{"id":"https://openalex.org/W2626054840","doi":"https://doi.org/10.1182/blood.v128.22.2789.2789","title":"Pattern of Central Nervous System (CNS) Involvement in Adult Acute Myeloid Leukemia (AML) and Its Impact on Outcome","display_name":"Pattern of Central Nervous System (CNS) Involvement in Adult Acute Myeloid Leukemia (AML) and Its Impact on Outcome","publication_year":2016,"publication_date":"2016-12-02","ids":{"openalex":"https://openalex.org/W2626054840","doi":"https://doi.org/10.1182/blood.v128.22.2789.2789","mag":"2626054840"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v128.22.2789.2789","doi":"https://doi.org/10.1182/blood.v128.22.2789.2789","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v128.22.2789.2789","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046702889","display_name":"Maria Ilaria Del Principe","orcid":"https://orcid.org/0000-0002-3958-0669","observed_orcids":["https://orcid.org/0000-0002-3958-0669"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Ilaria Del Principe","raw_affiliation_strings":["Hematology, University Tor Vergata of Rome, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, University Tor Vergata of Rome, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001967659","display_name":"Francesco Buccisano","orcid":"https://orcid.org/0000-0003-4320-9253","observed_orcids":["https://orcid.org/0000-0003-4320-9253"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Buccisano","raw_affiliation_strings":["Department of Hematology, University Tor Vergata, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, University Tor Vergata, Roma, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103011236","display_name":"Stefano Soddu","orcid":"https://orcid.org/0000-0002-1942-1230","observed_orcids":["https://orcid.org/0000-0002-1942-1230"]},"institutions":[{"id":"https://openalex.org/I4210112021","display_name":"Fondazione Gimema Onlus","ror":"https://ror.org/01b3n9g22","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210112021"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefano Soddu","raw_affiliation_strings":["GIMEMA Data Center, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GIMEMA Data Center, Roma, Italy","institution_ids":["https://openalex.org/I4210112021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029157287","display_name":"Luca Maurillo","orcid":"https://orcid.org/0000-0001-7297-4988","observed_orcids":["https://orcid.org/0000-0001-7297-4988"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Maurillo","raw_affiliation_strings":["Hematology, University Tor Vergata of Rome, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, University Tor Vergata of Rome, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083888788","display_name":"Mariagiovanna Cefalo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mariagiovanna Cefalo","raw_affiliation_strings":["Department of Hematology, University Tor Vergata, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, University Tor Vergata, Roma, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041966654","display_name":"Alfonso Piciocchi","orcid":"https://orcid.org/0000-0001-8648-885X","observed_orcids":["https://orcid.org/0000-0001-8648-885X"]},"institutions":[{"id":"https://openalex.org/I4210112021","display_name":"Fondazione Gimema Onlus","ror":"https://ror.org/01b3n9g22","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210112021"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alfonso Piciocchi","raw_affiliation_strings":["GIMEMA Data Center, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GIMEMA Data Center, Roma, Italy","institution_ids":["https://openalex.org/I4210112021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007507940","display_name":"Giovangiacinto Paterno","orcid":"https://orcid.org/0000-0002-8944-0795","observed_orcids":["https://orcid.org/0000-0002-8944-0795"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovangiacinto Paterno","raw_affiliation_strings":["University Tor Vergata, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006168476","display_name":"Chiara Sarlo","orcid":"https://orcid.org/0000-0001-7473-0717","observed_orcids":["https://orcid.org/0000-0001-7473-0717"]},"institutions":[{"id":"https://openalex.org/I155125353","display_name":"Universit\u00e0 Campus Bio-Medico","ror":"https://ror.org/04gqx4x78","country_code":"IT","type":"education","lineage":["https://openalex.org/I155125353"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Sarlo","raw_affiliation_strings":["Campus Bio Medico University, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Campus Bio Medico University, Roma, Italy","institution_ids":["https://openalex.org/I155125353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105779350","display_name":"Gottardo De Angelis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gottardo De Angelis","raw_affiliation_strings":["University Tor Vergata, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024765117","display_name":"Vittorio Forte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vittorio Forte","raw_affiliation_strings":["Department of Hematology, University Tor Vergata, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, University Tor Vergata, Roma, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011150147","display_name":"Maria Irno Consalvo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Irno Consalvo","raw_affiliation_strings":["Department of Hematology, University Tor Vergata, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, University Tor Vergata, Roma, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004949893","display_name":"Daniela Fraboni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniela Fraboni","raw_affiliation_strings":["University Tor Vergata Of Rome, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Tor Vergata Of Rome, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069419496","display_name":"Eleonora De Bellis","orcid":"https://orcid.org/0000-0002-2536-6397","observed_orcids":["https://orcid.org/0000-0002-2536-6397"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Eleonora De Bellis","raw_affiliation_strings":["University Tor Vergata, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113975452","display_name":"Annagiulia Zizzari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Annagiulia Zizzari","raw_affiliation_strings":["University Tor Vergata of Rome, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Tor Vergata of Rome, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054876863","display_name":"Mariadomenica Divona","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mariadomenica Divona","raw_affiliation_strings":["Hematology, University Tor Vergata, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, University Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061253161","display_name":"Giuseppe Sconocchia","orcid":"https://orcid.org/0000-0003-3260-4856","observed_orcids":["https://orcid.org/0000-0003-3260-4856"]},"institutions":[{"id":"https://openalex.org/I4210133672","display_name":"Istituto di Farmacologia Traslazionale","ror":"https://ror.org/03ta8pf33","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210133672","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Sconocchia","raw_affiliation_strings":["Institute of Translational Pharmacology, C.N.R, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Translational Pharmacology, C.N.R, Rome, Italy","institution_ids":["https://openalex.org/I4210133672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063825892","display_name":"Maria Teresa Voso","orcid":"https://orcid.org/0000-0002-6164-4761","observed_orcids":["https://orcid.org/0000-0002-6164-4761"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Teresa Voso","raw_affiliation_strings":["University Tor Vergata, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025869007","display_name":"Giovanni Del Poeta","orcid":"https://orcid.org/0000-0003-2443-1422","observed_orcids":["https://orcid.org/0000-0003-2443-1422"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Del Poeta","raw_affiliation_strings":["University Tor Vergata, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063111161","display_name":"Francesco Lo\u2010Coco","orcid":"https://orcid.org/0000-0002-9499-8005","observed_orcids":["https://orcid.org/0000-0002-9499-8005"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Lo Coco","raw_affiliation_strings":["University Tor Vergata, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080855457","display_name":"Sergio Amadori","orcid":"https://orcid.org/0000-0002-2356-8681","observed_orcids":["https://orcid.org/0000-0002-2356-8681"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sergio Amadori","raw_affiliation_strings":["University Tor Vergata, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047010545","display_name":"William Arcese","orcid":"https://orcid.org/0000-0001-5697-366X","observed_orcids":["https://orcid.org/0000-0001-5697-366X"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"William Arcese","raw_affiliation_strings":["University Tor Vergata, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Tor Vergata, Roma, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114377374","display_name":"Adriano Venditti","orcid":"https://orcid.org/0000-0002-0245-0553","observed_orcids":["https://orcid.org/0000-0002-0245-0553"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Adriano Venditti","raw_affiliation_strings":["University Tor Vergata, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Tor Vergata, Roma, Italy","institution_ids":["https://openalex.org/I116067653"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"128","issue":"22","first_page":"2789","last_page":"2789"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9679999947547913},{"id":"https://openalex.org/keywords/central-nervous-system-involvement","display_name":"central nervous system involvement","score":0.9779999852180481},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.8399999737739563},{"id":"https://openalex.org/keywords/flow-cytometry","display_name":"flow cytometry","score":0.8349999785423279},{"id":"https://openalex.org/keywords/conventional-cytology","display_name":"conventional cytology","score":0.8799999952316284},{"id":"https://openalex.org/keywords/diagnostic-lumbar-puncture","display_name":"diagnostic lumbar puncture","score":0.6909999847412109},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.4059999883174896},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7850000262260437},{"id":"https://openalex.org/keywords/cytarabine","display_name":"cytarabine","score":0.42899999022483826},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.3840000033378601},{"id":"https://openalex.org/keywords/prognostic-score","display_name":"prognostic score","score":0.4569999873638153},{"id":"https://openalex.org/keywords/adult-patients","display_name":"adult patients","score":0.34599998593330383},{"id":"https://openalex.org/keywords/treatment-outcomes","display_name":"treatment outcomes","score":0.367000013589859},{"id":"https://openalex.org/keywords/prognostic-value","display_name":"prognostic value","score":0.5540000200271606}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.812084436416626},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.554902970790863},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.5341851711273193},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5251840353012085},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.5120602250099182},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5110505819320679},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.444327175617218},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.43649348616600037},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.42470741271972656},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37555307149887085},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v128.22.2789.2789","doi":"https://doi.org/10.1182/blood.v128.22.2789.2789","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v128.22.2789.2789","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2793678400","https://openalex.org/W4405038550","https://openalex.org/W4405046124","https://openalex.org/W4283332849","https://openalex.org/W4391278537","https://openalex.org/W2984149164","https://openalex.org/W4401875776","https://openalex.org/W2598230510","https://openalex.org/W3213742663","https://openalex.org/W31058042"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Routine":[2],"diagnostic":[3],"lumbar":[4],"puncture":[5],"is":[6,25,50,79,532],"not":[7,381,399],"recommended":[8],"in":[9,38,61,77,99,190,300,353,422,429,453,467,527],"adult":[10],"patients":[11,148,154,224,316,320,357,406,427],"with":[12,111,200,337,394,493],"acute":[13],"myeloid":[14],"leukemia":[15],"(AML)":[16],"without":[17],"Central":[18],"Nervous":[19],"System":[20],"(CNS)":[21],"symptoms":[22],"and":[23,33,82,136,146,157,246,250,266,284,327,363,374,386,404,414,437,444,490,541,556,575,584],"little":[24],"known":[26],"about":[27],"the":[28,65,71,93,117,237,368,508],"incidence":[29,94,523],"of":[30,58,67,73,86,95,103,119,165,187,207,219,306,331,340,370,497,524,537],"CNS":[31,59,97,109,120,226,233,341,483,525,543,579,588],"involvement":[32,60,121,526],"its":[34],"impact":[35,118],"on":[36,122,243,254,563,578,587],"survival":[37],"these":[39,332],"patients.":[40,388],"Furthermore,":[41],"several":[42],"studies":[43,562],"have":[44],"demonstrated":[45],"that":[46,522],"flow":[47],"cytometry":[48],"(FCM)":[49],"superior":[51],"to":[52,91,107,115,329,367,418,471,473,487,506,568],"conventional":[53],"cytology":[54],"(CC)":[55],"for":[56,70],"detection":[57],"lymphoproliferative":[62],"disorders":[63],"but":[64],"role":[66],"this":[68,570],"approach":[69],"investigation":[72],"cerebrospinal":[74],"fluid":[75],"(CSF)":[76],"AML":[78,104,132,326,530],"unknown.":[80],"Design":[81],"Methods":[83],"The":[84,446],"aims":[85],"our":[87],"study":[88],"were":[89,126,169,225,232,241,298,310,351,416,465],"1)":[90],"determine":[92,472],"occult/manifest":[96],"disease":[98,110],"a":[100,217,338,450,468,494],"homogenous":[101],"series":[102,565],"patients;":[105],"2)":[106],"correlate":[108],"clinico-biologic":[112],"parameters;":[113],"3)":[114],"examine":[116],"outcome.":[123,479],"CSF":[124,167,191],"samples":[125,168],"collected":[127],"from":[128],"98":[129,166],"newly":[130,528],"diagnosed":[131,529],"patients,":[133,268],"62":[134],"males":[135],"36":[137],"females,":[138],"median":[139,272],"age":[140,273,458],"53":[141],"years":[142,503],"(range":[143],"18-75).":[144],"Sixty-five":[145],"33":[147,359],"aged":[149],"<60":[150],"and>60":[151],"years,":[152,275,280],"respectively.Seventy-one":[153],"received":[155],"standard":[156],"22":[158],"high-dose-ARA-C-based":[159],"regimens,":[160],"5":[161],"supportive":[162],"care.":[163],"All":[164],"examined":[170],"by":[171,177],"CC":[172,179,245],"whereas":[173],"90":[174],"(91%)":[175],"also":[176],"FCM.":[178],"positivity":[180,342,484,544],"was":[181,214,259,334,392,485,504],"defined":[182],"as":[183,216,269,271],"unequivocal":[184],"morphologic":[185],"evidence":[186],"leukemic":[188],"blast":[189],"and/or":[192],"white":[193],"blood":[194],"cells":[195],"count":[196],"(WBCc)":[197],"\u2265":[198],"5/\u00b5l":[199],"less":[201],"than":[202,314,428,534],"10":[203,210,239],"erythrocytes/\u00b5l.":[204],"A":[205],"cluster":[206],"at":[208,549],"least":[209],"phenotypically":[211],"abnormal":[212],"events":[213],"regarded":[215],"proof":[218],"FCM":[220,247,255],"positivity.":[221],"Results":[222],"Sixty-seven":[223],"negative":[227],"(CNS-)":[228],"while":[229],"thirty-one":[230],"(31%)":[231],"positive":[234,242],"(CNS+).":[235],"Among":[236],"last,":[238],"(10%)":[240],"both":[244,301],"(manifest":[248],"CNS+)":[249],"21":[251],"(21%)":[252],"only":[253,509],"(occult":[256],"CNS+).":[257],"There":[258],"an":[260],"equal":[261],"male/female":[262],"distribution":[263],"among":[264,312],"CNS-":[265,315,387,405,431],"CNS+":[267,313,385,403,426],"well":[270],"(52":[274],"range,":[276,281,287,293],"20-71,":[277],"vs":[278,344,408,433,439,462],"56":[279],"18-75,":[282],"p=NS)":[283],"WBCc(27.5":[285],"x109/L,":[286,289,292,295],"1,20-223":[288],"vs.":[290],"11,6":[291],"0,70-315":[294],"p=":[296,410,435],"NS)":[297],"similar":[299],"groups.":[302],"Instead,":[303],"higher":[304,533],"levels":[305],"lactate":[307],"dehydrogenase":[308],"(LDH)":[309],"observed":[311],"(p=.":[317],"01).":[318],"Forty-seven":[319],"(48%)":[321],"had":[322],"monoblastic/monocytic":[323],"or":[324,424],"myelomonocytic":[325],"belonging":[328],"one":[330],"categories":[333],"significantly":[335,383,420,491],"associated":[336,492],"condition":[339],"(55%":[343],"45%,":[345],"P":[346],"=":[347],"002).":[348],"Cytogenetic/genetic":[349,378],"data":[350,520],"available":[352],"82/98":[354],"(84%).":[355],"Twenty-for":[356],"(29%),":[358],"(39%),":[360],"12":[361,364],"(14%)":[362],"(14%),":[365],"belonged":[366],"category":[369],"favorable,":[371],"intermediate-I,":[372],"intermediate-II,":[373],"adverse":[375,463],"karyotype,":[376],"respectively.":[377],"characteristics":[379],"did":[380],"differed":[382],"between":[384,402],"Overall,":[389],"response":[390],"rate":[391,397],"70%,":[393],"complete":[395],"remission":[396],"being":[398],"statistically":[400],"different":[401],"(69%":[407],"81%":[409],"NS).":[411],"Five-year":[412],"DFS":[413,574,583],"OS":[415,514,576,585],"found":[417,486,505],"be":[419,488,507,547],"shorter":[421,495],"occult":[423,542],"manifest":[425,540],"those":[430],"(23%":[432],"50%":[434],".03":[436],"19%":[438],"46%,":[440],"p=.02,":[441],"respectively)(Figure":[442],"1A":[443],"1B).":[445],"prognostic":[447,511],"variables":[448],"achieving":[449],"statistical":[451],"significance":[452],"univariate":[454],"analysis":[455],"(CNS":[456],"status,":[457],",":[459],"WBCc,":[460],"favorable":[461],"karyotype)":[464],"challenged":[466],"multivariate":[469,481],"model":[470],"what":[474],"extent":[475],"they":[476],"affected":[477],"treatment":[478],"In":[480],"analysis,":[482],"independently":[489],"duration":[496],"DFS.(p=.03":[498],"HR=":[499,516],"0.46).":[500],"Age":[501],">50":[502],"independent":[510],"factor":[512],"affecting":[513],"(p=.01":[515],"2.26).":[517],"Conclusion":[518],"Our":[519],"suggest":[521],"pts":[531],"expected.":[535],"Regardless":[536],"neurologic":[538],"symptoms,":[539],"should":[545],"always":[546],"sought":[548],"diagnosis":[550],"since":[551],"it":[552],"may":[553],"affect":[554],"outcome":[555],"influence":[557],"therapeutic":[558],"decision.":[559],"Further":[560],"prospective":[561],"larger":[564],"are":[566],"warranted":[567],"confirm":[569],"data.":[571],"Figure":[572,581],"1":[573],"based":[577,586],"status":[580,589],"1.":[582],"Disclosures":[590],"Lo":[591],"Coco:":[592],"Teva:":[593],"Consultancy,":[594],"Honoraria,":[595,599],"Speakers":[596,600],"Bureau;":[597,601],"Lundbeck:":[598],"Novartis:":[602],"Consultancy;":[603,605],"Baxalta:":[604],"Pfizer:":[606],"Consultancy.":[607]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2017-06-23T00:00:00"}
