181,184,191,195,200,212],"contribution":[16],"of":[17,119,142,177],"villi":[19,56,102,146,168,196],"to":[20,153,190],"biomechanical":[22],"properties":[23],"circumferential":[25,207],"direction":[26],"guinea":[29,213],"pig":[30,214],"jejunum.":[31,215],"Eight":[32],"segments":[33,66],"were":[34,57,67,90,169],"used":[35],"this":[37],"study.":[38],"Each":[39],"20":[40],"cm":[41,51],"long":[42,52],"segment":[43,144,155],"was":[44,147,161,186,218],"excised":[45],"and":[46,88,96,116,209],"separated":[47],"into":[48,172],"two":[49],"10":[50],"segments.":[53,63],"mucosal":[55],"scraped":[58],"off":[59],"from":[60,74,92,103],"half":[61],"Then":[64],"pressurized":[68],"vitro":[70],"with":[71,82,114,130,136,156],"Krebs":[72],"solution":[73],"0\u201310":[75],"cmH2O":[76],"using":[77],"a":[78],"ramp":[79],"distension":[80],"protocol":[81],"simultaneous":[83],"diameter":[84],"recordings.":[85],"Circumferential":[86],"stresses":[87,208],"strains":[89,210],"computed":[91],"diameter,":[94],"pressure":[95],"zero-stress":[98,201],"state":[99,202],"data.":[100],"Removing":[101],"resulted":[106],"small":[108],"opening":[109],"angles":[110],"(139\u00b116":[111],"vs":[112,126,134],"189\u00b127":[113],"villi)":[115,137],"absolute":[117],"value":[118],"residual":[120],"strain":[121],"(inner:":[122],"\u22120.05":[123],"\u00b1":[124,128],"0.03":[125],"\u22120.33":[127],"0.06":[129],"villi;":[131],"outer:":[132],"0.11\u00b10.04":[133],"0.33\u00b10.08":[135],"(P<0.001).":[138],"stress-strain":[140,179],"curve":[141,185],"without":[145,163],"located":[148],"at":[149],"left":[151],"compared":[152],"villi,":[157],"indicating":[158],"wall":[160],"stiffer":[162],"villi.":[164],"However,":[165],"if":[166],"not":[170,197],"taken":[171],"account":[173],"computation":[176],"intact":[182],"segment,":[183],"only":[187,198],"partly":[188],"shifted":[189],"left.":[192],"In":[193],"conclusion,":[194],"affect":[199,206],"conformation":[203],"but":[204],"also":[205],"research":[217],"supported":[219],"by":[220],"Aalborg":[221],"Hospital.":[222]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}