{"id":"https://openalex.org/W2646719065","doi":"https://doi.org/10.1097/01.tp.0000521366.26157.d4","title":"Severe Rejection of the Intestine Allograft \u2013 Regeneration, Re-transplantation or Death?","display_name":"Severe Rejection of the Intestine Allograft \u2013 Regeneration, Re-transplantation or Death?","publication_year":2017,"publication_date":"2017-06-01","ids":{"openalex":"https://openalex.org/W2646719065","doi":"https://doi.org/10.1097/01.tp.0000521366.26157.d4","mag":"2646719065"},"language":"en","primary_location":{"id":"doi:10.1097/01.tp.0000521366.26157.d4","doi":"https://doi.org/10.1097/01.tp.0000521366.26157.d4","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.tp.0000521366.26157.d4","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037572716","display_name":"Debra Lynn Sudan","orcid":"https://orcid.org/0000-0003-4315-4459","observed_orcids":["https://orcid.org/0000-0003-4315-4459"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Debra Sudan","raw_affiliation_strings":["Surgery, Duke University, Durham, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, Duke University, Durham, NC, United States","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065742002","display_name":"Deepak S. Vikraman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deepak Vikraman","raw_affiliation_strings":["Surgery, Duke University, Durham, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, Duke University, Durham, NC, United States","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074963517","display_name":"Neil Sudan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neil Sudan","raw_affiliation_strings":["Surgery, Duke University, Durham, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, Duke University, Durham, NC, United States","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087850349","display_name":"Aparna S. Rege","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aparna Rege","raw_affiliation_strings":["Surgery, Duke University, Durham, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, Duke University, Durham, NC, United States","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022547634","display_name":"Alisha Mavis","orcid":"https://orcid.org/0000-0001-6258-4492","observed_orcids":["https://orcid.org/0000-0001-6258-4492"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alisha Mavis","raw_affiliation_strings":["Surgery, Duke University, Durham, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, Duke University, Durham, NC, United States","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015634326","display_name":"Maria Cristina Segovia","orcid":"https://orcid.org/0000-0003-1656-089X","observed_orcids":["https://orcid.org/0000-0003-1656-089X"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Christina Segovia","raw_affiliation_strings":["Surgery, Duke University, Durham, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, Duke University, Durham, NC, United States","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Diana Cardona","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diana Cardona","raw_affiliation_strings":["Surgery, Duke University, Durham, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, Duke University, Durham, NC, United States","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021750333","display_name":"David N. Howell","orcid":"https://orcid.org/0000-0001-7257-1767","observed_orcids":["https://orcid.org/0000-0001-7257-1767"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Howell","raw_affiliation_strings":["Surgery, Duke University, Durham, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, Duke University, Durham, NC, United States","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025324420","display_name":"Liara M. Gonzalez","orcid":"https://orcid.org/0000-0003-3972-2812","observed_orcids":["https://orcid.org/0000-0003-3972-2812"]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liara Gonzalez","raw_affiliation_strings":["Veterinary Surgery, North Carolina State University, Raleigh, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterinary Surgery, North Carolina State University, Raleigh, NC, United States","institution_ids":["https://openalex.org/I137902535"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.10791667,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"101","issue":"6S2","first_page":"S60","last_page":"S60"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.7724999785423279,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.7724999785423279,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.10209999978542328,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.09989999979734421,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intestinal-transplantation","display_name":"intestinal transplantation","score":0.7730000019073486},{"id":"https://openalex.org/keywords/intestinal-allograft","display_name":"intestinal allograft","score":0.7710000276565552},{"id":"https://openalex.org/keywords/re-epithelialization","display_name":"re-epithelialization","score":0.8999999761581421},{"id":"https://openalex.org/keywords/retransplantation","display_name":"retransplantation","score":0.847000002861023},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.7310000061988831},{"id":"https://openalex.org/keywords/intestinal-failure","display_name":"intestinal failure","score":0.7049999833106995},{"id":"https://openalex.org/keywords/pediatric-recipients","display_name":"pediatric recipients","score":0.7329999804496765},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.5680000185966492},{"id":"https://openalex.org/keywords/villous-atrophy","display_name":"villous atrophy","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7424304485321045},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.7337895631790161},{"id":"https://openalex.org/C66090201","wikidata":"https://www.wikidata.org/wiki/Q15995009","display_name":"Crypt","level":2,"score":0.6543068885803223},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5867282152175903},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.5548834204673767},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5393260717391968},{"id":"https://openalex.org/C2777882243","wikidata":"https://www.wikidata.org/wiki/Q11090","display_name":"Small intestine","level":2,"score":0.5203992128372192},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.5145332217216492},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47241297364234924},{"id":"https://openalex.org/C2776280935","wikidata":"https://www.wikidata.org/wiki/Q11083","display_name":"Large intestine","level":2,"score":0.4352715313434601},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.39233386516571045},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.1779956817626953},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/01.tp.0000521366.26157.d4","doi":"https://doi.org/10.1097/01.tp.0000521366.26157.d4","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.tp.0000521366.26157.d4","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2069104454","https://openalex.org/W3177325516","https://openalex.org/W1989647864","https://openalex.org/W2720291231","https://openalex.org/W2593333189","https://openalex.org/W2092518924","https://openalex.org/W2028993816","https://openalex.org/W2969853071","https://openalex.org/W2092461061","https://openalex.org/W2969390379"],"abstract_inverted_index":{"Background:":[0],"Miminal":[1],"information":[2],"is":[3,92,209,314,386],"available":[4],"regarding":[5],"the":[6,22,50,90,112,173,193,259,311,324,335,341,363,367,377,381,393],"incidence,":[7],"risk":[8,140],"factors":[9,364],"and":[10,40,52,94,130,146,180,189,197,229,243,250,279,316,372],"natural":[11],"history":[12],"of":[13,15,21,35,57,64,71,89,98,119,162,172,178,195,205,237,258,271,274,310,323,337,343,351,362,369,376,383,395],"episodes":[14,109,126],"severe":[16,55,96,142,163,213,238,255,338,349,370,384],"acute":[17,308],"rejection":[18,309],"(severe":[19],"AR)":[20],"intestine":[23,58,91,99,174,312,344,396],"allograft.":[24],"Methods:":[25],"We":[26],"reviewed":[27],"pathology":[28],"reports":[29],"from":[30],"38":[31],"transplant":[32],"episodes/31":[33],"recipients":[34,136,232,325],"intestine-inclusive":[36],"allografts":[37,186,249],"(isolated":[38],"intestine[ITx]":[39],"liver-inclusive":[41],"[LSB]":[42],"allografts)":[43],"performed":[44,221,265],"12/2009":[45],"-":[46],"12/2016":[47],"to":[48,157,288,331,346,388],"identify":[49],"incidence":[51],"outcomes":[53],"for":[54,141],"AR":[56,88,143,164,214,339,371,385],"allograft;":[59],"defined":[60],"as":[61],"complete":[62],"loss":[63],"villous":[65],"architecture":[66],"and/or":[67],"crypts":[68],"without":[69,262,348],"evidence":[70],"other":[72],"cause.":[73],"Univariate":[74],"analysis":[75],"was":[76,148,165,190,220,264],"performed,":[77],"categorical":[78],"variables":[79],"were":[80,137],"evaluated":[81],"using":[82],"Chi":[83],"Square":[84],"test.":[85],"Results:":[86],"Severe":[87,307],"frequent":[93,315],"a":[95,149],"complication":[97],"transplantation":[100,345],"[n":[101],"=":[102,116,293],"9(30%)":[103],"patients":[104,224,347],"experienced":[105],"10":[106],"episodes].":[107],"Most":[108],"occurred":[110,127,183],"within":[111],"first":[113],"month":[114],"(n":[115,292],"7;":[117],"mean":[118],"18":[120],"days":[121],"after":[122,133,212,235,277,380],"transplantation)":[123],"although":[124],"3":[125],"15,":[128],"45":[129],"68*":[131],"months":[132,234],"transplantation.":[134,397],"Pediatric":[135],"at":[138,227],"higher":[139,152],"than":[144],"adults":[145],"there":[147],"trend":[150],"toward":[151],"rates":[153],"in":[154,184,222,230,266,320,392],"ITx":[155],"compared":[156],"LSB":[158],"recipients.":[159],"The":[160,329],"development":[161,368],"associated":[166,191],"with":[167,176,192,200,247],"decreased":[168],"patient":[169,201,297],"survival.":[170,202],"Re-epithelialization":[171],"allograft":[175,196,313],"recovery":[177,204],"villi":[179],"crypt":[181],"structures":[182],"6":[185],"(5":[187],"recipients)":[188],"type":[194],"strongly":[198],"correlated":[199],"Full":[203],"absorptive":[206],"function":[207],"however":[208],"rare":[210],"(20%)":[211],"even":[215],"when":[216],"re-epithelialization":[217],"occurs.":[218],"Re-transplantation":[219],"4":[223,267],"(2":[225],"acutely":[226],"1month":[228],"2":[231,270],"9":[233],"onset":[236],"AR);":[239],"3/4":[240],"are":[241],"alive":[242],"well":[244],"off":[245],"PN":[246,286],"functional":[248],"have":[251],"not":[252],"had":[253],"recurrent":[254],"AR.":[256],"Explantation":[257],"bowel":[260],"graft":[261],"re-transplantation":[263],"additional":[268],"patients,":[269],"whom":[272],"died":[273,281],"infection":[275],"early":[276],"explant":[278],"1":[280,296],"3.5":[282],"years":[283],"later":[284],"on":[285,300,302],"due":[287],"advanced":[289],"liver":[290],"disease":[291],"1);":[294],"only":[295],"has":[298,317],"survived":[299],"long-term":[301],"PN.":[303],"(see":[304],"Table":[305],"1)FigureConclusions:":[306],"devastating":[318],"consequences":[319],"nearly":[321],"half":[322],"who":[326],"develop":[327],"it.":[328],"inability":[330],"predict":[332,373],"or":[333],"prevent":[334],"occurrence":[336,382],"limits":[340],"applicability":[342],"complications":[350],"intestinal":[352],"failure.":[353],"A":[354],"more":[355],"thorough":[356],"understanding":[357],"through":[358],"larger":[359],"multicenter":[360],"studies":[361],"that":[365],"impact":[366],"healing":[374],"(re-epithelialization":[375],"mucosal":[378],"surface)":[379],"crucial":[387],"making":[389],"further":[390],"advances":[391],"field":[394]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2017-06-30T00:00:00"}