{"id":"https://openalex.org/W2623685162","doi":"https://doi.org/10.1021/acs.accounts.6b00655","title":"Toward an Expanded Genome: Structural and Computational Characterization of an Artificially Expanded Genetic Information System","display_name":"Toward an Expanded Genome: Structural and Computational Characterization of an Artificially Expanded Genetic Information System","publication_year":2017,"publication_date":"2017-06-08","ids":{"openalex":"https://openalex.org/W2623685162","doi":"https://doi.org/10.1021/acs.accounts.6b00655","mag":"2623685162","pmid":"https://pubmed.ncbi.nlm.nih.gov/28594167","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5831158"},"language":"en","primary_location":{"id":"doi:10.1021/acs.accounts.6b00655","doi":"https://doi.org/10.1021/acs.accounts.6b00655","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.accounts.6b00655","pdf_url":null,"source":{"id":"https://openalex.org/S145378405","display_name":"Accounts of Chemical Research","issn_l":"0001-4842","issn":["0001-4842","1520-4898"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Accounts of Chemical Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC5831158","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033047262","display_name":"Nigel G. J. Richards","orcid":"https://orcid.org/0000-0002-0375-0881","observed_orcids":["https://orcid.org/0000-0002-0375-0881"]},"institutions":[{"id":"https://openalex.org/I4210163760","display_name":"Foundation for Applied Molecular Evolution","ror":"https://ror.org/052x5ps19","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210163760"]},{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Nigel G. J. Richards","raw_affiliation_strings":["Foundation for Applied Molecular Evolution, 13709 Progress Boulevard, Alachua, Florida 32615, United States","School of Chemistry, Cardiff University, Cardiff, CF10 3AT, United Kingdom,"],"raw_orcid":"https://orcid.org/0000-0002-0375-0881","affiliations":[{"raw_affiliation_string":"Foundation for Applied Molecular Evolution, 13709 Progress Boulevard, Alachua, Florida 32615, United States","institution_ids":["https://openalex.org/I4210163760"]},{"raw_affiliation_string":"School of Chemistry, Cardiff University, Cardiff, CF10 3AT, United Kingdom,","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041580310","display_name":"Millie M. Georgiadis","orcid":"https://orcid.org/0000-0003-2976-4576","observed_orcids":["https://orcid.org/0000-0003-2976-4576"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Millie M. Georgiadis","raw_affiliation_strings":["Department\rof Chemistry and Chemical Biology, Indiana University\u2212Purdue University Indianapolis, Indianapolis, Indiana 46202, United States","Department of Biochemistry & Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States"],"raw_orcid":"https://orcid.org/0000-0003-2976-4576","affiliations":[{"raw_affiliation_string":"Department\rof Chemistry and Chemical Biology, Indiana University\u2212Purdue University Indianapolis, Indianapolis, Indiana 46202, United States","institution_ids":["https://openalex.org/I55769427"]},{"raw_affiliation_string":"Department of Biochemistry & Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5041580310"],"corresponding_institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.6668,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.65434677,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"50","issue":"6","first_page":"1375","last_page":"1382"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.03189999982714653,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/expanded-genetic-alphabet","display_name":"expanded genetic alphabet","score":0.7039999961853027},{"id":"https://openalex.org/keywords/artificial-dna","display_name":"artificial DNA","score":0.47699999809265137},{"id":"https://openalex.org/keywords/dna-crystal-structure","display_name":"DNA crystal structure","score":0.48100000619888306},{"id":"https://openalex.org/keywords/electrostatic-potential","display_name":"electrostatic potential","score":0.6420000195503235},{"id":"https://openalex.org/keywords/hydrogen-bond-strength","display_name":"hydrogen bond strength","score":0.8119999766349792},{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"synthetic biology","score":0.5},{"id":"https://openalex.org/keywords/nucleobase-synthesis","display_name":"nucleobase synthesis","score":0.30799999833106995}],"concepts":[{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.6756268739700317},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.6180953979492188},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5599483251571655},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3698194622993469},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.35832566022872925},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.29735857248306274},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.274940550327301},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17422759532928467},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.16818436980247498}],"mesh":[{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005821","descriptor_name":"Genetic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1021/acs.accounts.6b00655","doi":"https://doi.org/10.1021/acs.accounts.6b00655","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.accounts.6b00655","pdf_url":null,"source":{"id":"https://openalex.org/S145378405","display_name":"Accounts of Chemical Research","issn_l":"0001-4842","issn":["0001-4842","1520-4898"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Accounts of Chemical Research","raw_type":"journal-article"},{"id":"pmid:28594167","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28594167","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Accounts of chemical research","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4958735","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5831158","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5831158","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5831158","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Acc Chem Res","raw_type":"Text"},{"id":"pmh:oai:https://orca.cardiff.ac.uk:102555","doi":null,"is_oa":true,"landing_page_url":"https://orca.cardiff.ac.uk/id/eprint/102555/1/POST%20PRINT.pdf","pdf_url":"https://orca.cardiff.ac.uk/id/eprint/102555/1/POST%20PRINT.pdf","source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:scholarworks.indianapolis.iu.edu:1805/15395","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1805/15395","pdf_url":null,"source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Author","raw_type":"Article"},{"id":"pmh:oai:scholarworks.iupui.edu:1805/15395","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1805/15395","pdf_url":null,"source":{"id":"https://openalex.org/S4306402593","display_name":"Purdue University Indianapolis (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Author","raw_type":"Article"},{"id":"mag:3022509543","doi":null,"is_oa":false,"landing_page_url":"https://scholarworks.iupui.edu/bitstream/1805/15395/1/richards-2017-toward.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306466013","display_name":"Author eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Author eBooks","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4958735","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5831158","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7748288217","display_name":"Structural studies of protein-nucleic acid interactions","funder_award_id":"R01GM055026","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320310263","display_name":"Indiana University-Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08"},{"id":"https://openalex.org/F4320320350","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1969847419","https://openalex.org/W1970335347","https://openalex.org/W1980722147","https://openalex.org/W1980803935","https://openalex.org/W1981225934","https://openalex.org/W1983266096","https://openalex.org/W1987456663","https://openalex.org/W1990356245","https://openalex.org/W1995953381","https://openalex.org/W1998222273","https://openalex.org/W2004440122","https://openalex.org/W2006442108","https://openalex.org/W2007434121","https://openalex.org/W2022889126","https://openalex.org/W2023639301","https://openalex.org/W2054436276","https://openalex.org/W2058308614","https://openalex.org/W2063606548","https://openalex.org/W2067879297","https://openalex.org/W2073253475","https://openalex.org/W2079397405","https://openalex.org/W2081046982","https://openalex.org/W2084868266","https://openalex.org/W2092084554","https://openalex.org/W2095145098","https://openalex.org/W2101867539","https://openalex.org/W2103622571","https://openalex.org/W2113078079","https://openalex.org/W2135184237","https://openalex.org/W2136729627","https://openalex.org/W2146373849","https://openalex.org/W2149041336","https://openalex.org/W2152093192","https://openalex.org/W2155844132","https://openalex.org/W2157902582","https://openalex.org/W2164903159","https://openalex.org/W2165855161","https://openalex.org/W2169336373","https://openalex.org/W2171830519","https://openalex.org/W2271641407","https://openalex.org/W2279720548","https://openalex.org/W2296743077","https://openalex.org/W2433523887","https://openalex.org/W2523626614","https://openalex.org/W2573385318","https://openalex.org/W2582888988","https://openalex.org/W2592805131"],"related_works":["https://openalex.org/W4211099659","https://openalex.org/W2550036365","https://openalex.org/W2104694288","https://openalex.org/W2902390075","https://openalex.org/W2146373849","https://openalex.org/W2021924157","https://openalex.org/W2523626614","https://openalex.org/W4415971689","https://openalex.org/W4403861434","https://openalex.org/W3131444922"],"abstract_inverted_index":{"Although":[0],"the":[1,33,50,54,70,83,86,100,130,145,174,204,226,236,260,280,304,318,341,370,384,396,405,409,419,426,430,453,464,483,488,502,507,533,553],"fundamental":[2,319],"properties":[3,84,101,281,308,320],"of":[4,19,37,53,63,85,99,102,114,142,160,168,172,206,247,279,282,297,309,321,343,383,393,399,401,447,452,527,540,556],"DNA":[5,22,38,75,104,166,240,284,311,351,550,569],"as":[6,181,276,332,510,559],"first":[7,34],"proposed":[8],"by":[9,108,153,334,418],"Watson":[10],"and":[11,25,45,82,89,156,187,208,216,250,257,289,306,329,412,459,529,551,563],"Crick":[12],"in":[13,40,43,47,92,138,203,229,235,244,367,425,437,439,450,468,487,500,517,544,552],"1953":[14],"provided":[15,107],"a":[16,112,135,231,245,267,391,440,444,474,497,513,537],"basic":[17],"understanding":[18,98,123,278,296],"how":[20,545],"duplex":[21,350,509,516],"was":[23,30,365,435],"organized":[24],"might":[26],"be":[27,58,264],"replicated,":[28],"it":[29,546],"not":[31],"until":[32],"crystal":[35,61,490],"structures":[36,62],"(Z-DNA":[39],"1979,":[41],"B-DNA":[42,389],"1980,":[44],"A-DNA":[46],"1982)":[48],"that":[49,73,197],"true":[51],"complexity":[52],"molecule":[55],"began":[56],"to":[57,122,128,164,180,254,265,355,387,407,413,512],"appreciated.":[59],"Many":[60],"oligonucleotides":[64],"have":[65,133,285],"since":[66],"shed":[67],"light":[68],"on":[69,303,395,463],"helical":[71,95,456],"forms":[72,192],"\"Watson-Crick\"":[74],"can":[76,566],"adopt,":[77],"their":[78,90,326],"associated":[79],"groove":[80],"widths,":[81],"nucleobase":[87,170,323,572],"pairs":[88,202,348,449],"interactions":[91,358],"all":[93],"three":[94,193],"forms.":[96],"Additional":[97],"Watson-Crick":[103,124,201,549],"has":[105,241],"been":[106,242],"computational":[109,290,530],"studies":[110,120,462],"employing":[111],"variety":[113],"theoretical":[115],"methods.":[116],"Together":[117],"with":[118,183,270,317,374],"these":[119,143,403],"devoted":[121],"DNA,":[125,542],"recent":[126],"efforts":[127],"expand":[129],"genetic":[131,148],"alphabet":[132],"founded":[134],"new":[136],"field":[137],"synthetic":[139],"biology.":[140],"One":[141],"efforts,":[144],"artificially":[146],"expanded":[147,272],"information":[149],"system":[150,372,386],"(AEGIS)":[151],"developed":[152],"Steven":[154],"Benner":[155],"co-workers,":[157],"takes":[158],"advantage":[159],"orthogonal":[161],"hydrogen":[162,195],"bonding":[163],"produce":[165],"comprised":[167],"six":[169],"pairs,":[171,324],"which":[173,480,565],"most":[175],"extensively":[176],"studied":[177],"is":[178,223,251],"referred":[179],"P:Z":[182,191,313,322,347,360,448],"P":[184,211],"being":[185,189,252],"2-amino-imidazo[1,2-a]-1,3,5-triazin-4(8H)-one)":[186],"Z":[188,217,222],"6-amino-5-nitro-2(1H)-pyridone.":[190],"edge-on":[194],"bonds":[196],"differ":[198],"from":[199,287,422,548],"standard":[200],"arrangement":[205],"acceptors":[207],"donor":[209],"groups;":[210],"presents":[212,218],"acceptor,":[213,214],"donor,":[215,219,220],"acceptor.":[221],"unique":[224],"among":[225],"AEGIS":[227,310,571],"nucleobases":[228],"having":[230],"nitro":[232],"group":[233],"present":[234],"major":[237,498],"groove.":[238],"PZ-containing":[239,508],"exploited":[243],"number":[246,392],"clinical":[248],"applications":[249],"used":[253],"develop":[255],"receptors":[256],"catalysts.":[258],"Ultimately,":[259],"grand":[261],"challenge":[262],"will":[263,294],"create":[266],"semisynthetic":[268],"organism":[269],"an":[271,353],"genome.":[273],"Furthermore,":[274],"just":[275],"our":[277,295],"natural":[283,376],"benefited":[286],"structural":[288,305,397,415,528],"characterization,":[291],"so":[292],"too":[293],"artificial":[298,541],"DNA.":[299],"This":[300,524],"Account":[301],"focuses":[302],"biophysical":[307],"containing":[312,570],"pairs.":[314,361,573],"We":[315,338],"begin":[316],"including":[325,344,378],"electrostatic":[327],"potential":[328],"hydrogen-bonding":[330],"energies,":[331],"elucidated":[333],"quantum":[335],"mechanical":[336],"calculations.":[337],"then":[339],"examine":[340],"impact":[342],"multiple":[345],"consecutive":[346],"into":[349],"providing":[352],"opportunity":[354],"investigate":[356],"stacking":[357,478,494],"between":[359],"The":[362],"self-complementary":[363],"5'-CTTATPPTAZZATAAG":[364],"crystallized":[366,436],"B-form":[368],"using":[369],"host-guest":[371,385],"along":[373],"analogous":[375],"sequences":[377,400,411],"Gs":[379],"or":[380],"As.":[381],"Use":[382],"characterize":[388],"obviates":[390],"limitations":[394],"characterization":[398],"interest;":[402],"include":[404],"ability":[406],"crystallize":[408],"desired":[410],"distinguish":[414],"effects":[416],"imparted":[417],"lattice":[420,442],"constraints":[421],"those":[423],"inherent":[424],"sequence":[427,466],"itself.":[428],"On":[429],"other":[431],"hand,":[432],"3/6ZP,":[433],"5'-CTTATPPPZZZATAAG,":[434],"A-form":[438,469,489],"DNA-only":[441],"allowing":[443],"comparative":[445],"analysis":[446],"two":[451],"biologically":[454],"relevant":[455],"forms:":[457],"A-":[458],"B-DNA.":[460],"Computational":[461],"3/6ZP":[465],"starting":[467],"provide":[470],"additional":[471],"evidence":[472],"for":[473,506,535],"more":[475],"energetically":[476],"favorable":[477],"interaction,":[479],"we":[481],"term":[482],"\"slide\"":[484],"conformer,":[485],"observed":[486,505],"structure;":[491],"this":[492],"unusual":[493],"interaction":[495],"plays":[496],"role":[499],"altering":[501],"conformational":[503],"dynamics":[504,522],"compared":[511],"GC-containing":[514],"\"control\"":[515],"long":[518],"time":[519],"scale":[520],"molecular":[521],"simulations.":[523],"combined":[525],"use":[526],"strategies":[531],"paves":[532],"way":[534],"obtaining":[536],"detailed":[538],"description":[539],"both":[543],"differs":[547],"rational":[554],"discovery":[555],"proteins,":[557],"such":[558],"endonucleases,":[560],"transcription":[561],"factors,":[562],"polymerases,":[564],"specifically":[567],"manipulate":[568]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2017-06-15T00:00:00"}