{"id":"https://openalex.org/W2625845277","doi":"https://doi.org/10.1002/sctm.16-0472","title":"Expansion of Umbilical Cord Blood Aldehyde Dehydrogenase Expressing Cells Generates Myeloid Progenitor Cells that Stimulate Limb Revascularization","display_name":"Expansion of Umbilical Cord Blood Aldehyde Dehydrogenase Expressing Cells Generates Myeloid Progenitor Cells that Stimulate Limb Revascularization","publication_year":2017,"publication_date":"2017-06-15","ids":{"openalex":"https://openalex.org/W2625845277","doi":"https://doi.org/10.1002/sctm.16-0472","mag":"2625845277","pmid":"https://pubmed.ncbi.nlm.nih.gov/28618138","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5689765"},"language":"en","primary_location":{"id":"doi:10.1002/sctm.16-0472","doi":"https://doi.org/10.1002/sctm.16-0472","is_oa":true,"landing_page_url":"https://doi.org/10.1002/sctm.16-0472","pdf_url":"https://academic.oup.com/stcltm/article-pdf/6/7/1607/42631527/stcltm_6_7_1607.pdf","source":{"id":"https://openalex.org/S2494728167","display_name":"Stem Cells Translational Medicine","issn_l":"2157-6564","issn":["2157-6564","2157-6580"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells Translational Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/stcltm/article-pdf/6/7/1607/42631527/stcltm_6_7_1607.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055020538","display_name":"David M. Putman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]},{"id":"https://openalex.org/I4405252475","display_name":"Robarts Research Institute","ror":"https://ror.org/01psf3m26","country_code":"CA","type":"facility","lineage":["https://openalex.org/I125749732","https://openalex.org/I4405252475"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"David M. Putman","raw_affiliation_strings":["a Molecular Medicine Research Laboratories, Krembil Centre for Stem Cell Biology, Robarts Research Institute, London, Ontario, Canada","b Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Molecular Medicine Research Laboratories, Krembil Centre for Stem Cell Biology, Robarts Research Institute, London, Ontario, Canada","institution_ids":["https://openalex.org/I4405252475"]},{"raw_affiliation_string":"b Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026992379","display_name":"Tyler T. Cooper","orcid":"https://orcid.org/0000-0003-4662-8816","observed_orcids":["https://orcid.org/0000-0003-4662-8816"]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]},{"id":"https://openalex.org/I4405252475","display_name":"Robarts Research Institute","ror":"https://ror.org/01psf3m26","country_code":"CA","type":"facility","lineage":["https://openalex.org/I125749732","https://openalex.org/I4405252475"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Tyler T. Cooper","raw_affiliation_strings":["a Molecular Medicine Research Laboratories, Krembil Centre for Stem Cell Biology, Robarts Research Institute, London, Ontario, Canada","b Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Molecular Medicine Research Laboratories, Krembil Centre for Stem Cell Biology, Robarts Research Institute, London, Ontario, Canada","institution_ids":["https://openalex.org/I4405252475"]},{"raw_affiliation_string":"b Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058217791","display_name":"Stephen E. Sherman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]},{"id":"https://openalex.org/I4405252475","display_name":"Robarts Research Institute","ror":"https://ror.org/01psf3m26","country_code":"CA","type":"facility","lineage":["https://openalex.org/I125749732","https://openalex.org/I4405252475"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Stephen E. Sherman","raw_affiliation_strings":["a Molecular Medicine Research Laboratories, Krembil Centre for Stem Cell Biology, Robarts Research Institute, London, Ontario, Canada","b Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Molecular Medicine Research Laboratories, Krembil Centre for Stem Cell Biology, Robarts Research Institute, London, Ontario, Canada","institution_ids":["https://openalex.org/I4405252475"]},{"raw_affiliation_string":"b Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027868479","display_name":"Ayesh K. Seneviratne","orcid":"https://orcid.org/0000-0003-1204-1224","observed_orcids":["https://orcid.org/0000-0003-1204-1224"]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]},{"id":"https://openalex.org/I4405252475","display_name":"Robarts Research Institute","ror":"https://ror.org/01psf3m26","country_code":"CA","type":"facility","lineage":["https://openalex.org/I125749732","https://openalex.org/I4405252475"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ayesh K. Seneviratne","raw_affiliation_strings":["a Molecular Medicine Research Laboratories, Krembil Centre for Stem Cell Biology, Robarts Research Institute, London, Ontario, Canada","b Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Molecular Medicine Research Laboratories, Krembil Centre for Stem Cell Biology, Robarts Research Institute, London, Ontario, Canada","institution_ids":["https://openalex.org/I4405252475"]},{"raw_affiliation_string":"b Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041307697","display_name":"Mark Keith Hewitt","orcid":"https://orcid.org/0000-0002-8258-995X","observed_orcids":["https://orcid.org/0000-0002-8258-995X"]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mark Hewitt","raw_affiliation_strings":["b Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"b Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050016828","display_name":"Gillian I. Bell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405252475","display_name":"Robarts Research Institute","ror":"https://ror.org/01psf3m26","country_code":"CA","type":"facility","lineage":["https://openalex.org/I125749732","https://openalex.org/I4405252475"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gillian I. Bell","raw_affiliation_strings":["a Molecular Medicine Research Laboratories, Krembil Centre for Stem Cell Biology, Robarts Research Institute, London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Molecular Medicine Research Laboratories, Krembil Centre for Stem Cell Biology, Robarts Research Institute, London, Ontario, Canada","institution_ids":["https://openalex.org/I4405252475"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064145593","display_name":"David A. Hess","orcid":"https://orcid.org/0000-0003-2186-3166","observed_orcids":["https://orcid.org/0000-0003-2186-3166"]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]},{"id":"https://openalex.org/I4405252475","display_name":"Robarts Research Institute","ror":"https://ror.org/01psf3m26","country_code":"CA","type":"facility","lineage":["https://openalex.org/I125749732","https://openalex.org/I4405252475"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"David A. Hess","raw_affiliation_strings":["a Molecular Medicine Research Laboratories, Krembil Centre for Stem Cell Biology, Robarts Research Institute, London, Ontario, Canada","b Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Molecular Medicine Research Laboratories, Krembil Centre for Stem Cell Biology, Robarts Research Institute, London, Ontario, Canada","institution_ids":["https://openalex.org/I4405252475"]},{"raw_affiliation_string":"b Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada","institution_ids":["https://openalex.org/I125749732"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5064145593"],"corresponding_institution_ids":["https://openalex.org/I125749732","https://openalex.org/I4405252475"],"apc_list":{"value":2963,"currency":"USD","value_usd":2963},"apc_paid":{"value":2963,"currency":"USD","value_usd":2963},"fwci":0.8763,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.68812102,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"6","issue":"7","first_page":"1607","last_page":"1619"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.5845000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.5845000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.37959998846054077,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.013100000098347664,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/umbilical-cord-blood","display_name":"umbilical cord blood","score":0.9869999885559082},{"id":"https://openalex.org/keywords/aldehyde-dehydrogenase","display_name":"aldehyde dehydrogenase","score":0.9869999885559082},{"id":"https://openalex.org/keywords/ex-vivo-expansion","display_name":"ex vivo expansion","score":0.8119999766349792},{"id":"https://openalex.org/keywords/myeloid-progenitor-cells","display_name":"myeloid progenitor cells","score":0.9020000100135803},{"id":"https://openalex.org/keywords/critical-limb-ischemia","display_name":"critical limb ischemia","score":0.8069999814033508},{"id":"https://openalex.org/keywords/peripheral-arterial-disease","display_name":"peripheral arterial disease","score":0.9139999747276306},{"id":"https://openalex.org/keywords/limb-revascularization","display_name":"limb revascularization","score":0.8930000066757202},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8519999980926514},{"id":"https://openalex.org/keywords/allogeneic-cell-therapy","display_name":"allogeneic cell therapy","score":0.7519999742507935},{"id":"https://openalex.org/keywords/hematopoietic-progenitor-cells","display_name":"hematopoietic progenitor cells","score":0.7630000114440918},{"id":"https://openalex.org/keywords/endothelial-cell-proliferation","display_name":"endothelial cell proliferation","score":0.7170000076293945},{"id":"https://openalex.org/keywords/capillary-density","display_name":"capillary density","score":0.6140000224113464},{"id":"https://openalex.org/keywords/microvascular-endothelial-cells","display_name":"microvascular endothelial cells","score":0.6669999957084656},{"id":"https://openalex.org/keywords/serum-free-culture","display_name":"serum-free culture","score":0.5339999794960022}],"concepts":[{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.7091993093490601},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.5654524564743042},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5654393434524536},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5211508274078369},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5010981559753418},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47659963369369507},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.45056384801864624},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4376784563064575},{"id":"https://openalex.org/C2776955114","wikidata":"https://www.wikidata.org/wiki/Q172563","display_name":"Umbilical cord","level":2,"score":0.42908382415771484},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.41710105538368225},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39980411529541016},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3825148642063141},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3823774456977844},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33080363273620605},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3128089904785156},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21988308429718018},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000444","descriptor_name":"Aldehyde Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000444","descriptor_name":"Aldehyde Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005121","descriptor_name":"Extremities","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D014470","descriptor_name":"Umbilical Cord","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014470","descriptor_name":"Umbilical Cord","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016688","descriptor_name":"Mice, Inbred NOD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017077","descriptor_name":"Culture Media, Conditioned","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023461","descriptor_name":"Myeloid Progenitor Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D023461","descriptor_name":"Myeloid Progenitor Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D023461","descriptor_name":"Myeloid Progenitor Cells","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D033581","descriptor_name":"Stem Cell Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1002/sctm.16-0472","doi":"https://doi.org/10.1002/sctm.16-0472","is_oa":true,"landing_page_url":"https://doi.org/10.1002/sctm.16-0472","pdf_url":"https://academic.oup.com/stcltm/article-pdf/6/7/1607/42631527/stcltm_6_7_1607.pdf","source":{"id":"https://openalex.org/S2494728167","display_name":"Stem Cells Translational Medicine","issn_l":"2157-6564","issn":["2157-6564","2157-6580"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells Translational Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4610250","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5689765","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:28618138","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28618138","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cells translational medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5689765","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5689765/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells Transl Med","raw_type":"Text"},{"id":"pmh:oai:ir.lib.uwo.ca:paedpub-2917","doi":null,"is_oa":false,"landing_page_url":"https://ir.lib.uwo.ca/paedpub/1909","pdf_url":null,"source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Paediatrics Publications","raw_type":"article"},{"id":"pmh:oai:uwo.scholaris.ca:20.500.14721/23319","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.1002/sctm.16-0472","pdf_url":null,"source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1002/sctm.16-0472","doi":"https://doi.org/10.1002/sctm.16-0472","is_oa":true,"landing_page_url":"https://doi.org/10.1002/sctm.16-0472","pdf_url":"https://academic.oup.com/stcltm/article-pdf/6/7/1607/42631527/stcltm_6_7_1607.pdf","source":{"id":"https://openalex.org/S2494728167","display_name":"Stem Cells Translational Medicine","issn_l":"2157-6564","issn":["2157-6564","2157-6580"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells Translational Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3272283556","display_name":null,"funder_award_id":"GIA-13-0001612","funder_id":"https://openalex.org/F4320307845","funder_display_name":"Heart and Stroke Foundation of Canada"}],"funders":[{"id":"https://openalex.org/F4320307845","display_name":"Heart and Stroke Foundation of Canada","ror":"https://ror.org/00qbpyp73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2625845277.pdf","grobid_xml":"https://content.openalex.org/works/W2625845277.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1502896205","https://openalex.org/W1631250427","https://openalex.org/W1647231487","https://openalex.org/W1973502066","https://openalex.org/W1976665683","https://openalex.org/W1979103623","https://openalex.org/W1985410550","https://openalex.org/W1985438884","https://openalex.org/W1986991023","https://openalex.org/W1992112921","https://openalex.org/W1992292208","https://openalex.org/W1994158540","https://openalex.org/W1994790910","https://openalex.org/W1995150248","https://openalex.org/W2001609725","https://openalex.org/W2012255417","https://openalex.org/W2014207848","https://openalex.org/W2031122447","https://openalex.org/W2033726327","https://openalex.org/W2035571272","https://openalex.org/W2035883624","https://openalex.org/W2040568539","https://openalex.org/W2042350316","https://openalex.org/W2046540377","https://openalex.org/W2053704719","https://openalex.org/W2054031422","https://openalex.org/W2063159095","https://openalex.org/W2068380542","https://openalex.org/W2080196370","https://openalex.org/W2084109090","https://openalex.org/W2090041902","https://openalex.org/W2090586658","https://openalex.org/W2095574203","https://openalex.org/W2097457623","https://openalex.org/W2109025917","https://openalex.org/W2110938570","https://openalex.org/W2111486034","https://openalex.org/W2112267683","https://openalex.org/W2115932678","https://openalex.org/W2120264291","https://openalex.org/W2125574670","https://openalex.org/W2125635123","https://openalex.org/W2130761693","https://openalex.org/W2132418620","https://openalex.org/W2137715553","https://openalex.org/W2143645289","https://openalex.org/W2151722542","https://openalex.org/W2151874885","https://openalex.org/W2162989910","https://openalex.org/W2163087495","https://openalex.org/W2169612578","https://openalex.org/W2201556161","https://openalex.org/W2288233919","https://openalex.org/W4297837082"],"related_works":["https://openalex.org/W2560544338","https://openalex.org/W1647231487","https://openalex.org/W2792532503","https://openalex.org/W28519262","https://openalex.org/W1599147544","https://openalex.org/W2014207848","https://openalex.org/W378776762","https://openalex.org/W2167370260","https://openalex.org/W2002801346","https://openalex.org/W2044104445"],"abstract_inverted_index":{"Abstract":[0],"Uncompromised":[1],"by":[2,51],"chronic":[3],"disease-related":[4],"comorbidities,":[5],"human":[6,211],"umbilical":[7],"cord":[8],"blood":[9,21],"(UCB)":[10],"progenitor":[11,106,242],"cells":[12,35,79,88,107,133,136,142,177,191,209,227,243],"with":[13,98,160,174,207],"high":[14,116],"aldehyde":[15],"dehydrogenase":[16],"activity":[17],"(ALDHhi":[18],"cells)":[19],"stimulate":[20],"vessel":[22,69],"regeneration":[23],"after":[24,118],"intra-muscular":[25],"transplantation.":[26],"However,":[27,120],"implementation":[28],"of":[29,44,55,76,82,113,131,146,151,239,247],"cellular":[30],"therapies":[31],"using":[32],"UCB":[33,77,86,124],"ALDHhi":[34,78,87,132,176,226],"for":[36,68,244],"critical":[37],"limb":[38,155,164],"ischemia,":[39],"the":[40,52,99,128,245],"most":[41],"severe":[42,45],"form":[43],"peripheral":[46],"artery":[47,162],"disease,":[48],"is":[49,103],"limited":[50],"rarity":[53],"(<0.5%)":[54],"these":[56],"cells.":[57],"Our":[58],"goal":[59],"was":[60],"to":[61,122,188,231],"generate":[62],"a":[63],"clinically-translatable,":[64],"allogeneic":[65],"cell":[66,181,214],"population":[67],"regenerative":[70],"therapies,":[71],"via":[72],"ex":[73],"vivo":[74],"expansion":[75,126],"without":[80],"loss":[81],"pro-angiogenic":[83,193,240],"potency.":[84],"Purified":[85],"were":[89],"expanded":[90,147,175,208],">18-fold":[91],"over":[92],"6-days":[93],"under":[94,219],"serum-free":[95],"conditions.":[96,223],"Consistent":[97],"concept":[100],"that":[101],"ALDH-activity":[102,117],"decreased":[104],"as":[105,235],"differentiate,":[108],"only":[109],"15.1%":[110],"\u00b1":[111],"1.3%":[112],"progeny":[114,148],"maintained":[115,192],"culture.":[119],"compared":[121,187],"fresh":[123],"cells,":[125],"increased":[127,184],"total":[129],"number":[130],"(2.7-fold),":[134],"CD34+/CD133+":[135],"(2.8-fold),":[137],"and":[138,153,183,196,202,216],"hematopoietic":[139,241],"colony":[140],"forming":[141],"(7.7-fold).":[143],"Remarkably,":[144],"injection":[145],"accelerated":[149],"recovery":[150],"perfusion":[152],"improved":[154],"usage":[156],"in":[157],"immunodeficient":[158],"mice":[159,172],"femoral":[161],"ligation-induced":[163],"ischemia.":[165],"At":[166],"7":[167],"or":[168],"28":[169],"days":[170],"post-transplantation,":[171],"transplanted":[173],"showed":[178],"augmented":[179,210],"endothelial":[180,213],"proliferation":[182],"capillary":[185],"density":[186],"controls.":[189],"Expanded":[190,224],"mRNA":[194],"expression":[195],"secreted":[197],"angiogenesis-associated":[198],"growth":[199,221],"factors,":[200],"chemokines,":[201],"matrix":[203],"modifying":[204],"proteins.":[205],"Coculture":[206],"microvascular":[212],"survival":[215],"tubule":[217],"formation":[218],"serum-starved,":[220],"factor-reduced":[222],"UCB-derived":[225],"represent":[228],"an":[229,236],"alternative":[230],"autologous":[232],"bone":[233],"marrow":[234],"accessible":[237],"source":[238],"refinement":[246],"vascular":[248],"regeneration-inductive":[249],"therapies.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2017-06-23T00:00:00"}
