{"id":"https://openalex.org/W2622288697","doi":"https://doi.org/10.1021/acs.orglett.7b01466","title":"Solid-Phase Synthesis of Oxetane Modified Peptides","display_name":"Solid-Phase Synthesis of Oxetane Modified Peptides","publication_year":2017,"publication_date":"2017-06-06","ids":{"openalex":"https://openalex.org/W2622288697","doi":"https://doi.org/10.1021/acs.orglett.7b01466","mag":"2622288697","pmid":"https://pubmed.ncbi.nlm.nih.gov/28585839"},"language":"en","primary_location":{"id":"doi:10.1021/acs.orglett.7b01466","doi":"https://doi.org/10.1021/acs.orglett.7b01466","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.orglett.7b01466","pdf_url":null,"source":{"id":"https://openalex.org/S201989124","display_name":"Organic Letters","issn_l":"1523-7052","issn":["1523-7052","1523-7060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000356241","display_name":"Jonathan D. Beadle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jonathan D. Beadle","raw_affiliation_strings":["Department\rof Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, U.K","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036184689","display_name":"Astrid Knuhtsen","orcid":"https://orcid.org/0000-0001-7622-5634","observed_orcids":["https://orcid.org/0000-0001-7622-5634"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Astrid Knuhtsen","raw_affiliation_strings":["School\rof Chemistry, University of Glasgow, Joseph Black Building, University\rAvenue, Glasgow G12 8QQ, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School\rof Chemistry, University of Glasgow, Joseph Black Building, University\rAvenue, Glasgow G12 8QQ, U.K","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024934573","display_name":"Alex Hoose","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alex Hoose","raw_affiliation_strings":["School\rof Chemistry, University of Glasgow, Joseph Black Building, University\rAvenue, Glasgow G12 8QQ, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School\rof Chemistry, University of Glasgow, Joseph Black Building, University\rAvenue, Glasgow G12 8QQ, U.K","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063676198","display_name":"Piotr Raubo","orcid":"https://orcid.org/0000-0002-2365-0976","observed_orcids":["https://orcid.org/0000-0002-2365-0976"]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Piotr Raubo","raw_affiliation_strings":["IMED\rOncology, AstraZeneca, 310 Cambridge Science Park, Milton Road, Cambridge CB4 0WG, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IMED\rOncology, AstraZeneca, 310 Cambridge Science Park, Milton Road, Cambridge CB4 0WG, U.K","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033695188","display_name":"Andrew G. Jamieson","orcid":"https://orcid.org/0000-0003-1726-7353","observed_orcids":["https://orcid.org/0000-0003-1726-7353"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Andrew G. Jamieson","raw_affiliation_strings":["School\rof Chemistry, University of Glasgow, Joseph Black Building, University\rAvenue, Glasgow G12 8QQ, U.K"],"raw_orcid":"https://orcid.org/0000-0003-1726-7353","affiliations":[{"raw_affiliation_string":"School\rof Chemistry, University of Glasgow, Joseph Black Building, University\rAvenue, Glasgow G12 8QQ, U.K","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010863533","display_name":"Michael Shipman","orcid":"https://orcid.org/0000-0002-3349-5594","observed_orcids":["https://orcid.org/0000-0002-3349-5594"]},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Michael Shipman","raw_affiliation_strings":["Department\rof Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, U.K"],"raw_orcid":"https://orcid.org/0000-0002-3349-5594","affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, U.K","institution_ids":["https://openalex.org/I39555362"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5010863533","https://openalex.org/A5033695188"],"corresponding_institution_ids":["https://openalex.org/I39555362","https://openalex.org/I7882870"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.6328,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.83194267,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"19","issue":"12","first_page":"3303","last_page":"3306"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/solid-phase-peptide-synthesis","display_name":"solid-phase peptide synthesis","score":0.875},{"id":"https://openalex.org/keywords/oxetanes","display_name":"oxetanes","score":0.7089999914169312},{"id":"https://openalex.org/keywords/peptidomimetics","display_name":"peptidomimetics","score":0.9679999947547913},{"id":"https://openalex.org/keywords/backbone-modification","display_name":"backbone modification","score":0.6769999861717224},{"id":"https://openalex.org/keywords/fmoc-spps","display_name":"Fmoc-SPPS","score":0.7009999752044678},{"id":"https://openalex.org/keywords/bradykinin","display_name":"bradykinin","score":0.9459999799728394},{"id":"https://openalex.org/keywords/enkephalin","display_name":"enkephalin","score":0.8399999737739563}],"concepts":[{"id":"https://openalex.org/C2780497619","wikidata":"https://www.wikidata.org/wiki/Q418107","display_name":"Oxetane","level":2,"score":0.9863206744194031},{"id":"https://openalex.org/C124790011","wikidata":"https://www.wikidata.org/wiki/Q2069797","display_name":"Peptidomimetic","level":3,"score":0.8983761072158813},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8596023321151733},{"id":"https://openalex.org/C2779138802","wikidata":"https://www.wikidata.org/wiki/Q418602","display_name":"Dipeptide","level":3,"score":0.8519412279129028},{"id":"https://openalex.org/C2776469878","wikidata":"https://www.wikidata.org/wiki/Q2026994","display_name":"Solid-phase synthesis","level":3,"score":0.7196963429450989},{"id":"https://openalex.org/C2780378348","wikidata":"https://www.wikidata.org/wiki/Q25351438","display_name":"Ring (chemistry)","level":2,"score":0.6472854018211365},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5965217351913452},{"id":"https://openalex.org/C2779809887","wikidata":"https://www.wikidata.org/wiki/Q14864278","display_name":"Peptide synthesis","level":3,"score":0.5744351148605347},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5515470504760742},{"id":"https://openalex.org/C2778439535","wikidata":"https://www.wikidata.org/wiki/Q188777","display_name":"Amide","level":2,"score":0.5198293328285217},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3932596445083618},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.21478518843650818},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06856751441955566}],"mesh":[{"descriptor_ui":"D004988","descriptor_name":"Ethers, Cyclic","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060327","descriptor_name":"Solid-Phase Synthesis Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/acs.orglett.7b01466","doi":"https://doi.org/10.1021/acs.orglett.7b01466","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.orglett.7b01466","pdf_url":null,"source":{"id":"https://openalex.org/S201989124","display_name":"Organic Letters","issn_l":"1523-7052","issn":["1523-7052","1523-7060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic Letters","raw_type":"journal-article"},{"id":"pmid:28585839","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28585839","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic letters","raw_type":"Journal Article"},{"id":"pmh:oai:wrap.warwick.ac.uk:88750","doi":null,"is_oa":false,"landing_page_url":"http://wrap.warwick.ac.uk/88750/7/WRAP-solid-phase-oxetane-modified-peptides-Beadle-2017.pdf","pdf_url":"http://wrap.warwick.ac.uk/88750/7/WRAP-solid-phase-oxetane-modified-peptides-Beadle-2017.pdf","source":{"id":"https://openalex.org/S4306400665","display_name":"Warwick Research Archive Portal (University of Warwick)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I39555362","host_organization_name":"University of Warwick","host_organization_lineage":["https://openalex.org/I39555362"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.gla.ac.uk:142474","doi":null,"is_oa":false,"landing_page_url":"http://eprints.gla.ac.uk/view/author/37188.html>,","pdf_url":null,"source":{"id":"https://openalex.org/S4210235606","display_name":"ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)","issn_l":"2622-8912","issn":["2622-8912","2622-8920"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/I4405259220","host_organization_name":"Institut Agama Islam Negeri Langsa","host_organization_lineage":["https://openalex.org/I4405259220"],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Articles"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1495909999","display_name":"Core Capability for Chemistry Research at the University of Warwick","funder_award_id":"EP/L027100/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1499739398","https://openalex.org/W1934784132","https://openalex.org/W1964580701","https://openalex.org/W1969350101","https://openalex.org/W1981174857","https://openalex.org/W1992450378","https://openalex.org/W1998129163","https://openalex.org/W2010543958","https://openalex.org/W2020026393","https://openalex.org/W2033743162","https://openalex.org/W2059792490","https://openalex.org/W2059862840","https://openalex.org/W2060846993","https://openalex.org/W2103729102","https://openalex.org/W2107982456","https://openalex.org/W2131016507","https://openalex.org/W2139268587","https://openalex.org/W2143271842","https://openalex.org/W2145654832","https://openalex.org/W2156546359","https://openalex.org/W2243713023","https://openalex.org/W2317183888","https://openalex.org/W2319717694","https://openalex.org/W2332925503","https://openalex.org/W2410171596","https://openalex.org/W2431276850","https://openalex.org/W2467404890","https://openalex.org/W2519006730","https://openalex.org/W2531981640","https://openalex.org/W2541652158","https://openalex.org/W2553739816","https://openalex.org/W2556148213","https://openalex.org/W2594242503","https://openalex.org/W2611328998","https://openalex.org/W4253650916","https://openalex.org/W4299993368"],"related_works":["https://openalex.org/W2903362512","https://openalex.org/W3037252485","https://openalex.org/W2010543958","https://openalex.org/W1871545954","https://openalex.org/W2332925503","https://openalex.org/W2094935419","https://openalex.org/W2949995637","https://openalex.org/W2093720898","https://openalex.org/W2014352546","https://openalex.org/W3185899234"],"abstract_inverted_index":{"Solid-phase":[0],"peptide":[1,41],"synthesis":[2],"(SPPS)":[3],"is":[4,18,49],"used":[5,50],"to":[6,51],"create":[7],"peptidomimetics":[8],"in":[9,33,36,57],"which":[10],"one":[11],"of":[12,55,64],"the":[13,65],"backbone":[14,61],"amide":[15],"C\u2550O":[16],"bonds":[17],"replaced":[19],"by":[20,43],"a":[21,53],"four-membered":[22],"oxetane":[23,26],"ring.":[24],"The":[25],"containing":[27],"dipeptide":[28],"building":[29],"blocks":[30],"are":[31],"made":[32],"three":[34],"steps":[35],"solution,":[37],"then":[38],"integrated":[39],"into":[40],"chains":[42],"conventional":[44],"Fmoc":[45],"SPPS.":[46],"This":[47],"methodology":[48],"make":[52],"range":[54],"peptides":[56],"high":[58],"purity":[59],"including":[60],"modified":[62],"derivatives":[63],"nonapeptide":[66],"bradykinin":[67],"and":[68,70],"Met-":[69],"Leu-enkephalin.":[71]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2017-06-15T00:00:00"}
