{"id":"https://openalex.org/W2625444591","doi":"https://doi.org/10.1200/jco.2013.31.15_suppl.11085","title":"The CAP-IASLC-AMP molecular testing guideline for the selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors.","display_name":"The CAP-IASLC-AMP molecular testing guideline for the selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors.","publication_year":2013,"publication_date":"2013-05-20","ids":{"openalex":"https://openalex.org/W2625444591","doi":"https://doi.org/10.1200/jco.2013.31.15_suppl.11085","mag":"2625444591"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2013.31.15_suppl.11085","doi":"https://doi.org/10.1200/jco.2013.31.15_suppl.11085","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2013.31.15_suppl.11085","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046345178","display_name":"Marc Ladanyi","orcid":"https://orcid.org/0000-0001-9055-7213","observed_orcids":["https://orcid.org/0000-0001-9055-7213"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc Ladanyi","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065513829","display_name":"Phillip T. Cagle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phil T. Cagle","raw_affiliation_strings":["The Methodist Hospital, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Methodist Hospital, Houston, TX","institution_ids":["https://openalex.org/I1295876152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020295260","display_name":"Mary Beth Beasley","orcid":"https://orcid.org/0000-0003-2340-1897","observed_orcids":["https://orcid.org/0000-0003-2340-1897"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mary Beth Beasley","raw_affiliation_strings":["Mount Sinai Medical Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mount Sinai Medical Center, New York, NY","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027709185","display_name":"Dhananjay Arun Chitale","orcid":"https://orcid.org/0000-0002-4421-6431","observed_orcids":["https://orcid.org/0000-0002-4421-6431"]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dhananjay Chitale","raw_affiliation_strings":["Department of Pathology, Henry Ford Health System, Detroit, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Henry Ford Health System, Detroit, MI","institution_ids":["https://openalex.org/I154057602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102899480","display_name":"Sanja \u0110a\u010di\u0107","orcid":"https://orcid.org/0000-0003-4197-3354","observed_orcids":["https://orcid.org/0000-0003-4197-3354"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanja Dacic","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022063365","display_name":"Giuseppe Giaccone","orcid":"https://orcid.org/0000-0002-7392-1965","observed_orcids":["https://orcid.org/0000-0002-7392-1965","https://orcid.org/0000-0002-5023-7562"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Giuseppe Giaccone","raw_affiliation_strings":["National Cancer Institute, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060720802","display_name":"Robert Brian Jenkins","orcid":"https://orcid.org/0000-0002-4049-694X","observed_orcids":["https://orcid.org/0000-0002-4049-694X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert B. Jenkins","raw_affiliation_strings":["Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100620133","display_name":"David J. Kwiatkowski","orcid":"https://orcid.org/0000-0002-5668-5219","observed_orcids":["https://orcid.org/0000-0002-5668-5219"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David J. Kwiatkowski","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113534468","display_name":"Juan\u2010Sebastian Saldivar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juan-Sebastian Saldivar","raw_affiliation_strings":["City of Hope National Medical Center, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"City of Hope National Medical Center, Duarte, CA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004696064","display_name":"Jeremy Andrew Squire","orcid":"https://orcid.org/0000-0002-9863-468X","observed_orcids":["https://orcid.org/0000-0002-9863-468X"]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jeremy Squire","raw_affiliation_strings":["Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075942051","display_name":"Erik Thunnissen","orcid":"https://orcid.org/0000-0001-5355-8508","observed_orcids":["https://orcid.org/0000-0001-5355-8508","https://orcid.org/0000-0003-0243-4657"]},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Erik Thunnissen","raw_affiliation_strings":["VU University Medical Center, Amsterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VU University Medical Center, Amsterdam, Netherlands","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035004148","display_name":"Neal Ian Lindeman","orcid":"https://orcid.org/0000-0002-7092-6859","observed_orcids":["https://orcid.org/0000-0002-7092-6859"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neal Ian Lindeman","raw_affiliation_strings":["Brigham and Women's Hospital/Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital/Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":13,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"15_suppl","first_page":"11085","last_page":"11085"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.8569999933242798},{"id":"https://openalex.org/keywords/egfr-mutation","display_name":"EGFR mutation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/alk-fusion","display_name":"ALK fusion","score":0.9279999732971191},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.972000002861023},{"id":"https://openalex.org/keywords/molecular-testing","display_name":"molecular testing","score":0.6539999842643738},{"id":"https://openalex.org/keywords/targeted-therapy-selection","display_name":"targeted therapy selection","score":0.5479999780654907},{"id":"https://openalex.org/keywords/non-small-cell-lung-adenocarcinoma","display_name":"non-small cell lung adenocarcinoma","score":0.8230000138282776},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.7749999761581421},{"id":"https://openalex.org/keywords/molecular-pathology","display_name":"molecular pathology","score":0.421999990940094},{"id":"https://openalex.org/keywords/expert-consensus-recommendations","display_name":"expert consensus recommendations","score":0.5230000019073486}],"concepts":[{"id":"https://openalex.org/C2780182762","wikidata":"https://www.wikidata.org/wiki/Q1630279","display_name":"Guideline","level":2,"score":0.7641780972480774},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7559376358985901},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5877482891082764},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.5170491337776184},{"id":"https://openalex.org/C2777267654","wikidata":"https://www.wikidata.org/wiki/Q3519023","display_name":"Test (biology)","level":2,"score":0.45571187138557434},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.44662293791770935},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38139528036117554},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.297243595123291},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2013.31.15_suppl.11085","doi":"https://doi.org/10.1200/jco.2013.31.15_suppl.11085","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2013.31.15_suppl.11085","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2138200001","https://openalex.org/W2514360855","https://openalex.org/W2140832617","https://openalex.org/W4250248802","https://openalex.org/W2401773525","https://openalex.org/W4234096669","https://openalex.org/W2031788787","https://openalex.org/W2785515282","https://openalex.org/W2929562051","https://openalex.org/W2055607329"],"abstract_inverted_index":{"11085":[0],"Background:":[1],"The":[2,198],"College":[3],"of":[4,14,37,69,76,137,193,219,249,279],"American":[5],"Pathologists":[6],"(CAP),":[7],"the":[8,12,19,34,77,138,143,169,172,175,180,277],"International":[9],"Association":[10,20],"for":[11,21,33,129,135,166,205,244,291],"Study":[13],"Lung":[15],"Cancer":[16],"(IASLC),":[17],"and":[18,44,50,55,57,84,88,145,179,195,208,225,229,238,251,260,263,273,296],"Molecular":[22],"Pathology":[23],"(AMP)":[24],"jointly":[25],"initiated":[26],"an":[27],"effort":[28],"to":[29,41,104,108,118,157,168,203,226,258],"establish":[30],"evidence-based":[31,200,283],"recommendations":[32,139,201],"molecular":[35,234,267],"analysis":[36],"lung":[38,255],"cancers":[39],"required":[40],"guide":[42],"EGFR-":[43],"ALK-directed":[45],"therapies,":[46],"addressing":[47,190],"which":[48],"patients":[49,213],"samples":[51],"should":[52,60],"be":[53,61],"tested,":[54],"when":[56],"how":[58],"testing":[59,231,253],"performed.":[62],"Methods:":[63],"Three":[64],"co-chairs":[65,144],"without":[66],"relevant":[67],"conflicts":[68],"interest":[70],"were":[71,91,102,116,124,164,242],"selected,":[72],"one":[73],"from":[74,93,96],"each":[75,136],"sponsoring":[78],"societies:":[79],"CAP":[80],"(P.T.C.),":[81],"IASLC":[82],"(M.L.),":[83],"AMP":[85],"(N.I.L.).":[86],"Writing":[87],"advisory":[89,173],"panels":[90],"formed":[92],"additional":[94],"experts":[95],"these":[97],"societies.":[98,183],"Unbiased":[99],"literature":[100],"searches":[101],"performed":[103],"capture":[105],"articles":[106,113,122],"up":[107],"February":[109],"2012,":[110],"yielding":[111],"1,533":[112],"whose":[114],"abstracts":[115],"screened":[117],"identify":[119],"521":[120],"pertinent":[121],"that":[123],"then":[125],"reviewed":[126],"in":[127,211,254,266],"detail":[128],"relevance.":[130],"Evidence":[131],"was":[132,155],"formally":[133],"graded":[134],"first":[140],"formulated":[141],"by":[142,286],"panel":[146],"members":[147],"at":[148,158],"a":[149],"public":[150,176],"meeting.":[151],"Each":[152],"guideline":[153,188],"section":[154],"assigned":[156],"least":[159],"two":[160],"panelists.":[161],"Successive":[162],"drafts":[163],"circulated":[165],"comments":[167],"writing":[170],"panel,":[171,174],"(online":[177],"posting),":[178],"three":[181],"professional":[182],"Results:":[184],"We":[185],"generated":[186,243],"37":[187],"items":[189],"14":[191],"areas":[192],"EGFR":[194,206,228,250],"ALK":[196,209,230,252],"testing.":[197,268],"major,":[199],"are":[202,289],"test":[204],"mutations":[207],"fusions":[210],"all":[212,245],"with":[214],"advanced":[215],"stage":[216],"adenocarcinoma,":[217],"regardless":[218],"sex,":[220],"race,":[221],"or":[222],"smoking":[223],"history,":[224],"prioritize":[227],"over":[232],"other":[233,246],"predictive":[235],"tests.":[236],"Recommendations":[237],"expert":[239,287],"consensus":[240],"opinions":[241],"key":[247],"aspects":[248],"cancer":[256],"related":[257],"oncology":[259],"pathology":[261],"practice":[262,275],"technical":[264],"issues":[265],"Conclusions:":[269],"As":[270],"scientific":[271],"discoveries":[272],"clinical":[274,281,294],"outpace":[276],"completion":[278],"randomized":[280],"trials,":[282],"guidelines":[284],"developed":[285],"practitioners":[288],"vital":[290],"communicating":[292],"emerging":[293],"standards":[295],"thereby":[297],"improving":[298],"patient":[299],"outcomes.":[300]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2017-06-23T00:00:00"}