{"id":"https://openalex.org/W2622495486","doi":null,"title":"Anti-tumor effect of primaquine compounds in human breast cancer cells","display_name":"Anti-tumor effect of primaquine compounds in human breast cancer cells","publication_year":2007,"publication_date":"2007-05-01","ids":{"openalex":"https://openalex.org/W2622495486","mag":"2622495486"},"language":"en","primary_location":{"id":"mag:2622495486","doi":null,"is_oa":false,"landing_page_url":"http://cancerres.aacrjournals.org/content/67/9_Supplement/444","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007790890","display_name":"Gunjan Gakhar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gunjan Gakhar","raw_affiliation_strings":["Kansas State Univ., Manhattan, KS;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kansas State Univ., Manhattan, KS;","institution_ids":["https://openalex.org/I189590672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083077945","display_name":"Takahiro Ohira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takahiro Ohira","raw_affiliation_strings":["Kansas State Univ., Manhattan, KS;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kansas State Univ., Manhattan, KS;","institution_ids":["https://openalex.org/I189590672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064018311","display_name":"Sreenivas Battina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sreenivas Battina","raw_affiliation_strings":["Kansas State Univ., Manhattan, KS;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kansas State Univ., Manhattan, KS;","institution_ids":["https://openalex.org/I189590672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080911765","display_name":"Duy H. Hua","orcid":"https://orcid.org/0000-0001-7179-0108","observed_orcids":["https://orcid.org/0000-0001-7179-0108"]},"institutions":[{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Duy H. Hua","raw_affiliation_strings":["Kansas State Univ., Manhattan, KS;"],"raw_orcid":"https://orcid.org/0000-0001-7179-0108","affiliations":[{"raw_affiliation_string":"Kansas State Univ., Manhattan, KS;","institution_ids":["https://openalex.org/I189590672"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108698755","display_name":"Thu Annelise Nguyen","orcid":"https://orcid.org/0000-0002-9952-3869","observed_orcids":["https://orcid.org/0000-0002-9952-3869","https://orcid.org/0009-0002-8685-8472"]},"institutions":[{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thu Annelise Nguyen","raw_affiliation_strings":["Kansas State Univ., Manhattan, KS;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kansas State Univ., Manhattan, KS;","institution_ids":["https://openalex.org/I189590672"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I189590672"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.29739426,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"67","issue":null,"first_page":"444","last_page":"444"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/substituted-quinolines","display_name":"substituted quinolines","score":0.9860000014305115},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.906000018119812},{"id":"https://openalex.org/keywords/gap-junctional-intercellular-communication","display_name":"gap junctional intercellular communication","score":0.9909999966621399},{"id":"https://openalex.org/keywords/connexins","display_name":"connexins","score":0.9760000109672546},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.9269999861717224},{"id":"https://openalex.org/keywords/colony-formation","display_name":"colony formation","score":0.8510000109672546},{"id":"https://openalex.org/keywords/mda-mb-453-cells","display_name":"MDA-MB-453 cells","score":0.9710000157356262},{"id":"https://openalex.org/keywords/t47d-cells","display_name":"T47D cells","score":0.9959999918937683},{"id":"https://openalex.org/keywords/computational-docking","display_name":"computational docking","score":0.45100000500679016},{"id":"https://openalex.org/keywords/dye-transfer","display_name":"dye transfer","score":0.3610000014305115}],"concepts":[{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.7027280926704407},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5692662596702576},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5441495180130005},{"id":"https://openalex.org/C158157758","wikidata":"https://www.wikidata.org/wiki/Q232438","display_name":"Gap junction","level":3,"score":0.5325796604156494},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.52816241979599},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.518884003162384},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.506393313407898},{"id":"https://openalex.org/C2776793103","wikidata":"https://www.wikidata.org/wiki/Q419834","display_name":"Primaquine","level":4,"score":0.5059558749198914},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4655595123767853},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4493003785610199},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43685898184776306},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.42358213663101196},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34072145819664},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3000161051750183},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27671724557876587},{"id":"https://openalex.org/C2777425658","wikidata":"https://www.wikidata.org/wiki/Q422438","display_name":"Chloroquine","level":3,"score":0.0659419596195221},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0642302930355072},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2622495486","doi":null,"is_oa":false,"landing_page_url":"http://cancerres.aacrjournals.org/content/67/9_Supplement/444","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8399999737739563,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2146777040","https://openalex.org/W2329081865","https://openalex.org/W2169079322","https://openalex.org/W1991846000","https://openalex.org/W2079021534","https://openalex.org/W3000086270","https://openalex.org/W2016551078","https://openalex.org/W2313955419","https://openalex.org/W2153939259","https://openalex.org/W2019899538"],"abstract_inverted_index":{"444":[0],"Purpose:":[2],"Cancer":[3,34],"in":[4,11,60,128,154,168,171,183,193,209,224,233,269,273],"part":[5],"is":[6,52,226],"caused":[7],"by":[8,91,191,217],"the":[9,28,92,98,102,117,120,125,140,144,169,198,202,206,230,246,252],"disruption":[10],"cell\u2019s":[12],"homeostasis,":[13],"affecting":[14],"its":[15],"ability":[16],"to":[17,19,46,53,63,84,115,180,229,244],"respond":[18],"extracellular":[20],"signals,":[21],"triggering":[22],"some":[23],"intracellular":[24],"events":[25],"which":[26],"affect":[27],"gap":[29,145],"junctional":[30],"intercellular":[31],"communication":[32],"(GJIC).":[33],"cells":[35,51,81,173],"have":[36,265],"reduced":[37],"or":[38],"altered":[39],"GJIC":[40,170,203,225],"capacity.":[41],"Therefore,":[42],"one":[43],"feasible":[44],"approach":[45],"reduce":[47],"growth":[48,108,187,195],"of":[49,119,249,251],"cancer":[50,70,131,157,236,276],"enhance/alter":[54],"GJIC.":[55,86],"Substituted":[56,135],"quinolines":[57,136],"were":[58,89,214],"used":[59],"this":[61],"study":[62],"find":[64],"their":[65],"effect":[66,118,153,232],"on":[67,97,124,139],"human":[68,129,155,234,274],"breast":[69,130,156,275],"cells.":[71,106,132,211,277],"Methods:":[73],"Parachute":[74],"assay":[75,109],"using":[76,110],"dye-labeled":[77],"donor":[78,103],"and":[79,104,174,204],"acceptor":[80,105],"was":[82,113,189],"performed":[83],"measure":[85],"The":[87],"results":[88,213,260],"obtained":[90],"flow":[93],"cytometric":[94],"analysis":[95],"based":[96,138],"dye":[99],"transfer":[100],"between":[101],"Colony":[107],"soft":[111],"agar":[112],"done":[114],"determine":[116],"primaquine":[121],"(PQ)":[122],"compounds":[123,264],"colony":[126,194,207],"formation":[127,208],"Results:":[134],"synthesized":[137],"computational":[141],"docking":[142],"with":[143],"junction":[146],"proteins":[147],"(connexins),":[148],"showed":[149,163],"a":[150,164,266],"tremendous":[151],"anti-tumor":[152,231,271],"cell":[158,176,237],"lines.":[159,177],"PQ1":[160,192],"(500":[161],"nM)":[162],"20-50":[165],"%":[166,186],"increase":[167,182,223],"MDA-MB-453":[172,210],"T47D":[175],"In":[178],"addition":[179],"an":[181,222],"GJIC,":[184],"80-95":[185],"attenuation":[188],"observed":[190,216],"assay.":[196],"On":[197],"contrary,":[199],"PQ3":[200],"decreased":[201],"increased":[205],"These":[212],"also":[215],"Saez":[218],"et":[219],"al.":[220],"that":[221,262],"directly":[227],"related":[228],"mammary":[235],"line.":[238],"Further":[239],"studies":[240],"are":[241],"being":[242],"conducted":[243],"know":[245],"exact":[247],"mechanism":[248],"action":[250],"substituted":[253],"quinolines.":[254],"Conclusions:":[256],"So":[257],"far":[258],"these":[259],"show":[261],"PQ":[263],"promising":[267],"role":[268],"exerting":[270],"activity":[272]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2017-06-15T00:00:00"}
