{"id":"https://openalex.org/W26426208","doi":null,"title":"Drug-induced encephalopathy secondary to non renal dosing of common medications in Two dialysis patients.","display_name":"Drug-induced encephalopathy secondary to non renal dosing of common medications in Two dialysis patients.","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W26426208","mag":"26426208","pmid":"https://pubmed.ncbi.nlm.nih.gov/19886325"},"language":"en","primary_location":{"id":"pmid:19886325","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19886325","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in peritoneal dialysis. Conference on Peritoneal Dialysis","raw_type":"Case Reports"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023618986","display_name":"Macaulay A C Onuigbo","orcid":"https://orcid.org/0000-0002-2601-5791","observed_orcids":["https://orcid.org/0000-0002-2601-5791"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Macaulay A C Onuigbo","raw_affiliation_strings":["College of Medicine, Mayo Clinic, Rochester, Minnesota, USA. onuigbo.macaulay@mayo.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Medicine, Mayo Clinic, Rochester, Minnesota, USA. onuigbo.macaulay@mayo.edu","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":null,"display_name":"David Nye","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Nye","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5084810310","display_name":"Peter Iloanya","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter C Iloanya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":14.593,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.98,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"25","issue":null,"first_page":"89","last_page":"91"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.8945000171661377,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.8945000171661377,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.04410000145435333,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.027799999341368675,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-induced-encephalopathy","display_name":"drug-induced encephalopathy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gabapentin","display_name":"gabapentin","score":0.8140000104904175},{"id":"https://openalex.org/keywords/acyclovir","display_name":"acyclovir","score":1.0},{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.8999999761581421},{"id":"https://openalex.org/keywords/dialysis","display_name":"dialysis","score":0.7910000085830688},{"id":"https://openalex.org/keywords/drug-induced-neurotoxicity","display_name":"drug-induced neurotoxicity","score":0.621999979019165},{"id":"https://openalex.org/keywords/residual-renal-function","display_name":"residual renal function","score":0.7710000276565552},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.4480000138282776},{"id":"https://openalex.org/keywords/antiviral-agents","display_name":"antiviral agents","score":0.5680000185966492},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.9480000138282776}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8769713640213013},{"id":"https://openalex.org/C2779978075","wikidata":"https://www.wikidata.org/wiki/Q202301","display_name":"Dialysis","level":2,"score":0.6769330501556396},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.616601288318634},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.5890601873397827},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5768755674362183},{"id":"https://openalex.org/C2778063415","wikidata":"https://www.wikidata.org/wiki/Q391744","display_name":"Hemodialysis","level":2,"score":0.5406962633132935},{"id":"https://openalex.org/C2779056158","wikidata":"https://www.wikidata.org/wiki/Q1756474","display_name":"Peritoneal dialysis","level":2,"score":0.5066335797309875},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.4958225190639496},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.49366769194602966},{"id":"https://openalex.org/C2778621155","wikidata":"https://www.wikidata.org/wiki/Q576349","display_name":"Encephalopathy","level":2,"score":0.4698423743247986},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.45451590418815613},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4174298644065857},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077206","descriptor_name":"Gabapentin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000212","descriptor_name":"Acyclovir","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000212","descriptor_name":"Acyclovir","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000588","descriptor_name":"Amines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000588","descriptor_name":"Amines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D003509","descriptor_name":"Cyclohexanecarboxylic Acids","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D003509","descriptor_name":"Cyclohexanecarboxylic Acids","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D006435","descriptor_name":"Renal Dialysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020258","descriptor_name":"Neurotoxicity Syndromes","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:19886325","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19886325","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in peritoneal dialysis. Conference on Peritoneal Dialysis","raw_type":"Case Reports"},{"id":"mag:26426208","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19886325","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W50181633","https://openalex.org/W1490603863","https://openalex.org/W1542233315","https://openalex.org/W1899606784","https://openalex.org/W1964012801","https://openalex.org/W1964534036","https://openalex.org/W1967895022","https://openalex.org/W1978158514","https://openalex.org/W1985264354","https://openalex.org/W2000439581","https://openalex.org/W2015583354","https://openalex.org/W2018722593","https://openalex.org/W2022167001","https://openalex.org/W2023773946","https://openalex.org/W2048265515","https://openalex.org/W2061494871","https://openalex.org/W2061565297","https://openalex.org/W2061882966","https://openalex.org/W2078853527","https://openalex.org/W2081963530","https://openalex.org/W2107706105","https://openalex.org/W2109984353","https://openalex.org/W2111818224","https://openalex.org/W2114071156","https://openalex.org/W2115593244","https://openalex.org/W2124516214","https://openalex.org/W2129361902","https://openalex.org/W2137155636","https://openalex.org/W2144189297","https://openalex.org/W2146479387","https://openalex.org/W2163735298","https://openalex.org/W2255756224","https://openalex.org/W2323149989"],"related_works":["https://openalex.org/W4297097827","https://openalex.org/W4397041856","https://openalex.org/W2264392841","https://openalex.org/W1990758618","https://openalex.org/W2045078485","https://openalex.org/W2124516214","https://openalex.org/W7204928967","https://openalex.org/W4396996694","https://openalex.org/W2115593244","https://openalex.org/W4300993032"],"abstract_inverted_index":{"The":[0],"U.S.":[1],"end-stage":[2],"renal":[3,91,173,178],"disease":[4],"(ESRD)":[5],"population":[6],"continues":[7],"to":[8,15,53,55,171],"increase.":[9],"Adjustment":[10],"of":[11,21,46,62,188,204],"several":[12,34],"drugs":[13],"administered":[14],"dialysis":[16,101,129],"patients":[17,99,132],"is":[18,38,51,81],"mandatory":[19],"because":[20],"decreased--and":[22],"sometimes":[23],"totally":[24],"absent--renal":[25],"clearances.":[26],"Gabapentin,":[27],"a":[28],"newer":[29],"anticonvulsant":[30],"increasingly":[31,206],"used":[32],"for":[33,176],"other":[35,153],"clinical":[36,138],"indications,":[37],"excreted":[39],"in":[40,58,90,136],"the":[41,70,115,144],"urine":[42],"unchanged.":[43],"Its":[44,77],"half-life":[45,80],"5":[47],"-":[48,83],"9":[49],"hours":[50,57],"increased":[52],"up":[54],"132":[56],"anuric":[59],"patients.":[60,162],"Excretion":[61],"acyclovir":[63,111],"an":[64],"antiviral":[65],"agent,":[66],"occurs":[67],"predominantly":[68],"through":[69],"kidney":[71],"(glomerular":[72],"filtration":[73],"and":[74,110,123,195],"tubular":[75],"secretion).":[76],"normal":[78,137],"plasma":[79],"2":[82,97],"3":[84,141],"hours;":[85],"dosage":[86],"modifications":[87,169],"are":[88,181],"obligatory":[89],"insufficiency.":[92],"In":[93,197],"2008,":[94],"we":[95],"encountered":[96],"ESRD":[98,146],"on":[100],"who":[102],"exhibited":[103],"significant":[104,193],"neurotoxicity":[105],"with":[106,160],"encephalopathy":[107],"after":[108,140],"gabapentin":[109],"were":[112,133],"given":[113],"at":[114],"usual":[116],"adult":[117],"doses.":[118],"Following":[119],"prompt":[120],"drug":[121,167,179],"discontinuation":[122],"continued":[124],"daily":[125],"hemodialysis":[126],"or":[127],"peritoneal":[128],"respectively,":[130],"both":[131],"discharged":[134],"home,":[135],"condition,":[139],"days.":[142],"With":[143],"increasing":[145,158],"(and":[147],"CKD)":[148],"populations,":[149],"health":[150,208],"care":[151,209],"providers":[152,164],"than":[154],"nephrologists":[155],"will":[156,191,201],"have":[157],"contact":[159],"these":[161],"Those":[163],"must":[165],"consider":[166],"dose":[168],"according":[170],"residual":[172],"function.":[174],"Algorithms":[175],"appropriate":[177],"dosing":[180],"available":[182],"from":[183],"various":[184],"sources.":[185],"Pragmatic":[186],"tactics":[187],"this":[189,199],"kind":[190],"avoid":[192],"morbidity":[194],"mortality.":[196],"addition,":[198],"approach":[200],"save":[202],"millions":[203],"now":[205],"scarce":[207],"dollars.":[210]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
