{"id":"https://openalex.org/W2625255885","doi":null,"title":"Determining HDAC8 Substrate Specificity.","display_name":"Determining HDAC8 Substrate Specificity.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2625255885","mag":"2625255885"},"language":"en","primary_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/108746","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/108746","pdf_url":"https://hdl.handle.net/2027.42/108746","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/2027.42/108746","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024506123","display_name":"Noah A. Wolfson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Noah A. Wolfson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5024506123"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hdac8","display_name":"HDAC8","score":0.9879999756813049},{"id":"https://openalex.org/keywords/histone-deacetylase","display_name":"histone deacetylase","score":0.9660000205039978},{"id":"https://openalex.org/keywords/substrate-specificity","display_name":"substrate specificity","score":0.953000009059906},{"id":"https://openalex.org/keywords/peptide-substrates","display_name":"peptide substrates","score":0.6520000100135803},{"id":"https://openalex.org/keywords/product-dissociation","display_name":"product dissociation","score":0.6320000290870667},{"id":"https://openalex.org/keywords/short-range-interactions","display_name":"short-range interactions","score":0.6470000147819519},{"id":"https://openalex.org/keywords/long-range-interactions","display_name":"long-range interactions","score":0.7289999723434448},{"id":"https://openalex.org/keywords/histone-tetramer","display_name":"histone tetramer","score":0.8019999861717224},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.7129999995231628}],"concepts":[{"id":"https://openalex.org/C2994592520","wikidata":"https://www.wikidata.org/wiki/Q5090496","display_name":"Substrate specificity","level":3,"score":0.49024373292922974},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.41522765159606934},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.32356250286102295},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29652634263038635},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12850981950759888},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.07432180643081665},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/108746","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/108746","pdf_url":"https://hdl.handle.net/2027.42/108746","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2625255885","doi":null,"is_oa":false,"landing_page_url":"https://deepblue.lib.umich.edu/bitstream/2027.42/108746/1/noahw_1.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/108746","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/108746","pdf_url":"https://hdl.handle.net/2027.42/108746","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1183679041","display_name":null,"funder_award_id":"GM40602","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4569188361","display_name":"Cellular Biotechnology Training Program (CBTP)","funder_award_id":"T32GM008353","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4847953975","display_name":"GRADUATE RESEARCH FELLOWSHIP PROGRAM","funder_award_id":"0718128","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G65427546","display_name":"Michigan Chemistry Biology Interface Training Program","funder_award_id":"T32GM008597","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000252416","display_name":null,"funder_award_id":"GM40602","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2625255885.pdf","grobid_xml":"https://content.openalex.org/works/W2625255885.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1970831921","https://openalex.org/W1977527516","https://openalex.org/W1977831138","https://openalex.org/W1978648714","https://openalex.org/W1995265717","https://openalex.org/W1998655934","https://openalex.org/W2003138942","https://openalex.org/W2013777434","https://openalex.org/W2027592225","https://openalex.org/W2040992378","https://openalex.org/W2044216740","https://openalex.org/W2056417267","https://openalex.org/W2056656235","https://openalex.org/W2060672431","https://openalex.org/W2061360494","https://openalex.org/W2072526811","https://openalex.org/W2073270810","https://openalex.org/W2101691020","https://openalex.org/W2112932391","https://openalex.org/W2116358602","https://openalex.org/W2123324115","https://openalex.org/W2126891469","https://openalex.org/W2131485957","https://openalex.org/W2152239569","https://openalex.org/W2153548688","https://openalex.org/W2366400801","https://openalex.org/W4214898406"],"related_works":["https://openalex.org/W7065211483","https://openalex.org/W2056474673","https://openalex.org/W2791550490","https://openalex.org/W2112932391","https://openalex.org/W3132846941","https://openalex.org/W2784769436","https://openalex.org/W2289124515","https://openalex.org/W2594023269","https://openalex.org/W2301598643","https://openalex.org/W2053644682"],"abstract_inverted_index":{"Histone":[0],"deacetylases":[1],"(HDACs)":[2],"are":[3,22],"a":[4,91,154,211,234],"group":[5],"of":[6,13,26,83,111,119,131,156,213,222],"18":[7],"enzymes":[8],"that":[9,94,153,184,203],"catalyze":[10],"the":[11,70,81,108,117,120,123,129,166,171,197,242],"deacetylation":[12,75,124],"acetyl":[14,172,219],"lysine":[15,20,220],"residues":[16,21],"in":[17,142,157,189,223],"proteins.":[18],"Acetyl":[19],"present":[23],"within":[24],"thousands":[25],"proteins,":[27],"and":[28,41,215,218],"acetylation/deacetylation":[29],"has":[30,186],"been":[31],"shown":[32],"to":[33,38,55,68,182,191,249],"affect":[34],"protein":[35,46],"properties":[36],"integral":[37],"cellular":[39],"homeostasis":[40],"disease":[42],"states.":[43],"Determining":[44],"which":[45,50],"is":[47,53,208],"deacetylated":[48],"by":[49,74,77,206,210],"HDAC":[51,62,239],"isozyme":[52],"central":[54],"understanding":[56],"biological":[57],"regulation.":[58],"To":[59],"better":[60],"identify":[61,250],"substrates,":[63],"I":[64,89,126,174,227],"developed":[65],"an":[66],"assay":[67],"measure":[69],"acetate":[71],"product":[72,231],"formed":[73],"catalyzed":[76],"metal-dependent":[78],"HDACs":[79],"for":[80,238,252],"evaluation":[82],"peptide":[84,97,113,134,193,198],"substrates.":[85,194,225],"Using":[86,122],"this":[87],"assay,":[88,125],"advanced":[90],"computational":[92],"algorithm":[93,105],"predicts":[95,107],"HDAC8":[96,132,147,159,185,207],"substrates":[98,114,135,160,251],"based":[99,115,164],"on":[100,116,165],"short":[101,214],"range":[102],"interactions.":[103],"This":[104],"accurately":[106],"catalytic":[109],"efficiency":[110],"7-mer":[112],"sequence":[118],"peptide.":[121],"also":[127,176],"demonstrated":[128],"reactivity":[130],"with":[133,139,146,196],"derived":[136],"from":[137],"proteins":[138],"increased":[140],"acetylation":[141],"vivo":[143,158,224],"upon":[144],"treatment":[145],"specific":[148],"inhibitors.":[149],"These":[150],"experiments":[151],"suggest":[152,202],"subset":[155],"can":[161],"be":[162],"predicted":[163],"six":[167],"amino":[168],"acids":[169],"flanking":[170],"lysine.":[173],"have":[175,228],"utilized":[177],"singly":[178],"acetylated":[179],"histone":[180],"tetramers":[181],"establish":[183],"enhanced":[187],"activity":[188],"comparison":[190],"corresponding":[192],"Combined":[195],"work,":[199],"these":[200,247],"results":[201],"molecular":[204],"recognition":[205],"determined":[209],"combination":[212],"long-range":[216],"interactions":[217],"accessibility":[221],"Additionally,":[226],"identified":[229],"slow":[230],"dissociation":[232],"as":[233],"novel":[235],"regulatory":[236],"method":[237],"activity.":[240],"In":[241],"future":[243],"we":[244],"will":[245],"expand":[246],"methods":[248],"other":[253],"HDACs.":[254]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-06-23T00:00:00"}
