{"id":"https://openalex.org/W2622496267","doi":"https://doi.org/10.1038/s41598-017-03837-z","title":"Integration of DNA methylation and gene transcription across nineteen cell types reveals cell type-specific and genomic region-dependent regulatory patterns","display_name":"Integration of DNA methylation and gene transcription across nineteen cell types reveals cell type-specific and genomic region-dependent regulatory patterns","publication_year":2017,"publication_date":"2017-06-09","ids":{"openalex":"https://openalex.org/W2622496267","doi":"https://doi.org/10.1038/s41598-017-03837-z","mag":"2622496267","pmid":"https://pubmed.ncbi.nlm.nih.gov/28620196","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5472622"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-017-03837-z","doi":"https://doi.org/10.1038/s41598-017-03837-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-017-03837-z","pdf_url":"https://www.nature.com/articles/s41598-017-03837-z.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-017-03837-z.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082800002","display_name":"Binhua Tang","orcid":"https://orcid.org/0000-0003-4744-5835","observed_orcids":["https://orcid.org/0000-0003-4744-5835"]},"institutions":[{"id":"https://openalex.org/I163340411","display_name":"Hohai University","ror":"https://ror.org/01wd4xt90","country_code":"CN","type":"education","lineage":["https://openalex.org/I163340411"]},{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Binhua Tang","raw_affiliation_strings":["Epigenetics & Function Group, School of the Internet of Things, Hohai University, Jiangsu, 213022, China","School of Public Health and Biostatistics, Shanghai Jiao Tong University, Shanghai, 200025, China"],"raw_orcid":"https://orcid.org/0000-0003-4744-5835","affiliations":[{"raw_affiliation_string":"Epigenetics & Function Group, School of the Internet of Things, Hohai University, Jiangsu, 213022, China","institution_ids":["https://openalex.org/I163340411"]},{"raw_affiliation_string":"School of Public Health and Biostatistics, Shanghai Jiao Tong University, Shanghai, 200025, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101552972","display_name":"Yufan Zhou","orcid":"https://orcid.org/0000-0002-8385-433X","observed_orcids":["https://orcid.org/0000-0002-8385-433X","https://orcid.org/0009-0005-3501-2268"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yufan Zhou","raw_affiliation_strings":["Department of Molecular Medicine, University of Texas Health Science Center, San Antonio, TX, 78229, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, University of Texas Health Science Center, San Antonio, TX, 78229, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037599974","display_name":"Chiou\u2010Miin Wang","orcid":"https://orcid.org/0000-0002-2681-725X","observed_orcids":["https://orcid.org/0000-0002-2681-725X"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chiou-Miin Wang","raw_affiliation_strings":["Department of Molecular Medicine, University of Texas Health Science Center, San Antonio, TX, 78229, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, University of Texas Health Science Center, San Antonio, TX, 78229, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049119185","display_name":"Tim H.\u2010M. Huang","orcid":"https://orcid.org/0000-0001-5985-9176","observed_orcids":["https://orcid.org/0000-0001-5985-9176"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tim H.-M. Huang","raw_affiliation_strings":["Department of Molecular Medicine, University of Texas Health Science Center, San Antonio, TX, 78229, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, University of Texas Health Science Center, San Antonio, TX, 78229, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066355670","display_name":"Victor X. Jin","orcid":"https://orcid.org/0000-0002-8765-3471","observed_orcids":["https://orcid.org/0000-0002-8765-3471"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Victor X. Jin","raw_affiliation_strings":["Department of Molecular Medicine, University of Texas Health Science Center, San Antonio, TX, 78229, USA. jinv@uthscsa.edu","Department of Molecular Medicine, University of Texas Health Science Center, San Antonio, TX, 78229, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, University of Texas Health Science Center, San Antonio, TX, 78229, USA. jinv@uthscsa.edu","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Department of Molecular Medicine, University of Texas Health Science Center, San Antonio, TX, 78229, USA","institution_ids":["https://openalex.org/I165951966"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5066355670"],"corresponding_institution_ids":["https://openalex.org/I165951966"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":1.675,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.83626446,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"7","issue":"1","first_page":"3626","last_page":"3626"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":1.0},{"id":"https://openalex.org/keywords/gene-transcription","display_name":"gene transcription","score":0.9520000219345093},{"id":"https://openalex.org/keywords/cell-type-specific-methylation","display_name":"cell type-specific methylation","score":0.9129999876022339},{"id":"https://openalex.org/keywords/differentially-methylated-regions","display_name":"differentially methylated regions","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cpg-islands","display_name":"CpG islands","score":0.7459999918937683},{"id":"https://openalex.org/keywords/promoter-methylation","display_name":"promoter methylation","score":0.9340000152587891},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.9350000023841858},{"id":"https://openalex.org/keywords/transcription-factor-binding","display_name":"transcription factor binding","score":0.9340000152587891},{"id":"https://openalex.org/keywords/multi-omics-integration","display_name":"multi-omics integration","score":0.7509999871253967},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.8104208707809448},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7632148265838623},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.6407579183578491},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5512115955352783},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5215346813201904},{"id":"https://openalex.org/C136953436","wikidata":"https://www.wikidata.org/wiki/Q6000286","display_name":"Illumina Methylation Assay","level":5,"score":0.5150322914123535},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5084761381149292},{"id":"https://openalex.org/C154253233","wikidata":"https://www.wikidata.org/wiki/Q14862240","display_name":"Differentially methylated regions","level":5,"score":0.49859094619750977},{"id":"https://openalex.org/C37080517","wikidata":"https://www.wikidata.org/wiki/Q18353747","display_name":"Epigenetics of physical exercise","level":5,"score":0.486215740442276},{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.4821486175060272},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.4816342890262604},{"id":"https://openalex.org/C3662595","wikidata":"https://www.wikidata.org/wiki/Q5205743","display_name":"DNA binding site","level":5,"score":0.43504321575164795},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4307779371738434},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4165896475315094},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3543187379837036},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35327810049057007}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012045","descriptor_name":"Regulatory Sequences, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41598-017-03837-z","doi":"https://doi.org/10.1038/s41598-017-03837-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-017-03837-z","pdf_url":"https://www.nature.com/articles/s41598-017-03837-z.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4325084","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5472622","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5472622","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5472622","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:28620196","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28620196","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b597d3a6847f4b45bc16c451c33629b7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b597d3a6847f4b45bc16c451c33629b7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-017-03837-z","doi":"https://doi.org/10.1038/s41598-017-03837-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-017-03837-z","pdf_url":"https://www.nature.com/articles/s41598-017-03837-z.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1123284351","display_name":"Systems Analysis of Epigenomic Architecture in Cancer Progression","funder_award_id":"U54CA217297","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1644832188","display_name":null,"funder_award_id":"BE2016655","funder_id":"https://openalex.org/F4320306202","funder_display_name":"Gordon and Betty Moore Foundation"},{"id":"https://openalex.org/G2289909747","display_name":null,"funder_award_id":"BK20161196","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G2765297562","display_name":null,"funder_award_id":"2016B08914","funder_id":"https://openalex.org/F4320306202","funder_display_name":"Gordon and Betty Moore Foundation"},{"id":"https://openalex.org/G3446954139","display_name":null,"funder_award_id":"RP150600","funder_id":"https://openalex.org/F4320332686","funder_display_name":"University of Texas Health Science Center at San Antonio"},{"id":"https://openalex.org/G3521042763","display_name":"The Single-Cell Biopsy and Characterization Core (SBCC) at The University of Texas Health Science at San Antonio","funder_award_id":"RP150600","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"},{"id":"https://openalex.org/G404151974","display_name":null,"funder_award_id":"2016B08914","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5190657771","display_name":null,"funder_award_id":"RP150600","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5686018404","display_name":null,"funder_award_id":"BE2016655","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6709856309","display_name":"Novel epigenetic paradigm in endometrial cancer recurrence","funder_award_id":"R01CA172279","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7030894098","display_name":"Omics analysis of three-dimensional transcriptional regulation","funder_award_id":"R01GM114142","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8213452828","display_name":null,"funder_award_id":"BK20161196","funder_id":"https://openalex.org/F4320306202","funder_display_name":"Gordon and Betty Moore Foundation"},{"id":"https://openalex.org/G8245516829","display_name":null,"funder_award_id":"CE20155050","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8461265337","display_name":null,"funder_award_id":"CE20155050","funder_id":"https://openalex.org/F4320306202","funder_display_name":"Gordon and Betty Moore Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306202","display_name":"Gordon and Betty Moore Foundation","ror":"https://ror.org/006wxqw41"},{"id":"https://openalex.org/F4320308129","display_name":"Cancer Prevention and Research Institute of Texas","ror":"https://ror.org/0003xa228"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332686","display_name":"University of Texas Health Science Center at San Antonio","ror":"https://ror.org/02f6dcw23"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2622496267.pdf","grobid_xml":"https://content.openalex.org/works/W2622496267.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W103650626","https://openalex.org/W1544691147","https://openalex.org/W1578537223","https://openalex.org/W1821797507","https://openalex.org/W1963590871","https://openalex.org/W1984714342","https://openalex.org/W1987557775","https://openalex.org/W1991959431","https://openalex.org/W1997639391","https://openalex.org/W1997792415","https://openalex.org/W2012462525","https://openalex.org/W2015749074","https://openalex.org/W2017502278","https://openalex.org/W2030808038","https://openalex.org/W2034594496","https://openalex.org/W2046387526","https://openalex.org/W2059099579","https://openalex.org/W2060075610","https://openalex.org/W2069739265","https://openalex.org/W2100117788","https://openalex.org/W2108234281","https://openalex.org/W2109715726","https://openalex.org/W2110881699","https://openalex.org/W2115321397","https://openalex.org/W2115899293","https://openalex.org/W2119393622","https://openalex.org/W2125397535","https://openalex.org/W2127192982","https://openalex.org/W2128130893","https://openalex.org/W2128609874","https://openalex.org/W2135497302","https://openalex.org/W2137147070","https://openalex.org/W2145171782","https://openalex.org/W2147841875","https://openalex.org/W2148521032","https://openalex.org/W2150194502","https://openalex.org/W2150936392","https://openalex.org/W2152239989","https://openalex.org/W2152642144","https://openalex.org/W2156124720","https://openalex.org/W2164690942","https://openalex.org/W2166466845","https://openalex.org/W2169556367","https://openalex.org/W2170551349","https://openalex.org/W2259938310","https://openalex.org/W2309481081","https://openalex.org/W2339513403","https://openalex.org/W2507593442","https://openalex.org/W2560609509"],"related_works":["https://openalex.org/W2184884430","https://openalex.org/W2923862378","https://openalex.org/W2154476908","https://openalex.org/W4256131725","https://openalex.org/W6920734939","https://openalex.org/W2258491606","https://openalex.org/W4414622677","https://openalex.org/W808690569","https://openalex.org/W3003540881","https://openalex.org/W2146390965"],"abstract_inverted_index":{"Despite":[0],"numerous":[1],"studies":[2],"done":[3],"on":[4,15,133],"understanding":[5],"the":[6,78,107,150,159],"role":[7],"of":[8,18,32,140,180],"DNA":[9,23,33,110,141],"methylation,":[10,111],"limited":[11],"work":[12],"has":[13,129],"focused":[14],"systems":[16],"integration":[17],"cell":[19,37,46,72,79,85,152,166],"type-specific":[20,47,73,80,167],"interplay":[21,156],"between":[22,158],"methylation":[24,34,81,128,142],"and":[25,56,66,118,143,168,173],"gene":[26,116,121],"transcription.":[27],"Through":[28],"a":[29,100,175],"genome-wide":[30],"analysis":[31,164],"across":[35,82,149],"19":[36,151],"types":[38,153],"with":[39,91],"T-47D":[40,71],"as":[41],"reference,":[42],"we":[43],"identified":[44],"106,252":[45],"differentially-methylated":[48],"CpGs":[49],"categorized":[50],"into":[51],"7,537":[52],"differentially":[53],"(46.6%":[54],"hyper-":[55],"53.4%":[57],"hypo-)":[58],"methylated":[59],"regions.":[60,138],"We":[61,97],"found":[62],"44%":[63],"promoter":[64],"regions":[65],"75%":[67],"CpG":[68],"islands":[69],"were":[70],"methylated.":[74],"Pyrosequencing":[75],"experiments":[76],"validated":[77],"three":[83],"benchmark":[84],"lines.":[86],"Interestingly,":[87],"these":[88],"DMRs":[89],"overlapped":[90],"1,145":[92],"known":[93],"tumor":[94,119],"suppressor":[95,120],"genes.":[96],"then":[98],"developed":[99],"Bayesian":[101],"Gaussian":[102],"Regression":[103],"model":[104,124],"to":[105],"measure":[106],"relationship":[108],"among":[109],"genomic":[112,169],"segment":[113],"distribution,":[114],"differential":[115],"expression":[117],"status.":[122],"The":[123],"uncovered":[125],"that":[126],"3'UTR":[127],"much":[130],"less":[131],"impact":[132],"transcriptional":[134],"activity":[135],"than":[136],"other":[137],"Integration":[139],"82":[144],"transcription":[145],"factor":[146],"binding":[147],"information":[148],"suggested":[154],"diverse":[155],"patterns":[157,172],"two":[160],"regulators.":[161],"Our":[162],"integrative":[163],"reveals":[165],"region-dependent":[170],"regulatory":[171],"provides":[174],"perspective":[176],"for":[177],"integrating":[178],"hundreds":[179],"various":[181],"omics-seq":[182],"data":[183],"together.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-06-15T00:00:00"}