{"id":"https://openalex.org/W26268271","doi":null,"title":"Double Bence Jones proteinuria.","display_name":"Double Bence Jones proteinuria.","publication_year":1990,"publication_date":"1990-09-01","ids":{"openalex":"https://openalex.org/W26268271","mag":"26268271","pmid":"https://pubmed.ncbi.nlm.nih.gov/2117911"},"language":"en","primary_location":{"id":"pmid:2117911","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2117911","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of pathology & laboratory medicine","raw_type":"Case Reports"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078510038","display_name":"Tadashi KANOH","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Kanoh","raw_affiliation_strings":["Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"last","author":{"id":null,"display_name":"K Yago","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Yago","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.00352306,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"114","issue":"9","first_page":"991","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9829999804496765},{"id":"https://openalex.org/keywords/bence-jones-protein","display_name":"Bence Jones protein","score":0.7250000238418579},{"id":"https://openalex.org/keywords/kappa-light-chain","display_name":"kappa light chain","score":0.7839999794960022},{"id":"https://openalex.org/keywords/lambda-light-chain","display_name":"lambda light chain","score":1.0},{"id":"https://openalex.org/keywords/monoclonal-light-chains","display_name":"monoclonal immunoglobulin light chains","score":0.7919999957084656},{"id":"https://openalex.org/keywords/russell-bodies","display_name":"Russell bodies","score":0.8569999933242798},{"id":"https://openalex.org/keywords/immunofixation","display_name":"immunofixation","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C52697466","wikidata":"https://www.wikidata.org/wiki/Q424176","display_name":"Bence Jones protein","level":4,"score":0.9733095169067383},{"id":"https://openalex.org/C2778724333","wikidata":"https://www.wikidata.org/wiki/Q14401","display_name":"Kappa","level":2,"score":0.6518683433532715},{"id":"https://openalex.org/C2778808339","wikidata":"https://www.wikidata.org/wiki/Q2785444","display_name":"Immunofixation","level":5,"score":0.5955045223236084},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.5862422585487366},{"id":"https://openalex.org/C36394416","wikidata":"https://www.wikidata.org/wiki/Q949267","display_name":"Immunoglobulin light chain","level":3,"score":0.5791858434677124},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.5425240993499756},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4471040368080139},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.43876075744628906},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32224202156066895},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.3174932301044464},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.26175975799560547},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.1690521538257599},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.1536073386669159},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.13842904567718506},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13445675373077393},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.06985822319984436},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001536","descriptor_name":"Bence Jones Protein","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001536","descriptor_name":"Bence Jones Protein","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004587","descriptor_name":"Electrophoresis, Agar Gel","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004588","descriptor_name":"Electrophoresis, Cellulose Acetate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007145","descriptor_name":"Immunoglobulin kappa-Chains","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007146","descriptor_name":"Immunoglobulin lambda-Chains","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007147","descriptor_name":"Immunoglobulin Light Chains","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011507","descriptor_name":"Proteinuria","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011507","descriptor_name":"Proteinuria","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011507","descriptor_name":"Proteinuria","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2117911","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2117911","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of pathology & laboratory medicine","raw_type":"Case Reports"},{"id":"mag:26268271","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2117911","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1987043226","https://openalex.org/W2143283175","https://openalex.org/W1970294505","https://openalex.org/W2144620252","https://openalex.org/W1517426034","https://openalex.org/W2057729145","https://openalex.org/W2000298239","https://openalex.org/W2088443563","https://openalex.org/W2056278989","https://openalex.org/W2116839388","https://openalex.org/W2169564731","https://openalex.org/W2109461542","https://openalex.org/W2055547152","https://openalex.org/W2063559126","https://openalex.org/W2005196996","https://openalex.org/W2071112818","https://openalex.org/W2303841070","https://openalex.org/W2160011388"],"related_works":["https://openalex.org/W1927525851","https://openalex.org/W1922305439","https://openalex.org/W2045194725","https://openalex.org/W2038665059","https://openalex.org/W1958736899","https://openalex.org/W2326648271","https://openalex.org/W2116310055","https://openalex.org/W2411169406","https://openalex.org/W2593855546","https://openalex.org/W2399648896"],"abstract_inverted_index":{"We":[0],"have":[1],"recently":[2],"observed":[3],"an":[4],"unusual":[5],"case":[6],"of":[7,21,35,47,68,76,106,109,127],"multiple":[8],"myeloma":[9,36],"with":[10,53,61],"double":[11,31,42,94,110],"Bence":[12,73,95,111],"Jones":[13,74,96,112],"proteinuria.":[14,97],"Immunofixation":[15],"clearly":[16],"demonstrated":[17],"monoclonal":[18],"light":[19],"chains":[20],"both":[22,77],"kappa":[23,78],"and":[24,79],"lambda":[25,80],"type":[26],"in":[27,86,93,101],"the":[28,56,87,104],"urine.":[29],"By":[30],"immunofluorescence":[32],"staining,":[33],"11%":[34],"cells":[37,67],"were":[38],"found":[39,85],"to":[40,89,103,122],"be":[41],"producers.":[43],"The":[44],"marginal":[45],"portion":[46],"cytoplasmic":[48],"Russell":[49],"bodies":[50],"was":[51,58],"stained":[52,60],"anti-lambda,":[54],"while":[55],"core":[57],"diffusely":[59],"anti-kappa.":[62],"Our":[63],"results":[64],"indicated":[65],"that":[66],"common":[69],"clonal":[70],"origin":[71],"produced":[72],"proteins":[75],"type.":[81],"No":[82],"reference":[83],"is":[84],"literature":[88],"such":[90],"a":[91,124],"finding":[92],"In":[98],"this":[99,117,128],"article,":[100],"addition":[102],"summary":[105],"nine":[107],"cases":[108],"proteinuria,":[113],"possible":[114],"explanations":[115],"for":[116],"rare":[118],"phenomenon":[119],"are":[120],"described":[121],"give":[123],"better":[125],"understanding":[126],"entity.":[129]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}