{"id":"https://openalex.org/W2624677839","doi":null,"title":"Search for DNA Methylation Biomarkers in the Circulating DNA of Prostate and Colorectal Cancer","display_name":"Search for DNA Methylation Biomarkers in the Circulating DNA of Prostate and Colorectal Cancer","publication_year":2012,"publication_date":"2012-08-15","ids":{"openalex":"https://openalex.org/W2624677839","mag":"2624677839"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/32617","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/32617","pdf_url":"https://utoronto.scholaris.ca/bitstreams/5dc966e0-02bc-48e1-92cd-4749e4f2de5e/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/5dc966e0-02bc-48e1-92cd-4749e4f2de5e/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100737803","display_name":"Mina Park","orcid":"https://orcid.org/0000-0002-2005-7560","observed_orcids":["https://orcid.org/0000-0002-2005-7560"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mina Park","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2005-7560","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5100737803"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9496999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9496999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.04179999977350235,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cell-free-dna","display_name":"cell-free DNA","score":0.8209999799728394},{"id":"https://openalex.org/keywords/plasma-dna","display_name":"plasma DNA","score":0.7009999752044678},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8100000023841858},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":1.0},{"id":"https://openalex.org/keywords/epigenetic-biomarkers","display_name":"epigenetic biomarkers","score":0.9399999976158142},{"id":"https://openalex.org/keywords/early-cancer-detection","display_name":"early cancer detection","score":0.8149999976158142},{"id":"https://openalex.org/keywords/tumor-screening","display_name":"cancer screening","score":0.7649999856948853},{"id":"https://openalex.org/keywords/cpg-islands","display_name":"CpG islands","score":0.7580000162124634},{"id":"https://openalex.org/keywords/differential-methylation","display_name":"differential methylation","score":0.5759999752044678},{"id":"https://openalex.org/keywords/bisulfite-pyrosequencing","display_name":"bisulfite pyrosequencing","score":0.7590000033378601},{"id":"https://openalex.org/keywords/tiling-microarrays","display_name":"tiling microarrays","score":0.7940000295639038}],"concepts":[{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7088159918785095},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5170091390609741},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5019195079803467},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4907432794570923},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4890323579311371},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48650234937667847},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44525274634361267},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.42729848623275757},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3358660936355591},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29209673404693604},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18859073519706726},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13424521684646606},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0720163881778717}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/32617","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/32617","pdf_url":"https://utoronto.scholaris.ca/bitstreams/5dc966e0-02bc-48e1-92cd-4749e4f2de5e/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:collectionscanada.gc.ca:OTU.1807/32617","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1807/32617","pdf_url":null,"source":{"id":"https://openalex.org/S4306402307","display_name":"Library and Archives Canada (Government of Canada)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802286613","host_organization_name":"Government of Canada","host_organization_lineage":["https://openalex.org/I2802286613"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2624677839","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/bitstream/1807/32617/1/Park_Mina_201206_MSc_thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/32617","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/32617","pdf_url":"https://utoronto.scholaris.ca/bitstreams/5dc966e0-02bc-48e1-92cd-4749e4f2de5e/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2624677839.pdf","grobid_xml":"https://content.openalex.org/works/W2624677839.grobid-xml"},"referenced_works_count":171,"referenced_works":["https://openalex.org/W52085803","https://openalex.org/W75606232","https://openalex.org/W91108901","https://openalex.org/W144306197","https://openalex.org/W1249058925","https://openalex.org/W1505696417","https://openalex.org/W1540791800","https://openalex.org/W1550107968","https://openalex.org/W1556996865","https://openalex.org/W1560377790","https://openalex.org/W1574433403","https://openalex.org/W1579447084","https://openalex.org/W1602504912","https://openalex.org/W1606687529","https://openalex.org/W1633962291","https://openalex.org/W1644997609","https://openalex.org/W1658127082","https://openalex.org/W1781296206","https://openalex.org/W1849446486","https://openalex.org/W1906037527","https://openalex.org/W1919687837","https://openalex.org/W1963780936","https://openalex.org/W1963853602","https://openalex.org/W1964884630","https://openalex.org/W1965262464","https://openalex.org/W1966362486","https://openalex.org/W1966485273","https://openalex.org/W1968331471","https://openalex.org/W1971261512","https://openalex.org/W1971964553","https://openalex.org/W1972272357","https://openalex.org/W1973043309","https://openalex.org/W1974359182","https://openalex.org/W1974747095","https://openalex.org/W1974995008","https://openalex.org/W1977772936","https://openalex.org/W1978419388","https://openalex.org/W1981232037","https://openalex.org/W1981989535","https://openalex.org/W1982417455","https://openalex.org/W1983058303","https://openalex.org/W1984130135","https://openalex.org/W1985805774","https://openalex.org/W1990915258","https://openalex.org/W1993453915","https://openalex.org/W1994465394","https://openalex.org/W1994932189","https://openalex.org/W1995470989","https://openalex.org/W1997453048","https://openalex.org/W1997492763","https://openalex.org/W1998517881","https://openalex.org/W1999510229","https://openalex.org/W2000636252","https://openalex.org/W2002384741","https://openalex.org/W2002557807","https://openalex.org/W2003281975","https://openalex.org/W2004078197","https://openalex.org/W2005251132","https://openalex.org/W2006883241","https://openalex.org/W2011890326","https://openalex.org/W2013469922","https://openalex.org/W2014495816","https://openalex.org/W2015438948","https://openalex.org/W2019893869","https://openalex.org/W2024543108","https://openalex.org/W2024819383","https://openalex.org/W2025266714","https://openalex.org/W2026530445","https://openalex.org/W2027212435","https://openalex.org/W2029484950","https://openalex.org/W2031205682","https://openalex.org/W2033609079","https://openalex.org/W2035031341","https://openalex.org/W2036300762","https://openalex.org/W2038449573","https://openalex.org/W2038918129","https://openalex.org/W2040257851","https://openalex.org/W2040754208","https://openalex.org/W2041103350","https://openalex.org/W2043033879","https://openalex.org/W2043516790","https://openalex.org/W2046509449","https://openalex.org/W2050574264","https://openalex.org/W2051082355","https://openalex.org/W2053447630","https://openalex.org/W2053458759","https://openalex.org/W2053954823","https://openalex.org/W2058440954","https://openalex.org/W2058487126","https://openalex.org/W2058629813","https://openalex.org/W2059490612","https://openalex.org/W2060446375","https://openalex.org/W2060503951","https://openalex.org/W2062093164","https://openalex.org/W2065498897","https://openalex.org/W2067486047","https://openalex.org/W2069786312","https://openalex.org/W2071154937","https://openalex.org/W2071947369","https://openalex.org/W2072003197","https://openalex.org/W2074257955","https://openalex.org/W2081008050","https://openalex.org/W2081098333","https://openalex.org/W2082620103","https://openalex.org/W2082809341","https://openalex.org/W2084662944","https://openalex.org/W2084748297","https://openalex.org/W2086535617","https://openalex.org/W2088556112","https://openalex.org/W2089388848","https://openalex.org/W2091742177","https://openalex.org/W2095228410","https://openalex.org/W2095728717","https://openalex.org/W2096643260","https://openalex.org/W2099224719","https://openalex.org/W2100457151","https://openalex.org/W2100675674","https://openalex.org/W2102368084","https://openalex.org/W2102576865","https://openalex.org/W2106816824","https://openalex.org/W2107021610","https://openalex.org/W2107038650","https://openalex.org/W2107205304","https://openalex.org/W2107972234","https://openalex.org/W2108664872","https://openalex.org/W2109130949","https://openalex.org/W2111489677","https://openalex.org/W2115578647","https://openalex.org/W2115802074","https://openalex.org/W2120768446","https://openalex.org/W2120865735","https://openalex.org/W2121081236","https://openalex.org/W2121417064","https://openalex.org/W2125147512","https://openalex.org/W2127540087","https://openalex.org/W2128146359","https://openalex.org/W2131230517","https://openalex.org/W2131474316","https://openalex.org/W2133912281","https://openalex.org/W2135611636","https://openalex.org/W2138457013","https://openalex.org/W2139224474","https://openalex.org/W2141380480","https://openalex.org/W2141730018","https://openalex.org/W2142191516","https://openalex.org/W2143264090","https://openalex.org/W2143468879","https://openalex.org/W2143658931","https://openalex.org/W2144590980","https://openalex.org/W2144823751","https://openalex.org/W2145541031","https://openalex.org/W2148345265","https://openalex.org/W2148521032","https://openalex.org/W2149655654","https://openalex.org/W2150027485","https://openalex.org/W2151110250","https://openalex.org/W2152275257","https://openalex.org/W2153466675","https://openalex.org/W2154929782","https://openalex.org/W2156858528","https://openalex.org/W2157731375","https://openalex.org/W2158396304","https://openalex.org/W2158687684","https://openalex.org/W2160234594","https://openalex.org/W2161380492","https://openalex.org/W2164050575","https://openalex.org/W2165056748","https://openalex.org/W2169858868","https://openalex.org/W2414254744","https://openalex.org/W2418350636","https://openalex.org/W2418496196"],"related_works":["https://openalex.org/W2774010499","https://openalex.org/W2110986932","https://openalex.org/W2605359372","https://openalex.org/W2176076958","https://openalex.org/W2074159076","https://openalex.org/W2739520683","https://openalex.org/W4225897643","https://openalex.org/W2621163719","https://openalex.org/W2804761030","https://openalex.org/W4385330983"],"abstract_inverted_index":{"Early":[0],"diagnosis":[1,16],"represents":[2],"an":[3],"effective":[4],"way":[5],"to":[6,63],"improve":[7],"patient":[8],"prognosis":[9],"in":[10,27,43,120,134],"cancer.":[11,55,135],"New":[12],"opportunities":[13],"for":[14,128],"cancer":[15,52,91],"and":[17,74,83,93],"screening":[18],"may":[19],"arise":[20],"from":[21,99],"identification":[22,130],"of":[23,40,47,81,117,131],"cancer-specific":[24],"epigenetic":[25,132],"alterations":[26],"the":[28,38,44,121,129],"cell-free":[29],"circulating":[30],"DNA":[31,41,66,118],"(cirDNA).":[32],"This":[33],"study":[34],"investigated":[35],"biomarkers":[36,133],"at":[37],"level":[39],"methylation":[42,88,119],"plasma":[45],"cirDNA":[46,122],"individuals":[48],"affected":[49],"with":[50,109],"prostate":[51,90],"or":[53],"colorectal":[54],"A":[56,79],"methylation-sensitive":[57],"restriction":[58],"enzyme-based":[59],"method":[60],"was":[61],"used":[62],"enrich":[64],"methylated":[65],"fractions,":[67],"which":[68],"were":[69],"interrogated":[70],"on":[71],"CpG":[72],"island":[73],"human":[75],"genome":[76],"tiling":[77],"microarrays.":[78],"number":[80],"genes":[82],"non-coding":[84],"loci":[85,97],"exhibited":[86],"differential":[87],"between":[89],"patients":[92],"controls.":[94],"The":[95],"candidate":[96],"identified":[98],"these":[100],"microarray":[101],"experiments":[102],"underwent":[103],"verification":[104],"by":[105],"bisulfite":[106],"modification":[107],"coupled":[108],"pyrosequencing.":[110],"Our":[111],"results":[112],"suggest":[113],"that":[114],"microarray-based":[115],"studies":[116],"can":[123],"be":[124],"a":[125],"promising":[126],"avenue":[127]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2017-06-23T00:00:00"}
