{"id":"https://openalex.org/W2625547100","doi":null,"title":"Targeting Neuromimicry in Prostate Cancer Metastasis","display_name":"Targeting Neuromimicry in Prostate Cancer Metastasis","publication_year":2016,"publication_date":"2016-10-01","ids":{"openalex":"https://openalex.org/W2625547100","mag":"2625547100"},"language":"en","primary_location":{"id":"mag:2625547100","doi":null,"is_oa":false,"landing_page_url":"https://apps.dtic.mil/sti/pdfs/AD1095937.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064197142","display_name":"Boyang Jason Wu","orcid":"https://orcid.org/0000-0002-2823-3573","observed_orcids":["https://orcid.org/0000-0002-2823-3573"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Boyang Jason Wu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2823-3573","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5064197142"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.8065999746322632,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.8065999746322632,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.18440000712871552,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/monoamine-oxidase-a","display_name":"monoamine oxidase A","score":0.925000011920929},{"id":"https://openalex.org/keywords/prostate-cancer-metastasis","display_name":"prostate cancer metastasis","score":0.8859999775886536},{"id":"https://openalex.org/keywords/clorgyline","display_name":"clorgyline","score":0.9399999976158142},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.8240000009536743},{"id":"https://openalex.org/keywords/orthotopic-xenograft-model","display_name":"orthotopic xenograft","score":0.7670000195503235}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7980639934539795},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6841298937797546},{"id":"https://openalex.org/C114461151","wikidata":"https://www.wikidata.org/wiki/Q14888415","display_name":"Monoamine oxidase A","level":4,"score":0.6470254063606262},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.6247177720069885},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5943841338157654},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5400112867355347},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.443403422832489},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4034658670425415},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40234375},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3985655605792999},{"id":"https://openalex.org/C2776024655","wikidata":"https://www.wikidata.org/wiki/Q410867","display_name":"Monoamine oxidase","level":3,"score":0.3767547905445099},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.35003724694252014},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3491087555885315},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.16472288966178894},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08301150798797607},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2625547100","doi":null,"is_oa":false,"landing_page_url":"https://apps.dtic.mil/sti/pdfs/AD1095937.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1785629757","https://openalex.org/W1855737037","https://openalex.org/W1975577875","https://openalex.org/W1992280242","https://openalex.org/W2000158828","https://openalex.org/W2003213153","https://openalex.org/W2005558806","https://openalex.org/W2009017218","https://openalex.org/W2022875692","https://openalex.org/W2027525928","https://openalex.org/W2028716069","https://openalex.org/W2036008499","https://openalex.org/W2037248793","https://openalex.org/W2040046803","https://openalex.org/W2048744408","https://openalex.org/W2053662837","https://openalex.org/W2055184276","https://openalex.org/W2055489437","https://openalex.org/W2061165132","https://openalex.org/W2066216276","https://openalex.org/W2066845679","https://openalex.org/W2069830786","https://openalex.org/W2083320374","https://openalex.org/W2084292519","https://openalex.org/W2085040862","https://openalex.org/W2088076795","https://openalex.org/W2098820114","https://openalex.org/W2104892374","https://openalex.org/W2113701976","https://openalex.org/W2114471035","https://openalex.org/W2114906532","https://openalex.org/W2117387587","https://openalex.org/W2130687125","https://openalex.org/W2144680000","https://openalex.org/W2144713347","https://openalex.org/W2146629163","https://openalex.org/W2148242912","https://openalex.org/W2149218924","https://openalex.org/W2149472336","https://openalex.org/W2156854438","https://openalex.org/W2170476872","https://openalex.org/W2171429997","https://openalex.org/W2414822843","https://openalex.org/W2531068218"],"related_works":["https://openalex.org/W1487706442","https://openalex.org/W2000158828","https://openalex.org/W2978466094","https://openalex.org/W4320495790","https://openalex.org/W4366166989","https://openalex.org/W4250832835","https://openalex.org/W6964058134","https://openalex.org/W3120036594","https://openalex.org/W6908037559","https://openalex.org/W4220853977"],"abstract_inverted_index":{"Abstract":[0],":":[1],"The":[2],"purpose":[3],"of":[4,15,41,50,69,77],"this":[5,42],"project":[6],"is":[7],"to":[8,66,100],"investigate":[9],"the":[10,38],"functional":[11],"and":[12,22,33,46,56,72,85,98,106,127],"mechanistic":[13],"roles":[14],"a":[16,48],"neural":[17],"enzyme":[18],"monoamine":[19],"oxidase":[20],"A(MAOA)":[21],"its":[23],"downstream":[24],"neuronal":[25],"factors":[26],"in":[27,83,86,108,129],"mediating":[28],"prostate":[29,34,59,79,95,124],"cancer-nerve":[30],"reciprocal":[31],"interactions":[32],"cancer":[35,60],"metastasis.":[36],"Throughout":[37],"Year":[39],"1":[40],"study,":[43],"we":[44,116],"established":[45],"validated":[47],"series":[49],"stable":[51,67],"wild-type":[52],"control,":[53],"MAOA":[54,92,119],"overexpressing,":[55],"MAOA-knockdown":[57],"human":[58],"cells":[61],"which":[62],"were":[63],"further":[64],"subjected":[65],"labeling":[68],"fluorescence":[70],"protein":[71],"luciferase":[73],"for":[74],"subsequent":[75],"visualization":[76],"MAOA-mediated":[78],"cancer-never":[80],"cell":[81],"communication":[82],"vitro":[84],"vivo.":[87],"We":[88],"also":[89],"demonstrated":[90],"that":[91,118],"significantly":[93],"promoted":[94],"tumor":[96,125],"growth":[97,126],"metastasis":[99],"distant":[101],"organs,":[102],"including":[103],"intestine,":[104],"liver":[105],"lung,":[107],"different":[109],"orthotopic":[110],"xenograft":[111],"mouse":[112],"models.":[113],"In":[114],"addition,":[115],"showed":[117],"inhibitor":[120],"clorgyline":[121],"effectively":[122],"inhibited":[123],"progression":[128],"mice.":[130]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2017-06-23T00:00:00"}