{"id":"https://openalex.org/W2622924972","doi":null,"title":"Is Tetrahydrocannabinol (THC)/Cannabidiol (CBD) Oromucosal Spray an Effective Adjuvant Therapy for Multiple Sclerosis Patients Who Suffer From Central Neuropathic Pain?","display_name":"Is Tetrahydrocannabinol (THC)/Cannabidiol (CBD) Oromucosal Spray an Effective Adjuvant Therapy for Multiple Sclerosis Patients Who Suffer From Central Neuropathic Pain?","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2622924972","mag":"2622924972"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.pcom.edu:pa_systematic_reviews-1303","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.pcom.edu/pa_systematic_reviews/300","pdf_url":"https://digitalcommons.pcom.edu/cgi/viewcontent.cgi?article=1303&context=pa_systematic_reviews","source":{"id":"https://openalex.org/S4377196547","display_name":"Digital Commons - PCOM (Philadelphia College of Osteopathic Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I106460735","host_organization_name":"Philadelphia College of Osteopathic Medicine","host_organization_lineage":["https://openalex.org/I106460735"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PCOM Physician Assistant Studies Student Scholarship","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.pcom.edu/cgi/viewcontent.cgi?article=1303&context=pa_systematic_reviews","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050064255","display_name":"Evan Taxin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Evan Taxin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5050064255"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.22132546,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tetrahydrocannabinol","display_name":"tetrahydrocannabinol","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cannabidiol","display_name":"cannabidiol","score":1.0},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9639999866485596},{"id":"https://openalex.org/keywords/central-pain","display_name":"central pain","score":0.9980000257492065},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.9160000085830688},{"id":"https://openalex.org/keywords/pain-intensity","display_name":"pain intensity","score":0.5070000290870667},{"id":"https://openalex.org/keywords/cannabinoids","display_name":"cannabinoids","score":0.5339999794960022},{"id":"https://openalex.org/keywords/analgesic-therapy","display_name":"analgesic treatment","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C2776895053","wikidata":"https://www.wikidata.org/wiki/Q422917","display_name":"Cannabidiol","level":3,"score":0.9843180179595947},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7856590747833252},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.7727859616279602},{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.7374178767204285},{"id":"https://openalex.org/C2778563155","wikidata":"https://www.wikidata.org/wiki/Q190067","display_name":"Tetrahydrocannabinol","level":4,"score":0.6693413853645325},{"id":"https://openalex.org/C2777056318","wikidata":"https://www.wikidata.org/wiki/Q79817","display_name":"Cannabis","level":2,"score":0.537721574306488},{"id":"https://openalex.org/C2909046181","wikidata":"https://www.wikidata.org/wiki/Q190067","display_name":"\u03949-tetrahydrocannabinol","level":4,"score":0.5188732743263245},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.4463801681995392},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.40999847650527954},{"id":"https://openalex.org/C2780871563","wikidata":"https://www.wikidata.org/wiki/Q422936","display_name":"Cannabinoid","level":3,"score":0.3411005139350891},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.32977294921875},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.14200538396835327},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13753661513328552},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.11857554316520691},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.07761973142623901},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.pcom.edu:pa_systematic_reviews-1303","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.pcom.edu/pa_systematic_reviews/300","pdf_url":"https://digitalcommons.pcom.edu/cgi/viewcontent.cgi?article=1303&context=pa_systematic_reviews","source":{"id":"https://openalex.org/S4377196547","display_name":"Digital Commons - PCOM (Philadelphia College of Osteopathic Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I106460735","host_organization_name":"Philadelphia College of Osteopathic Medicine","host_organization_lineage":["https://openalex.org/I106460735"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PCOM Physician Assistant Studies Student Scholarship","raw_type":"text"},{"id":"mag:2622924972","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.pcom.edu/cgi/viewcontent.cgi?article=1303&context=pa_systematic_reviews","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.pcom.edu:pa_systematic_reviews-1303","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.pcom.edu/pa_systematic_reviews/300","pdf_url":"https://digitalcommons.pcom.edu/cgi/viewcontent.cgi?article=1303&context=pa_systematic_reviews","source":{"id":"https://openalex.org/S4377196547","display_name":"Digital Commons - PCOM (Philadelphia College of Osteopathic Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I106460735","host_organization_name":"Philadelphia College of Osteopathic Medicine","host_organization_lineage":["https://openalex.org/I106460735"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PCOM Physician Assistant Studies Student Scholarship","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2622924972.pdf","grobid_xml":"https://content.openalex.org/works/W2622924972.grobid-xml"},"referenced_works_count":2,"referenced_works":["https://openalex.org/W1980502203","https://openalex.org/W2133097372"],"related_works":["https://openalex.org/W1980502203","https://openalex.org/W2339703004","https://openalex.org/W1996712837","https://openalex.org/W2016068746","https://openalex.org/W2146626244","https://openalex.org/W2809478012","https://openalex.org/W2134057375","https://openalex.org/W2172817754","https://openalex.org/W2261324865","https://openalex.org/W1987613482"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1,65,101,265],"objective":[2],"of":[3,40,67,76,87,104,171,212,226,267],"this":[4,130],"selective":[5],"EBM":[6],"review":[7,39],"is":[8],"to":[9,81,109,146,208,229,234,255,261],"determine":[10],"whether":[11],"or":[12],"not":[13,285],"\u201cIs":[14],"Tetrahydrocannabinol":[15],"(THC)/Cannabidiol":[16],"(CBD)":[17],"oromucosal":[18,251,269],"spray":[19,252,270],"an":[20,94],"effective":[21],"adjuvant":[22],"therapy":[23],"for":[24],"Multiple":[25],"Sclerosis":[26],"(MS)":[27],"patients":[28,218,276],"who":[29,219,277],"suffer":[30,278],"from":[31,279,289],"central":[32,77,246,280],"neuropathic":[33,78,231,247,281],"pain":[34,79,96,172,197,232,248,282,287],"(CNP)?\u201d":[35],"STUDY":[36],"DESIGN:":[37],"Systematic":[38],"three":[41,238],"randomized":[42,54,120],"controlled":[43,55,121],"trials":[44,122],"published":[45],"between":[46,139],"2005-2013,":[47],"all":[48],"English":[49],"language.":[50],"DATA":[51],"SOURCES:":[52],"Three":[53,119],"studies":[56,239],"were":[57,91,107,127,215,220],"obtained":[58],"using":[59,93],"PubMed":[60],"and":[61,74,123,143,283],"MedLine.":[62],"OUTCOMES":[63],"MEASURED:":[64],"outcome":[66],"each":[68],"study":[69],"was":[70,165],"the":[71,85,88,111,115,140,184,213],"subject\u2019s":[72],"incidence":[73],"severity":[75],"compared":[80,207,254,260],"their":[82],"baseline":[83],"at":[84,98],"beginning":[86],"study.":[89],"Outcomes":[90],"measured":[92],"11-point":[95],"scale":[97],"various":[99],"intervals.":[100],"average":[102],"scores":[103,198],"these":[105],"participants":[106],"used":[108,128],"compare":[110],"control":[112,209],"group":[113,142,145],"versus":[114],"intervention":[116,186],"group.":[117,187,210,264],"RESULTS:":[118],"uncontrolled,":[124],"extension":[125],"trial":[126],"in":[129,183,196,217,244,274],"review.":[131],"Langford":[132],"et":[133,160,189],"al":[134,161,190],"demonstrated":[135,240],"a":[136,166,192,223,262],"mean":[137,169,194,245],"difference":[138],"THC/CBD":[141,185,268],"placebo-controlled":[144],"be":[147,272],"(odds":[148],"ratio":[149],"1.31":[150],"[95%":[151],"CI,":[152],"1.01-2.57":[153],"points];":[154],"P=0.046)":[155],"after":[156],"10":[157],"weeks.":[158],"Rog":[159],"found":[162],"that":[163],"there":[164],"statistically":[167,241],"significant":[168,193,242],"reduction":[170,195,243],"intensity":[173],"(Mean":[174],"change":[175],"-2.7;":[176],"95%":[177,201],"CI:":[178,202],"-3.4":[179],"\u2013":[180],"2.0":[181],"(p=0.005))":[182],"Hoggart":[188],"showed":[191],"(-0.96":[199],"points;":[200],"-1.59,":[203],"-0.32,":[204],"(p=0.004))":[205],"when":[206],"All":[211,237],"results":[214],"observed":[216],"already":[221],"on":[222],"stable":[224],"regimen":[225],"analgesic":[227],"medications":[228],"treat":[230],"related":[233],"MS.":[235],"CONCLUSIONS:":[236],"with":[249],"THC-CBD":[250],"as":[253,257,259],"baseline,":[256],"well":[258],"placebo-control":[263],"addition":[266],"should":[271],"considered":[273],"MS":[275],"do":[284],"receive":[286],"relief":[288],"standard":[290],"therapy.":[291]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-06-15T00:00:00"}
