{"id":"https://openalex.org/W2622650595","doi":null,"title":"Implicaci\u00f3n de los micrornas en la obtenci\u00f3n de c\u00e9lulas productoras de insulina a partir de c\u00e9lulas troncales pluripotentes","display_name":"Implicaci\u00f3n de los micrornas en la obtenci\u00f3n de c\u00e9lulas productoras de insulina a partir de c\u00e9lulas troncales pluripotentes","publication_year":2017,"publication_date":"2017-05-08","ids":{"openalex":"https://openalex.org/W2622650595","mag":"2622650595"},"language":"es","primary_location":{"id":"pmh:oai:dnet:idus________::76f248438e14cc71496edcbff697276c","doi":null,"is_oa":true,"landing_page_url":"https://idus.us.es/handle/11441/61117","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://idus.us.es/handle/11441/61117","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023457282","display_name":"L\u00f3pez Beas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L\u00f3pez Beas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113853252","display_name":"Emilio Javier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emilio Javier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.9729999899864197},{"id":"https://openalex.org/keywords/insulin-producing-cells","display_name":"insulin-producing cells","score":0.828000009059906},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.8330000042915344},{"id":"https://openalex.org/keywords/embryonic-stem-cells","display_name":"embryonic stem cells","score":0.7870000004768372},{"id":"https://openalex.org/keywords/pluripotent-stem-cells","display_name":"pluripotent stem cells","score":0.7590000033378601},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.7390000224113464},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.6940000057220459},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.5090000033378601},{"id":"https://openalex.org/keywords/microrna-mimics","display_name":"miRNA mimics","score":0.38999998569488525},{"id":"https://openalex.org/keywords/mirna-inhibitors","display_name":"miRNA inhibitors","score":0.628000020980835},{"id":"https://openalex.org/keywords/cellular-reprogramming","display_name":"cellular reprogramming","score":0.43299999833106995},{"id":"https://openalex.org/keywords/cell-free-therapy","display_name":"cell-free therapy","score":0.8700000047683716}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.7466787099838257},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3385457396507263},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2892826795578003},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.2623128294944763}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:dnet:idus________::76f248438e14cc71496edcbff697276c","doi":null,"is_oa":true,"landing_page_url":"https://idus.us.es/handle/11441/61117","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:idus.us.es:11441/61117","doi":null,"is_oa":true,"landing_page_url":"https://idus.us.es/handle/11441/61117","pdf_url":null,"source":{"id":"https://openalex.org/S4306401665","display_name":"Deposito de Investigacion Universidad de Sevilla (University of Seville)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79238269","host_organization_name":"Universidad de Sevilla","host_organization_lineage":["https://openalex.org/I79238269"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2622650595","doi":null,"is_oa":false,"landing_page_url":"https://digital.csic.es/bitstream/10261/166204/1/implicaMICROrnas.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dnet:idus________::76f248438e14cc71496edcbff697276c","doi":null,"is_oa":true,"landing_page_url":"https://idus.us.es/handle/11441/61117","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2904432422","https://openalex.org/W2279478152","https://openalex.org/W2484857797","https://openalex.org/W2590046674","https://openalex.org/W7037538343","https://openalex.org/W3003465869","https://openalex.org/W7120566401","https://openalex.org/W406966012","https://openalex.org/W2261600537","https://openalex.org/W3010305443"],"abstract_inverted_index":{"La":[0,108,326,436],"diabetes":[1],"mellitus":[2],"(DM)":[3],"es":[4,65,635],"un":[5,147,162,171,292,318,358,451,539,551,639],"desorden":[6],"metab\u00f3lico":[7],"que":[8,41,75,96,198,228,308,316,376,429,518,524,547,641],"aparece":[9],"cuando":[10,18],"el":[11,19,60,69,140,239,282,401,456,470,486,520,548,605,651,664],"p\u00e1ncreas":[12],"no":[13,21,368],"produce":[14,42],"insulina":[15,25,118,189,213,495,561,578,593],"suficiente":[16,260],"o":[17],"organismo":[20],"utiliza":[22],"eficazmente":[23],"la":[24,29,33,63,66,88,92,99,106,132,157,174,218,248,296,306,324,340,383,394,422,459,555,568,575,587,614,627,661,667],"dando":[26],"lugar":[27],"a":[28,44,336,562,574,644],"incapacidad":[30],"para":[31,103,127,246,261,281,490,538,621,660],"mantener":[32],"normoglucemia,":[34],"desencadenando":[35],"una":[36,122,128,150,262,337,416,509,607],"situaci\u00f3n":[37],"de":[38,62,71,79,87,94,110,117,121,125,131,159,180,182,188,212,231,241,244,270,274,284,298,305,331,339,346,348,355,366,374,385,396,404,407,411,418,421,440,446,458,463,472,475,488,494,530,557,560,564,570,577,580,583,589,592,599,601,610,619,629,631,654,666,671],"hiperglucemia":[39],"cr\u00f3nica":[40],"da\u00f1os":[43],"corto":[45],"y":[46,52,153,176,214,250,276,342,409,448,461,484,502,522,633,663],"largo":[47],"plazo":[48],"en":[49,59,68,173,196,220,258,311,328,334,382,393,425,433,442,455,477,512,535,554,597,616,675],"muchos":[50,670],"\u00f3rganos":[51],"sistemas":[53],"del":[54,84,178,344],"organismo.":[55],"Un":[56],"aspecto":[57],"central":[58],"desarrollo":[61,410,541],"DM":[64,89],"reducci\u00f3n":[67],"n\u00famero":[70],"c\u00e9lulas":[72,112,115,126,160,183,186,200,210,253,350,353,443,479,492,558,565,572,590,623],"beta":[73,101,254],"pancre\u00e1ticas":[74,255],"son":[76,146,272,286,371],"las":[77,111,199,268,349,386,478,571],"encargadas":[78],"producir":[80],"insulina.":[81],"Las":[82],"limitaciones":[83],"tratamiento":[85,665],"actual":[86],"han":[90,226],"estimulado":[91],"b\u00fasqueda":[93],"terapias":[95],"permitan":[97],"restaurar":[98],"masa":[100],"perdida":[102],"conseguir":[104,170],"alcanzar":[105],"normoglucemia.":[107],"diferenciaci\u00f3n":[109,181,232,285,307,347,406,462,489],"pluripotenciales":[113,184,351],"hacia":[114,185,209,323,352],"productoras":[116,187,211,354,493,559,591],"permitir\u00eda":[119],"disponer":[120],"fuente":[123],"inagotable":[124],"terapia":[129,264],"alternativa":[130],"DM.":[133],"Sin":[134,266,612],"embargo,":[135,267,613],"los":[136,229,278,299,312,372,397,513,517,531,581,617,655,672],"m\u00e9todos":[137],"disponibles":[138],"hasta":[139],"momento":[141,606],"presentan":[142],"varios":[143,525],"inconvenientes":[144],"como":[145,302,370,505,528,657],"bajo":[148],"rendimiento,":[149],"dif\u00edcil":[151],"reproducibilidad":[152],"baja":[154],"eficacia":[155,175,249,341],"con":[156,161,508],"generaci\u00f3n":[158,588],"fenotipo":[163],"inmaduro.":[164],"Por":[165],"lo":[166],"tanto,":[167],"ser\u00e1":[168],"fundamental":[169],"aumento":[172],"eficiencia":[177,343],"proceso":[179,283,319,345,487],"totalmente":[190],"maduras.":[191],"Nuestro":[192],"grupo":[193],"fue":[194],"pionero":[195],"demostrar":[197],"troncales":[201,444,480],"embrionarias":[202],"(CTEs)":[203],"murinas":[204],"pueden":[205,235,430],"diferenciarse":[206],"in":[207,216,233],"vitro":[208,234],"revertir":[215],"vivo":[217],"glucemia":[219],"modelos":[221,674],"murinos":[222],"diab\u00e9ticos,":[223],"estudios":[224],"posteriores":[225],"demostrado":[227],"protocolos":[230],"ser":[236],"optimizados":[237],"mediante":[238,357,594,626],"uso":[240],"diversos":[242,426],"factores":[243,279,303,600,630],"crecimiento":[245,602,632],"aumentar":[247],"eficiencia,":[251],"consiguiendo":[252],"maduras":[256],"funcionales":[257,625],"cantidad":[259],"posible":[263],"celular.":[265],"etapas":[269],"maduraci\u00f3n":[271,620],"susceptibles":[273],"mejoras":[275],"adem\u00e1s":[277],"necesarios":[280,537],"extremadamente":[287],"caros,":[288],"esto":[289],"ha":[290],"suscitado":[291],"gran":[293],"inter\u00e9s":[294],"por":[295,363,604],"investigaci\u00f3n":[297,332],"microRNAs":[300],"(miRNAs)":[301],"clave":[304],"podr\u00edan":[309],"sustituirlos":[310],"protocolos,":[313],"al":[314],"tiempo":[315],"proporcionan":[317],"m\u00e1s":[320,533],"f\u00e1cilmente":[321],"inducible":[322],"diferenciaci\u00f3n.":[325],"propuesta":[327],"este":[329],"trabajo":[330],"gira":[333],"torno":[335],"mejora":[338,615],"insulina,":[356],"mecanismo":[359],"regulador":[360],"innovador":[361],"ejercido":[362],"peque\u00f1as":[364],"mol\u00e9culas":[365,419],"RNAs":[367],"codificantes":[369],"miRNAs,":[373],"forma":[375],"podr\u00e1n":[377],"constituir":[378],"herramientas":[379,659],"moleculares":[380],"\u00fatiles":[381],"manipulaci\u00f3n":[384],"CTEs.":[387],"Los":[388,543,647],"miRNAs":[389,441,476,507,532,595,634,656],"est\u00e1n":[390],"probablemente":[391],"implicados":[392],"mayor\u00eda":[395],"procesos":[398,618],"biol\u00f3gicos,":[399],"incluyendo":[400],"desarrollo,":[402],"transducci\u00f3n":[403],"se\u00f1ales,":[405],"tejidos":[408],"enfermedades.":[412],"En":[413,466,585],"mam\u00edferos":[414],"constituyen":[415],"clase":[417],"reguladores":[420],"expresi\u00f3n":[423,437,473,510],"g\u00e9nica":[424],"tipos":[427],"celulares":[428],"expresarse":[431],"espec\u00edficamente":[432],"diferentes":[434],"tejidos.":[435],"com\u00fan":[438],"similar":[439],"pluripotentes":[445,481],"roedores":[447],"humanos":[449],"sugiere":[450],"importante":[452,552],"papel":[453,553],"funcional":[454],"control":[457],"auto\u2010renovaci\u00f3n":[460],"estas":[464],"c\u00e9lulas.":[465],"nuestro":[467],"trabajo,":[468],"identificamos":[469],"perfil":[471],"espec\u00edfico":[474],"(Familia":[482],"miR\u2010302)":[483],"durante":[485],"obtener":[491,622],"(miR\u20107,":[496],"\u2010375,":[497],"\u2010373,":[498],"15a/b,":[499],"\u201016,":[500],"\u2010148a":[501],"\u201029b),":[503],"as\u00ed":[504],"aquellos":[506],"preferente":[511],"islotes":[514],"pancre\u00e1ticos,":[515],"entre":[516],"destacan":[519],"miR\u20107":[521,549],"miR\u2010375,":[523],"trabajos":[526],"sit\u00faan":[527],"dos":[529],"abundantes":[534],"p\u00e1ncreas,":[536],"correcto":[540],"pancre\u00e1tico.":[542],"resultados":[544],"obtenidos":[545],"revelan":[546],"posee":[550],"obtenci\u00f3n":[556],"partir":[563],"troncales,":[566],"mejorando":[567],"sensibilidad":[569],"obtenidas":[573],"liberaci\u00f3n":[576],"dependiente":[579],"est\u00edmulos":[582],"glucosa.":[584],"conclusi\u00f3n,":[586],"espec\u00edficos":[596],"ausencia":[598],"resulta":[603],"meta":[608],"lejana":[609],"alcanzar.":[611],"completamente":[624],"combinaci\u00f3n":[628],"prometedora,":[636],"aunque":[637],"constituye":[638],"enfoque":[640],"se":[642],"enfrenta":[643],"m\u00faltiples":[645],"desaf\u00edos.":[646],"pr\u00f3ximos":[648],"a\u00f1os":[649],"revelaran":[650],"potencial":[652],"real":[653],"nuevas":[658],"prevenci\u00f3n":[662],"DM,":[668],"revolucionando":[669],"actuales":[673],"ciencias":[676],"biom\u00e9dicas.":[677]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2017-06-15T00:00:00"}