{"id":"https://openalex.org/W2632978006","doi":"https://doi.org/10.3390/ijms18061319","title":"The Intersection of NGF/TrkA Signaling and Amyloid Precursor Protein Processing in Alzheimer\u2019s Disease Neuropathology","display_name":"The Intersection of NGF/TrkA Signaling and Amyloid Precursor Protein Processing in Alzheimer\u2019s Disease Neuropathology","publication_year":2017,"publication_date":"2017-06-20","ids":{"openalex":"https://openalex.org/W2632978006","doi":"https://doi.org/10.3390/ijms18061319","mag":"2632978006","pmid":"https://pubmed.ncbi.nlm.nih.gov/28632177","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5486140"},"language":"en","primary_location":{"id":"doi:10.3390/ijms18061319","doi":"https://doi.org/10.3390/ijms18061319","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms18061319","pdf_url":"https://www.mdpi.com/1422-0067/18/6/1319/pdf?version=1498032026","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/18/6/1319/pdf?version=1498032026","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113878056","display_name":"Nadia Canu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Nadia Canu","raw_affiliation_strings":["Department of System Medicine, University of Rome \u201cTor Vergata\u201d, Via Montpellier 1, 00137 Rome, Italy","Institute of Cellular Biology and Neurobiology, National Council of Research Rome, Via del Fosso del Fiorano 64, 00143 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of System Medicine, University of Rome \u201cTor Vergata\u201d, Via Montpellier 1, 00137 Rome, Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"Institute of Cellular Biology and Neurobiology, National Council of Research Rome, Via del Fosso del Fiorano 64, 00143 Rome, Italy","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042666528","display_name":"Giuseppina Amadoro","orcid":"https://orcid.org/0000-0003-2080-2951","observed_orcids":["https://orcid.org/0000-0003-2080-2951"]},"institutions":[{"id":"https://openalex.org/I4210133672","display_name":"Istituto di Farmacologia Traslazionale","ror":"https://ror.org/03ta8pf33","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210133672","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppina Amadoro","raw_affiliation_strings":["Institute of Translational Pharmacology, National Research Council (CNR) Rome, Via Fosso del Cavaliere 100, 00133 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Translational Pharmacology, National Research Council (CNR) Rome, Via Fosso del Cavaliere 100, 00133 Rome, Italy","institution_ids":["https://openalex.org/I4210133672","https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029818421","display_name":"Viviana Triaca","orcid":"https://orcid.org/0000-0001-8290-7279","observed_orcids":["https://orcid.org/0000-0001-8290-7279"]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Viviana Triaca","raw_affiliation_strings":["Institute of Cellular Biology and Neurobiology, National Council of Research Rome, Via del Fosso del Fiorano 64, 00143 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cellular Biology and Neurobiology, National Council of Research Rome, Via del Fosso del Fiorano 64, 00143 Rome, Italy","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058669578","display_name":"Valentina Latina","orcid":"https://orcid.org/0000-0002-6057-6154","observed_orcids":["https://orcid.org/0000-0002-6057-6154"]},"institutions":[{"id":"https://openalex.org/I4210133672","display_name":"Istituto di Farmacologia Traslazionale","ror":"https://ror.org/03ta8pf33","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210133672","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valentina Latina","raw_affiliation_strings":["Institute of Translational Pharmacology, National Research Council (CNR) Rome, Via Fosso del Cavaliere 100, 00133 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Translational Pharmacology, National Research Council (CNR) Rome, Via Fosso del Cavaliere 100, 00133 Rome, Italy","institution_ids":["https://openalex.org/I4210133672","https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011309792","display_name":"Valentina Sposato","orcid":"https://orcid.org/0000-0001-8081-0692","observed_orcids":["https://orcid.org/0000-0001-8081-0692"]},"institutions":[{"id":"https://openalex.org/I4210142264","display_name":"European Brain Research Institute","ror":"https://ror.org/03ay27p09","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210142264"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valentina Sposato","raw_affiliation_strings":["European Brain Research Institute Rome, Via del Fosso del Fiorano 64, 00143 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Brain Research Institute Rome, Via del Fosso del Fiorano 64, 00143 Rome, Italy","institution_ids":["https://openalex.org/I4210142264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081590385","display_name":"Veronica Corsetti","orcid":"https://orcid.org/0000-0001-6862-2998","observed_orcids":["https://orcid.org/0000-0001-6862-2998"]},"institutions":[{"id":"https://openalex.org/I4210142264","display_name":"European Brain Research Institute","ror":"https://ror.org/03ay27p09","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210142264"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Veronica Corsetti","raw_affiliation_strings":["European Brain Research Institute Rome, Via del Fosso del Fiorano 64, 00143 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Brain Research Institute Rome, Via del Fosso del Fiorano 64, 00143 Rome, Italy","institution_ids":["https://openalex.org/I4210142264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089278763","display_name":"Cinzia Severini","orcid":"https://orcid.org/0000-0002-6932-704X","observed_orcids":["https://orcid.org/0000-0002-6932-704X"]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cinzia Severini","raw_affiliation_strings":["Institute of Cellular Biology and Neurobiology, National Council of Research Rome, Via del Fosso del Fiorano 64, 00143 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cellular Biology and Neurobiology, National Council of Research Rome, Via del Fosso del Fiorano 64, 00143 Rome, Italy","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110136821","display_name":"Maria Teresa Ciotti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Teresa Ciotti","raw_affiliation_strings":["Institute of Cellular Biology and Neurobiology, National Council of Research Rome, Via del Fosso del Fiorano 64, 00143 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cellular Biology and Neurobiology, National Council of Research Rome, Via del Fosso del Fiorano 64, 00143 Rome, Italy","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059406139","display_name":"Pietro Calissano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142264","display_name":"European Brain Research Institute","ror":"https://ror.org/03ay27p09","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210142264"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Pietro Calissano","raw_affiliation_strings":["European Brain Research Institute Rome, Via del Fosso del Fiorano 64, 00143 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Brain Research Institute Rome, Via del Fosso del Fiorano 64, 00143 Rome, Italy","institution_ids":["https://openalex.org/I4210142264"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5059406139"],"corresponding_institution_ids":["https://openalex.org/I4210142264"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.7045,"has_fulltext":true,"cited_by_count":70,"citation_normalized_percentile":{"value":0.54603399,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"18","issue":"6","first_page":"1319","last_page":"1319"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":0.9559999704360962},{"id":"https://openalex.org/keywords/trka","display_name":"TrkA","score":0.9769999980926514},{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.8980000019073486},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9309999942779541},{"id":"https://openalex.org/keywords/basal-forebrain-cholinergic-neurons","display_name":"basal forebrain cholinergic neurons","score":0.9330000281333923},{"id":"https://openalex.org/keywords/synapse-loss","display_name":"synaptic loss","score":0.7429999709129333},{"id":"https://openalex.org/keywords/amyloid-beta-deposition","display_name":"amyloid-beta deposition","score":0.9179999828338623},{"id":"https://openalex.org/keywords/septo-hippocampal-system","display_name":"septo-hippocampal system","score":0.8999999761581421},{"id":"https://openalex.org/keywords/ngf-trka-signaling","display_name":"NGF/TrkA signaling","score":0.7990000247955322}],"concepts":[{"id":"https://openalex.org/C171034665","wikidata":"https://www.wikidata.org/wiki/Q14897694","display_name":"Tropomyosin receptor kinase A","level":4,"score":0.7513127326965332},{"id":"https://openalex.org/C2778423431","wikidata":"https://www.wikidata.org/wiki/Q417782","display_name":"Nerve growth factor","level":3,"score":0.6926736235618591},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.6087017059326172},{"id":"https://openalex.org/C104966671","wikidata":"https://www.wikidata.org/wiki/Q12167532","display_name":"Cholinergic neuron","level":3,"score":0.5425695776939392},{"id":"https://openalex.org/C56703729","wikidata":"https://www.wikidata.org/wiki/Q14897872","display_name":"Low-affinity nerve growth factor receptor","level":4,"score":0.5140577554702759},{"id":"https://openalex.org/C2780130745","wikidata":"https://www.wikidata.org/wiki/Q1650750","display_name":"Neuropathology","level":3,"score":0.5095951557159424},{"id":"https://openalex.org/C177907266","wikidata":"https://www.wikidata.org/wiki/Q17155455","display_name":"P3 peptide","level":5,"score":0.4992527961730957},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47265660762786865},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4638744592666626},{"id":"https://openalex.org/C2776287375","wikidata":"https://www.wikidata.org/wiki/Q3407681","display_name":"Basal forebrain","level":3,"score":0.44302898645401},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.43987351655960083},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.4339582920074463},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.3683582544326782},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3393021523952484},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2935534119606018},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25911945104599},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2123010754585266},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11341997981071472},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0653020441532135}],"mesh":[{"descriptor_ui":"D000069338","descriptor_name":"Neuropathology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020917","descriptor_name":"Receptor, trkA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020932","descriptor_name":"Nerve Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058227","descriptor_name":"Amyloidogenic Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059329","descriptor_name":"Cholinergic Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3390/ijms18061319","doi":"https://doi.org/10.3390/ijms18061319","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms18061319","pdf_url":"https://www.mdpi.com/1422-0067/18/6/1319/pdf?version=1498032026","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5486140","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5486140","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:28632177","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28632177","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:art.torvergata.it:2108/185136","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2108/185136","pdf_url":null,"source":{"id":"https://openalex.org/S4306400993","display_name":"Cineca Institutional Research Information System (Tor Vergata University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I116067653","host_organization_name":"University of Rome Tor Vergata","host_organization_lineage":["https://openalex.org/I116067653"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:6592cf13925245a5bfcbf4426db9d05d","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/6592cf13925245a5bfcbf4426db9d05d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 18, Iss 6, p 1319 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms18061319","doi":"https://doi.org/10.3390/ijms18061319","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms18061319","pdf_url":"https://www.mdpi.com/1422-0067/18/6/1319/pdf?version=1498032026","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8607341727","display_name":null,"funder_award_id":"732678","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"}],"funders":[{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2632978006.pdf","grobid_xml":"https://content.openalex.org/works/W2632978006.grobid-xml"},"referenced_works_count":151,"referenced_works":["https://openalex.org/W81293131","https://openalex.org/W141636555","https://openalex.org/W1484830181","https://openalex.org/W1487346158","https://openalex.org/W1492009115","https://openalex.org/W1494415215","https://openalex.org/W1536410620","https://openalex.org/W1560623477","https://openalex.org/W1568303755","https://openalex.org/W1582490571","https://openalex.org/W1590041608","https://openalex.org/W1615644378","https://openalex.org/W1673416974","https://openalex.org/W1710345371","https://openalex.org/W1751080816","https://openalex.org/W1820013501","https://openalex.org/W1928313261","https://openalex.org/W1933828059","https://openalex.org/W1934321504","https://openalex.org/W1946603937","https://openalex.org/W1961744561","https://openalex.org/W1963635405","https://openalex.org/W1965861972","https://openalex.org/W1966507933","https://openalex.org/W1967601924","https://openalex.org/W1967656140","https://openalex.org/W1968553823","https://openalex.org/W1968937229","https://openalex.org/W1969411923","https://openalex.org/W1969479602","https://openalex.org/W1970991806","https://openalex.org/W1974433379","https://openalex.org/W1977150341","https://openalex.org/W1978012364","https://openalex.org/W1983462674","https://openalex.org/W1984748656","https://openalex.org/W1985822867","https://openalex.org/W1989272234","https://openalex.org/W1989875198","https://openalex.org/W1990752558","https://openalex.org/W1995289808","https://openalex.org/W1995490147","https://openalex.org/W1997957892","https://openalex.org/W1998268103","https://openalex.org/W1999466646","https://openalex.org/W2000797303","https://openalex.org/W2001704669","https://openalex.org/W2004926126","https://openalex.org/W2006021491","https://openalex.org/W2011258376","https://openalex.org/W2015522247","https://openalex.org/W2018024956","https://openalex.org/W2018414133","https://openalex.org/W2018477409","https://openalex.org/W2019843044","https://openalex.org/W2022532556","https://openalex.org/W2023149435","https://openalex.org/W2024776401","https://openalex.org/W2026970282","https://openalex.org/W2029897612","https://openalex.org/W2030602441","https://openalex.org/W2031102771","https://openalex.org/W2032098659","https://openalex.org/W2033603470","https://openalex.org/W2034491173","https://openalex.org/W2035352282","https://openalex.org/W2038013184","https://openalex.org/W2039103451","https://openalex.org/W2040732053","https://openalex.org/W2041863676","https://openalex.org/W2042255467","https://openalex.org/W2044034001","https://openalex.org/W2047631658","https://openalex.org/W2048740905","https://openalex.org/W2052578894","https://openalex.org/W2055149392","https://openalex.org/W2055453151","https://openalex.org/W2056313099","https://openalex.org/W2056400639","https://openalex.org/W2057840062","https://openalex.org/W2059809766","https://openalex.org/W2061071032","https://openalex.org/W2065174137","https://openalex.org/W2066898830","https://openalex.org/W2067725853","https://openalex.org/W2070522079","https://openalex.org/W2073375325","https://openalex.org/W2073724760","https://openalex.org/W2073935838","https://openalex.org/W2075043084","https://openalex.org/W2077662314","https://openalex.org/W2081533023","https://openalex.org/W2081768153","https://openalex.org/W2082042615","https://openalex.org/W2082429191","https://openalex.org/W2083752135","https://openalex.org/W2085435800","https://openalex.org/W2091721738","https://openalex.org/W2091829752","https://openalex.org/W2093374391","https://openalex.org/W2096410114","https://openalex.org/W2097391583","https://openalex.org/W2103126447","https://openalex.org/W2105704879","https://openalex.org/W2109366922","https://openalex.org/W2110888808","https://openalex.org/W2111040212","https://openalex.org/W2111200377","https://openalex.org/W2111842613","https://openalex.org/W2113861816","https://openalex.org/W2118346831","https://openalex.org/W2121448546","https://openalex.org/W2122522567","https://openalex.org/W2128960139","https://openalex.org/W2130562676","https://openalex.org/W2132590272","https://openalex.org/W2133966135","https://openalex.org/W2134529514","https://openalex.org/W2134538979","https://openalex.org/W2137176838","https://openalex.org/W2138784057","https://openalex.org/W2139502834","https://openalex.org/W2140957390","https://openalex.org/W2141650485","https://openalex.org/W2142796354","https://openalex.org/W2144178897","https://openalex.org/W2145328569","https://openalex.org/W2149117501","https://openalex.org/W2150617090","https://openalex.org/W2150926635","https://openalex.org/W2151278240","https://openalex.org/W2151714165","https://openalex.org/W2154874779","https://openalex.org/W2156326104","https://openalex.org/W2157183944","https://openalex.org/W2157860584","https://openalex.org/W2161483044","https://openalex.org/W2164856255","https://openalex.org/W2165065340","https://openalex.org/W2219832559","https://openalex.org/W2291435159","https://openalex.org/W2318541701","https://openalex.org/W2326436529","https://openalex.org/W2336783249","https://openalex.org/W2413954632","https://openalex.org/W2543721277","https://openalex.org/W2563682884","https://openalex.org/W2581545215","https://openalex.org/W2593689031","https://openalex.org/W2602707905","https://openalex.org/W4231985646"],"related_works":["https://openalex.org/W3193514517","https://openalex.org/W2004641424","https://openalex.org/W2042025152","https://openalex.org/W2336783249","https://openalex.org/W2068797515","https://openalex.org/W2091721738","https://openalex.org/W2123477840","https://openalex.org/W2004926126","https://openalex.org/W2056973257","https://openalex.org/W2543721277"],"abstract_inverted_index":{"Dysfunction":[0],"of":[1,24,42,71,92,101,121,130,146,160,194],"nerve":[2],"growth":[3],"factor":[4],"(NGF)":[5],"and":[6,62,107,171,191],"its":[7],"high-affinity":[8],"Tropomyosin":[9],"receptor":[10,14,83],"kinase":[11],"A":[12],"(TrkA)":[13],"has":[15],"been":[16],"suggested":[17],"to":[18,20,46,85,139,152,156,179],"contribute":[19],"the":[21,32,52,56,69,79,98,105,122,128,140,144,157,161,195,200],"selective":[22],"degeneration":[23],"basal":[25],"forebrain":[26],"cholinergic":[27,189],"neurons":[28],"(BFCN)":[29],"associated":[30],"with":[31],"progressive":[33],"cognitive":[34],"decline":[35],"in":[36,50,97,199],"Alzheimer's":[37],"disease":[38],"(AD).":[39],"The":[40],"aim":[41],"this":[43],"review":[44],"is":[45,75],"describe":[47],"our":[48],"progress":[49],"elucidating":[51],"molecular":[53],"mechanisms":[54],"underlying":[55],"dynamic":[57],"interplay":[58],"between":[59],"NGF/TrkA":[60,147,197],"signaling":[61,148],"amyloid":[63],"precursor":[64],"protein":[65],"(APP)":[66],"metabolism":[67,129],"within":[68],"context":[70],"AD":[72,154,184],"neuropathology.":[73],"This":[74],"mainly":[76],"based":[77],"on":[78,88],"finding":[80],"that":[81,103],"TrkA":[82,141],"binding":[84,138],"APP":[86,102,131],"depends":[87],"a":[89],"minimal":[90],"stretch":[91],"~20":[93],"amino":[94],"acids":[95],"located":[96],"juxtamembrane/extracellular":[99],"domain":[100],"carries":[104],"\u03b1-":[106],"\u03b2-secretase":[108],"cleavage":[109],"sites.":[110],"Here,":[111],"we":[112],"provide":[113],"evidence":[114],"that:":[115],"(i)":[116],"NGF":[117],"could":[118,149],"be":[119,150],"one":[120],"\"routing\"":[123],"proteins":[124],"responsible":[125],"for":[126,183],"modulating":[127],"from":[132],"amyloidogenic":[133],"towards":[134],"non-amyloidogenic":[135],"processing":[136],"via":[137],"receptor;":[142],"(ii)":[143],"loss":[145],"linked":[151],"sporadic":[153],"contributing":[155],"classical":[158],"hallmarks":[159],"neuropathology,":[162],"such":[163],"as":[164],"synaptic":[165],"loss,":[166],"\u03b2-amyloid":[167],"peptide":[168],"(A\u03b2)":[169],"deposition":[170],"tau":[172],"abnormalities.":[173],"These":[174],"findings":[175],"will":[176],"hopefully":[177],"help":[178],"design":[180],"therapeutic":[181],"strategies":[182],"treatment":[185],"aimed":[186],"at":[187],"preserving":[188],"function":[190],"anti-amyloidogenic":[192],"activity":[193],"physiological":[196],"pathway":[198],"septo-hippocampal":[201],"system.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-06-30T00:00:00"}
