{"id":"https://openalex.org/W2625201215","doi":"https://doi.org/10.1104/pp.17.00576","title":"The Enzyme Activity and Substrate Specificity of Two Major Cinnamyl Alcohol Dehydrogenases in Sorghum ( Sorghum bicolor ), SbCAD2 and SbCAD4","display_name":"The Enzyme Activity and Substrate Specificity of Two Major Cinnamyl Alcohol Dehydrogenases in Sorghum ( Sorghum bicolor ), SbCAD2 and SbCAD4","publication_year":2017,"publication_date":"2017-06-12","ids":{"openalex":"https://openalex.org/W2625201215","doi":"https://doi.org/10.1104/pp.17.00576","mag":"2625201215","pmid":"https://pubmed.ncbi.nlm.nih.gov/28606901","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5543964"},"language":"en","primary_location":{"id":"doi:10.1104/pp.17.00576","doi":"https://doi.org/10.1104/pp.17.00576","is_oa":false,"landing_page_url":"https://doi.org/10.1104/pp.17.00576","pdf_url":null,"source":{"id":"https://openalex.org/S42294715","display_name":"PLANT PHYSIOLOGY","issn_l":"0032-0889","issn":["0032-0889","1532-2548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5543964","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110678933","display_name":"Se\u2010Young Jun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Se-Young Jun","raw_affiliation_strings":["Department of Chemistry, Washington State University, Pullman, Washington 99164","aDepartment of Chemistry, Washington State University, Pullman, Washington 99164"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Washington State University, Pullman, Washington 99164","institution_ids":["https://openalex.org/I72951846"]},{"raw_affiliation_string":"aDepartment of Chemistry, Washington State University, Pullman, Washington 99164","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Alexander M. Walker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander M. Walker","raw_affiliation_strings":["School of Molecular Biosciences, Washington State University, Pullman, Washington 99164","bSchool of Molecular Biosciences, Washington State University, Pullman, Washington 99164"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Molecular Biosciences, Washington State University, Pullman, Washington 99164","institution_ids":["https://openalex.org/I72951846"]},{"raw_affiliation_string":"bSchool of Molecular Biosciences, Washington State University, Pullman, Washington 99164","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045485691","display_name":"Hoon Kim","orcid":"https://orcid.org/0000-0001-7425-7464","observed_orcids":["https://orcid.org/0000-0001-7425-7464"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I2801044051","display_name":"Great Lakes Bioenergy Research Center","ror":"https://ror.org/01ca2by25","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I2801044051"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hoon Kim","raw_affiliation_strings":["Department of Biochemistry and Department of Energy Great Lakes Bioenergy Research Center, University of Wisconsin, Madison, Wisconsin 53726","cDepartment of Biochemistry and Department of Energy Great Lakes Bioenergy Research Center, University of Wisconsin, Madison, Wisconsin 53726"],"raw_orcid":"https://orcid.org/0000-0001-7425-7464","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Department of Energy Great Lakes Bioenergy Research Center, University of Wisconsin, Madison, Wisconsin 53726","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I2801044051"]},{"raw_affiliation_string":"cDepartment of Biochemistry and Department of Energy Great Lakes Bioenergy Research Center, University of Wisconsin, Madison, Wisconsin 53726","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I2801044051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087103346","display_name":"John Ralph","orcid":"https://orcid.org/0000-0002-6093-4521","observed_orcids":["https://orcid.org/0000-0002-6093-4521"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I2801044051","display_name":"Great Lakes Bioenergy Research Center","ror":"https://ror.org/01ca2by25","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I2801044051"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Ralph","raw_affiliation_strings":["Department of Biochemistry and Department of Energy Great Lakes Bioenergy Research Center, University of Wisconsin, Madison, Wisconsin 53726","cDepartment of Biochemistry and Department of Energy Great Lakes Bioenergy Research Center, University of Wisconsin, Madison, Wisconsin 53726"],"raw_orcid":"https://orcid.org/0000-0002-6093-4521","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Department of Energy Great Lakes Bioenergy Research Center, University of Wisconsin, Madison, Wisconsin 53726","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I2801044051"]},{"raw_affiliation_string":"cDepartment of Biochemistry and Department of Energy Great Lakes Bioenergy Research Center, University of Wisconsin, Madison, Wisconsin 53726","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I2801044051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000304681","display_name":"Wilfred Vermerris","orcid":"https://orcid.org/0000-0002-4582-3436","observed_orcids":["https://orcid.org/0000-0002-4582-3436"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I4405265380","display_name":"Institute of Food and Agricultural Sciences","ror":"https://ror.org/04mm87038","country_code":"US","type":"facility","lineage":["https://openalex.org/I33213144","https://openalex.org/I4405265380"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wilfred Vermerris","raw_affiliation_strings":["Department of Microbiology and Cell Science, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, Florida 32610","University of Florida, Genetics Institute, Gainesville, Florida 32610","dDepartment of Microbiology and Cell Science, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, Florida 32610","eUniversity of Florida, Genetics Institute, Gainesville, Florida 32610"],"raw_orcid":"https://orcid.org/0000-0002-4582-3436","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Cell Science, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, Florida 32610","institution_ids":["https://openalex.org/I33213144","https://openalex.org/I4405265380"]},{"raw_affiliation_string":"University of Florida, Genetics Institute, Gainesville, Florida 32610","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"dDepartment of Microbiology and Cell Science, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, Florida 32610","institution_ids":["https://openalex.org/I33213144","https://openalex.org/I4405265380"]},{"raw_affiliation_string":"eUniversity of Florida, Genetics Institute, Gainesville, Florida 32610","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085952747","display_name":"Scott E. Sattler","orcid":"https://orcid.org/0000-0002-6814-4073","observed_orcids":["https://orcid.org/0000-0002-6814-4073"]},"institutions":[{"id":"https://openalex.org/I1312222531","display_name":"Agricultural Research Service","ror":"https://ror.org/02d2m2044","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I1336096307","display_name":"United States Department of Agriculture","ror":"https://ror.org/01na82s61","country_code":"US","type":"government","lineage":["https://openalex.org/I1336096307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott E. Sattler","raw_affiliation_strings":["United States Department of Agriculture-Agricultural Research Service, Wheat, Sorghum, and Forage Research Unit, Lincoln, Nebraska 68583","fUnited States Department of Agriculture-Agricultural Research Service, Wheat, Sorghum, and Forage Research Unit, Lincoln, Nebraska 68583"],"raw_orcid":"https://orcid.org/0000-0002-6814-4073","affiliations":[{"raw_affiliation_string":"United States Department of Agriculture-Agricultural Research Service, Wheat, Sorghum, and Forage Research Unit, Lincoln, Nebraska 68583","institution_ids":["https://openalex.org/I1312222531","https://openalex.org/I1336096307"]},{"raw_affiliation_string":"fUnited States Department of Agriculture-Agricultural Research Service, Wheat, Sorghum, and Forage Research Unit, Lincoln, Nebraska 68583","institution_ids":["https://openalex.org/I1312222531","https://openalex.org/I1336096307"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071667418","display_name":"ChulHee Kang","orcid":"https://orcid.org/0000-0002-0693-7860","observed_orcids":["https://orcid.org/0000-0002-0693-7860"]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ChulHee Kang","raw_affiliation_strings":["Department of Chemistry, Washington State University, Pullman, Washington 99164","School of Molecular Biosciences, Washington State University, Pullman, Washington 99164","aDepartment of Chemistry, Washington State University, Pullman, Washington 99164","bSchool of Molecular Biosciences, Washington State University, Pullman, Washington 99164"],"raw_orcid":"https://orcid.org/0000-0002-0693-7860","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Washington State University, Pullman, Washington 99164","institution_ids":["https://openalex.org/I72951846"]},{"raw_affiliation_string":"School of Molecular Biosciences, Washington State University, Pullman, Washington 99164","institution_ids":["https://openalex.org/I72951846"]},{"raw_affiliation_string":"aDepartment of Chemistry, Washington State University, Pullman, Washington 99164","institution_ids":["https://openalex.org/I72951846"]},{"raw_affiliation_string":"bSchool of Molecular Biosciences, Washington State University, Pullman, Washington 99164","institution_ids":["https://openalex.org/I72951846"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3851,"currency":"USD","value_usd":3851},"apc_paid":null,"fwci":1.5995,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.81090499,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"174","issue":"4","first_page":"2128","last_page":"2145"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11208","display_name":"Lignin and Wood Chemistry","score":0.6470000147819519,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11208","display_name":"Lignin and Wood Chemistry","score":0.6470000147819519,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11237","display_name":"Plant Gene Expression Analysis","score":0.28610000014305115,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10869","display_name":"Polysaccharides and Plant Cell Walls","score":0.025100000202655792,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cinnamyl-alcohol-dehydrogenase","display_name":"cinnamyl alcohol dehydrogenase","score":1.0},{"id":"https://openalex.org/keywords/sorghum","display_name":"sorghum","score":0.9330000281333923},{"id":"https://openalex.org/keywords/monolignol-biosynthesis","display_name":"monolignol biosynthesis","score":0.9200000166893005},{"id":"https://openalex.org/keywords/lignin-biosynthesis","display_name":"lignin biosynthesis","score":0.8619999885559082},{"id":"https://openalex.org/keywords/substrate-specificity","display_name":"substrate specificity","score":0.8759999871253967},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.7749999761581421},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.7350000143051147},{"id":"https://openalex.org/keywords/site-directed-mutagenesis","display_name":"site-directed mutagenesis","score":0.8100000023841858},{"id":"https://openalex.org/keywords/coniferaldehyde","display_name":"coniferyl aldehyde","score":0.777999997138977},{"id":"https://openalex.org/keywords/sinapaldehyde","display_name":"sinapaldehyde","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nadph-dependent-reduction","display_name":"NADPH-dependent reduction","score":0.7540000081062317},{"id":"https://openalex.org/keywords/biomass-processing","display_name":"biomass processing","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C2780678855","wikidata":"https://www.wikidata.org/wiki/Q3025640","display_name":"Monolignol","level":4,"score":0.9747735261917114},{"id":"https://openalex.org/C2780186017","wikidata":"https://www.wikidata.org/wiki/Q1148842","display_name":"Cinnamyl-alcohol dehydrogenase","level":4,"score":0.8793531656265259},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6232727766036987},{"id":"https://openalex.org/C2781052789","wikidata":"https://www.wikidata.org/wiki/Q184817","display_name":"Lignin","level":2,"score":0.6019893884658813},{"id":"https://openalex.org/C2780440420","wikidata":"https://www.wikidata.org/wiki/Q204030","display_name":"Cinnamyl alcohol","level":4,"score":0.550137460231781},{"id":"https://openalex.org/C2775988993","wikidata":"https://www.wikidata.org/wiki/Q158695","display_name":"Arabidopsis thaliana","level":4,"score":0.5082737803459167},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.48906025290489197},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47608819603919983},{"id":"https://openalex.org/C2780848231","wikidata":"https://www.wikidata.org/wiki/Q3123184","display_name":"Sweet sorghum","level":3,"score":0.4521973729133606},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.4205670654773712},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4070459008216858},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36232489347457886},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.29415956139564514},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.2618253827095032},{"id":"https://openalex.org/C2778157034","wikidata":"https://www.wikidata.org/wiki/Q12111","display_name":"Sorghum","level":2,"score":0.16995567083358765},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14463037252426147},{"id":"https://openalex.org/C2777435628","wikidata":"https://www.wikidata.org/wiki/Q204036","display_name":"Cinnamaldehyde","level":3,"score":0.08629456162452698},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.07623210549354553},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000429","descriptor_name":"Alcohol Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000429","descriptor_name":"Alcohol Oxidoreductases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010940","descriptor_name":"Plant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010940","descriptor_name":"Plant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045868","descriptor_name":"Sorghum","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1104/pp.17.00576","doi":"https://doi.org/10.1104/pp.17.00576","is_oa":false,"landing_page_url":"https://doi.org/10.1104/pp.17.00576","pdf_url":null,"source":{"id":"https://openalex.org/S42294715","display_name":"PLANT PHYSIOLOGY","issn_l":"0032-0889","issn":["0032-0889","1532-2548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5543964","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5543964","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant Physiol","raw_type":"Text"},{"id":"pmid:28606901","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28606901","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant physiology","raw_type":"Journal Article"},{"id":"pmh:oai:osti.gov:1363722","doi":null,"is_oa":false,"landing_page_url":"https://www.osti.gov/biblio/1363722","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5543964","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5543964","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant Physiol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G245241062","display_name":null,"funder_award_id":"DE-PI0000031","funder_id":"https://openalex.org/F4320338290","funder_display_name":"National Renewable Energy Laboratory"},{"id":"https://openalex.org/G650867824","display_name":"Roles of Calsequestrin in the Control of Calcium Signals in Health and Disease","funder_award_id":"R01GM111254","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7714489378","display_name":"TAS::89 0227:: TAS RECOVERY ACT - BIOENERGY RESEARCH CENTER CAPITAL EQUIPMENT - GLBRC","funder_award_id":"DEFC0207ER64494","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G8685713483","display_name":null,"funder_award_id":"2011-67009-30026","funder_id":"https://openalex.org/F4320332299","funder_display_name":"National Institute of Food and Agriculture"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320306203","display_name":"M.J. Murdock Charitable Trust","ror":"https://ror.org/02hxgd925"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332299","display_name":"National Institute of Food and Agriculture","ror":"https://ror.org/05qx3fv49"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320338290","display_name":"National Renewable Energy Laboratory","ror":"https://ror.org/036266993"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W15864163","https://openalex.org/W1480956210","https://openalex.org/W1489206827","https://openalex.org/W1539796472","https://openalex.org/W1550327100","https://openalex.org/W1598028551","https://openalex.org/W1681177208","https://openalex.org/W1887893362","https://openalex.org/W1955690476","https://openalex.org/W1966159501","https://openalex.org/W1976836655","https://openalex.org/W1979974711","https://openalex.org/W1980405610","https://openalex.org/W1980898701","https://openalex.org/W1981489995","https://openalex.org/W1993673609","https://openalex.org/W1994604929","https://openalex.org/W1994608297","https://openalex.org/W1996082337","https://openalex.org/W2000382572","https://openalex.org/W2000856135","https://openalex.org/W2002310840","https://openalex.org/W2002988274","https://openalex.org/W2003604861","https://openalex.org/W2005172971","https://openalex.org/W2007177054","https://openalex.org/W2009590202","https://openalex.org/W2009627793","https://openalex.org/W2011567004","https://openalex.org/W2027218365","https://openalex.org/W2028858946","https://openalex.org/W2034874262","https://openalex.org/W2035503835","https://openalex.org/W2035632664","https://openalex.org/W2038019996","https://openalex.org/W2040665850","https://openalex.org/W2045435533","https://openalex.org/W2048120948","https://openalex.org/W2049655576","https://openalex.org/W2069518913","https://openalex.org/W2074268267","https://openalex.org/W2078268337","https://openalex.org/W2085301582","https://openalex.org/W2085392887","https://openalex.org/W2086187764","https://openalex.org/W2087205775","https://openalex.org/W2091348851","https://openalex.org/W2098648303","https://openalex.org/W2105300971","https://openalex.org/W2106911146","https://openalex.org/W2108959691","https://openalex.org/W2113443252","https://openalex.org/W2114622716","https://openalex.org/W2119273703","https://openalex.org/W2120745885","https://openalex.org/W2124026197","https://openalex.org/W2124307786","https://openalex.org/W2127130852","https://openalex.org/W2128623540","https://openalex.org/W2129434797","https://openalex.org/W2134967712","https://openalex.org/W2137329388","https://openalex.org/W2157959147","https://openalex.org/W2163914455","https://openalex.org/W2164974062","https://openalex.org/W2165278495","https://openalex.org/W2167949243","https://openalex.org/W2168245648","https://openalex.org/W2169656112","https://openalex.org/W2169821755","https://openalex.org/W2170799652","https://openalex.org/W2180229411","https://openalex.org/W2240868859","https://openalex.org/W2408185896","https://openalex.org/W2515839181","https://openalex.org/W2549181324","https://openalex.org/W2566435034"],"related_works":["https://openalex.org/W2022614647","https://openalex.org/W2002988274","https://openalex.org/W2142594546","https://openalex.org/W2038661659","https://openalex.org/W6993098287","https://openalex.org/W2165278495","https://openalex.org/W2069518913","https://openalex.org/W2113443252","https://openalex.org/W2028858946","https://openalex.org/W2135434444"],"abstract_inverted_index":{"Cinnamyl":[0],"alcohol":[1,101],"dehydrogenase":[2],"(CAD)":[3],"catalyzes":[4],"the":[5,32,133,152,174],"final":[6],"step":[7],"in":[8,20,29,34,43,46,68,87,151,179,186],"monolignol":[9,30],"biosynthesis,":[10,31],"reducing":[11],"sinapaldehyde,":[12,158],"coniferaldehyde,":[13],"and":[14,37,49,66,82,90,97,117,131,141,169],"p-coumaraldehyde":[15,156],"to":[16,92,197],"their":[17,85,138],"corresponding":[18],"alcohols":[19],"an":[21],"NADPH-dependent":[22],"manner.":[23],"Because":[24],"of":[25,39,51,56,71,108,165],"its":[26,148],"terminal":[27],"location":[28],"variation":[33],"substrate":[35,139,149],"specificity":[36,140],"activity":[38,91],"CAD":[40,59,111,177],"can":[41],"result":[42],"significant":[44],"changes":[45],"overall":[47],"composition":[48],"amount":[50],"lignin.":[52],"Our":[53],"in-depth":[54],"characterization":[55],"two":[57],"major":[58,176],"isoforms,":[60],"SbCAD2":[61],"(Brown":[62],"midrib":[63],"6":[64],"[bmr6])":[65],"SbCAD4,":[67],"lignifying":[69],"tissues":[70],"sorghum":[72],"(Sorghum":[73],"bicolor),":[74],"a":[75,109,118,191],"strategic":[76],"plant":[77],"for":[78,137],"generating":[79],"renewable":[80],"chemicals":[81],"fuels,":[83],"indicates":[84],"similarity":[86],"both":[88,166],"structure":[89,107],"Arabidopsis":[93],"(Arabidopsis":[94],"thaliana)":[95],"CAD5":[96],"Populus":[98],"tremuloides":[99],"sinapyl":[100],"dehydrogenase,":[102],"respectively.":[103],"This":[104],"first":[105],"crystal":[106],"monocot":[110],"combined":[112],"with":[113,128,159,184],"enzyme":[114],"kinetic":[115],"data":[116],"catalytic":[119,161],"model":[120],"supported":[121],"by":[122],"site-directed":[123],"mutagenesis":[124],"allows":[125],"full":[126],"comparison":[127],"dicot":[129],"CADs":[130],"elucidates":[132],"potential":[134],"signature":[135],"sequence":[136],"activity.":[142],"The":[143],"L119W/G301F-SbCAD4":[144,185],"double":[145],"mutant":[146],"displayed":[147],"preference":[150],"order":[153],"coniferaldehyde":[154],">":[155,157],"higher":[160],"efficiency":[162],"than":[163],"that":[164,193],"wild-type":[167],"SbCAD4":[168,172,183],"SbCAD2.":[170],"As":[171],"is":[173,194],"only":[175],"isoform":[178],"bmr6":[180,187],"mutants,":[181],"replacing":[182],"plants":[188],"could":[189],"produce":[190],"phenotype":[192],"more":[195],"amenable":[196],"biomass":[198],"processing.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-06-23T00:00:00"}