{"id":"https://openalex.org/W2636750004","doi":"https://doi.org/10.1177/2045893217716659","title":"Combination targeted pulmonary hypertension therapy in the resolution of Dasatinib\u2010associated pulmonary arterial hypertension","display_name":"Combination targeted pulmonary hypertension therapy in the resolution of Dasatinib\u2010associated pulmonary arterial hypertension","publication_year":2017,"publication_date":"2017-06-23","ids":{"openalex":"https://openalex.org/W2636750004","doi":"https://doi.org/10.1177/2045893217716659","mag":"2636750004","pmid":"https://pubmed.ncbi.nlm.nih.gov/28644066","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5703121"},"language":"en","primary_location":{"id":"doi:10.1177/2045893217716659","doi":"https://doi.org/10.1177/2045893217716659","is_oa":true,"landing_page_url":"https://doi.org/10.1177/2045893217716659","pdf_url":null,"source":{"id":"https://openalex.org/S2764573606","display_name":"Pulmonary Circulation","issn_l":"2045-8932","issn":["2045-8932","2045-8940"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pulmonary Circulation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1177/2045893217716659","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011538718","display_name":"Arun Jose","orcid":"https://orcid.org/0000-0001-7109-2692","observed_orcids":["https://orcid.org/0000-0001-7109-2692"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Arun Jose","raw_affiliation_strings":["Pulmonary, Critical Care, and Sleep Medicine Division, The George Washington University, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary, Critical Care, and Sleep Medicine Division, The George Washington University, Washington, DC, USA","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041917404","display_name":"Hind Rafei","orcid":"https://orcid.org/0000-0002-5724-4183","observed_orcids":["https://orcid.org/0000-0002-5724-4183"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hind Rafei","raw_affiliation_strings":["Department of Medicine, The George Washington University, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, The George Washington University, Washington, DC, USA","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108981724","display_name":"Jalil Ahari","orcid":"https://orcid.org/0000-0003-2794-3773","observed_orcids":["https://orcid.org/0000-0003-2794-3773"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jalil Ahari","raw_affiliation_strings":["Pulmonary, Critical Care, and Sleep Medicine Division, The George Washington University, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary, Critical Care, and Sleep Medicine Division, The George Washington University, Washington, DC, USA","institution_ids":["https://openalex.org/I193531525"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5011538718"],"corresponding_institution_ids":["https://openalex.org/I193531525"],"apc_list":{"value":2310,"currency":"USD","value_usd":2310},"apc_paid":{"value":2310,"currency":"USD","value_usd":2310},"fwci":0.6248,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.71624775,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"7","issue":"4","first_page":"803","last_page":"807"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12199","display_name":"Vascular Anomalies and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dasatinib","display_name":"dasatinib","score":0.9620000123977661},{"id":"https://openalex.org/keywords/pulmonary-arterial-hypertension","display_name":"pulmonary arterial hypertension","score":0.9110000133514404},{"id":"https://openalex.org/keywords/drug-induced-pulmonary-arterial-hypertension","display_name":"drug-induced pulmonary arterial hypertension","score":0.8180000185966492},{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.9190000295639038},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitor-adverse-effects","display_name":"tyrosine kinase inhibitor adverse effects","score":0.7829999923706055},{"id":"https://openalex.org/keywords/pulmonary-vasodilator-therapy","display_name":"pulmonary vasodilator therapy","score":0.8759999871253967},{"id":"https://openalex.org/keywords/endothelin-receptor-antagonists","display_name":"endothelin receptor antagonists","score":0.9639999866485596},{"id":"https://openalex.org/keywords/phosphodiesterase-5-inhibitors","display_name":"phosphodiesterase-5 inhibitors","score":0.9980000257492065},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.9020000100135803}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9450148940086365},{"id":"https://openalex.org/C2779536868","wikidata":"https://www.wikidata.org/wiki/Q419940","display_name":"Dasatinib","level":4,"score":0.9348594546318054},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.7043942809104919},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.552447497844696},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4989898204803467},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.48701292276382446},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.4595997929573059},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.45839130878448486},{"id":"https://openalex.org/C144980905","wikidata":"https://www.wikidata.org/wiki/Q24721308","display_name":"Endothelin receptor","level":3,"score":0.43294772505760193},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.4076555371284485},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3678886294364929},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.2916737198829651},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.15595820546150208},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1177/2045893217716659","doi":"https://doi.org/10.1177/2045893217716659","is_oa":true,"landing_page_url":"https://doi.org/10.1177/2045893217716659","pdf_url":null,"source":{"id":"https://openalex.org/S2764573606","display_name":"Pulmonary Circulation","issn_l":"2045-8932","issn":["2045-8932","2045-8940"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pulmonary Circulation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5703121","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5703121","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pulm Circ","raw_type":"Text"},{"id":"pmid:28644066","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28644066","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pulmonary circulation","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.1177/2045893217716659","doi":"https://doi.org/10.1177/2045893217716659","is_oa":true,"landing_page_url":"https://doi.org/10.1177/2045893217716659","pdf_url":null,"source":{"id":"https://openalex.org/S2764573606","display_name":"Pulmonary Circulation","issn_l":"2045-8932","issn":["2045-8932","2045-8940"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pulmonary Circulation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W68265282","https://openalex.org/W1944742142","https://openalex.org/W1979770196","https://openalex.org/W2036823605","https://openalex.org/W2065851457","https://openalex.org/W2070507117","https://openalex.org/W2105057140","https://openalex.org/W2112229901","https://openalex.org/W2132235493","https://openalex.org/W2178295104","https://openalex.org/W2187708517","https://openalex.org/W2336822157","https://openalex.org/W2344087772","https://openalex.org/W2496712281","https://openalex.org/W2600212366"],"related_works":["https://openalex.org/W2804661892","https://openalex.org/W3190182340","https://openalex.org/W2981111390","https://openalex.org/W7161565651","https://openalex.org/W2982090896","https://openalex.org/W2776524542","https://openalex.org/W2414030522","https://openalex.org/W2592029471","https://openalex.org/W2787106719","https://openalex.org/W2187708517"],"abstract_inverted_index":{"Dasatinib":[0],"is":[1,18,28,36,115],"a":[2,19,51,57,85],"small-molecule":[3],"tyrosine":[4],"kinase":[5],"inhibitor":[6],"used":[7],"in":[8,56,103],"the":[9,97,106],"treatment":[10,27,73],"of":[11,26,30,41,53,99,109],"hematological":[12],"malignancies.":[13],"Pulmonary":[14],"arterial":[15],"hypertension":[16,43],"(PAH)":[17],"rare":[20],"but":[21,112],"known":[22],"complication.":[23],"The":[24],"mainstay":[25],"cessation":[29],"Dasatinib,":[31],"and":[32,66,69,84,105],"while":[33],"clinical":[34,68],"improvement":[35],"rapid,":[37],"complete":[38,67,107],"hemodynamic":[39,70],"resolution":[40,71,108],"pulmonary":[42,76],"(PH)":[44],"still":[45],"remains":[46],"exceedingly":[47],"uncommon.":[48],"We":[49],"present":[50],"case":[52,89],"Dasatinib-induced":[54],"PAH":[55],"woman":[58],"with":[59,74],"chronic":[60],"myeloid":[61],"leukemia,":[62],"who":[63],"demonstrated":[64],"rapid":[65],"following":[72],"combination":[75,104],"vasodilator":[77],"therapy":[78],"using":[79],"an":[80,94],"endothelin":[81],"receptor":[82],"antagonist":[83],"phosphodiesterase-5":[86],"inhibitor.":[87],"This":[88],"suggests":[90],"there":[91],"may":[92],"be":[93],"association":[95],"between":[96],"use":[98],"targeted":[100],"PH":[101],"medication":[102],"dasatinib-associated":[110],"PAH,":[111],"further":[113],"investigation":[114],"required.":[116]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-06-30T00:00:00"}
