{"id":"https://openalex.org/W2625007576","doi":null,"title":"Localization of secretases involved in the processing of \u03b2- Amyloid precursor protein related to alzheimer\u2019s disease","display_name":"Localization of secretases involved in the processing of \u03b2- Amyloid precursor protein related to alzheimer\u2019s disease","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2625007576","mag":"2625007576"},"language":"en","primary_location":{"id":"pmh:oai:estudogeral.sib.uc.pt:10316/24894","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10316/24894","pdf_url":"https://estudogeral.uc.pt/bitstream/10316/24894/1/Localization%20of%20Secretases%20Involved%20in%20the%20%20Processing%20of%20Beta-Amyloid%20Precursor%20Protein%20related%20to%20Alzheimer%27s%20Disease_A~1.PDF","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_bdcc"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://estudogeral.uc.pt/bitstream/10316/24894/1/Localization%20of%20Secretases%20Involved%20in%20the%20%20Processing%20of%20Beta-Amyloid%20Precursor%20Protein%20related%20to%20Alzheimer%27s%20Disease_A~1.PDF","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085754928","display_name":"Anna Pli\u00e1ssova","orcid":"https://orcid.org/0000-0002-4403-745X","observed_orcids":["https://orcid.org/0000-0002-4403-745X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Anna Pli\u00e1ssova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5085754928"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9229999780654907},{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.8799999952316284},{"id":"https://openalex.org/keywords/secretases","display_name":"secretases","score":0.8429999947547913},{"id":"https://openalex.org/keywords/bace1","display_name":"BACE1","score":0.7960000038146973},{"id":"https://openalex.org/keywords/adam10","display_name":"ADAM10","score":0.8889999985694885},{"id":"https://openalex.org/keywords/presenilin-1","display_name":"presenilin 1","score":0.9190000295639038},{"id":"https://openalex.org/keywords/synaptic-localization","display_name":"synaptic localization","score":0.597000002861023},{"id":"https://openalex.org/keywords/presynaptic-terminals","display_name":"presynaptic terminals","score":0.8130000233650208},{"id":"https://openalex.org/keywords/postsynaptic-density","display_name":"postsynaptic density","score":0.6740000247955322},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.7960000038146973},{"id":"https://openalex.org/keywords/glutamatergic-synapses","display_name":"glutamatergic synapses","score":0.8339999914169312},{"id":"https://openalex.org/keywords/gabaergic-synapses","display_name":"GABAergic synapses","score":0.996999979019165},{"id":"https://openalex.org/keywords/synaptosomes","display_name":"synaptosomes","score":0.6420000195503235},{"id":"https://openalex.org/keywords/age-related-changes","display_name":"age-related changes","score":0.5239999890327454},{"id":"https://openalex.org/keywords/animal-models-of-alzheimer-s-disease","display_name":"animal models of Alzheimer's disease","score":0.777999997138977},{"id":"https://openalex.org/keywords/synaptic-dysfunction","display_name":"synaptic dysfunction","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C36103677","wikidata":"https://www.wikidata.org/wiki/Q4749551","display_name":"Amyloid precursor protein secretase","level":5,"score":0.7097122073173523},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5823421478271484},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.579352080821991},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.457893431186676},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.44712644815444946},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4301036596298218},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3519979417324066},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25758376717567444},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19753530621528625}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:estudogeral.sib.uc.pt:10316/24894","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10316/24894","pdf_url":"https://estudogeral.uc.pt/bitstream/10316/24894/1/Localization%20of%20Secretases%20Involved%20in%20the%20%20Processing%20of%20Beta-Amyloid%20Precursor%20Protein%20related%20to%20Alzheimer%27s%20Disease_A~1.PDF","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_bdcc"},{"id":"pmh:oai:estudogeral.uc.pt:10316/24894","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10316/24894","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},{"id":"mag:2625007576","doi":null,"is_oa":false,"landing_page_url":"https://estudogeral.sib.uc.pt/bitstream/10316/24894/1/Localization%20of%20Secretases%20Involved%20in%20the%20%20Processing%20of%20Beta-Amyloid%20Precursor%20Protein%20related%20to%20Alzheimer%27s%20Disease_A~1.PDF","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:estudogeral.sib.uc.pt:10316/24894","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10316/24894","pdf_url":"https://estudogeral.uc.pt/bitstream/10316/24894/1/Localization%20of%20Secretases%20Involved%20in%20the%20%20Processing%20of%20Beta-Amyloid%20Precursor%20Protein%20related%20to%20Alzheimer%27s%20Disease_A~1.PDF","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_bdcc"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2625007576.pdf","grobid_xml":"https://content.openalex.org/works/W2625007576.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1743419595","https://openalex.org/W1898172578","https://openalex.org/W1965280907","https://openalex.org/W1968900405","https://openalex.org/W1981813071","https://openalex.org/W1982751676","https://openalex.org/W1985988204","https://openalex.org/W2008739673","https://openalex.org/W2015680326","https://openalex.org/W2015798402","https://openalex.org/W2016667221","https://openalex.org/W2017021169","https://openalex.org/W2026399828","https://openalex.org/W2029054457","https://openalex.org/W2038350410","https://openalex.org/W2042600422","https://openalex.org/W2043029471","https://openalex.org/W2051226585","https://openalex.org/W2056666484","https://openalex.org/W2057672006","https://openalex.org/W2066116456","https://openalex.org/W2076868543","https://openalex.org/W2079749054","https://openalex.org/W2079861976","https://openalex.org/W2080250606","https://openalex.org/W2082724893","https://openalex.org/W2085435800","https://openalex.org/W2086717125","https://openalex.org/W2093426751","https://openalex.org/W2093994899","https://openalex.org/W2106126875","https://openalex.org/W2131180711","https://openalex.org/W2133019124","https://openalex.org/W2140432027","https://openalex.org/W2144457644","https://openalex.org/W2147292139","https://openalex.org/W2147435466","https://openalex.org/W2155949745"],"related_works":["https://openalex.org/W4252399966","https://openalex.org/W4253917959","https://openalex.org/W2470139856","https://openalex.org/W2256994925","https://openalex.org/W6980260095","https://openalex.org/W7061261258","https://openalex.org/W1980749733","https://openalex.org/W2003102313","https://openalex.org/W1035185106","https://openalex.org/W2047245492"],"abstract_inverted_index":{"As":[0],"fases":[1,110],"iniciais":[2,111,701],"da":[3,32,35,41,74,112,131,161,183,236,250,252,255,260,266,321,348,385,389,520,560,562,567,576,583,585,591,612,629,631,634,640,672,686,702],"doen\u00e7a":[4,69,230,322,577,663,703],"de":[5,43,49,55,70,105,120,139,150,163,201,214,229,231,278,290,298,302,310,316,323,329,364,368,371,378,417,457,495,529,531,536,546,553,595,625,647,654,664,694,704,715],"Alzheimer":[6,232,665],"s\u00e3o":[7,28],"caracterizadas":[8],"por":[9,19,98,270,593],"altera\u00e7\u00f5es":[10,157,655],"na":[11,68,453,518],"efici\u00eancia":[12],"sin\u00e1ptica,":[13],"que":[14,52,99,285,332,402,425,446,469,476,484,499,510,667],"se":[15,50,95,151,153,224,410,438,450,502],"pensa":[16],"serem":[17],"causadas":[18],"olig\u00f3meros":[20],"sol\u00faveis":[21],"dos":[22],"pept\u00eddeos":[23,27],"\u03b2-amil\u00f3ide":[24,38],"(A\u03b2).":[25],"Estes":[26],"formados":[29],"a":[30,53,57,72,124,126,173,199,208,225,234,248,288,300,314,326,334,344,403,405,408,426,431,434,447,470,485,488,603,652,658,662,684,690,709],"partir":[31,289,301,315],"clivagem":[33],"proteol\u00edtica":[34],"prote\u00edna":[36],"precursora":[37],"(APP),":[39],"atrav\u00e9s":[40,384],"a\u00e7\u00e3o":[42],"secretases":[44,78,187,240,393,478,638],"(\u03b1-":[45,79,188,257],"e":[46,76,81,129,133,176,181,185,190,203,219,221,227,238,247,259,273,281,312,340,350,391,398,407,442,466,481,487,497,522,525,610,614,636,639,660,674,692,697,706],"\u03b2-).":[47],"Apesar":[48],"saber":[51],"forma\u00e7\u00e3o":[54],"A\u03b2":[56],"n\u00edvel":[58,127,432],"sin\u00e1ptico":[59,128],"\u00e9":[60,472],"provavelmente":[61],"crucial":[62],"para":[63,360,683,689,712],"o":[64,118,148,565,680,713],"dano":[65],"inicialmente":[66],"verificado":[67],"Alzheimer,":[71,578,705],"distribui\u00e7\u00e3o":[73,125,155,174,235,245,345],"APP":[75,132,184,202,237,349,365,390,427,471,486,521,563,613,635,673],"das":[77,134,186,204,239,336,351,387,392,523,607,615,637,675],"\u03b2-":[80,189],"\u03b3-)":[82],"envolvidas":[83],"no":[84,195,666],"seu":[85],"processamento":[86],"proteol\u00edtico,":[87],"em":[88,136,142,158,211,241,275,366,394,413,460,493,538,551,617,643,699],"diferentes":[89,137,212,374,644],"terminais":[90,140,215,242,282,414,461,507,645],"nervosos,":[91,141,216,415],"permanece":[92],"desconhecida.":[93],"N\u00e3o":[94],"sabe":[96],"ainda":[97,115,343,498],"raz\u00e3o":[100],"apenas":[101],"alguns":[102],"tipos":[103,138,213],"espec\u00edficos":[104],"sinapses":[106,695],"sofrem":[107],"degenera\u00e7\u00e3o":[108,693],"nas":[109],"doen\u00e7a.":[113],"\u00c9":[114],"mais":[116,473,504],"surpreendente":[117],"facto":[119,149],"n\u00e3o":[121,418,514],"ser":[122,710],"conhecida":[123],"subsin\u00e1ptico":[130],"secretases,":[135,205,616],"diversas":[143],"regi\u00f5es":[144,618],"cerebrais,":[145],"bem":[146,206,587,627],"como":[147,207,588,628],"desconhecer":[152],"esta":[154,500],"sofre":[156],"modelos":[159,320,575],"animais":[160],"patologia":[162],"Alzheimer.":[164,324],"Os":[165,597],"principais":[166],"objetivos":[167],"deste":[168],"trabalho":[169],"eram:":[170],"i)":[171],"investigar":[172,223],"sin\u00e1ptica":[175,246,609],"sub-sin\u00e1ptica":[177,346,611],"(zonas":[178],"pr\u00e9-,":[179,338],"p\u00f3s-":[180,339],"extra-sin\u00e1pticas)":[182],"\u03b3-),":[191],"com":[192,295,307,373,540,564,657,661],"particular":[193,687],"foco":[194],"hipocampo,":[196,464],"ii)":[197],"definir":[198],"presen\u00e7a":[200],"sua":[209,641],"co-localiza\u00e7\u00e3o":[210],"principalmente":[217,452],"glutamat\u00e9rgicos":[218,508],"GABA\u00e9rgicos":[220],"iii)":[222],"idade":[226,568,659],"condi\u00e7\u00f5es":[228],"afectam":[233],"nervosos.":[243],"A":[244],"densidade":[249,519,561,671],"APP,":[251,404],"BACE1":[253,480,489],"(\u03b2-secretase),":[254],"ADAM-10":[256],"secretase)":[258],"presenilina":[261],"-1":[262],"(PS1,":[263],"um":[264,327,357,589],"componente":[265],"\u03b3-secretase)":[267],"foram":[268,286],"avaliadas":[269],"Western":[271],"blot":[272],"imunocitoqu\u00edmica,":[274,459],"prepara\u00e7\u00f5es":[276],"sin\u00e1pticas":[277],"hipocampo":[279,377,530],"(sinaptossomas":[280],"nervosos":[283,646],"purificados),":[284],"obtidas":[287],"murganhos":[291,303,317,379,532,541,572],"machos":[292],"adultos":[293,381,533,543],"C57/Bl6,":[294],"2-3":[296],"meses":[297,309,535,545],"idade,":[299,311],"do":[304,463,475,509,621,623],"mesmo":[305],"tipo,":[306],"9":[308],"tamb\u00e9m":[313,356,650],"triplos":[318,573],"transg\u00e9nicos":[319,574],"Recorrendo":[325],"protocolo":[328],"fracionamento":[330],"sin\u00e1ptico,":[331],"permite":[333],"separa\u00e7\u00e3o":[335],"frac\u00e7\u00f5es":[337],"extrasin\u00e1pticas,":[341],"avali\u00e1mos":[342],"relativa":[347,633],"secretases.":[352,676],"Al\u00e9m":[353],"disso,":[354],"fizemos":[355],"estudo":[358,601],"preliminar":[359],"determinar":[361],"os":[362],"n\u00edveis":[363],"amostras":[367,552],"c\u00e9rebro":[369,554,624],"humano":[370,555],"indiv\u00edduos":[372],"idades.":[375],"No":[376],"jovens":[380,542],"(2-3":[382,544],"meses),":[383],"compara\u00e7\u00e3o":[386,539],"imunoreactividades":[388],"sinaptossomas":[395,528],"(terminais":[396],"nervosos)":[397],"membranas":[399],"totais,":[400],"verific\u00e1mos":[401,556],"\u03b1-":[406,435,524],"\u03b2-secretases":[409],"encontram":[411],"presentes":[412],"apesar":[416],"estarem":[419],"enriquecidas":[420],"nos":[421,506,511,527],"sinaptossomas.":[422],"Tamb\u00e9m":[423],"observ\u00e1mos":[424,579],"est\u00e1":[428],"localizada":[429],"preferencialmente":[430],"pr\u00e9-sin\u00e1ptico,":[433],"secretase":[436,501],"(ADAM10)":[437],"encontra":[439,451,503],"distribu\u00edda":[440],"pr\u00e9-":[441],"extra-sinapticamente,":[443],"ao":[444],"passo":[445,682],"\u03b2-secretase":[448],"(BACE1)":[449],"fra\u00e7\u00e3o":[454],"extra-sin\u00e1ptica.":[455],"Atrav\u00e9s":[456],"an\u00e1lise":[458,594,605],"pr\u00e9-sin\u00e1pticos":[462],"purificados":[465],"plaqueados,":[467],"verificamos":[468],"abundante":[474],"as":[477],"(ADAM10,":[479],"presenilina1,":[482],"PS1),":[483],"est\u00e3o":[490],"parcialmente":[491],"co-localizadas":[492],"cerca":[494],"40%":[496],"presente":[505],"GABA\u00e9rgicos.":[512],"Inesperadamente,":[513],"observamos":[515],"diferen\u00e7as":[516],"significativas":[517],"\u03b2-secretases,":[526],"(9":[534],"idade),":[537],"idade).":[547],"Por":[548],"outro":[549],"lado,":[550],"uma":[557,580],"clara":[558,581],"diminui\u00e7\u00e3o":[559,582],"aumento":[566,590],"(resultados":[569],"preliminares).":[570],"Em":[571],"imunoreactividade":[584],"ADAM10,":[586],"PS1,":[592],"imunocitoqu\u00edmica.":[596],"resultados":[598],"apresentados":[599],"neste":[600],"representam":[602],"primeira":[604],"comparativa":[606],"distribui\u00e7\u00f5es":[608],"corticais":[619],"(principalmente":[620],"hipocampo)":[622],"murganhos,":[626],"avalia\u00e7\u00e3o":[630],"abund\u00e2ncia":[632],"co-localiza\u00e7\u00e3o,":[642],"hipocampo.":[648],"Foi":[649],"avaliada":[651],"exist\u00eancia":[653],"relacionadas":[656],"diz":[668],"respeito":[669],"\u00e0":[670],"Este":[677],"projeto":[678],"constitui":[679],"primeiro":[681],"compreens\u00e3o":[685],"susceptibilidade":[688],"disfun\u00e7\u00e3o":[691],"glutamat\u00e9rgicas":[696],"GABA\u00e9rgicas,":[698],"etapas":[700],"pode":[707],"vir":[708],"\u00fatil":[711],"desenvolvimento":[714],"novas":[716],"estrat\u00e9gias":[717],"terap\u00eauticas.":[718]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2017-06-23T00:00:00"}
