{"id":"https://openalex.org/W2625715650","doi":"https://doi.org/10.3389/fnins.2017.00340","title":"Osthole Stimulated Neural Stem Cells Differentiation into Neurons in an Alzheimer's Disease Cell Model via Upregulation of MicroRNA-9 and Rescued the Functional Impairment of Hippocampal Neurons in APP/PS1 Transgenic Mice","display_name":"Osthole Stimulated Neural Stem Cells Differentiation into Neurons in an Alzheimer's Disease Cell Model via Upregulation of MicroRNA-9 and Rescued the Functional Impairment of Hippocampal Neurons in APP/PS1 Transgenic Mice","publication_year":2017,"publication_date":"2017-06-12","ids":{"openalex":"https://openalex.org/W2625715650","doi":"https://doi.org/10.3389/fnins.2017.00340","mag":"2625715650","pmid":"https://pubmed.ncbi.nlm.nih.gov/28659755","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5468409"},"language":"en","primary_location":{"id":"doi:10.3389/fnins.2017.00340","doi":"https://doi.org/10.3389/fnins.2017.00340","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2017.00340","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2017.00340/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fnins.2017.00340/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101665221","display_name":"Shaoheng Li","orcid":"https://orcid.org/0000-0002-5294-6928","observed_orcids":["https://orcid.org/0000-0002-5294-6928"]},"institutions":[{"id":"https://openalex.org/I2800959905","display_name":"Liaoning University of Traditional Chinese Medicine","ror":"https://ror.org/030e3n504","country_code":"CN","type":"education","lineage":["https://openalex.org/I2800959905"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shao-Heng Li","raw_affiliation_strings":["Department of Pharmacology, School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, China","institution_ids":["https://openalex.org/I2800959905"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Peng Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140813","display_name":"First Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/055w74b96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Gao","raw_affiliation_strings":["Department of Anesthesiology, First Affiliated Hospital of Dalian Medical University, Dalian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, First Affiliated Hospital of Dalian Medical University, Dalian, China","institution_ids":["https://openalex.org/I4210140813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103211182","display_name":"Litong Wang","orcid":"https://orcid.org/0000-0003-0238-5496","observed_orcids":["https://orcid.org/0000-0003-0238-5496"]},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]},{"id":"https://openalex.org/I4210100868","display_name":"Second Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/012f2cn18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210100868"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li-Tong Wang","raw_affiliation_strings":["Department of Neurological Rehabilitation, Second Affiliated Hospital of Dalian Medical University, Dalian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Rehabilitation, Second Affiliated Hospital of Dalian Medical University, Dalian, China","institution_ids":["https://openalex.org/I191996457","https://openalex.org/I4210100868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103245738","display_name":"Yuhui Yan","orcid":"https://orcid.org/0000-0001-6214-2205","observed_orcids":["https://orcid.org/0000-0001-6214-2205"]},"institutions":[{"id":"https://openalex.org/I2800959905","display_name":"Liaoning University of Traditional Chinese Medicine","ror":"https://ror.org/030e3n504","country_code":"CN","type":"education","lineage":["https://openalex.org/I2800959905"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu-Hui Yan","raw_affiliation_strings":["Department of Pharmacology, School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, China","institution_ids":["https://openalex.org/I2800959905"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100767034","display_name":"Yang Xia","orcid":"https://orcid.org/0000-0001-8783-1592","observed_orcids":["https://orcid.org/0000-0001-8783-1592"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Yang Xia","raw_affiliation_strings":["Department of Engineering, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Engineering, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100612517","display_name":"Jie Song","orcid":"https://orcid.org/0000-0002-9559-0634","observed_orcids":["https://orcid.org/0000-0002-9559-0634"]},"institutions":[{"id":"https://openalex.org/I2800959905","display_name":"Liaoning University of Traditional Chinese Medicine","ror":"https://ror.org/030e3n504","country_code":"CN","type":"education","lineage":["https://openalex.org/I2800959905"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Song","raw_affiliation_strings":["Department of Pharmacology, School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, China","institution_ids":["https://openalex.org/I2800959905"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100455605","display_name":"Hongyan Li","orcid":"https://orcid.org/0000-0003-3823-4788","observed_orcids":["https://orcid.org/0000-0003-3823-4788"]},"institutions":[{"id":"https://openalex.org/I2800959905","display_name":"Liaoning University of Traditional Chinese Medicine","ror":"https://ror.org/030e3n504","country_code":"CN","type":"education","lineage":["https://openalex.org/I2800959905"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong-Yan Li","raw_affiliation_strings":["Department of Pharmacology, School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, China","institution_ids":["https://openalex.org/I2800959905"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070291467","display_name":"Jingxian Yang","orcid":"https://orcid.org/0000-0002-3928-7745","observed_orcids":["https://orcid.org/0000-0002-3928-7745"]},"institutions":[{"id":"https://openalex.org/I2800959905","display_name":"Liaoning University of Traditional Chinese Medicine","ror":"https://ror.org/030e3n504","country_code":"CN","type":"education","lineage":["https://openalex.org/I2800959905"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jing-Xian Yang","raw_affiliation_strings":["Department of Pharmacology, School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, China","institution_ids":["https://openalex.org/I2800959905"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5070291467"],"corresponding_institution_ids":["https://openalex.org/I2800959905"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":1.7313,"has_fulltext":true,"cited_by_count":53,"citation_normalized_percentile":{"value":0.82551397,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"11","issue":null,"first_page":"340","last_page":"340"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.030500000342726707,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osthole","display_name":"osthole","score":0.9269999861717224},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9760000109672546},{"id":"https://openalex.org/keywords/neural-stem-cell-differentiation","display_name":"neural stem cell differentiation","score":0.8679999709129333},{"id":"https://openalex.org/keywords/mir-9","display_name":"miR-9","score":0.8119999766349792},{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.9290000200271606},{"id":"https://openalex.org/keywords/app-ps1-mice","display_name":"APP/PS1 mice","score":0.8830000162124634},{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.7450000047683716},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.7350000143051147},{"id":"https://openalex.org/keywords/hippocampal-neurons","display_name":"hippocampal neurons","score":0.8849999904632568},{"id":"https://openalex.org/keywords/neurogenesis","display_name":"neurogenesis","score":0.8360000252723694},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9100000262260437},{"id":"https://openalex.org/keywords/coumarins","display_name":"coumarins","score":0.7009999752044678},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.9150000214576721}],"concepts":[{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.8271889090538025},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.6991218328475952},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.6161735653877258},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6006475687026978},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.5820561051368713},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.4595983624458313},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.44501224160194397},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4208940863609314},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4184446334838867},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.41379913687705994},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.38463401794433594},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.37207484245300293},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3264288902282715},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2822858691215515},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2544715404510498},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12359589338302612},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fnins.2017.00340","doi":"https://doi.org/10.3389/fnins.2017.00340","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2017.00340","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2017.00340/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4332015","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5468409","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:28659755","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28659755","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5468409","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5468409/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Neurosci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:cc34215418dc401490e2491214410420","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/cc34215418dc401490e2491214410420","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Neuroscience, Vol 11 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fnins.2017.00340","doi":"https://doi.org/10.3389/fnins.2017.00340","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2017.00340","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2017.00340/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4757139629","display_name":null,"funder_award_id":"81173580","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324783","display_name":"Liaoning University","ror":"https://ror.org/03xpwj629"},{"id":"https://openalex.org/F4320325418","display_name":"Liaoning University of Traditional Chinese Medicine","ror":"https://ror.org/030e3n504"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2625715650.pdf","grobid_xml":"https://content.openalex.org/works/W2625715650.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W1761416507","https://openalex.org/W1894408449","https://openalex.org/W1964264655","https://openalex.org/W1965285922","https://openalex.org/W1965306643","https://openalex.org/W1972388701","https://openalex.org/W1977310968","https://openalex.org/W1980825524","https://openalex.org/W1981293839","https://openalex.org/W1982110977","https://openalex.org/W1982162410","https://openalex.org/W1987252926","https://openalex.org/W1993576110","https://openalex.org/W1994702544","https://openalex.org/W2000418014","https://openalex.org/W2006565235","https://openalex.org/W2013940038","https://openalex.org/W2015348924","https://openalex.org/W2018496107","https://openalex.org/W2019127856","https://openalex.org/W2023657227","https://openalex.org/W2025549697","https://openalex.org/W2025902983","https://openalex.org/W2031472162","https://openalex.org/W2034565408","https://openalex.org/W2036556087","https://openalex.org/W2039076728","https://openalex.org/W2044987522","https://openalex.org/W2056147363","https://openalex.org/W2060170946","https://openalex.org/W2063182418","https://openalex.org/W2064356751","https://openalex.org/W2065569210","https://openalex.org/W2067994194","https://openalex.org/W2070410958","https://openalex.org/W2070664959","https://openalex.org/W2082429191","https://openalex.org/W2084470501","https://openalex.org/W2089136965","https://openalex.org/W2092041474","https://openalex.org/W2095422335","https://openalex.org/W2100358595","https://openalex.org/W2102753200","https://openalex.org/W2103975650","https://openalex.org/W2114356223","https://openalex.org/W2117381245","https://openalex.org/W2118629432","https://openalex.org/W2123437653","https://openalex.org/W2129267808","https://openalex.org/W2133809030","https://openalex.org/W2135137137","https://openalex.org/W2146993367","https://openalex.org/W2149146453","https://openalex.org/W2168334242","https://openalex.org/W2172437260","https://openalex.org/W2174079611","https://openalex.org/W2331377788","https://openalex.org/W2332391819","https://openalex.org/W2343783837","https://openalex.org/W2417885480","https://openalex.org/W2463704048","https://openalex.org/W2919705191","https://openalex.org/W6665261382"],"related_works":["https://openalex.org/W3016863675","https://openalex.org/W2463704048","https://openalex.org/W1761416507","https://openalex.org/W2069802516","https://openalex.org/W2123437653","https://openalex.org/W2343783837","https://openalex.org/W2135137137","https://openalex.org/W2969162246","https://openalex.org/W4220863758","https://openalex.org/W2750226710"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1,8],"(AD)":[2],"is":[3,11,190],"the":[4,25,57,97,137,171,177],"most":[5],"serious":[6],"neurodegenerative":[7,200],"worldwide":[9],"and":[10,17,60,69,108,135,161,180],"characterized":[12],"by":[13,131],"progressive":[14],"cognitive":[15,155],"impairment":[16,164],"multiple":[18],"neurological":[19],"changes,":[20],"including":[21],"neuronal":[22,40],"loss":[23],"in":[24,67,70,80,112,141,147],"brain.":[26],"However,":[27],"there":[28],"are":[29],"no":[30],"available":[31],"drugs":[32],"to":[33,47,94],"delay":[34],"or":[35,198],"cure":[36],"this":[37],"disease.":[38],"Consequently,":[39],"replacement":[41],"therapy":[42],"may":[43],"be":[44,90],"a":[45,52,77,91,191],"strategy":[46],"treat":[48],"AD.":[49,95],"Osthole":[50],"(Ost),":[51],"natural":[53],"coumarin":[54],"derivative,":[55],"crosses":[56],"blood-brain":[58],"barrier":[59],"exerts":[61],"strong":[62],"neuroprotective":[63],"effects":[64,179],"against":[65,185],"AD":[66,197],"vitro":[68],"vivo.":[71],"Recently,":[72],"microRNAs":[73],"(miRNAs)":[74],"have":[75],"demonstrated":[76],"crucial":[78],"role":[79],"pathological":[81],"processes":[82],"of":[83,165,170,176,183,196],"AD,":[84,186],"implying":[85],"that":[86,188],"targeting":[87],"miRNAs":[88],"could":[89,104],"therapeutic":[92],"approach":[93],"In":[96,143],"present":[98,172],"study,":[99],"we":[100],"investigated":[101],"whether":[102],"Ost":[103,145,184,189],"enhance":[105],"cell":[106,110],"viability":[107],"prevent":[109],"death":[111],"amyloid":[113],"precursor":[114],"protein":[115],"(APP)-expressing":[116],"neural":[117],"stem":[118],"cells":[119],"(NSCs)":[120],"as":[121,123],"well":[122],"promote":[124],"APP-expressing":[125],"NSCs":[126],"differentiation":[127],"into":[128],"more":[129],"neurons":[130],"upregulating":[132],"microRNA":[133],"(miR)-9":[134],"inhibiting":[136],"Notch":[138],"signaling":[139],"pathway":[140],"vitro.":[142],"addition,":[144],"treatment":[146,195],"APP/PS1":[148],"double":[149],"transgenic":[150],"(Tg)":[151],"mice":[152],"markedly":[153],"restored":[154],"functions,":[156],"reduced":[157],"A\u03b2":[158],"plague":[159],"production":[160],"rescued":[162],"functional":[163],"hippocampal":[166],"neurons.":[167],"The":[168],"results":[169],"study":[173],"provides":[174],"evidence":[175],"neurogenesis":[178],"neurobiological":[181],"mechanisms":[182],"suggesting":[187],"promising":[192],"drug":[193],"for":[194],"other":[199],"diseases.":[201]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2017-06-23T00:00:00"}
