{"id":"https://openalex.org/W2624327367","doi":"https://doi.org/10.2217/bmm-2017-0143","title":"Circulating Endothelial Cells and Their Subsets: Novel Biomarkers for Cancer","display_name":"Circulating Endothelial Cells and Their Subsets: Novel Biomarkers for Cancer","publication_year":2017,"publication_date":"2017-06-09","ids":{"openalex":"https://openalex.org/W2624327367","doi":"https://doi.org/10.2217/bmm-2017-0143","mag":"2624327367","pmid":"https://pubmed.ncbi.nlm.nih.gov/28597689"},"language":"en","primary_location":{"id":"doi:10.2217/bmm-2017-0143","doi":"https://doi.org/10.2217/bmm-2017-0143","is_oa":false,"landing_page_url":"https://doi.org/10.2217/bmm-2017-0143","pdf_url":null,"source":{"id":"https://openalex.org/S130557755","display_name":"Biomarkers in Medicine","issn_l":"1752-0363","issn":["1752-0363","1752-0371"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomarkers in Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033825198","display_name":"Fangbin Zhou","orcid":"https://orcid.org/0000-0002-9668-7649","observed_orcids":["https://orcid.org/0000-0002-9668-7649"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]},{"id":"https://openalex.org/I4210105608","display_name":"ShenZhen People\u2019s Hospital","ror":"https://ror.org/01hcefx46","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105608"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fangbin Zhou","raw_affiliation_strings":["Department of Oncology,The Second Clinical Medical College,Shenzhen People\u2019s Hospital,Jinan University,\r          Shenzhen\r          518020,\r          China","Integrated Chinese & Western Medicine Postdoctoral Research Station,Jinan University, Guangzhou 510632, China","Department of Oncology, The Second Clinical Medical College, Shenzhen People's Hospital, Jinan University, Shenzhen 518020, China Integrated Chinese & Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou 510632, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology,The Second Clinical Medical College,Shenzhen People\u2019s Hospital,Jinan University,\r          Shenzhen\r          518020,\r          China","institution_ids":["https://openalex.org/I159948400","https://openalex.org/I4210105608"]},{"raw_affiliation_string":"Integrated Chinese & Western Medicine Postdoctoral Research Station,Jinan University, Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]},{"raw_affiliation_string":"Department of Oncology, The Second Clinical Medical College, Shenzhen People's Hospital, Jinan University, Shenzhen 518020, China Integrated Chinese & Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400","https://openalex.org/I4210105608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086655719","display_name":"Yaying Zhou","orcid":"https://orcid.org/0000-0003-2632-5201","observed_orcids":["https://orcid.org/0000-0003-2632-5201"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]},{"id":"https://openalex.org/I4210105608","display_name":"ShenZhen People\u2019s Hospital","ror":"https://ror.org/01hcefx46","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105608"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaying Zhou","raw_affiliation_strings":["Clinical Medical Research Center, The Second Clinical Medical College, Shenzhen People's Hospital, Jinan University, Shenzhen 518020, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Medical Research Center, The Second Clinical Medical College, Shenzhen People's Hospital, Jinan University, Shenzhen 518020, China","institution_ids":["https://openalex.org/I159948400","https://openalex.org/I4210105608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078181925","display_name":"Jun Dong","orcid":"https://orcid.org/0000-0002-6064-0814","observed_orcids":["https://orcid.org/0000-0002-6064-0814"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Dong","raw_affiliation_strings":["Department of Pathophysiology,Key Laboratory of the State Administration of Traditional Chinese Medicine,Medical College of Jinan University,\r          Guangzhou\r          510632,\r          China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathophysiology,Key Laboratory of the State Administration of Traditional Chinese Medicine,Medical College of Jinan University,\r          Guangzhou\r          510632,\r          China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091208875","display_name":"Wenyong Tan","orcid":"https://orcid.org/0000-0002-2706-4149","observed_orcids":["https://orcid.org/0000-0002-2706-4149"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]},{"id":"https://openalex.org/I4210105608","display_name":"ShenZhen People\u2019s Hospital","ror":"https://ror.org/01hcefx46","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105608"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenyong Tan","raw_affiliation_strings":["Department of Oncology,The Second Clinical Medical College,Shenzhen People\u2019s Hospital,Jinan University,\r          Shenzhen\r          518020,\r          China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology,The Second Clinical Medical College,Shenzhen People\u2019s Hospital,Jinan University,\r          Shenzhen\r          518020,\r          China","institution_ids":["https://openalex.org/I159948400","https://openalex.org/I4210105608"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5842,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.60434968,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"11","issue":"8","first_page":"665","last_page":"676"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circulating-endothelial-cells","display_name":"circulating endothelial cells","score":1.0},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.9229999780654907},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8050000071525574},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.8040000200271606},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.5870000123977661},{"id":"https://openalex.org/keywords/endothelial-phenotype","display_name":"endothelial phenotype","score":0.6480000019073486},{"id":"https://openalex.org/keywords/treatment-response-monitoring","display_name":"treatment response monitoring","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8321529030799866},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.6874361634254456},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6805840730667114},{"id":"https://openalex.org/C141341695","wikidata":"https://www.wikidata.org/wiki/Q2368661","display_name":"Surrogate endpoint","level":2,"score":0.5899890661239624},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4567883610725403},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.44849562644958496},{"id":"https://openalex.org/C3017616150","wikidata":"https://www.wikidata.org/wiki/Q1069330","display_name":"Diagnostic biomarker","level":3,"score":0.4342321455478668},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.41094234585762024},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3559117615222931},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3023530840873718},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.29864197969436646},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27788078784942627},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09820157289505005},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.2217/bmm-2017-0143","doi":"https://doi.org/10.2217/bmm-2017-0143","is_oa":false,"landing_page_url":"https://doi.org/10.2217/bmm-2017-0143","pdf_url":null,"source":{"id":"https://openalex.org/S130557755","display_name":"Biomarkers in Medicine","issn_l":"1752-0363","issn":["1752-0363","1752-0371"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomarkers in Medicine","raw_type":"journal-article"},{"id":"pmid:28597689","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28597689","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomarkers in medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320335767","display_name":"Sanming Project of Medicine in Shenzhen","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":88,"referenced_works":["https://openalex.org/W204030213","https://openalex.org/W1493971026","https://openalex.org/W1499075785","https://openalex.org/W1502896205","https://openalex.org/W1520156967","https://openalex.org/W1702507500","https://openalex.org/W1810708577","https://openalex.org/W1848616724","https://openalex.org/W1873768429","https://openalex.org/W1968539943","https://openalex.org/W1969205064","https://openalex.org/W1973232671","https://openalex.org/W1975394913","https://openalex.org/W1978139448","https://openalex.org/W1980545700","https://openalex.org/W1981330733","https://openalex.org/W1982515641","https://openalex.org/W1982651263","https://openalex.org/W1983541079","https://openalex.org/W1986991023","https://openalex.org/W1990120645","https://openalex.org/W1993245079","https://openalex.org/W2001720727","https://openalex.org/W2005156700","https://openalex.org/W2005433514","https://openalex.org/W2009372533","https://openalex.org/W2012708129","https://openalex.org/W2020310648","https://openalex.org/W2022234182","https://openalex.org/W2025546737","https://openalex.org/W2027009674","https://openalex.org/W2040647931","https://openalex.org/W2041111766","https://openalex.org/W2044892099","https://openalex.org/W2045609038","https://openalex.org/W2048829586","https://openalex.org/W2049466721","https://openalex.org/W2051379819","https://openalex.org/W2053704719","https://openalex.org/W2053938092","https://openalex.org/W2058348397","https://openalex.org/W2060233529","https://openalex.org/W2063021537","https://openalex.org/W2067205033","https://openalex.org/W2067888443","https://openalex.org/W2068994530","https://openalex.org/W2070353588","https://openalex.org/W2073618702","https://openalex.org/W2074626917","https://openalex.org/W2075895818","https://openalex.org/W2081704237","https://openalex.org/W2084837257","https://openalex.org/W2088965264","https://openalex.org/W2089778616","https://openalex.org/W2090131524","https://openalex.org/W2094320065","https://openalex.org/W2098161879","https://openalex.org/W2101290420","https://openalex.org/W2115874718","https://openalex.org/W2117013761","https://openalex.org/W2117433781","https://openalex.org/W2117713501","https://openalex.org/W2121731125","https://openalex.org/W2126958845","https://openalex.org/W2135165880","https://openalex.org/W2138636755","https://openalex.org/W2143622618","https://openalex.org/W2143903091","https://openalex.org/W2145120452","https://openalex.org/W2145835533","https://openalex.org/W2146700377","https://openalex.org/W2147535764","https://openalex.org/W2148848877","https://openalex.org/W2149235121","https://openalex.org/W2153273886","https://openalex.org/W2156376884","https://openalex.org/W2157769714","https://openalex.org/W2159789252","https://openalex.org/W2161708429","https://openalex.org/W2164177263","https://openalex.org/W2166084034","https://openalex.org/W2219386182","https://openalex.org/W2274172560","https://openalex.org/W2298526927","https://openalex.org/W2401183309","https://openalex.org/W2468868288","https://openalex.org/W2521381490","https://openalex.org/W4229983880"],"related_works":["https://openalex.org/W2020310648","https://openalex.org/W2126313084","https://openalex.org/W2048829586","https://openalex.org/W2081704237","https://openalex.org/W2122181353","https://openalex.org/W2332168754","https://openalex.org/W4230761681","https://openalex.org/W2216856279","https://openalex.org/W2088965264","https://openalex.org/W2053915767"],"abstract_inverted_index":{"Angiogenesis":[0],"contributes":[1],"to":[2,56],"the":[3,23,31,57,62,84,101],"growth":[4],"of":[5,25,33,59,66,89,94,104],"solid":[6],"tumors.":[7],"Antiangiogenic":[8],"agents":[9],"are":[10],"widely":[11],"used":[12],"in":[13,22,87,111],"various":[14],"cancers":[15],"and":[16,43,64,68,76,92,114],"considerable":[17],"efforts":[18],"have":[19,72],"been":[20,74],"made":[21],"development":[24],"novel":[26],"biomarkers":[27],"that":[28],"can":[29],"predict":[30],"outcome":[32],"an":[34],"anticancer":[35],"treatment.":[36],"Of":[37],"those,":[38],"circulating":[39],"endothelial":[40],"cells":[41],"(CECs)":[42],"their":[44,69,98,116],"subsets":[45],"constitute":[46],"a":[47,108],"surrogate":[48,109],"tool":[49],"for":[50],"monitoring":[51],"disease":[52],"activity.":[53],"However,":[54],"owing":[55],"lack":[58],"standardization":[60],"on":[61,83],"phenotypes":[63,91],"detection":[65,93],"CECs":[67,95],"subsets,":[70],"results":[71],"always":[73],"inconsistent":[75],"uninterpretable.":[77],"In":[78],"this":[79],"review,":[80],"we":[81],"focus":[82],"biological":[85],"characteristics":[86],"terms":[88],"physiology,":[90],"along":[96],"with":[97],"subsets;":[99],"review":[100],"current":[102],"scenario":[103],"CEC":[105],"enumeration":[106],"as":[107],"biomarker":[110],"clinical":[112],"oncology;":[113],"explore":[115],"future":[117],"potential":[118],"applications.":[119]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2017-06-15T00:00:00"}
