{"id":"https://openalex.org/W2623960437","doi":null,"title":"Developing RNA diagnostics for studying healthy human ageing","display_name":"Developing RNA diagnostics for studying healthy human ageing","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2623960437","mag":"2623960437"},"language":"en","primary_location":{"id":"pmh:oai:dspace.lboro.ac.uk:2134/24708","doi":null,"is_oa":true,"landing_page_url":"https://dspace.lboro.ac.uk/2134/24708","pdf_url":"https://dspace.lboro.ac.uk/2134/24708","source":{"id":"https://openalex.org/S4306401023","display_name":"Loughborough University Institutional Repository (Loughborough University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143804889","host_organization_name":"Loughborough University","host_organization_lineage":["https://openalex.org/I143804889"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dspace.lboro.ac.uk/2134/24708","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051021881","display_name":"Sanjana Sood","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sanjana Sood","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5051021881"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.6377000212669373,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.6377000212669373,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.16869999468326569,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.13840000331401825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-aging","display_name":"human aging","score":0.8069999814033508},{"id":"https://openalex.org/keywords/rna-biomarkers","display_name":"RNA biomarkers","score":0.8870000243186951},{"id":"https://openalex.org/keywords/age-related-chronic-diseases","display_name":"age-related chronic diseases","score":0.6859999895095825},{"id":"https://openalex.org/keywords/transcriptomics","display_name":"transcriptomics","score":0.6380000114440918},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.7229999899864197},{"id":"https://openalex.org/keywords/clinical-phenotype","display_name":"clinical phenotype","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.7690834403038025},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.6248094439506531},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4563766419887543},{"id":"https://openalex.org/C3019892597","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Healthy ageing","level":3,"score":0.4290027618408203},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3925662636756897},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35385483503341675},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33124351501464844},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.32208147644996643},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2952900826931},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.17613869905471802},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16066905856132507}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:dspace.lboro.ac.uk:2134/24708","doi":null,"is_oa":true,"landing_page_url":"https://dspace.lboro.ac.uk/2134/24708","pdf_url":"https://dspace.lboro.ac.uk/2134/24708","source":{"id":"https://openalex.org/S4306401023","display_name":"Loughborough University Institutional Repository (Loughborough University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143804889","host_organization_name":"Loughborough University","host_organization_lineage":["https://openalex.org/I143804889"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:oai:figshare.com:article/9610139","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/Developing_RNA_diagnostics_for_studying_healthy_human_ageing/9610139","pdf_url":null,"source":{"id":"https://openalex.org/S4306402585","display_name":"Loughborough University Research Repository (Loughborough University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143804889","host_organization_name":"Loughborough University","host_organization_lineage":["https://openalex.org/I143804889"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2623960437","doi":null,"is_oa":false,"landing_page_url":"https://repository.lboro.ac.uk/articles/Developing_RNA_diagnostics_for_studying_healthy_human_ageing/9610139/files/17257139.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dspace.lboro.ac.uk:2134/24708","doi":null,"is_oa":true,"landing_page_url":"https://dspace.lboro.ac.uk/2134/24708","pdf_url":"https://dspace.lboro.ac.uk/2134/24708","source":{"id":"https://openalex.org/S4306401023","display_name":"Loughborough University Institutional Repository (Loughborough University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143804889","host_organization_name":"Loughborough University","host_organization_lineage":["https://openalex.org/I143804889"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2623960437.pdf","grobid_xml":"https://content.openalex.org/works/W2623960437.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W1794466473","https://openalex.org/W2063508090","https://openalex.org/W2064310741","https://openalex.org/W2069049877","https://openalex.org/W2074151559","https://openalex.org/W2110065044","https://openalex.org/W2144243194"],"related_works":["https://openalex.org/W2482307880","https://openalex.org/W2158316324","https://openalex.org/W2099535442","https://openalex.org/W2596600437","https://openalex.org/W6921382731","https://openalex.org/W2899420672","https://openalex.org/W4301123250","https://openalex.org/W4411231013","https://openalex.org/W7162504390","https://openalex.org/W7223165994"],"abstract_inverted_index":{"Developing":[0],"strategies":[1],"to":[2,79,100,126],"cope":[3],"with":[4,40,117],"increase":[5],"in":[6,37,58,65],"the":[7,17,23],"ageing":[8,24],"population":[9],"and":[10,54,56,97,112,140,148],"age-related":[11],"chronic":[12],"diseases":[13,49,53],"is":[14],"one":[15],"of":[16,22,46,67,75,86],"societies":[18],"biggest":[19],"challenges.The":[20],"characteristics":[21],"process":[25],"shows":[26],"significant":[27],"inter-individual":[28],"variation.Building":[29],"genomic":[30],"signatures":[31],"that":[32],"could":[33],"account":[34],"for":[35,71,82,110],"variation":[36],"health":[38],"outcomes":[39],"age":[41,111],"may":[42],"facilitate":[43],"early":[44],"prognosis":[45],"individual":[47],"age-correlated":[48],"(e.g.cancer,":[50],"coronary":[51],"artery":[52],"dementia)":[55],"help":[57],"developing":[59],"better":[60],"targeted":[61],"treatments":[62],"provided":[63],"years":[64],"advance":[66],"acquiring":[68],"disabling":[69],"symptoms":[70],"these":[72,118],"diseases.The":[73],"aim":[74],"this":[76],"thesis":[77],"was":[78],"explore":[80],"methods":[81,99],"diagnosing":[83],"molecular":[84,108],"features":[85],"human":[87,103],"ageing.In":[88],"particular,":[89],"we":[90,136],"utilise":[91],"multi-platform":[92],"transcriptomics,":[93],"independent":[94],"clinical":[95,114],"data":[96,128],"classification":[98],"evaluate":[101],"which":[102,113],"tissues":[104,132],"demonstrate":[105],"a":[106,138,153],"reproducible":[107],"signature":[109,147],"phenotypes":[115],"correlated":[116],"new":[119],"RNA":[120,127,146],"biomarkers.Using":[121],"machine-learning":[122],"approach":[123],"(kNN),":[124],"applied":[125],"derived":[129],"from":[130,133],"muscle":[131],"healthy":[134],"donors,":[135],"developed":[137],"novel":[139],"statistically":[141],"robust":[142],"neuro-muscular":[143],"150":[144],"probe-set":[145],"demonstrated":[149],"its":[150],"potential":[151],"as":[152],"health-status":[154],"diagnostic.Validated":[155],"using":[156]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2017-06-15T00:00:00"}