{"id":"https://openalex.org/W2622797151","doi":null,"title":"Strukturelle und funktionelle Analyse ausgew\u00e4hlter High Mobility Group Gene des Haushundes","display_name":"Strukturelle und funktionelle Analyse ausgew\u00e4hlter High Mobility Group Gene des Haushundes","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2622797151","mag":"2622797151"},"language":"de","primary_location":{"id":"pmh:oai:elib.suub.uni-bremen.de:DISS/00101803","doi":null,"is_oa":false,"landing_page_url":"http://elib.suub.uni-bremen.de/peid=D00101803","pdf_url":null,"source":{"id":"https://openalex.org/S7407064325","display_name":"State and University Library Bremen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://nbn-resolving.de/<identifier scheme=\"urn:nbn:de\">urn:nbn:de:gbv:46-00101803-12</identifier>","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110176890","display_name":"Jan T. Soller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jan T. Soller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5110176890"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-mobility-group-proteins","display_name":"high mobility group proteins","score":0.7509999871253967},{"id":"https://openalex.org/keywords/hmga1","display_name":"HMGA1","score":0.9359999895095825},{"id":"https://openalex.org/keywords/hmga2","display_name":"HMGA2","score":1.0},{"id":"https://openalex.org/keywords/thada","display_name":"THADA","score":0.9639999866485596},{"id":"https://openalex.org/keywords/rage","display_name":"RAGE","score":0.8629999756813049},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7559999823570251},{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":0.828000009059906},{"id":"https://openalex.org/keywords/canine-cancer-models","display_name":"dogs as cancer models","score":0.6079999804496765},{"id":"https://openalex.org/keywords/adeno-associated-virus-gene-therapy","display_name":"adeno-associated virus gene therapy","score":0.7829999923706055},{"id":"https://openalex.org/keywords/receptor-for-advanced-glycation-end-products","display_name":"receptor for advanced glycation end products","score":0.8859999775886536},{"id":"https://openalex.org/keywords/langerhans-cell-histiocytosis","display_name":"Langerhans cell histiocytosis","score":0.9039999842643738},{"id":"https://openalex.org/keywords/cytokine-evolution","display_name":"cytokine evolution","score":0.6140000224113464},{"id":"https://openalex.org/keywords/comparative-genomics","display_name":"comparative genomics","score":0.7300000190734863},{"id":"https://openalex.org/keywords/tumor-inflammation","display_name":"tumor inflammation","score":0.6629999876022339},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8690000176429749}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5877600908279419},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5792937278747559},{"id":"https://openalex.org/C2778857457","wikidata":"https://www.wikidata.org/wiki/Q153641","display_name":"Rage (emotion)","level":2,"score":0.5447489023208618},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5210858583450317},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5019946098327637},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.49176791310310364},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.4197341203689575},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3625115752220154},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.08615383505821228},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:elib.suub.uni-bremen.de:DISS/00101803","doi":null,"is_oa":false,"landing_page_url":"http://elib.suub.uni-bremen.de/peid=D00101803","pdf_url":null,"source":{"id":"https://openalex.org/S7407064325","display_name":"State and University Library Bremen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://nbn-resolving.de/<identifier scheme=\"urn:nbn:de\">urn:nbn:de:gbv:46-00101803-12</identifier>","raw_type":null},{"id":"mag:2622797151","doi":null,"is_oa":false,"landing_page_url":"http://elib.suub.uni-bremen.de/edocs/00101803-1.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":157,"referenced_works":["https://openalex.org/W25119911","https://openalex.org/W143049927","https://openalex.org/W1246228224","https://openalex.org/W1497670593","https://openalex.org/W1503258737","https://openalex.org/W1514047633","https://openalex.org/W1515994079","https://openalex.org/W1519012701","https://openalex.org/W1519139333","https://openalex.org/W1564784499","https://openalex.org/W1570533268","https://openalex.org/W1677573439","https://openalex.org/W1750328031","https://openalex.org/W1773515121","https://openalex.org/W1840001967","https://openalex.org/W1871855518","https://openalex.org/W1900976126","https://openalex.org/W1927950101","https://openalex.org/W1966783750","https://openalex.org/W1972293204","https://openalex.org/W1972459018","https://openalex.org/W1973614272","https://openalex.org/W1974943956","https://openalex.org/W1975489737","https://openalex.org/W1976839668","https://openalex.org/W1978718183","https://openalex.org/W1980130680","https://openalex.org/W1981163610","https://openalex.org/W1981571079","https://openalex.org/W1982096171","https://openalex.org/W1983701023","https://openalex.org/W1985236743","https://openalex.org/W1985327918","https://openalex.org/W1986439538","https://openalex.org/W1986569944","https://openalex.org/W1987796811","https://openalex.org/W1990365963","https://openalex.org/W1990596307","https://openalex.org/W1991016287","https://openalex.org/W1991590043","https://openalex.org/W1992484293","https://openalex.org/W1998145026","https://openalex.org/W2002196322","https://openalex.org/W2003460356","https://openalex.org/W2003813921","https://openalex.org/W2004129980","https://openalex.org/W2004437604","https://openalex.org/W2007281508","https://openalex.org/W2010023946","https://openalex.org/W2010275742","https://openalex.org/W2011084166","https://openalex.org/W2011107382","https://openalex.org/W2011382030","https://openalex.org/W2012681341","https://openalex.org/W2013635556","https://openalex.org/W2016710605","https://openalex.org/W2017257491","https://openalex.org/W2017311565","https://openalex.org/W2018715206","https://openalex.org/W2026475341","https://openalex.org/W2027253716","https://openalex.org/W2038036971","https://openalex.org/W2038123205","https://openalex.org/W2043421492","https://openalex.org/W2045068887","https://openalex.org/W2046436315","https://openalex.org/W2047964022","https://openalex.org/W2049102122","https://openalex.org/W2049167261","https://openalex.org/W2052746932","https://openalex.org/W2053618423","https://openalex.org/W2054162441","https://openalex.org/W2054647745","https://openalex.org/W2056020419","https://openalex.org/W2056021062","https://openalex.org/W2056140464","https://openalex.org/W2056943423","https://openalex.org/W2065801408","https://openalex.org/W2066804997","https://openalex.org/W2069208386","https://openalex.org/W2071675524","https://openalex.org/W2072151603","https://openalex.org/W2073714833","https://openalex.org/W2075712201","https://openalex.org/W2076735302","https://openalex.org/W2077290313","https://openalex.org/W2077629906","https://openalex.org/W2078109078","https://openalex.org/W2078917040","https://openalex.org/W2078998053","https://openalex.org/W2080273024","https://openalex.org/W2081807421","https://openalex.org/W2082072812","https://openalex.org/W2082163698","https://openalex.org/W2087436694","https://openalex.org/W2095078633","https://openalex.org/W2095530287","https://openalex.org/W2096158027","https://openalex.org/W2097513054","https://openalex.org/W2098625105","https://openalex.org/W2103017472","https://openalex.org/W2106084953","https://openalex.org/W2106537213","https://openalex.org/W2108118664","https://openalex.org/W2108222684","https://openalex.org/W2108567554","https://openalex.org/W2108627173","https://openalex.org/W2109448891","https://openalex.org/W2109923945","https://openalex.org/W2110810866","https://openalex.org/W2112132580","https://openalex.org/W2112665047","https://openalex.org/W2113116667","https://openalex.org/W2114611642","https://openalex.org/W2115293825","https://openalex.org/W2116305874","https://openalex.org/W2117245895","https://openalex.org/W2117690477","https://openalex.org/W2117783767","https://openalex.org/W2120842870","https://openalex.org/W2123168045","https://openalex.org/W2125215650","https://openalex.org/W2127800750","https://openalex.org/W2128903974","https://openalex.org/W2129328366","https://openalex.org/W2129942107","https://openalex.org/W2130479394","https://openalex.org/W2132404990","https://openalex.org/W2134201576","https://openalex.org/W2135229956","https://openalex.org/W2137649483","https://openalex.org/W2139299054","https://openalex.org/W2141805477","https://openalex.org/W2142439096","https://openalex.org/W2144474538","https://openalex.org/W2144725045","https://openalex.org/W2145069891","https://openalex.org/W2146391433","https://openalex.org/W2148300469","https://openalex.org/W2153693413","https://openalex.org/W2156617360","https://openalex.org/W2157186965","https://openalex.org/W2161619169","https://openalex.org/W2163194813","https://openalex.org/W2164339570","https://openalex.org/W2166753481","https://openalex.org/W2167837485","https://openalex.org/W2170400833","https://openalex.org/W2170647698","https://openalex.org/W2171436908","https://openalex.org/W2187387640","https://openalex.org/W2409723727","https://openalex.org/W2410322445","https://openalex.org/W2419077917","https://openalex.org/W2419179378","https://openalex.org/W4391201207","https://openalex.org/W7099200879"],"related_works":["https://openalex.org/W7015438085","https://openalex.org/W7034382156","https://openalex.org/W7033900516","https://openalex.org/W2912714357","https://openalex.org/W7064743930","https://openalex.org/W7025118679","https://openalex.org/W2730762250","https://openalex.org/W7064875649","https://openalex.org/W7037960822","https://openalex.org/W2071164164"],"abstract_inverted_index":{"Medical":[0],"advances":[1],"due":[2],"to":[3,17,48,63,74,161,320],"scientific":[4],"research":[5],"made":[6],"remarkable":[7],"progress":[8],"in":[9,61,96,122,170,309],"the":[10,18,29,41,50,57,67,97,108,115,130,149,173,184,207,217,239,259,270,280,283,301,322],"past":[11],"decades":[12],"fighting":[13],"cancer.":[14,80],"Nevertheless":[15],"according":[16],"United":[19],"Nation":[20],"s":[21],"World":[22],"Cancer":[23],"Report":[24],"2008":[25],"tumour":[26,71,82,112,119,157,215,260],"diseases":[27,72,83,120],"are":[28,84,148,292],"leading":[30],"cause":[31],"of":[32,70,99,104,114,129,143,156,176,186,203,209,253,272,282,290,300,307,325,347],"death":[33],"with":[34,183,195],"7.6":[35],"million":[36,40],"deaths":[37],"and":[38,65,73,89,91,111,117,132,139,153,192,211,241,244,258,275,297,343,349],"12.4":[39],"new":[42,76],"cancer":[43,49],"cases":[44],"a":[45,164,177,214],"year.":[46],"According":[47,160],"dog":[51],"as":[52,316,328,330],"an":[53,187,250,266,317],"animal":[54,318],"model":[55,60,319],"joins":[56],"popular":[58],"rodent":[59],"order":[62,171],"study":[64],"understand":[66],"molecular":[68,127,233,323],"genetics":[69,324],"develop":[75],"therapeutic":[77,166],"strategies":[78],"against":[79],"Canine":[81],"distinguished":[85],"by":[86,126],"spontaneous":[87],"development":[88],"dogs":[90,312],"humans":[92],"share":[93],"striking":[94],"similarities":[95,234],"case":[98],"oncology.":[100],"The":[101,228],"main":[102],"part":[103],"this":[105,162,333],"thesis":[106],"comprises":[107],"comparative":[109],"genomics":[110],"biology":[113],"human":[116,240,350],"canine":[118,178,218,242,302,348],"focusing":[121],"particular":[123,278],"prostate":[124,179],"carcinomas":[125],"characterisation":[128],"genes":[131,147],"proteins":[133],"HMGA1,":[134],"HMGA2,":[135],"THADA,":[136],"RAGE,":[137],"TNFalpha,":[138],"IL-alpha/beta.":[140],"Genomic":[141],"characterisations":[142],"high":[144],"evolutionary":[145,340],"conserved":[146,232,341],"fundamentals":[150],"for":[151,200,220],"functional":[152],"structural":[154],"analysis":[155],"relevant":[158],"genes.":[159],"principle":[163],"gene":[165,342],"approach":[167],"was":[168,198,226],"developed":[169],"inhibit":[172],"HMGA":[174],"expression":[175],"carcinoma":[180],"cell":[181,285],"line":[182],"help":[185],"adeno-associated":[188],"virus":[189],"vector.":[190],"Furthermore":[191],"alternative":[193],"method":[194],"gold":[196],"nanoparticles":[197],"established":[199],"efficient":[201],"transfection":[202],"eukaryotic":[204],"cells.":[205],"In":[206,247,277,332],"context":[208],"inflammation":[210],"angiogenesis":[212],"during":[213,269,279],"disease":[216],"receptor":[219],"advanced":[221],"glycation":[222],"end":[223],"products":[224],"(RAGE)":[225],"analysed.":[227],"results":[229],"showed":[230],"highly":[231],"(N.B.":[235],"ligand-receptor":[236],"domains)":[237],"between":[238],"RAGE":[243],"its":[245],"isoforms.":[246],"both":[248],"species":[249],"aberrant":[251],"Expression":[252],"cytokines":[254,291,351],"e.g.":[255],"interleukin-1":[256],"(IL-1alpha/beta)":[257],"necrosis":[261],"factor":[262],"alpha":[263],"(TNFalpha)":[264],"plays":[265],"important":[267],"role":[268],"initiation":[271],"immune":[273],"response":[274],"inflammation.":[276],"course":[281],"Langerhans":[284],"histiocytosis":[286,304,327],"(LCH)":[287],"large":[288],"quantities":[289],"produced.":[293],"Interestingly":[294],"most":[295],"clinical":[296],"pathological":[298],"features":[299],"malignant":[303,326],"resemble":[305],"those":[306],"LCH":[308],"humans.":[310],"Finally":[311],"could":[313],"be":[314],"used":[315],"elucidate":[321],"well":[329],"LCH.":[331],"connection":[334],"nucleic":[335],"base":[336],"pair":[337],"substitution":[338],"within":[339],"amino":[344],"acid":[345],"sequences":[346],"were":[352],"investigated.":[353]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-06-15T00:00:00"}