{"id":"https://openalex.org/W26368345","doi":null,"title":"Evaluation in vivo and ex vivo of a new stabilized 99mTc-labeled minigastrin derivative","display_name":"Evaluation in vivo and ex vivo of a new stabilized 99mTc-labeled minigastrin derivative","publication_year":2008,"publication_date":"2008-05-01","ids":{"openalex":"https://openalex.org/W26368345","mag":"26368345"},"language":"en","primary_location":{"id":"mag:26368345","doi":null,"is_oa":false,"landing_page_url":"http://jnm.snmjournals.org/content/49/supplement_1/289P.4","pdf_url":null,"source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Nuclear Medicine","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011328619","display_name":"Elisabeth von Guggenberg","orcid":"https://orcid.org/0000-0003-4944-4705","observed_orcids":["https://orcid.org/0000-0003-4944-4705"]},"institutions":[{"id":"https://openalex.org/I143397708","display_name":"Innsbruck Medical University","ror":"https://ror.org/03pt86f80","country_code":"AT","type":"education","lineage":["https://openalex.org/I143397708"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Elisabeth von Guggenberg","raw_affiliation_strings":["Clinical Department of Nuclear Medicine, Innsbruck Medical University, Innsbruck, Austria;"],"raw_orcid":"https://orcid.org/0000-0003-4944-4705","affiliations":[{"raw_affiliation_string":"Clinical Department of Nuclear Medicine, Innsbruck Medical University, Innsbruck, Austria;","institution_ids":["https://openalex.org/I143397708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053883492","display_name":"Anna Helbok","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143397708","display_name":"Innsbruck Medical University","ror":"https://ror.org/03pt86f80","country_code":"AT","type":"education","lineage":["https://openalex.org/I143397708"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Anna Helbok","raw_affiliation_strings":["Clinical Department of Nuclear Medicine, Innsbruck Medical University, Innsbruck, Austria;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Department of Nuclear Medicine, Innsbruck Medical University, Innsbruck, Austria;","institution_ids":["https://openalex.org/I143397708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112903935","display_name":"Stephen J. Mather","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307195382","display_name":"St Bartholomew's Hospital","ror":"https://ror.org/00nh9x179","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1307195382","https://openalex.org/I225661044"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stephen J. Mather","raw_affiliation_strings":["Department of Nuclear Medicine, St. Bartholomew's Hospital, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, St. Bartholomew's Hospital, London, United Kingdom","institution_ids":["https://openalex.org/I1307195382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015672622","display_name":"Andreas Artl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andreas Artl","raw_affiliation_strings":["piCHEM Research & Development, Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"piCHEM Research & Development, Graz, Austria","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017213061","display_name":"Clemens Decristoforo","orcid":"https://orcid.org/0000-0003-0566-4036","observed_orcids":["https://orcid.org/0000-0003-0566-4036"]},"institutions":[{"id":"https://openalex.org/I143397708","display_name":"Innsbruck Medical University","ror":"https://ror.org/03pt86f80","country_code":"AT","type":"education","lineage":["https://openalex.org/I143397708"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Clemens Decristoforo","raw_affiliation_strings":["Clinical Department of Nuclear Medicine, Innsbruck Medical University, Innsbruck, Austria;"],"raw_orcid":"https://orcid.org/0000-0003-0566-4036","affiliations":[{"raw_affiliation_string":"Clinical Department of Nuclear Medicine, Innsbruck Medical University, Innsbruck, Austria;","institution_ids":["https://openalex.org/I143397708"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00529101,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"49","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cck2-receptor","display_name":"CCK2 receptor","score":0.7919999957084656},{"id":"https://openalex.org/keywords/cyclization","display_name":"cyclization","score":0.5839999914169312},{"id":"https://openalex.org/keywords/peptide-stabilization","display_name":"peptide stabilization","score":0.5519999861717224},{"id":"https://openalex.org/keywords/radiochemical-stability","display_name":"radiochemical stability","score":0.6150000095367432},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.7630000114440918},{"id":"https://openalex.org/keywords/tumor-uptake","display_name":"tumor uptake","score":0.6399999856948853},{"id":"https://openalex.org/keywords/spect-ct-imaging","display_name":"SPECT/CT imaging","score":0.6819999814033508},{"id":"https://openalex.org/keywords/peptide-degradation","display_name":"peptide degradation","score":0.3160000145435333},{"id":"https://openalex.org/keywords/medullary-thyroid-carcinoma","display_name":"medullary thyroid carcinoma","score":0.7670000195503235},{"id":"https://openalex.org/keywords/small-cell-lung-cancer","display_name":"small cell lung cancer","score":0.8640000224113464},{"id":"https://openalex.org/keywords/radioligand-metabolism","display_name":"radioligand metabolism","score":0.5220000147819519}],"concepts":[{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.934511125087738},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.8579602241516113},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.8450554609298706},{"id":"https://openalex.org/C67847695","wikidata":"https://www.wikidata.org/wiki/Q626478","display_name":"Radioligand","level":3,"score":0.7244088053703308},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6899900436401367},{"id":"https://openalex.org/C29331040","wikidata":"https://www.wikidata.org/wiki/Q7239554","display_name":"Preclinical imaging","level":3,"score":0.4982585906982422},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4674340784549713},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.43926599621772766},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.4351620674133301},{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.424445778131485},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3058090806007385},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13390949368476868},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:26368345","doi":null,"is_oa":false,"landing_page_url":"http://jnm.snmjournals.org/content/49/supplement_1/289P.4","pdf_url":null,"source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Nuclear Medicine","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2055043917","https://openalex.org/W1907629755","https://openalex.org/W2909434496","https://openalex.org/W2322685957","https://openalex.org/W2023711227","https://openalex.org/W3092293617","https://openalex.org/W2039586733","https://openalex.org/W2800103705","https://openalex.org/W2736431839","https://openalex.org/W7096844160"],"abstract_inverted_index":{"1235":[0],"Objectives:":[2],"The":[3,155,201],"development":[4],"of":[5,14,29,40,66,220,230,241],"radiolabeled":[6,231],"Minigastrin":[7],"(MG)":[8],"derivatives":[9],"for":[10],"imaging":[11,58],"and":[12,21,51,96,102,129,162,177,196,212,244],"therapy":[13],"CCK2-receptor":[15,107],"expressing":[16,108],"tumors":[17],"such":[18],"as":[19,99],"MTC":[20],"SCLC":[22],"has":[23],"been":[24],"hampered":[25],"by":[26,46,70,73,89,133,247],"low":[27,178],"stability":[28,159,229],"the":[30,38,49,94,143,170,208,228,242],"native":[31],"peptide.":[32],"In":[33,169],"this":[34],"study":[35],"we":[36],"describe":[37],"evaluation":[39],"a":[41,224],"new":[42],"99mTc-labeled":[43],"analog":[44],"stabilized":[45],"cyclisation,":[47],"comparing":[48],"organ":[50,243],"tumor":[52,118,172,245],"uptake":[53,165,180,187,246],"in":[54,82,106,116,126,142,160,166,181,194,215,252],"vivo":[55,195,256],"using":[56],"micro-SPECT/CT":[57],"with":[59,80,91,97,152,254],"quantification":[60],"ex":[61,199,255],"vivo.":[62,200,216],"Methods:":[64],"Cyclisation":[65,219],"MG":[67,221],"was":[68,86,114,191,235,251],"achieved":[69],"replacing":[71],"Gly":[72],"DLys":[74],"at":[75,93,148],"Pos":[76,83],"9":[77],"allowing":[78,146],"cyclisation":[79],"DGlu":[81],"1.":[84],"99mTc-labelling":[85,147],"carried":[87],"out":[88],"derivatisation":[90],"HYNIC":[92],"N-terminal":[95],"EDDA":[98],"coligand.":[100],"Stability":[101],"receptor":[103,163],"mediated":[104,164],"internalization":[105],"AR4-2J":[109,117,167],"cells":[110],"were":[111,131,184],"evaluated.":[112],"Biodistribution":[113],"studied":[115],"bearing":[119],"nude":[120],"mice,":[121],"including":[122],"NanoSPECT/CT":[123],"imaging.":[124],"Metabolites":[125],"urine,":[127],"liver":[128],"kidneys":[130],"analyzed":[132],"HPLC.":[134],"Results:":[136],"Cyclo-MG":[137],"showed":[138],"improved":[139],"radiochemical":[140],"purity":[141],"labelling":[144],"process,":[145],"high":[149,153,158],"specific":[150],"activities":[151],"yields.":[154],"radioligand":[156],"revealed":[157],"vitro":[161],"cells.":[168],"animal":[171],"model":[173],"fast":[174],"renal":[175],"clearance":[176],"unspecific":[179],"most":[182],"organs":[183],"observed.":[185],"Tumor":[186],"1":[188],"h":[189],"p.i.":[190],"3.26":[192],"%ID/g":[193,198],"3.61":[197],"metabolite":[202],"analysis":[203],"indicated":[204],"rapid":[205],"conversion":[206],"into":[207],"linear":[209,238],"peptide":[210],"sequence":[211],"enzymatic":[213],"degradation":[214],"Conclusions:":[218],"only":[222],"had":[223],"limited":[225],"effect":[226],"on":[227],"MG.":[232],"Overall":[233],"biodistribution":[234],"comparable":[236],"to":[237],"analogs.":[239],"Quantification":[240],"SPECT/CT":[248],"image":[249],"fusion":[250],"accordance":[253],"data.":[258]},"counts_by_year":[],"updated_date":"2026-08-08T07:41:36.138363","created_date":"2016-06-24T00:00:00"}