{"id":"https://openalex.org/W2621999105","doi":null,"title":"Preliminary study integrating CACNA1C rs1006737, hippocampal and amygdala volumes, and peripheral endothelial function in youth with bipolar disorder","display_name":"Preliminary study integrating CACNA1C rs1006737, hippocampal and amygdala volumes, and peripheral endothelial function in youth with bipolar disorder","publication_year":2015,"publication_date":"2015-11-01","ids":{"openalex":"https://openalex.org/W2621999105","mag":"2621999105"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/71443","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/71443","pdf_url":"https://utoronto.scholaris.ca/bitstreams/dfae14b5-5680-4801-8fc5-3b2fcf61fcb7/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/dfae14b5-5680-4801-8fc5-3b2fcf61fcb7/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101929093","display_name":"Xiao Ou","orcid":"https://orcid.org/0000-0001-9941-5086","observed_orcids":["https://orcid.org/0000-0001-9941-5086"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Xiao Ou","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9941-5086","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5101929093"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":0.984000027179718},{"id":"https://openalex.org/keywords/hippocampal-volume","display_name":"hippocampal volume","score":0.7400000095367432},{"id":"https://openalex.org/keywords/amygdala-volume","display_name":"amygdala volume","score":1.0},{"id":"https://openalex.org/keywords/endothelial-function","display_name":"endothelial function","score":0.9419999718666077},{"id":"https://openalex.org/keywords/reactive-hyperemia-index","display_name":"reactive hyperemia index","score":0.9929999709129333},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.7080000042915344},{"id":"https://openalex.org/keywords/adolescents","display_name":"adolescents","score":0.625},{"id":"https://openalex.org/keywords/vascular-dysfunction","display_name":"vascular dysfunction","score":0.6639999747276306},{"id":"https://openalex.org/keywords/neuroimaging-genetics","display_name":"neuroimaging genetics","score":0.5139999985694885}],"concepts":[{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.6806066632270813},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.6320029497146606},{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.5619314312934875},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5336741805076599},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.5282496809959412},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.49094322323799133},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3322966694831848},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2328414022922516},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.1351640522480011}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/71443","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/71443","pdf_url":"https://utoronto.scholaris.ca/bitstreams/dfae14b5-5680-4801-8fc5-3b2fcf61fcb7/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2621999105","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/handle/1807/71443","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/71443","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/71443","pdf_url":"https://utoronto.scholaris.ca/bitstreams/dfae14b5-5680-4801-8fc5-3b2fcf61fcb7/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2621999105.pdf","grobid_xml":"https://content.openalex.org/works/W2621999105.grobid-xml"},"referenced_works_count":183,"referenced_works":["https://openalex.org/W28259713","https://openalex.org/W63530261","https://openalex.org/W146241754","https://openalex.org/W1512582702","https://openalex.org/W1530648036","https://openalex.org/W1551871005","https://openalex.org/W1583309920","https://openalex.org/W1598901374","https://openalex.org/W1779998563","https://openalex.org/W1890365091","https://openalex.org/W1897313079","https://openalex.org/W1963525383","https://openalex.org/W1965200476","https://openalex.org/W1966846181","https://openalex.org/W1967319815","https://openalex.org/W1968910493","https://openalex.org/W1970071203","https://openalex.org/W1971231611","https://openalex.org/W1974103634","https://openalex.org/W1976027227","https://openalex.org/W1976525747","https://openalex.org/W1977370435","https://openalex.org/W1978028209","https://openalex.org/W1978473122","https://openalex.org/W1980445357","https://openalex.org/W1980708245","https://openalex.org/W1980935828","https://openalex.org/W1984344128","https://openalex.org/W1986414397","https://openalex.org/W1987092120","https://openalex.org/W1989190407","https://openalex.org/W1989524155","https://openalex.org/W1991137238","https://openalex.org/W1992235145","https://openalex.org/W1993156826","https://openalex.org/W1997800609","https://openalex.org/W1998026858","https://openalex.org/W1999384062","https://openalex.org/W2004702938","https://openalex.org/W2006240898","https://openalex.org/W2009359462","https://openalex.org/W2013524893","https://openalex.org/W2013616449","https://openalex.org/W2015907312","https://openalex.org/W2019823288","https://openalex.org/W2022737042","https://openalex.org/W2023280641","https://openalex.org/W2023721895","https://openalex.org/W2024324080","https://openalex.org/W2025220591","https://openalex.org/W2025785448","https://openalex.org/W2026483099","https://openalex.org/W2027651287","https://openalex.org/W2028829892","https://openalex.org/W2029355073","https://openalex.org/W2030142462","https://openalex.org/W2030239128","https://openalex.org/W2032263243","https://openalex.org/W2032266474","https://openalex.org/W2033564458","https://openalex.org/W2033877733","https://openalex.org/W2034420866","https://openalex.org/W2035897560","https://openalex.org/W2036940388","https://openalex.org/W2039271434","https://openalex.org/W2040089027","https://openalex.org/W2041695697","https://openalex.org/W2043834761","https://openalex.org/W2044537463","https://openalex.org/W2044682081","https://openalex.org/W2046394984","https://openalex.org/W2046525566","https://openalex.org/W2048490730","https://openalex.org/W2049367879","https://openalex.org/W2049644913","https://openalex.org/W2051442292","https://openalex.org/W2051474210","https://openalex.org/W2052542292","https://openalex.org/W2053850273","https://openalex.org/W2054759047","https://openalex.org/W2055048118","https://openalex.org/W2055628680","https://openalex.org/W2056437482","https://openalex.org/W2056871133","https://openalex.org/W2057093924","https://openalex.org/W2057680708","https://openalex.org/W2057947737","https://openalex.org/W2058064579","https://openalex.org/W2058623711","https://openalex.org/W2058871198","https://openalex.org/W2059747380","https://openalex.org/W2059962099","https://openalex.org/W2060393124","https://openalex.org/W2061291232","https://openalex.org/W2061730652","https://openalex.org/W2066272389","https://openalex.org/W2066484607","https://openalex.org/W2067690490","https://openalex.org/W2068673490","https://openalex.org/W2070661549","https://openalex.org/W2075783651","https://openalex.org/W2077264199","https://openalex.org/W2078814832","https://openalex.org/W2080438854","https://openalex.org/W2081463778","https://openalex.org/W2083481797","https://openalex.org/W2084246956","https://openalex.org/W2086189477","https://openalex.org/W2086380049","https://openalex.org/W2087380461","https://openalex.org/W2089119365","https://openalex.org/W2090443073","https://openalex.org/W2090844409","https://openalex.org/W2091085835","https://openalex.org/W2092276420","https://openalex.org/W2094621685","https://openalex.org/W2096492990","https://openalex.org/W2097185673","https://openalex.org/W2101835986","https://openalex.org/W2103879771","https://openalex.org/W2104153167","https://openalex.org/W2105659365","https://openalex.org/W2107769626","https://openalex.org/W2109228085","https://openalex.org/W2112520390","https://openalex.org/W2113064385","https://openalex.org/W2113823824","https://openalex.org/W2114776324","https://openalex.org/W2115600578","https://openalex.org/W2115932177","https://openalex.org/W2115943979","https://openalex.org/W2116281278","https://openalex.org/W2117629429","https://openalex.org/W2120835853","https://openalex.org/W2122281432","https://openalex.org/W2122796918","https://openalex.org/W2123565319","https://openalex.org/W2123593542","https://openalex.org/W2125632358","https://openalex.org/W2126315306","https://openalex.org/W2127442418","https://openalex.org/W2127961883","https://openalex.org/W2133054185","https://openalex.org/W2134182910","https://openalex.org/W2134242881","https://openalex.org/W2135822343","https://openalex.org/W2136429263","https://openalex.org/W2137746168","https://openalex.org/W2137993589","https://openalex.org/W2140054173","https://openalex.org/W2141041835","https://openalex.org/W2141401431","https://openalex.org/W2142037089","https://openalex.org/W2143350876","https://openalex.org/W2143693375","https://openalex.org/W2146609951","https://openalex.org/W2146625223","https://openalex.org/W2146738944","https://openalex.org/W2148104813","https://openalex.org/W2148983264","https://openalex.org/W2151130155","https://openalex.org/W2151284870","https://openalex.org/W2151639793","https://openalex.org/W2153391036","https://openalex.org/W2155628709","https://openalex.org/W2157178636","https://openalex.org/W2158521887","https://openalex.org/W2158553737","https://openalex.org/W2158991820","https://openalex.org/W2159957894","https://openalex.org/W2163274894","https://openalex.org/W2164619935","https://openalex.org/W2164988082","https://openalex.org/W2165041692","https://openalex.org/W2167194664","https://openalex.org/W2169192753","https://openalex.org/W2169657200","https://openalex.org/W2258165450","https://openalex.org/W2326537864","https://openalex.org/W2332589285","https://openalex.org/W2408552022","https://openalex.org/W2468358945","https://openalex.org/W2468882045"],"related_works":["https://openalex.org/W3048765227","https://openalex.org/W4315927952","https://openalex.org/W241219989","https://openalex.org/W2942418519","https://openalex.org/W1998026858","https://openalex.org/W2147763080","https://openalex.org/W2609079961","https://openalex.org/W2054265820","https://openalex.org/W6957970889","https://openalex.org/W2917892572"],"abstract_inverted_index":{"Multiple":[0],"genome":[1],"wide":[2],"association":[3],"studies":[4],"have":[5],"identified":[6],"a":[7,30,43,122,142],"bipolar":[8],"disorder":[9],"(BD)":[10],"-":[11],"risk":[12,91],"allele":[13,92],"polymorphism":[14],"(CACNA1C":[15],"rs1006737).":[16],"rs1006737":[17,137],"is":[18],"implicated":[19],"in":[20,23,54,81,97,118,128],"neurostructural":[21],"differences":[22],"non-BD":[24],"carriers.":[25],"As":[26],"CACNA1C":[27,136],"codes":[28],"for":[29,34,46],"protein":[31],"subunit":[32],"responsible":[33],"endothelial":[35,69],"function,":[36],"we":[37],"predicted":[38],"it":[39],"might":[40],"serve":[41],"as":[42,141],"genetic":[44],"underpinning":[45],"both":[47],"the":[48,82,90,98,129],"cardiovascular":[49],"and":[50,67,101,121,147],"neurological":[51],"phenotypes":[52],"seen":[53],"BD.":[55],"Fifty":[56],"adolescents":[57],"(25":[58],"healthy":[59,87,106],"controls,":[60],"25":[61],"BD)":[62],"completed":[63],"genotyping,":[64],"structural":[65],"scans,":[66],"an":[68],"function":[70],"test":[71],"[reactive":[72],"hyperemia":[73],"index":[74],"(RHI)].":[75],"No":[76],"gene":[77],"effects":[78],"were":[79],"observed":[80,127],"amygdala":[83,102],"or":[84],"hippocampus,":[85],"however":[86],"carriers":[88],"of":[89,131],"showed":[93],"trending":[94],"reduced":[95],"volume":[96,117],"bilateral":[99],"hippocampus":[100,116,130],"when":[103],"compared":[104],"to":[105],"non-carriers.":[107],"Furthermore,":[108],"RHI":[109],"was":[110,126],"non-significantly":[111],"negatively":[112],"correlated":[113],"with":[114],"left":[115],"HC":[119],"non-carriers,":[120],"significant":[123],"gene-RHI":[124],"interaction":[125],"HC.":[132],"These":[133],"findings":[134],"suggest":[135],"warrants":[138],"further":[139],"study":[140],"potential":[143],"bridge":[144],"between":[145],"BD":[146],"vascular":[148],"dysfunction.":[149]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2017-06-15T00:00:00"}
