{"id":"https://openalex.org/W2621924249","doi":"https://doi.org/10.16016/j.1000-5404.201610128","title":"Toll\u6837\u53d7\u4f534/\u6838\u8f6c\u5f55\u56e0\u5b50-\u03baB\u4fe1\u53f7\u901a\u8def\u4fc3\u8fdb\u9ad8\u78f7\u8bf1\u5bfc\u8840\u7ba1\u5e73\u6ed1\u808c\u7ec6\u80de\u9499\u5316","display_name":"Toll\u6837\u53d7\u4f534/\u6838\u8f6c\u5f55\u56e0\u5b50-\u03baB\u4fe1\u53f7\u901a\u8def\u4fc3\u8fdb\u9ad8\u78f7\u8bf1\u5bfc\u8840\u7ba1\u5e73\u6ed1\u808c\u7ec6\u80de\u9499\u5316","publication_year":2017,"publication_date":"2017-04-30","ids":{"openalex":"https://openalex.org/W2621924249","doi":"https://doi.org/10.16016/j.1000-5404.201610128","mag":"2621924249"},"language":"zh","primary_location":{"id":"mag:2621924249","doi":"https://doi.org/10.16016/j.1000-5404.201610128","is_oa":false,"landing_page_url":"http://aammt.tmmu.edu.cn/Upload/rhtml/201610128.htm","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071416132","display_name":"\u5f20\u9053\u6d77","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u5f20\u9053\u6d77","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018100091","display_name":"Haidao Zhang","orcid":"https://orcid.org/0009-0002-0346-5631","observed_orcids":["https://orcid.org/0009-0002-0346-5631"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haidao Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043822443","display_name":"\u8096\u5802\u5229","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u8096\u5802\u5229","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109701563","display_name":"Tangli Xiao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao Tangli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043890023","display_name":"\u4f59\u5f66\u9716","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u4f59\u5f66\u9716","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108605073","display_name":"Yu Yanlin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu Yanlin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054425061","display_name":"Liu guo Liang","orcid":"https://orcid.org/0000-0001-9491-8821","observed_orcids":["https://orcid.org/0000-0001-9491-8821"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liu guo Liang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100322344","display_name":"Liang Liu","orcid":"https://orcid.org/0000-0001-8630-7430","observed_orcids":["https://orcid.org/0000-0001-8630-7430"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liang Liu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8630-7430","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033080900","display_name":"\u5218\u6c38","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u5218\u6c38","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100371155","display_name":"Yong U. Liu","orcid":"https://orcid.org/0000-0003-4079-2156","observed_orcids":["https://orcid.org/0000-0003-4079-2156","https://orcid.org/0000-0003-1278-7114"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yong Liu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4079-2156","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"\u90d1\u660c\u73b2","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u90d1\u660c\u73b2","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100547369","display_name":"Zheng Changling","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zheng Changling","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080203403","display_name":"\u8042\u51cc","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u8042\u51cc","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100539579","display_name":"Nie Ling","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nie Ling","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052932163","display_name":"\u8d75\u666f\u5b8f","orcid":"https://orcid.org/0000-0001-9750-3285","observed_orcids":["https://orcid.org/0000-0001-9750-3285"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u8d75\u666f\u5b8f","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Jinghong Zhao","orcid":"https://orcid.org/0000-0001-6895-2743","observed_orcids":["https://orcid.org/0000-0001-6895-2743"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jinghong Zhao","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6895-2743","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0722067,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.9819999933242798},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9580000042915344},{"id":"https://openalex.org/keywords/hyperphosphatemia","display_name":"hyperphosphatemia","score":0.9139999747276306},{"id":"https://openalex.org/keywords/vascular-calcification","display_name":"vascular calcification","score":0.871999979019165},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.9919999837875366},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.8450000286102295},{"id":"https://openalex.org/keywords/pyrrolidine-dithiocarbamate","display_name":"pyrrolidine dithiocarbamate","score":0.8799999952316284},{"id":"https://openalex.org/keywords/bmp-2","display_name":"BMP-2","score":0.7879999876022339},{"id":"https://openalex.org/keywords/runx2","display_name":"Runx2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/sm22alpha","display_name":"SM22\u03b1","score":0.9819999933242798},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.777999997138977},{"id":"https://openalex.org/keywords/phosphate-induced-calcification","display_name":"phosphate-induced calcification","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C2780983412","wikidata":"https://www.wikidata.org/wiki/Q7263769","display_name":"Pyrrolidine dithiocarbamate","level":4,"score":0.9508582353591919},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.7555068731307983},{"id":"https://openalex.org/C2776363554","wikidata":"https://www.wikidata.org/wiki/Q14907085","display_name":"RUNX2","level":4,"score":0.7055409550666809},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.5745031833648682},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.5689208507537842},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4970298111438751},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.4969311058521271},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.47315749526023865},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.44483301043510437},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.44142210483551025},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.43384888768196106},{"id":"https://openalex.org/C30352789","wikidata":"https://www.wikidata.org/wiki/Q14903153","display_name":"Bone morphogenetic protein 2","level":3,"score":0.4249570071697235},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.40825119614601135},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37531399726867676},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3660730719566345},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3121436834335327},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2513071596622467},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.187371164560318},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.16109997034072876},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11391186714172363},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.09856921434402466},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.0},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2621924249","doi":"https://doi.org/10.16016/j.1000-5404.201610128","is_oa":false,"landing_page_url":"http://aammt.tmmu.edu.cn/Upload/rhtml/201610128.htm","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2772674286","https://openalex.org/W2341132171","https://openalex.org/W3029381143","https://openalex.org/W1972259310","https://openalex.org/W3116267821","https://openalex.org/W7035200065","https://openalex.org/W4407789858","https://openalex.org/W2382524125","https://openalex.org/W2092661616","https://openalex.org/W3025920087"],"abstract_inverted_index":{"\u76ee\u7684\u63a2\u8ba8Toll\u6837\u53d7\u4f534":[0],"(Toll-like":[1],"receptor":[2],"4\uff0cTLR4)/\u6838\u8f6c\u5f55\u56e0\u5b50-\u03baB":[3],"(nuclear":[4],"transcription":[5,32],"factor":[6,33],"\u03baB\uff0cNF-\u03baB)":[7],"\u4fe1\u53f7\u901a\u8def\u5bf9\u9ad8\u78f7\u8bf1\u5bfc\u5c0f\u9f20\u8840\u7ba1\u5e73\u6ed1\u808c\u7ec6\u80de":[8],"(vascular":[9],"smooth":[10],"muscle":[11],"cells\uff0cVSMCs)":[12],"\u6210\u9aa8\u6837\u5206\u5316\u4ee5\u53ca\u8840\u7ba1\u9499\u5316\u8fc7\u7a0b\u7684\u5f71\u54cd\u3002\n":[13],"\u65b9\u6cd5\u4f53\u5916\u57f9\u517b\u5c0f\u9f20\u8840\u7ba1\u5e73\u6ed1\u808c\u7ec6\u80de\u7cfb\u3002\u9996\u5148\u5c06\u5b9e\u9a8c\u5206\u4e3a\u6b63\u5e38\u5bf9\u7167\u7ec4\u548c\u9ad8\u78f7\u7ec4\uff0c\u89c2\u5bdf\u9ad8\u78f7\u5bf9VSMCs\u7684\u5f71\u54cd\uff1b\u5176\u6b21\u5206\u4e3a\u6b63\u5e38\u5bf9\u7167\u7ec4\u3001NF-\u03baB\u6291\u5236\u5242\u5421\u54af\u70f7\u4e8c\u786b\u4ee3\u6c28\u57fa\u7532\u9178\u916f":[15],"(pyrrolidine":[16],"dithiocarbamate\uff0cPDTC)":[17],"\u7ec4":[18],"(PDTC\u7ec4)\u3001\u9ad8\u78f7\u7ec4\u548c\u9ad8\u78f7+PDTC\u7ec4\uff0c\u89c2\u5bdfPDTC\u5bf9\u9ad8\u78f7\u8bf1\u5bfc\u7684VSMCs\u6210\u9aa8\u6837\u5206\u5316\u53ca\u9499\u5316\u7684\u6291\u5236\u4f5c\u7528\uff1b\u6700\u540e\u5206\u4e3a\u6b63\u5e38\u5bf9\u7167\u7ec4\u3001\u6b63\u5e38\u5bf9\u7167+control":[19],"siRNA\u7ec4\u3001\u6b63\u5e38\u5bf9\u7167+TLR4":[20],"siRNA\u7ec4\u3001\u9ad8\u78f7\u7ec4\u3001\u9ad8\u78f7+control":[21],"siRNA\u7ec4\u3001\u9ad8\u78f7+TLR":[22],"siRNA\u7ec4\uff0c\u89c2\u5bdfTLR4\u57fa\u56e0\u7684\u5c0f\u5206\u5b50\u5e72\u6270RNA":[23],"(siRNA)":[24],"\u5bf9\u9ad8\u78f7\u8bf1\u5bfc\u7684VSMCs\u6210\u9aa8\u6837\u5206\u5316\u53ca\u9499\u5316\u7684\u6291\u5236\u4f5c\u7528\u3002\u91c7\u7528\u831c\u7d20\u7ea2S\u67d3\u8272\u89c2\u5bdf\u9ad8\u78f7\u5bf9\u7ec6\u80de\u9499\u76d0\u6c89\u79ef\u7684\u5f71\u54cd\uff0cWestern":[25],"blot\u68c0\u6d4bTLR4\u3001p-NF-\u03baB\u3001SM22\u03b1\u3001\u9aa8\u5f62\u6001\u53d1\u751f\u86cb\u767d2":[26],"(bone":[27],"morphogenic":[28],"protein2,":[29],"BMP2)\u3001Runt\u76f8\u5173\u8f6c\u5f55\u56e0\u5b502":[30],"(runt-related":[31],"2\uff0cRunx2)":[34],"\u7684\u8868\u8fbe\u53d8\u5316\u3002\n":[35],"\u7ed3\u679c\u4e0e\u6b63\u5e38\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0c\u9ad8\u78f7\u5904\u7406\u540e\uff0cVSMCs\u7684\u9499\u76d0\u6c89\u79ef\u660e\u663e\u589e\u591a[(0.079\u00b10.011)":[37],"vs":[38,43,48,52,57,63,67,76],"(0.193\u00b1":[39],"0.017)\uff0cP":[40],"<":[41,45,50,54,59,65,69,72,78],"0.01]\uff0cTLR4[(0.228\u00b10.008)":[42],"(0.526\u00b10.017)\uff0cP":[44],"0.01]\u3001p-NF-\u03baB":[46],"[(0.271\u00b10.003)":[47],"(0.454\u00b10.008)\uff0cP":[49],"0.01]\u86cb\u767d\u7684\u8868\u8fbe\u660e\u663e\u5347\u9ad8\uff0c\u4e0e\u6210\u9aa8\u6837\u5206\u5316\u53ca\u9499\u5316\u76f8\u5173\u7684BMP2\u3001Runx2\u86cb\u767d\u8868\u8fbe\u4ea6\u660e\u663e\u5347\u9ad8\uff0c\u800c\u5e73\u6ed1\u808c\u7ec6\u80de\u6807\u5fd7\u7269SM22\u03b1\u8868\u8fbe\u5219\u51cf\u5c11\uff1b\u52a0\u5165PDTC\u5904\u7406\u540e\uff0c\u9ad8\u78f7\u72b6\u6001\u4e0b\u7684VSMCs\u7684\u9499\u76d0\u6c89\u79ef\u660e\u663e\u964d\u4f4e[(0.121\u00b10.013)":[51],"(0.217\u00b10.031)\uff0cP":[53],"0.01]\uff0cp-NF-\u03baB":[55],"[(0.094\u00b10.006)":[56],"(0.380\u00b10.009)\uff0cP":[58],"0.01]\u8868\u8fbe\u660e\u663e\u53d7\u6291\u5236\uff0cBMP2\u548cRUNX2\u8868\u8fbe\u660e\u663e\u4e0b\u964d\uff0c\u800cSM22\u03b1\u7684\u8868\u8fbe\u5219\u660e\u663e\u4e0a\u8c03\uff1b\u9ad8\u78f7\u72b6\u6001\u4e0b\uff0c\u5e94\u7528TLR4":[60],"siRNA\u8f6c\u67d3VSMCs\u540e\uff0cVSMCs\u7684TLR4":[61],"[(0.117\u00b10.047)":[62],"(0.377\u00b10.012)\uff0cP":[64],"0.01]\u8868\u8fbe\u660e\u663e\u53d7\u6291\u5236\uff0c\u540c\u6837\uff0cp-NF-\u03baB[(0.264\u00b10.013)":[66],"(0.601\u00b10.027)\uff0cP":[68],"0.01]\u7684\u8868\u8fbe\u4ea6\u660e\u663e\u4e0b\u964d\uff0cBMP2\u548cRunx2":[70],"(P":[71],"0.01)":[73],"\u86cb\u767d\u7684\u8868\u8fbe\u660e\u663e\u53d7\u6291\uff0c\u800cSM22\u03b1":[74],"[(0.321\u00b10.011)":[75],"(0.194\u00b10.004)\uff0cP":[77],"0.01]\u7684\u8868\u8fbe\u5219\u660e\u663e\u4e0a\u5347\u3002\n":[79],"\u7ed3\u8bba\u9ad8\u78f7\u53ef\u80fd\u901a\u8fc7TLR4/NF-\u03baB\u4fe1\u53f7\u901a\u8def\u8bf1\u5bfcVSMCs\u6210\u9aa8\u6837\u5206\u5316\u53ca\u9499\u5316\u3002":[81]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2017-06-15T00:00:00"}